2024
Meningeal lymphatic vessel dysfunction driven by CGRP signaling causes migraine-like pain in mice
Thomas J, Schindler E, Gottschalk C. Meningeal lymphatic vessel dysfunction driven by CGRP signaling causes migraine-like pain in mice. Journal Of Clinical Investigation 2024, 134: e182556. PMID: 39087472, PMCID: PMC11290958, DOI: 10.1172/jci182556.Peer-Reviewed Original ResearchConceptsBlocking CGRP signalingCGRP receptor componentsMigraine-like painCervical lymph nodesGap junction proteinPrimary headache disordersLymphatic vessel dysfunctionAcute migrainePharmacological blockadeLymph nodesHeadache disordersNeurological symptomsJunction proteinsCGRPLymphatic vesselsMeningeal lymphatic vesselsInducible knockoutVessel dysfunctionMigraineReceptor componentsHeadachePainPathophysiologyDysfunctionMice
2021
Cluster Headache: Clinical Characteristics and Opportunities to Enhance Quality of Life
Grinberg AS, Best RD, Min KM, Schindler EAD, Koo BB, Sico JJ, Seng EK. Cluster Headache: Clinical Characteristics and Opportunities to Enhance Quality of Life. Current Pain And Headache Reports 2021, 25: 65. PMID: 34668084, DOI: 10.1007/s11916-021-00979-8.Peer-Reviewed Original ResearchConceptsQuality of lifeCluster headacheCommon psychiatric comorbiditiesCurrent clinical carePsychological treatmentPrimary headache disordersRecent FindingsPeopleClinical characteristicsSevere painPsychiatric comorbidityDisease burdenHeadache disordersClinical careDepressive symptomsGeneral populationHeadacheSuicidal ideationAutonomic featuresBehavioral interventionsCommitment TherapyPsychological factorsTreatmentBurdenComorbiditiesPain