Elise Liu, MD, PhD
Cards
About
Research
Publications
2024
Dendritic Cells in Food Allergy, Treatment, and Tolerance
Liu E, Yin X, Siniscalco E, Eisenbarth S. Dendritic Cells in Food Allergy, Treatment, and Tolerance. Journal Of Allergy And Clinical Immunology 2024 PMID: 38971539, DOI: 10.1016/j.jaci.2024.06.017.Peer-Reviewed Original ResearchAntigen presenting cellsDendritic cellsFood allergyOral tolerancePresenting cellsAllergic sensitizationPeripheral T regulatory cellsDevelopment of oral toleranceGut dendritic cellsT regulatory cellsDendritic cell subsetsLimited treatment optionsAdaptive immune responsesFood immunotherapyEpicutaneous immunotherapyCell subsetsTolerogenic programAlarmin releaseTreatment optionsLangerhans cellsFood toleranceInnocuous antigensSurface markersInflammatory conditionsImmune response- Liu, E.G., Tan, J., Munoz, J.S., Shabanova, V., Eisenbarth, S.C., Leeds, S. Food matrix composition affects the allergenicity of baked egg products. J Allergy Clin Immunol Pract, 2024.Peer-Reviewed Original Research In Press
Food Matrix Composition Affects the Allergenicity of Baked Egg Products
Liu E, Tan J, Munoz J, Shabanova V, Eisenbarth S, Leeds S. Food Matrix Composition Affects the Allergenicity of Baked Egg Products. The Journal Of Allergy And Clinical Immunology In Practice 2024 PMID: 38670261, DOI: 10.1016/j.jaip.2024.04.032.Peer-Reviewed Original ResearchEgg allergensEgg productionFood matricesExtract ovalbuminFood matrix compositionAllergenicity of eggBaked eggMuffin recipeQuantify ovalbuminRice muffinsRice flourWheat flourBlocking ELISAWheat muffinsFood ingredientsMuffinsHeated eggEgg proteinsEgg-allergic patientsWheatEggsFood allergic reactionsReduced allergenicityFlourFoodNovel and emerging tests for food allergy
Liu E, Eisenbarth S. Novel and emerging tests for food allergy. 2024, 698-709. DOI: 10.1016/b978-0-323-96018-2.00081-x.Peer-Reviewed Original ResearchFood allergyActivation testingSkin prick testingRisk of developmentAvailable clinical testsSkin barrier permeabilityLow predictive valueInflammatory markersPrick testingIgE testingImmunoglobulin EBarrier permeabilityAllergyPromising biomarkerPredictive valueClinical testsGenetic testingLack of testingCellular profilingMarkersWidespread useTestingImmunoglobulinBiomarkersSeverity
2023
Metabolic fitness of IgA+ plasma cells in the gut requires DOCK8
Zhang B, Chen S, Yin X, McBride C, Gertie J, Yurieva M, Bielecka A, Hoffmann B, Hinson J, Grassmann J, Xu L, Siniscalco E, Soldatenko A, Hoyt L, Joseph J, Norton E, Uthaman G, Palm N, Liu E, Eisenbarth S, Williams A. Metabolic fitness of IgA+ plasma cells in the gut requires DOCK8. Mucosal Immunology 2023, 17: 431-449. PMID: 38159726, DOI: 10.1016/j.mucimm.2023.12.001.Peer-Reviewed Original ResearchPlasma cellsLamina propriaT cell-dependent antigensCytokinesis 8 (DOCK8) mutationsDOCK8-deficient miceMucosal IgA productionRecurrent gastrointestinal infectionGut lamina propriaPoor antibody responseIgA class switchingAntigen-specific IgAEarly B cell activationLong-term survivalB cell activationGut IgAFood antigensAntibody responseIgA productionImmune homeostasisGastrointestinal infectionsPrimary immunodeficiencyT cellsPC compartmentB cellsCell activation
2022
Food-specific immunoglobulin A does not correlate with natural tolerance to peanut or egg allergens
Liu E, Zhang B, Martin V, Anthonypillai J, Kraft M, Grishin A, Grishina G, Catanzaro J, Chinthrajah S, Sindher T, Manohar M, Quake A, Nadeau K, Burks A, Kim E, Kulis M, Henning A, Jones S, Leung D, Sicherer S, Wood R, Yuan Q, Shreffler W, Sampson H, Shabanova V, Eisenbarth S. Food-specific immunoglobulin A does not correlate with natural tolerance to peanut or egg allergens. Science Translational Medicine 2022, 14: eabq0599. PMID: 36383680, PMCID: PMC10219469, DOI: 10.1126/scitranslmed.abq0599.Peer-Reviewed Original ResearchConceptsPeanut allergyFood allergyEpitope specificityPredominant antibody isotypePeanut-specific IgEDifferent epitope specificitiesSimilar epitope specificityAtopic childrenEgg allergyOral toleranceAllergic infantsImmune exclusionEgg toleranceAntibody isotypesImmunoglobulin ACommensal floraSeparate cohortAllergyEgg allergensInfant stoolHealthy adultsIgAProtective roleOlder childrenChildren
2021
Surplus sterols suppress Salmonella -specific IgA
Liu E, Eisenbarth S. Surplus sterols suppress Salmonella -specific IgA. Science Immunology 2021, 6 DOI: 10.1126/sciimmunol.abn3793.Commentaries, Editorials and LettersOral anaphylaxis to peanut in a mouse model is associated with gut permeability but not with Tlr4 or Dock8 mutations
Gertie JA, Zhang B, Liu EG, Hoyt LR, Yin X, Xu L, Long LL, Soldatenko A, Gowthaman U, Williams A, Eisenbarth SC. Oral anaphylaxis to peanut in a mouse model is associated with gut permeability but not with Tlr4 or Dock8 mutations. Journal Of Allergy And Clinical Immunology 2021, 149: 262-274. PMID: 34051223, PMCID: PMC8626534, DOI: 10.1016/j.jaci.2021.05.015.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAnimalsArachisDisease Models, AnimalFemaleGastrointestinal MicrobiomeGenetic Predisposition to DiseaseGuanine Nucleotide Exchange FactorsIntestinal MucosaMaleMice, Inbred C3HMice, Inbred C57BLMutationPassive Cutaneous AnaphylaxisPeanut HypersensitivityPermeabilitySpecies SpecificityToll-Like Receptor 4ConceptsC3H/HeJ miceGut permeabilityHeJ miceOral anaphylaxisPeanut challengeFood allergyMouse modelToll-like receptor 4BALB/c miceCytokinesis 8 (DOCK8) mutationsEnhanced gut permeabilityOral peanut challengesDOCK8 functionIngested allergenImmunologic mechanismsAnaphylaxis responsesImmunologic pathwaysAllergic diseasesC57BL/6 micePeanut allergyAntibody responseC miceReceptor 4DOCK8 mutationsIntraperitoneal challengeWheat oral immunotherapy
Leeds S, Liu EG, Nowak-Wegrzyn A. Wheat oral immunotherapy. Current Opinion In Allergy And Clinical Immunology 2021, 21: 269-277. PMID: 33840798, DOI: 10.1097/aci.0000000000000743.Peer-Reviewed Original ResearchConceptsWheat oral immunotherapyOral immunotherapyMaintenance dosesSevere reactionsFood allergy epidemiologyLow maintenance dosesNonrandomized clinical trialRisk of reactionSustained unresponsivenessSuccessful desensitizationAdjunct therapeuticsFood allergyTrial protocolClinical trialsAllergic reactionsAllergy epidemiologyHuman trialsSafety outcomesHead comparisonAugmenting factorSmall sample sizeTrialsFood modificationImmunotherapyDosesThe role of immunoglobulin A in oral tolerance and food allergy
Pier J, Liu EG, Eisenbarth S, Järvinen KM. The role of immunoglobulin A in oral tolerance and food allergy. Annals Of Allergy Asthma & Immunology 2021, 126: 467-468. PMID: 33548469, PMCID: PMC8102345, DOI: 10.1016/j.anai.2021.01.028.Peer-Reviewed Original Research
Academic Achievements and Community Involvement
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Board Certifications
Allergy & Immunology
- Certification Organization
- AB of Allergy & Immunology
- Original Certification Date
- 2021
Links & Media
News
- April 22, 2024
Beyond Weight Loss: Five Yale Experts on the Benefits of Exercise
- March 19, 2024Source: Prevention
10 Food Allergy Symptoms in Adults, and How to Treat and Prevent a Reaction
- February 26, 2024
Elise Liu Receives 2024 AAAAI Foundation Faculty Development Award
- May 08, 2023
Liu Wins ASCI Emerging-Generation Award