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Eduardo Groisman, PhD

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Waldemar Von Zedtwitz Professor of Microbial Pathogenesis



Waldemar Von Zedtwitz Professor of Microbial Pathogenesis


I am a geneticist who studies the mechanisms that enable bacteria to cause disease and to further human health. I received a MS in Biochemistry from the University of Buenos Aires and a PhD from the University of Chicago. After spending 20 years in the faculty of the Washington University School of Medicine, I joined the Yale School of Medicine in 2010. For 19 years, I was a member of the Howard Hughes Medical Institute.


Education & Training

University of Chicago (1986)
University of Buenos Aires (1980)



Our research seeks answers to a fundamental biological question: How does an organism know when, where and for long to turn a gene on or off? We address this question by investigating bacterial species that establish intimate interactions with animal hosts.

All organisms respond to a change in their environment by modifying their behavior. We are interested in identifying the specific signals that denote a given environment, the nature of the sensors that detect such signals, and how the sensors transmit this information to the regulators implementing a response that enables the organism to survive and prosper in the new condition.

We investigate the gastroenteritis- and typhoid fever-causing Salmonella entericaand the gut symbiotic bacteria Escherichia coli and Bacteroides thetaiotaomicron.

We have been examining protein sensors that detect extracellular signals and RNA sensors that monitor cellular metabolites and ions. These investigations led both to the discovery of the first signal transduction systems that sense extracytoplasmic magnesium and ferric iron and to the first mRNAs that respond to cytoplasmic magnesium and ATP.

Our research focuses on understanding:

  • how bacteria integrate multiple signals into a cellular response,
  • the mechanisms by which a given signal elicits distinct responses from co-regulated targets,
  • how bacteria from the gut microbiome compete for resources,
  • the genetic basis for phenotypic differences that distinguish closely related bacterial species, such as a pathogen and a symbiont,
  • the biochemical function of novel proteins and
  • the genetic control of virulence factors.

Medical Subject Headings (MeSH)

Biological Evolution; Ecology; Genetics; Infectious Disease Medicine; Microbiota; Signal Transduction

Research at a Glance

Yale Co-Authors

Frequent collaborators of Eduardo Groisman's published research.





Academic Achievements and Community Involvement

  • honor


  • honor

    Junior Faculty Research Award

  • honor

    Research Career Development Award

  • honor

    Elected to Fellowship

  • honor

    Elected to Fellowship

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