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FEDS: a Novel Fluorescence-Based High-Throughput Method for Measuring DNA Supercoiling In Vivo.

Map of SupR, a supercoiling reporter plasmid for enterobacteria.

A Physiological Basis for Nonheritable Antibiotic Resistance.The BT4338 regulon in bacteria experiencing carbon limitation.

The three core cellular processes (chromosome replication, transcription, and translation) and coregulatory relationships among them.

A Master Regulator of Bacteroides Thetaiotaomicron Gut Colonization Controls Carbohydrate Utilization and an Alternative Protein Synthesis Factor.

The BT4338 regulon in bacteria experiencing carbon limitation.

Activator of One Protease Transforms Into Inhibitor of Another in Response to Nutritional Signals.

Acetyl-CoA-promoted acetylation of the HspQ protein increases the specificity of the Lon and ClpAP proteases.

The Expanded Specificity and Physiological Role of a Widespread N-degron Recognin.

Candidate ClpS substrates revealed by proteomics.

Salmonella Expresses Foreign Genes During Infection by Degrading Their Silencer.

Salmonella expresses horizontally transferred genes by degrading their silencer, H-NS. HTGs are transcriptionally repressed by H-NS, which binds to their regulatory regions.

Dietary sugar silences a colonization factor in a mammalian gut symbiont.

Dietary components are believed to influence the composition of the gut microbiota by serving as nutrients to a subset of microbes, thereby favoring their expansion. However, we now report that dietary fructose and glucose, which are prevalent in the Western diet, specifically silence a protein that is necessary for gut colonization, but not for utilization of these sugars, by the human gut commensal Bacteroides thetaiotaomicron. Our findings underscore a role for dietary sugars that escape absorption by the host intestine and reach the microbiota: regulation of gut colonization by beneficial microbes independently of supplying nutrients to the microbiota.