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Activator of One Protease Transforms Into Inhibitor of Another in Response to Nutritional Signals.

Acetyl-CoA-promoted acetylation of the HspQ protein increases the specificity of the Lon and ClpAP proteases.

The Expanded Specificity and Physiological Role of a Widespread N-degron Recognin.

Candidate ClpS substrates revealed by proteomics.

Salmonella Expresses Foreign Genes During Infection by Degrading Their Silencer.

Salmonella expresses horizontally transferred genes by degrading their silencer, H-NS. HTGs are transcriptionally repressed by H-NS, which binds to their regulatory regions.

Dietary sugar silences a colonization factor in a mammalian gut symbiont.

Dietary components are believed to influence the composition of the gut microbiota by serving as nutrients to a subset of microbes, thereby favoring their expansion. However, we now report that dietary fructose and glucose, which are prevalent in the Western diet, specifically silence a protein that is necessary for gut colonization, but not for utilization of these sugars, by the human gut commensal Bacteroides thetaiotaomicron. Our findings underscore a role for dietary sugars that escape absorption by the host intestine and reach the microbiota: regulation of gut colonization by beneficial microbes independently of supplying nutrients to the microbiota.