2024
The thermoneutral zone in women takes an “arctic” shift compared to men
Brychta R, McGehee S, Huang S, Leitner B, Duckworth C, Fletcher L, Kim K, Cassimatis T, Israni N, Lea H, Lentz T, Pierce A, Jiang A, LaMunion S, Thomas R, Ishihara A, Courville A, Yang S, Reitman M, Cypess A, Chen K. The thermoneutral zone in women takes an “arctic” shift compared to men. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2311116121. PMID: 38683977, PMCID: PMC11087792, DOI: 10.1073/pnas.2311116121.Peer-Reviewed Original Research
2019
Quantification of the Capacity for Cold-Induced Thermogenesis in Young Men With and Without Obesity
Brychta RJ, Huang S, Wang J, Leitner BP, Hattenbach JD, Bell SL, Fletcher LA, Wood R, Idelson CR, Duckworth CJ, McGehee S, Courville AB, Bernstein SB, Reitman ML, Cypess AM, Chen KY. Quantification of the Capacity for Cold-Induced Thermogenesis in Young Men With and Without Obesity. The Journal Of Clinical Endocrinology & Metabolism 2019, 104: 4865-4878. PMID: 31150063, PMCID: PMC6733495, DOI: 10.1210/jc.2019-00728.Peer-Reviewed Original ResearchConceptsCold-induced thermogenesisLean menEnergy expenditureBrown fatBrown fat activitySkeletal muscle activityOvert shiveringInpatient protocolLean subjectsObesityTreatment opportunitiesMuscle activityFat activityBasal metabolic rateSkin temperature changesCold exposureNonshivering thermogenesisBasal heat productionYoung menMenThermogenesisFurther studiesRoom calorimeterFatMetabolic rate
2018
Regulation of Human Adipose Tissue Activation, Gallbladder Size, and Bile Acid Metabolism by a β3-Adrenergic Receptor Agonist
Baskin AS, Linderman JD, Brychta RJ, McGehee S, Anflick-Chames E, Cero C, Johnson JW, O'Mara AE, Fletcher LA, Leitner BP, Duckworth CJ, Huang S, Cai H, Garraffo HM, Millo CM, Dieckmann W, Tolstikov V, Chen EY, Gao F, Narain NR, Kiebish MA, Walter PJ, Herscovitch P, Chen KY, Cypess AM. Regulation of Human Adipose Tissue Activation, Gallbladder Size, and Bile Acid Metabolism by a β3-Adrenergic Receptor Agonist. Diabetes 2018, 67: db180462. PMID: 29980535, PMCID: PMC6152342, DOI: 10.2337/db18-0462.Peer-Reviewed Original ResearchMeSH KeywordsAcetanilidesAdipose Tissue, BrownAdolescentAdrenergic beta-AgonistsAdultAgedAged, 80 and overAnimalsBile Acids and SaltsGallbladderHealthy VolunteersHumansMiceMice, Inbred C57BLMiddle AgedReceptors, Adrenergic, betaReceptors, Adrenergic, beta-3RNA, MessengerThermogenesisThiazolesYoung AdultConceptsBile acid metabolismΒ3-adrenergic receptor agonistBrown adipose tissueReceptor agonistGallbladder sizeSelective β3-AR agonistΒ3-AR agonist mirabegronPositron emission tomography/White adipose tissue lipolysisUrinary bladder relaxationΒ3-AR mRNADose-proportional increaseDoses of placeboObesity-related complicationsBAT metabolic activityEmission tomography/Adipose tissue lipolysisHuman β3-ARAcid metabolismΒ3-AR agonistConjugated bile acidsGallbladder relaxationBladder relaxationOveractive bladderHealthy menKinetics of human brown adipose tissue activation and deactivation
Leitner BP, Weiner LS, Desir M, Kahn PA, Selen DJ, Tsang C, Kolodny GM, Cypess AM. Kinetics of human brown adipose tissue activation and deactivation. International Journal Of Obesity 2018, 43: 633-637. PMID: 29795459, PMCID: PMC6252171, DOI: 10.1038/s41366-018-0104-3.Peer-Reviewed Original ResearchConceptsBrown adipose tissueBAT volumeMetabolic diseasesBrown adipose tissue activationActive brown adipose tissueCold exposureHuman BAT thermogenesisBAT glucose uptakePrevention of obesityPET/CT imagingBAT activationBAT thermogenesisClinical trialsAdipose tissueHealthy adultsCold stimulationTissue activationCT imagingGlucose uptakeDuration of stimuliPotential targetCessation of coolingObesityDiseaseActivation