Brooks Leitner, PhD, MD
he/him/his
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Research
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Featured Publications
Multimodal analysis suggests differential immuno-metabolic crosstalk in lung squamous cell carcinoma and adenocarcinoma
Leitner BP, Givechian KB, Ospanova S, Beisenbayeva A, Politi K, Perry RJ. Multimodal analysis suggests differential immuno-metabolic crosstalk in lung squamous cell carcinoma and adenocarcinoma. Npj Precision Oncology 2022, 6: 8. PMID: 35087143, PMCID: PMC8795406, DOI: 10.1038/s41698-021-00248-2.Peer-Reviewed Original ResearchNon-small cell lung cancerLung squamous cell carcinomaBody mass indexSquamous cell carcinomaLung adenocarcinomaHigher glucose uptakeVisceral adiposityVisceral fatCell carcinomaLung cancerGlucose uptakeTreatment of NSCLCHigher body mass indexTumor-infiltrating T cellsImmune checkpoint inhibitionCell lung cancerHigh visceral fatPET/CT imagingTumors of patientsPrecision therapy approachesTumor glucose uptakePrecision medicine approachLUSC tumorsPrognostic gene expressionAdjunct therapyInsulin and cancer: a tangled web
Leitner BP, Siebel S, Akingbesote ND, Zhang X, Perry RJ. Insulin and cancer: a tangled web. Biochemical Journal 2022, 479: 583-607. PMID: 35244142, PMCID: PMC9022985, DOI: 10.1042/bcj20210134.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsRepresentation of American Indian and Alaska Native Individuals in Academic Medical Training
Forrest LL, Leitner BP, Guzman C, Brodt E, Odonkor CA. Representation of American Indian and Alaska Native Individuals in Academic Medical Training. JAMA Network Open 2022, 5: e2143398. PMID: 35024836, PMCID: PMC8759009, DOI: 10.1001/jamanetworkopen.2021.43398.Peer-Reviewed Original ResearchWhite and Brown Adipose Tissue in Obesity and Diabetes
Leitner B, Martinez-Tellez B. White and Brown Adipose Tissue in Obesity and Diabetes. 2020, 55-69. DOI: 10.1007/978-3-030-53370-0_5.ChaptersWhite adipose tissueBrown adipose tissueAdipose tissueTotal body massSevere insulin resistanceAdipose tissue typesEnergy storage tissueBody massInsulin resistanceObese humansImmune regulationFunctional roleType 2Hormone productionNoninvasive imagingPotential mechanismsEnergy expenditureObesityDiabetesRecent scientific advancesTissueDynamic tissueHuman energy expenditureHuman physiologyFuture investigationsMapping of human brown adipose tissue in lean and obese young men
Leitner BP, Huang S, Brychta RJ, Duckworth CJ, Baskin AS, McGehee S, Tal I, Dieckmann W, Gupta G, Kolodny GM, Pacak K, Herscovitch P, Cypess AM, Chen KY. Mapping of human brown adipose tissue in lean and obese young men. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 8649-8654. PMID: 28739898, PMCID: PMC5559032, DOI: 10.1073/pnas.1705287114.Peer-Reviewed Original ResearchConceptsBrown adipose tissueHuman brown adipose tissueAdipose tissueActivity of BATPositron emission tomography/computerized tomographyTomography/computerized tomographyActivated Brown Adipose TissueFluorodeoxyglucose positron emission tomography/computerized tomographyActive brown adipose tissueCold exposureSpecific adipose depotsObese young menHealthy young menYoung menAcute cold exposureLean menObese menBAT volumeTotal body massThermogenic potentialAdipose depotsAnatomic characteristicsFascial layersMetabolic diseasesComputerized tomographyTissue-specific reprogramming of glutamine metabolism maintains tolerance to sepsis
Leitner B, Lee W, Zhu W, Zhang X, Gaspar R, Li Z, Rabinowitz J, Perry R. Tissue-specific reprogramming of glutamine metabolism maintains tolerance to sepsis. PLOS ONE 2023, 18: e0286525. PMID: 37410734, PMCID: PMC10325078, DOI: 10.1371/journal.pone.0286525.Peer-Reviewed Original ResearchConceptsTCA cycle anaplerosisGlobal mitochondrial dysfunctionAromatic amino acid transportAmino acid transportTissue-specific metabolic responsesMurine polymicrobial sepsis modelMetabolic signaturesAntioxidant metabolismGlutathione biosynthesisMitochondrial metabolismTCA cycleGreat therapeutic interestEnergetic demandsPolymicrobial sepsis modelAntioxidant synthesisUnique metabolic signatureGlutamine metabolismMitochondrial dysfunctionAcid transportMuscle transcriptomicsGlutathione cyclingATP ratioIsotope tracingCritical illnessReduced expressionProteomic profiling demonstrates inflammatory and endotheliopathy signatures associated with impaired cardiopulmonary exercise hemodynamic profile in Post Acute Sequelae of SARS‐CoV‐2 infection (PASC) syndrome
Singh I, Leitner B, Wang Y, Zhang H, Joseph P, Lutchmansingh D, Gulati M, Possick J, Damsky W, Hwa J, Heerdt P, Chun H. Proteomic profiling demonstrates inflammatory and endotheliopathy signatures associated with impaired cardiopulmonary exercise hemodynamic profile in Post Acute Sequelae of SARS‐CoV‐2 infection (PASC) syndrome. Pulmonary Circulation 2023, 13: e12220. PMID: 37091121, PMCID: PMC10113513, DOI: 10.1002/pul2.12220.Peer-Reviewed Original ResearchInvasive cardiopulmonary exercise testPASC patientsPost-acute sequelaeAcute sequelaeInfection syndromeUnexplained exertional intoleranceCardiopulmonary exercise testSystemic oxygen deliveryPersistent inflammatory stateVenous blood plasmaExertional intolerancePeak exerciseEndothelial dysfunctionHemodynamic profileInflammatory stateExercise testFibrotic processPathophysiological hallmarkAberrant protein expressionExpression of proteinsOxygen deliveryOxygen extractionProteomic profilingPatientsPhysiologic responses
2024
Small molecule inhibition of glycogen synthase I reduces muscle glycogen content and improves biomarkers in a mouse model of Pompe disease
Gaspar R, Sakuma I, Nasiri A, Hubbard B, LaMoia T, Leitner B, Tep S, Xi Y, Greene E, Ullman J, Petersen K, Shulman G. Small molecule inhibition of glycogen synthase I reduces muscle glycogen content and improves biomarkers in a mouse model of Pompe disease. AJP Endocrinology And Metabolism 2024 PMID: 39171753, DOI: 10.1152/ajpendo.00175.2024.Peer-Reviewed Original ResearchGAA-KO miceMouse model of Pompe diseaseModel of Pompe diseasePompe diseaseMetabolic dysregulationRegular chowMouse modelSmall molecule inhibitionInsulin sensitivityReduced spontaneous activityGroups of male miceEnzyme acid alpha-glucosidaseProgressive muscle weaknessImprove metabolic dysregulationSynthase IWhole-body insulin sensitivityAcid alpha-glucosidaseImproved glucose toleranceIncreased AMPK phosphorylationWT miceAbnormal accumulation of glycogenGlycogen storage disorderMale miceSpontaneous activityImproved biomarkersThe thermoneutral zone in women takes an “arctic” shift compared to men
Brychta R, McGehee S, Huang S, Leitner B, Duckworth C, Fletcher L, Kim K, Cassimatis T, Israni N, Lea H, Lentz T, Pierce A, Jiang A, LaMunion S, Thomas R, Ishihara A, Courville A, Yang S, Reitman M, Cypess A, Chen K. The thermoneutral zone in women takes an “arctic” shift compared to men. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2311116121. PMID: 38683977, PMCID: PMC11087792, DOI: 10.1073/pnas.2311116121.Peer-Reviewed Original Research
2023
Dichloroacetate as a novel pharmaceutical treatment for cancer-related fatigue in melanoma
Zhang X, Lee W, Leitner B, Zhu W, Fosam A, Li Z, Gaspar R, Halberstam A, Robles B, Rabinowitz J, Perry R. Dichloroacetate as a novel pharmaceutical treatment for cancer-related fatigue in melanoma. AJP Endocrinology And Metabolism 2023, 325: e363-e375. PMID: 37646579, PMCID: PMC10642987, DOI: 10.1152/ajpendo.00105.2023.Peer-Reviewed Original ResearchConceptsCancer-related fatigueNovel pharmaceutical treatmentsPhysical functionPharmaceutical treatmentTumor growthCancer treatmentStandard cancer treatmentTumor-bearing miceLate-stage tumorsEffective pharmaceutical treatmentMurine cancer modelsNew metabolic targetsMultiple cancer typesAdjuvant therapyCommon complicationPatients' qualitySymptom managementClinical trialsMurine modelPotential therapyPharmaceutical therapySmall molecule inhibitorsCancer modelDCA treatmentLactate concentration
News
News
- September 14, 2023
Organ Systems Respond Uniquely to Fight Sepsis
- April 27, 2023
Study Uncovers Reduced Exercise Tolerance and Other Changes in Long COVID
- January 11, 2023
Discoveries & Impact (January 2023)