Featured Publications
Mapping of human brown adipose tissue in lean and obese young men
Leitner BP, Huang S, Brychta RJ, Duckworth CJ, Baskin AS, McGehee S, Tal I, Dieckmann W, Gupta G, Kolodny GM, Pacak K, Herscovitch P, Cypess AM, Chen KY. Mapping of human brown adipose tissue in lean and obese young men. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 8649-8654. PMID: 28739898, PMCID: PMC5559032, DOI: 10.1073/pnas.1705287114.Peer-Reviewed Original ResearchMeSH KeywordsAdipose Tissue, BrownAdiposityAdultBody Mass IndexGlucose-6-PhosphateHumansMaleObesityPositron-Emission TomographyTomography, X-Ray ComputedConceptsBrown adipose tissueHuman brown adipose tissueAdipose tissueActivity of BATPositron emission tomography/computerized tomographyTomography/computerized tomographyActivated Brown Adipose TissueFluorodeoxyglucose positron emission tomography/computerized tomographyActive brown adipose tissueCold exposureSpecific adipose depotsObese young menHealthy young menYoung menAcute cold exposureLean menObese menBAT volumeTotal body massThermogenic potentialAdipose depotsAnatomic characteristicsFascial layersMetabolic diseasesComputerized tomography
2024
The thermoneutral zone in women takes an “arctic” shift compared to men
Brychta R, McGehee S, Huang S, Leitner B, Duckworth C, Fletcher L, Kim K, Cassimatis T, Israni N, Lea H, Lentz T, Pierce A, Jiang A, LaMunion S, Thomas R, Ishihara A, Courville A, Yang S, Reitman M, Cypess A, Chen K. The thermoneutral zone in women takes an “arctic” shift compared to men. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2311116121. PMID: 38683977, PMCID: PMC11087792, DOI: 10.1073/pnas.2311116121.Peer-Reviewed Original Research
2020
Chronic mirabegron treatment increases human brown fat, HDL cholesterol, and insulin sensitivity
O'Mara A, Johnson J, Linderman J, Brychta R, McGehee S, Fletcher L, Fink Y, Kapuria D, Cassimatis T, Kelsey N, Cero C, Sater Z, Piccinini F, Baskin A, Leitner B, Cai H, Millo C, Dieckmann W, Walter M, Javitt N, Rotman Y, Walter P, Ader M, Bergman R, Herscovitch P, Chen K, Cypess A. Chronic mirabegron treatment increases human brown fat, HDL cholesterol, and insulin sensitivity. Journal Of Clinical Investigation 2020, 130: 2209-2219. PMID: 31961826, PMCID: PMC7190915, DOI: 10.1172/jci131126.Peer-Reviewed Original ResearchConceptsBAT metabolic activityIntravenous glucose tolerance testGlucose tolerance testΒ3-AR agonistInsulin sensitivityTolerance testMetabolic diseasesObesity-related metabolic diseasesWhite adipose tissue lipolysisBrown adipose tissue thermogenesisOpen-label studyTotal bile acidsHuman brown fatHigher insulin sensitivityAdipose tissue lipolysisAdipose tissue thermogenesisPET/CTΒ3-adrenergic receptor agonistIntramural Research ProgramChronic pharmacological stimulationMetabolic activityMirabegron therapyMirabegron treatmentPrimary endpointSecondary endpointsSexual Dimorphisms in Adult Human Brown Adipose Tissue
Fletcher L, Kim K, Leitner B, Cassimatis T, O’Mara A, Johnson J, Halprin M, McGehee S, Brychta R, Cypess A, Chen K. Sexual Dimorphisms in Adult Human Brown Adipose Tissue. Obesity 2020, 28: 241-246. PMID: 31970907, PMCID: PMC6986330, DOI: 10.1002/oby.22698.Peer-Reviewed Original ResearchMeSH KeywordsAdipose Tissue, BrownAdiposityAdolescentAdultFemaleFluorodeoxyglucose F18HumansMaleObesitySex CharacteristicsYoung AdultConceptsBrown adipose tissueF-fluorodeoxyglucose uptakeBAT volumeAdipose tissueAdult human brown adipose tissueCold-activated brown adipose tissueInterscapular brown adipose tissueGlucose uptakeTotal BAT volumeHuman brown adipose tissueBAT glucose uptakeBody weight regulationPositron emission tomographyOvert shiveringDistribution of BATLean womenAnatomical distributionBAT depotsWeight regulationHours of exposureHuman newbornsComputerized tomographyEmission tomographyYoung womenWomen
2019
Quantification of the Capacity for Cold-Induced Thermogenesis in Young Men With and Without Obesity
Brychta RJ, Huang S, Wang J, Leitner BP, Hattenbach JD, Bell SL, Fletcher LA, Wood R, Idelson CR, Duckworth CJ, McGehee S, Courville AB, Bernstein SB, Reitman ML, Cypess AM, Chen KY. Quantification of the Capacity for Cold-Induced Thermogenesis in Young Men With and Without Obesity. The Journal Of Clinical Endocrinology & Metabolism 2019, 104: 4865-4878. PMID: 31150063, PMCID: PMC6733495, DOI: 10.1210/jc.2019-00728.Peer-Reviewed Original ResearchMeSH KeywordsAdipose Tissue, BrownAdolescentAdultBasal MetabolismBody CompositionBody Mass IndexCold TemperatureEnergy MetabolismHumansMaleObesityThermogenesisYoung AdultConceptsCold-induced thermogenesisLean menEnergy expenditureBrown fatBrown fat activitySkeletal muscle activityOvert shiveringInpatient protocolLean subjectsObesityTreatment opportunitiesMuscle activityFat activityBasal metabolic rateSkin temperature changesCold exposureNonshivering thermogenesisBasal heat productionYoung menMenThermogenesisFurther studiesRoom calorimeterFatMetabolic rateWhole Body and Regional Quantification of Active Human Brown Adipose Tissue Using 18F-FDG PET/CT.
Kim K, Huang S, Fletcher LA, O'Mara AE, Tal I, Brychta RJ, Cypess AM, Chen KY, Leitner BP. Whole Body and Regional Quantification of Active Human Brown Adipose Tissue Using 18F-FDG PET/CT. Journal Of Visualized Experiments 2019 PMID: 30985755, DOI: 10.3791/58469.Peer-Reviewed Original ResearchMeSH KeywordsAdipose Tissue, BrownAlgorithmsFluorodeoxyglucose F18HumansImage Processing, Computer-AssistedPositron Emission Tomography Computed TomographyConceptsHuman brown adipose tissueBrown adipose tissueAdipose tissueF-FDG PET/CT scanF-fluorodeoxyglucose positron emission tomographyPET/CT scansThermogenic capacityBAT thermogenic capacityActive adipose tissuePET/CTPositron emission tomographyBAT volumeTomography scanNovel therapiesAnatomical distributionCT scanMetabolic disordersPharmacological activationEmission tomographyPotential targetWhole bodyBody temperatureTissueScansRegional quantification
2018
Regulation of Human Adipose Tissue Activation, Gallbladder Size, and Bile Acid Metabolism by a β3-Adrenergic Receptor Agonist
Baskin AS, Linderman JD, Brychta RJ, McGehee S, Anflick-Chames E, Cero C, Johnson JW, O'Mara AE, Fletcher LA, Leitner BP, Duckworth CJ, Huang S, Cai H, Garraffo HM, Millo CM, Dieckmann W, Tolstikov V, Chen EY, Gao F, Narain NR, Kiebish MA, Walter PJ, Herscovitch P, Chen KY, Cypess AM. Regulation of Human Adipose Tissue Activation, Gallbladder Size, and Bile Acid Metabolism by a β3-Adrenergic Receptor Agonist. Diabetes 2018, 67: db180462. PMID: 29980535, PMCID: PMC6152342, DOI: 10.2337/db18-0462.Peer-Reviewed Original ResearchMeSH KeywordsAcetanilidesAdipose Tissue, BrownAdolescentAdrenergic beta-AgonistsAdultAgedAged, 80 and overAnimalsBile Acids and SaltsGallbladderHealthy VolunteersHumansMiceMice, Inbred C57BLMiddle AgedReceptors, Adrenergic, betaReceptors, Adrenergic, beta-3RNA, MessengerThermogenesisThiazolesYoung AdultConceptsBile acid metabolismΒ3-adrenergic receptor agonistBrown adipose tissueReceptor agonistGallbladder sizeSelective β3-AR agonistΒ3-AR agonist mirabegronPositron emission tomography/White adipose tissue lipolysisUrinary bladder relaxationΒ3-AR mRNADose-proportional increaseDoses of placeboObesity-related complicationsBAT metabolic activityEmission tomography/Adipose tissue lipolysisHuman β3-ARAcid metabolismΒ3-AR agonistConjugated bile acidsGallbladder relaxationBladder relaxationOveractive bladderHealthy menKinetics of human brown adipose tissue activation and deactivation
Leitner BP, Weiner LS, Desir M, Kahn PA, Selen DJ, Tsang C, Kolodny GM, Cypess AM. Kinetics of human brown adipose tissue activation and deactivation. International Journal Of Obesity 2018, 43: 633-637. PMID: 29795459, PMCID: PMC6252171, DOI: 10.1038/s41366-018-0104-3.Peer-Reviewed Original ResearchConceptsBrown adipose tissueBAT volumeMetabolic diseasesBrown adipose tissue activationActive brown adipose tissueCold exposureHuman BAT thermogenesisBAT glucose uptakePrevention of obesityPET/CT imagingBAT activationBAT thermogenesisClinical trialsAdipose tissueHealthy adultsCold stimulationTissue activationCT imagingGlucose uptakeDuration of stimuliPotential targetCessation of coolingObesityDiseaseActivation