Featured Publications
Insulin and cancer: a tangled web
Leitner BP, Siebel S, Akingbesote ND, Zhang X, Perry RJ. Insulin and cancer: a tangled web. Biochemical Journal 2022, 479: 583-607. PMID: 35244142, PMCID: PMC9022985, DOI: 10.1042/bcj20210134.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsWhite and Brown Adipose Tissue in Obesity and Diabetes
Leitner B, Martinez-Tellez B. White and Brown Adipose Tissue in Obesity and Diabetes. 2020, 55-69. DOI: 10.1007/978-3-030-53370-0_5.ChaptersWhite adipose tissueBrown adipose tissueAdipose tissueTotal body massSevere insulin resistanceAdipose tissue typesEnergy storage tissueBody massInsulin resistanceObese humansImmune regulationFunctional roleType 2Hormone productionNoninvasive imagingPotential mechanismsEnergy expenditureObesityDiabetesRecent scientific advancesTissueDynamic tissueHuman energy expenditureHuman physiologyFuture investigations
2020
The Impact of Obesity on Tumor Glucose Uptake in Breast and Lung Cancer
Leitner BP, Perry RJ. The Impact of Obesity on Tumor Glucose Uptake in Breast and Lung Cancer. JNCI Cancer Spectrum 2020, 4: pkaa007. PMID: 32368718, PMCID: PMC7190208, DOI: 10.1093/jncics/pkaa007.Peer-Reviewed Original ResearchBody mass indexTumor glucose uptakeLung cancerGlucose uptakeGlucose metabolismNon-small cell lung cancerHigher body mass indexObesity-cancer linkImpact of obesityCell lung cancerSquamous cell carcinomaSoft tissue sarcomasAltered glucose metabolismPoor clinical prognosisTumor glucose metabolismMass indexPoor outcomeTissue sarcomasCell carcinomaTomography/Clinical prognosisBreast cancerProtective effectObesityCancer
2019
Quantification of the Capacity for Cold-Induced Thermogenesis in Young Men With and Without Obesity
Brychta RJ, Huang S, Wang J, Leitner BP, Hattenbach JD, Bell SL, Fletcher LA, Wood R, Idelson CR, Duckworth CJ, McGehee S, Courville AB, Bernstein SB, Reitman ML, Cypess AM, Chen KY. Quantification of the Capacity for Cold-Induced Thermogenesis in Young Men With and Without Obesity. The Journal Of Clinical Endocrinology & Metabolism 2019, 104: 4865-4878. PMID: 31150063, PMCID: PMC6733495, DOI: 10.1210/jc.2019-00728.Peer-Reviewed Original ResearchConceptsCold-induced thermogenesisLean menEnergy expenditureBrown fatBrown fat activitySkeletal muscle activityOvert shiveringInpatient protocolLean subjectsObesityTreatment opportunitiesMuscle activityFat activityBasal metabolic rateSkin temperature changesCold exposureNonshivering thermogenesisBasal heat productionYoung menMenThermogenesisFurther studiesRoom calorimeterFatMetabolic rate
2018
Kinetics of human brown adipose tissue activation and deactivation
Leitner BP, Weiner LS, Desir M, Kahn PA, Selen DJ, Tsang C, Kolodny GM, Cypess AM. Kinetics of human brown adipose tissue activation and deactivation. International Journal Of Obesity 2018, 43: 633-637. PMID: 29795459, PMCID: PMC6252171, DOI: 10.1038/s41366-018-0104-3.Peer-Reviewed Original ResearchConceptsBrown adipose tissueBAT volumeMetabolic diseasesBrown adipose tissue activationActive brown adipose tissueCold exposureHuman BAT thermogenesisBAT glucose uptakePrevention of obesityPET/CT imagingBAT activationBAT thermogenesisClinical trialsAdipose tissueHealthy adultsCold stimulationTissue activationCT imagingGlucose uptakeDuration of stimuliPotential targetCessation of coolingObesityDiseaseActivation