Featured Publications
White and Brown Adipose Tissue in Obesity and Diabetes
Leitner B, Martinez-Tellez B. White and Brown Adipose Tissue in Obesity and Diabetes. 2020, 55-69. DOI: 10.1007/978-3-030-53370-0_5.ChaptersWhite adipose tissueBrown adipose tissueAdipose tissueTotal body massSevere insulin resistanceAdipose tissue typesEnergy storage tissueBody massInsulin resistanceObese humansImmune regulationFunctional roleType 2Hormone productionNoninvasive imagingPotential mechanismsEnergy expenditureObesityDiabetesRecent scientific advancesTissueDynamic tissueHuman energy expenditureHuman physiologyFuture investigations
2020
MON-593 Single-Dose Effects of Anti-Obesity Drugs on Human Basal Metabolic Rate
Israni N, Cassimatis T, Fletcher L, Leitner B, Duckworth C, Hattenbach J, Bell S, McGehee S, Brychta R, Courville A, Bernstein S, Muniyappa R, Reitman M, Cypess A, Chen K. MON-593 Single-Dose Effects of Anti-Obesity Drugs on Human Basal Metabolic Rate. Journal Of The Endocrine Society 2020, 4: mon-593. PMCID: PMC7209218, DOI: 10.1210/jendso/bvaa046.366.Peer-Reviewed Original ResearchAnti-obesity drugsHeart rateBasal metabolic rateEnergy expenditureRespiratory quotientSympathetic nervous system activityRandomized cross-over studyPrespecified primary outcomeSingle-dose effectsDrug-naïve subjectsCross-over studyClinical research unitNervous system activityWhole-room indirect calorimeterLong-term interventionsSelf-reported hungerSecondary outcomesArterial pressureHunger scoresPrimary outcomeWashout periodAppetite suppressionChronic useSingle doseAcute effects
2019
Quantification of the Capacity for Cold-Induced Thermogenesis in Young Men With and Without Obesity
Brychta RJ, Huang S, Wang J, Leitner BP, Hattenbach JD, Bell SL, Fletcher LA, Wood R, Idelson CR, Duckworth CJ, McGehee S, Courville AB, Bernstein SB, Reitman ML, Cypess AM, Chen KY. Quantification of the Capacity for Cold-Induced Thermogenesis in Young Men With and Without Obesity. The Journal Of Clinical Endocrinology & Metabolism 2019, 104: 4865-4878. PMID: 31150063, PMCID: PMC6733495, DOI: 10.1210/jc.2019-00728.Peer-Reviewed Original ResearchConceptsCold-induced thermogenesisLean menEnergy expenditureBrown fatBrown fat activitySkeletal muscle activityOvert shiveringInpatient protocolLean subjectsObesityTreatment opportunitiesMuscle activityFat activityBasal metabolic rateSkin temperature changesCold exposureNonshivering thermogenesisBasal heat productionYoung menMenThermogenesisFurther studiesRoom calorimeterFatMetabolic rate
2018
Differences in Energy Expenditure between Respiratory Chamber and Metabolic Ward in Inpatient Men and Women
ZHOU M, HOWARD R, RABEL A, SEDMAK C, CAI H, WALTER P, BRYCHTA R, FLETCHER L, LEITNER B, GUO J, SIKDER S, COURVILLE A, BERNSTEIN S, GREWAL S, MUNIYAPPA R, CHEN K, HALL K. Differences in Energy Expenditure between Respiratory Chamber and Metabolic Ward in Inpatient Men and Women. Diabetes 2018, 67 DOI: 10.2337/db18-297-lb.Peer-Reviewed Original ResearchKcal/dayMetabolic wardEnergy expenditureRespiratory chamberClass I obesityNIH Clinical CenterLack of exerciseEnergy expenditure differencesInpatient stayClinical centersHealthy volunteersInpatient menCycle ergometryAverage energy expenditureDaily energy expenditureStudy participantsWardsInpatient roomFurther studiesExpenditure differencesMenDaysWeeksWomenCurrent study