Featured Publications
Mapping of human brown adipose tissue in lean and obese young men
Leitner BP, Huang S, Brychta RJ, Duckworth CJ, Baskin AS, McGehee S, Tal I, Dieckmann W, Gupta G, Kolodny GM, Pacak K, Herscovitch P, Cypess AM, Chen KY. Mapping of human brown adipose tissue in lean and obese young men. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 8649-8654. PMID: 28739898, PMCID: PMC5559032, DOI: 10.1073/pnas.1705287114.Peer-Reviewed Original ResearchConceptsBrown adipose tissueHuman brown adipose tissueAdipose tissueActivity of BATPositron emission tomography/computerized tomographyTomography/computerized tomographyActivated Brown Adipose TissueFluorodeoxyglucose positron emission tomography/computerized tomographyActive brown adipose tissueCold exposureSpecific adipose depotsObese young menHealthy young menYoung menAcute cold exposureLean menObese menBAT volumeTotal body massThermogenic potentialAdipose depotsAnatomic characteristicsFascial layersMetabolic diseasesComputerized tomography
2020
Sexual Dimorphisms in Adult Human Brown Adipose Tissue
Fletcher L, Kim K, Leitner B, Cassimatis T, O’Mara A, Johnson J, Halprin M, McGehee S, Brychta R, Cypess A, Chen K. Sexual Dimorphisms in Adult Human Brown Adipose Tissue. Obesity 2020, 28: 241-246. PMID: 31970907, PMCID: PMC6986330, DOI: 10.1002/oby.22698.Peer-Reviewed Original ResearchConceptsBrown adipose tissueF-fluorodeoxyglucose uptakeBAT volumeAdipose tissueAdult human brown adipose tissueCold-activated brown adipose tissueInterscapular brown adipose tissueGlucose uptakeTotal BAT volumeHuman brown adipose tissueBAT glucose uptakeBody weight regulationPositron emission tomographyOvert shiveringDistribution of BATLean womenAnatomical distributionBAT depotsWeight regulationHours of exposureHuman newbornsComputerized tomographyEmission tomographyYoung womenWomen
2019
Whole Body and Regional Quantification of Active Human Brown Adipose Tissue Using 18F-FDG PET/CT.
Kim K, Huang S, Fletcher LA, O'Mara AE, Tal I, Brychta RJ, Cypess AM, Chen KY, Leitner BP. Whole Body and Regional Quantification of Active Human Brown Adipose Tissue Using 18F-FDG PET/CT. Journal Of Visualized Experiments 2019 PMID: 30985755, DOI: 10.3791/58469.Peer-Reviewed Original ResearchConceptsHuman brown adipose tissueBrown adipose tissueAdipose tissueF-FDG PET/CT scanF-fluorodeoxyglucose positron emission tomographyPET/CT scansThermogenic capacityBAT thermogenic capacityActive adipose tissuePET/CTPositron emission tomographyBAT volumeTomography scanNovel therapiesAnatomical distributionCT scanMetabolic disordersPharmacological activationEmission tomographyPotential targetWhole bodyBody temperatureTissueScansRegional quantification
2018
Physiological Responses to Daily Use of Beta-Three Adrenergic Receptor Agonist, Mirabegron
O'MARA A, CYPESS A, CERO C, JOHNSON J, LINDERMAN J, LEITNER B, FLETCHER L, BRYCHTA R, KAPURIA D, MCGEHEE S, ROTMAN Y. Physiological Responses to Daily Use of Beta-Three Adrenergic Receptor Agonist, Mirabegron. Diabetes 2018, 67 DOI: 10.2337/db18-1146-p.Peer-Reviewed Original ResearchRate-pressure productNon-esterified fatty acidsBrown adipose tissueSerum non-esterified fatty acidsCold exposureWeeks of treatmentBAT metabolic activityHealthy female volunteersAdrenergic receptor agonistPET/CTΒ3-adrenergic receptor agonistDaily mirabegronCardiovascular stimulationPrimary endpointSecondary endpointsChronic treatmentBAT volumeLiver steatosisMetabolic healthPressure productTreatment optionsInsulin sensitivityPharmacotherapeutic approachesReceptor agonistAcute effectsKinetics of human brown adipose tissue activation and deactivation
Leitner BP, Weiner LS, Desir M, Kahn PA, Selen DJ, Tsang C, Kolodny GM, Cypess AM. Kinetics of human brown adipose tissue activation and deactivation. International Journal Of Obesity 2018, 43: 633-637. PMID: 29795459, PMCID: PMC6252171, DOI: 10.1038/s41366-018-0104-3.Peer-Reviewed Original ResearchConceptsBrown adipose tissueBAT volumeMetabolic diseasesBrown adipose tissue activationActive brown adipose tissueCold exposureHuman BAT thermogenesisBAT glucose uptakePrevention of obesityPET/CT imagingBAT activationBAT thermogenesisClinical trialsAdipose tissueHealthy adultsCold stimulationTissue activationCT imagingGlucose uptakeDuration of stimuliPotential targetCessation of coolingObesityDiseaseActivation