Anjelica Gonzalez, PhD
ProfessorCards
About
Research
Publications
2025
Engineered microvascular basement membrane mimetic for real‐time neutrophil tracking in the microvascular wall
Morales L, Kim C, Pan Y, Scheuring S, Gonzalez A. Engineered microvascular basement membrane mimetic for real‐time neutrophil tracking in the microvascular wall. Bioengineering & Translational Medicine 2025 DOI: 10.1002/btm2.70008.Peer-Reviewed Original Research
2024
Ezrin drives adaptation of monocytes to the inflamed lung microenvironment
Gudneppanavar R, Di Pietro C, H Öz H, Zhang P, Cheng E, Huang P, Tebaldi T, Biancon G, Halene S, Hoppe A, Kim C, Gonzalez A, Krause D, Egan M, Gupta N, Murray T, Bruscia E. Ezrin drives adaptation of monocytes to the inflamed lung microenvironment. Cell Death & Disease 2024, 15: 864. PMID: 39613751, PMCID: PMC11607083, DOI: 10.1038/s41419-024-07255-8.Peer-Reviewed Original ResearchConceptsActivation of focal adhesion kinaseExtracellular matrixActin-binding proteinsFocal adhesion kinaseLung extracellular matrixKnock-out mouse modelProtein kinase signalingCortical cytoskeletonLoss of ezrinKinase signalingPlasma membraneCell migrationSignaling pathwayEzrinResponse to lipopolysaccharideTissue-resident macrophagesMouse modelLipopolysaccharideCytoskeletonEzrin expressionLung microenvironmentKinaseMonocyte recruitmentProteinAktZFYVE21 promotes endothelial nitric oxide signaling and vascular barrier function in the kidney during aging
Jiang Q, Song G, He L, Li X, Jiang B, Wang Q, Wang S, Kim C, Barkestani M, Lopez R, Fan M, Wanniarachchi K, Quaranta M, Tian X, Mani A, Gonzalez A, Goodwin J, Sessa W, Ishibe S, Jane-Wit D. ZFYVE21 promotes endothelial nitric oxide signaling and vascular barrier function in the kidney during aging. Kidney International 2024, 106: 419-432. PMID: 38797325, PMCID: PMC11343665, DOI: 10.1016/j.kint.2024.05.007.Peer-Reviewed Original ResearchVascular barrier functionEndothelial cellsReduced endothelial nitric oxideRegulator of vascular barrier functionEndothelial nitric oxide signalingENOS activityEndosome-associated proteinsBarrier functionKidney organ culturesEndothelial nitric oxideAkt-dependent mannerNitric oxide donorGTPase Rab5Nitric oxide signalingZFYVE21Live cell imagingKidney insufficiencyReporter miceTrafficking mechanismsAccelerated aging phenotypeKnockout miceInterstitial edemaKidney functionVesicular populationOxide donorEzrin drives adaptation of monocytes to the inflamed lung microenvironment.
Gudneppanavar R, Di Pietro C, Oez H, Zhang P, Huang P, Braga C, Tebaldi T, Biancon G, Kim C, Gonzalez A, Halene S, Krause D, Egan M, Gupta N, Murray T, Bruscia E. Ezrin drives adaptation of monocytes to the inflamed lung microenvironment. The Journal Of Immunology 2024, 212: 0078_5418-0078_5418. DOI: 10.4049/jimmunol.212.supp.0078.5418.Peer-Reviewed Original ResearchRNA-seqActin-binding protein ezrinF-actin distributionImmune response to bacteriaCystic fibrosisIn vitro functional studiesResponse to bacteriaIncreased expression of pro-inflammatory markersCytoskeleton rearrangementF-actinResponse to lung infectionExpressed genesProtein ezrinTranscriptional profilesExpression of pro-inflammatory markersPlasma membranePro-inflammatory markersFunctional studiesEzrinLung extracellular matrixCF miceExtracellular matrixWT micePI3K/Akt signalingLung infectionTGF-β1 Drives Integrin-Dependent Pericyte Migration and Microvascular Destabilization in Fibrotic Disease
Pellowe A, Wu M, Kang T, Chung T, Ledesma-Mendoza A, Herzog E, Levchenko A, Odell I, Varga J, Gonzalez A. TGF-β1 Drives Integrin-Dependent Pericyte Migration and Microvascular Destabilization in Fibrotic Disease. American Journal Of Pathology 2024, 194: 1171-1184. PMID: 38548268, PMCID: PMC11220919, DOI: 10.1016/j.ajpath.2024.02.021.Peer-Reviewed Original ResearchMechanosensing regulates tissue repair program in macrophages
Meizlish M, Kimura Y, Pope S, Matta R, Kim C, Philip N, Meyaard L, Gonzalez A, Medzhitov R. Mechanosensing regulates tissue repair program in macrophages. Science Advances 2024, 10: eadk6906. PMID: 38478620, PMCID: PMC10936955, DOI: 10.1126/sciadv.adk6906.Peer-Reviewed Original ResearchConceptsExtracellular matrixRegulate chromatin accessibilityTissue repair programGene expression programsCytoskeletal dynamicsChromatin accessibilityAmoeboid migrationCytoskeletal remodelingBiochemical signalsTissue homeostasisExpression programsColony-stimulating factor-1Tissue-resident macrophagesFactor 1MechanosensingRegulating tissue repairTissue integrityMacrophagesTissueThree-dimensional environmentRepair programHomeostasis
2022
Endothelial Thrombopoietin Receptor Controls Eosinophil Trafficking in Asthma and Chronic Rhinosinusitis
Korde A, Haslip M, Ahangari F, Pober J, Chupp G, Manes P, Gonzalez A, Takyar S. Endothelial Thrombopoietin Receptor Controls Eosinophil Trafficking in Asthma and Chronic Rhinosinusitis. 2022, a5684-a5684. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5684.Peer-Reviewed Original Research
2018
Physical and biochemical interactions drive fibrocytes accumulation in the scleroderma lung matrix
Sun H, Winkler J, Minasyan M, Pan H, Desai O, Pellowe A, Li J, Peng X, Gonzalez A, Herzog E. Physical and biochemical interactions drive fibrocytes accumulation in the scleroderma lung matrix. 2018, lsc-1176. DOI: 10.1183/13993003.congress-2018.lsc-1176.Peer-Reviewed Original ResearchStroke Repair via Biomimicry of the Subventricular Zone
Matta R, Gonzalez A. Stroke Repair via Biomimicry of the Subventricular Zone. Frontiers In Materials 2018, 5: 15. DOI: 10.3389/fmats.2018.00015.Peer-Reviewed Original ResearchSubventricular zoneFunctional recoverySVZ nicheParticular neural stem cellsCurrent stroke therapiesEndogenous reparative mechanismsPeri-infarct areaBlood-brain barrierCause of deathEndogenous repair mechanismsMagnetic resonance imagingStem cellsNeural stem cellsResident cell typesSVZ microenvironmentCell typesStroke therapyNeurons migrateReparative mechanismsAxonal connectionsEpendymal cellsFunctional restorationResident cellsResonance imagingStroke repair
2015
Proteomic Analysis of the Pericyte Derived Extracellular Matrix
Brown L, Sava P, Garcia C, Gonzalez A. Proteomic Analysis of the Pericyte Derived Extracellular Matrix. Cellular And Molecular Bioengineering 2015, 8: 349-363. DOI: 10.1007/s12195-015-0408-5.Peer-Reviewed Original ResearchMatrix proteinsStructural ECM proteinsBasic cellular responsesExtracellular matrix proteinsFunctional annotationProteomic analysisRegulatory signalsCell rufflingECM proteinsCellular responsesWestern blot analysisECM componentsExtracellular matrixEndothelial cell tubule formationFirst characterizationProteinMigratory velocityBlot analysisTubule formationECMNeutrophil polarizationStructural collagenVascular integrityLC/MS-MSBasement membrane