Alan Dardik
MD/PhD, FACS, DFSVS, FAHA
he/him/his
Professor of Surgery (Vascular) and of Cellular and Molecular Physiology; Vice Chair, Faculty Affairs, Surgery
Biography
Research & Publications
Patient Care
News
Locations
Appointments
Biography
Dr. Alan Dardik is a surgeon-scientist who harnesses the power of molecular biology to achieve a modern understanding of vascular disease, and then use the basic science laboratory to ultimately benefit patients with vascular diseases.
Dr. Dardik trained at Yale, the University of Pennsylvania, and the Johns Hopkins Hospital before his appointment to the Yale faculty in 2001. Dr. Dardik focuses his clinical practice on teaching at the VA Connecticut, where he was formerly the Chief of Vascular Surgery. Dr. Dardik has won the C. Elton Cahow Award for Outstanding Faculty Teaching from Yale’s Department of Surgery and the Faculty Teaching Award from St. Mary’s Hospital. Dr. Dardik is also a Vice Chair of Yale’s Department of Surgery where he is charged with Faculty Affairs, and he has served as Yale's Interim Division Chief of Vascular and Endovascular Surgery.
The Dardik laboratory studies the healing and function of blood vessels, fistulae and vessel patches that are used in patients having vascular surgery. The laboratory is trying to understand the fundamental molecular mechanisms by which vein graft adaptation and arteriovenous fistula maturation result in positive remodeling and successful adaptation to the arterial environment, yet often proceed, in the long-term, to neointimal hyperplasia and failure. The laboratory also studies novel methods to deliver stem cells to diabetic wounds. The laboratory is funded from the NIH as well as Yale's Department of Surgery.
Dr. Dardik currently serves as the Editor-in-Chief for the newly launched journal JVS-Vascular Science; he is the past President of the New England Society for Vascular Surgery, the Association of VA Surgeons as well as of the International Society for Vascular Surgery. Dr. Dardik has run several national and international meetings, including the Society for Vascular Surgery Vascular Research Initiatives Conference, and has served on numerous peer review committees including review for the NIH, the VA, and Vascular Cures. Dr. Dardik has edited several textbooks including “Vascular Surgery: A Global Perspective” and “Stem cell therapy for vascular diseases.”
Education & Training
- FellowVascular Surgery; The Johns Hopkins Hospital (2001)
- Chief ResidentGeneral Surgery; The Johns Hopkins Hospital (2000)
- Specialist RegistrarThe John Radcliffe Hospital, Oxford, England (1999)
- ResidentThe Johns Hopkins Hospital (1999)
- Postdoctoral Fellow (NIH F32)Johns Hopkins University (1997)
- MD/PhDUniversity of Pennsylvania (1993)
- BSYale University, Computer Science (1986)
Activities
- Taking vessel identity from bench to bedside: The joys of being a surgeon-scientistCalgary, AB, Canada 2022The McPhedran Lecture, The University of Calgary
- Lessons from the human umbilical vein biograftNaples, Campania, Italy 2022Vintage Pride: Open Surgery in the Treatment of Critical Ischemia
- Why should cardiovascular surgeons care about translational research?Yokohama, Kanagawa, Japan 2022the 52nd Annual Meeting of the Japanese Society for Cardiovascular Surgery
- Behavior of bovine pericardial patchesStrasbourg, Grand Est, France 2021The 12th European Symposium for Vascular Biomaterials
- The RADAR Technique of Arteriovenous Fistula CreationBeijing, Beijing, China 2021the 13th China Endovascular Course (CEC 2021)
- Paclitaxel eluting technology, where do we stand?Beijing, Beijing, China 2021The 6th China Vascular Congress CVC 2021
- RADAR: The artery to vein configuration of AVFSingapore, Singapore 2021Dialysis Access Synergy DASy Rainbow meeting
- Systemic Inflammatory Disease is Associated With Type II Endoleak and Late Interventions After Endovascular Aneurysm Repair; Using the epidemiology of chronic limb-threatening ischemia to estimate the number of patients amenable to different types of therapyTokyo, Tokyo, Japan 202048th annual meeting of the Japanese Society for Vascular Surgery
- Stem cell therapy for PAD: where are we with human trials?Rio de Janeiro, RJ, Brazil 2020XV PanAmerican Congress in Vascular and Endovascular Surgery (iPAN 2020)
- Urgent carotid surgery for TIA and strokeBeijing, Beijing, China 2020The 5th China Vascular Congress CVC 2020
- Unmet clinical needs to improve the outcome of vein graftsStockholm, Stockholm County, Sweden 2020European Society for Vascular Surgery Translational Meeting
- Delivery of stem cells in biomimetic engineered scaffolds promotes healing of diabetic ulcersTianjin, Tianjin, China 2019The 4th China Vascular Congress CVC 2019
- Improving the outcome of vein grafts and fistulae: Should surgeons turn veins into arteries?Stockholm, Stockholm County, Sweden 2019Invited lecture, Karolinska University
- Designing optimal outcomes for the radial-cephalic fistula: RADAR guides the wayBeijing, Beijing, China 2018The 3rd China Vascular Congress CVC 2018
- Engineering vessel identity from bench to bedside: Eph to RADARLondon, England, United Kingdom 2018Keynote lecture, Frontiers of Simulation and Experimentation for Personalized Cardiovascular Management and Treatment Conference
- Improving the outcome of vein grafts and fistulae: Should surgeons turn veins into arteries?Ottawa, ON, Canada 2018Visiting Professor, Department of Surgery
- Taking vessel identity from bench to bedside: Eph to RADARBeijing, Beijing, China 2017Chinese Chapter Congress of the International Union of Angiology, 13th annual Chinese Capital Vascular Symposium
- Improving the outcome of vein grafts and fistulae: Should surgeons turn veins into arteries?Banff, AB, Canada 2017Keynote lecture, the 39th Annual Scientific Meeting of the Canadian Society for Vascular Surgery
- Improving the outcome of vein grafts and fistulae: Should surgeons turn veins into arteries?Beijing, Beijing, China 2017Keynote lecture, The 2nd China Vascular Congress CVC 2017
- Eph-B4 regulation of AV fistula maturationCambridge, England, United Kingdom 2016Invited lecture, 15th annual Cambridge-Yale Vascular Biology Research Program
- Will Eph receptors improve results of vascular remodeling?Nice, Provence-Alpes-Côte d'Azur, France 2016Visiting Professor lecture, University of Nice, Nice, France
- Delivery Of Mesenchymal Stem Cells In Biomimetic Engineered Scaffolds Promotes Healing Of Diabetic UlcersLondon, England, United Kingdom 201616th Annual Meeting of the Tissue and Cell Engineering Society
- Improving the outcome of vein grafts and fistulae: Should surgeons turn veins into arteries?Tokyo, Tokyo, Japan 201644th annual meeting of the Japanese Society for Vascular Surgery
- How do veins and patches adapt to their new surgical environment?Tokyo, Tokyo, Japan 2016Invited lecture, Department of Surgery, University of Tokyo, Tokyo, Japan
- Presidential AddressAthens, Attica, Greece 2015Annual meeting of the International Society for Vascular Surgery
- How do vascular interventions fail, and what are the opportunities?London, England, United Kingdom 2015Invited lecture, Department of Mechanical Engineering, University College of London
- 1) Metabolic Syndrome Predicts High Risk Status for Vascular Surgery; 2) What is different about carotid angioplasty in elderly patients?Changsha, Hunan, China 20159th China Southern Endovascular Congress; 6th Wang Zhong Gao Vascular Forum
- Surgical alchemy: Do surgeons turn veins into arteries?Frankfurt am Main, Hesse, Germany 2015Keynote lecture, European Society for Vascular Surgery spring meeting
- Hypoxia-activated mesenchymal stem cells: A novel therapy for diabetic woundsLondon, England, United Kingdom 2014Invited lecture, Institute of Biomedical Engineering
- Effects of Metabolic Syndrome on Outcomes in Vascular SurgeryGuangzhou, Guangdong Province, China 2014Faculty organizer, ISVS 2014 China meeting
- Changing veins into arteries: How does Eph-B4 regulate vessel identity?Milano, Lombardy, Italy 2014Visiting Professor lecture, University of Milan
- CEA: What is the current best patch if any? CEA. Quel est le meilleur patch (s'il existe) ?Paris, Ile-de-France, France 2014Controversies & Updates in Vascular Surgery 2014
- 1) Advanced age and disease predict lack of satisfaction after iliac stent placement; 2) Factors for consideration for endovascular repair of aortic dissection: a Yale University perspective; 3) Current trends in the treatment of diabetic foot in AmericaBeijing, Beijing, China 2013Visiting Professor, Department of Surgery, XuanWu Hospital
- 1) Advanced Age and Disease Predict Lack of Satisfaction After Iliac Stent Placement. 2) Factors for consideration for endovascular repair of aortic dissections: A Yale University perspective. 3) Current trends in the treatment of diabetic foot in America (associated Diabetic Foot Symposium).Beijing, Beijing, China 20131st annual Chinese Chapter Congress of the International Union of Angiology
- Do surgeons turn veins into arteries?Guangzhou, Guangdong Province, China 2013Visiting Professor lecture, Department of Surgery
- Preoperative Management of the Surgical PatientBelo Horizonte, Minas Gerais, Brazil 2013Visiting Professor lecture, Department of Surgery
- Changing veins into arteries: How does Eph-B4 regulate vessel identity?Nice, Provence-Alpes-Cote d'Azur, France 2013Visiting Professor lecture, Department of Vascular Surgery, Hôpital St. Roch
- What do animal models of ischemia teach us about therapeutic angiogenesis?Stanmore, England, United Kingdom 2013Visiting Professor lecture, Surgical Grand Rounds, Royal National Orthopaedic Hospital
- 1) How do pericardial patches heal after surgery? 2) Durability considerations for EVAR : selection choices and long term outcomes. 3) Factors for Consideration for Endovascular repair of aortic dissections: a Yale University perspectiveChangsha, Jiangxi Sheng, China 2012Invited lectures, 11th annual China National Congress of Vascular Surgery
- Understanding vein adaptation to the arterial environmentCambridge, England, United Kingdom 201211th annual Cambridge-Yale Vascular Biology Research Program
- 1) Behavior of venous grafts and pericardial patches after surgery. 2) Is endovascular treatment the first choice for all patients with PAD? Is there still a role for open surgery? 3) Is it possible to treat TASC D lesions with endovascular techniques? 4) Management of carotid stenosis: What is best, CEA CAS or medical therapy? What do the randomized studies say?Belo Horizonte, Minas Gerais, Brazil 201212th Annual Meeting of the Encontro Mineiro De Angiologia e Cirurgia Vascular
- 1) Endovascular Therapy by vascular surgeons in USA. 2) Therapy for PAD: Strategies by Vascular Surgeons in the USANagano-shi, Nagano, Japan 201240th annual meeting of the Japanese Society of Vascular Surgery
- Healing of vascular grafts and patches: Lessons for tissue engineersLeeds, England, United Kingdom 2011Visiting Professor lecture, Department of Surgery
- Modern Alchemy: Turning veins into arteriesOxford, United Kingdom 2011The Litchfield Lecturership
- Can surgeons turn veins into arteries?London, England, United Kingdom 2011Visiting Professor lecture, Department of Surgery
- New Research on the Etiology of Abdominal Aortic AneurysmsChangsha, Jiangxi Sheng, China 2011Keynote Speaker, 4th China National Symposium on Vascular Disease
- Does a high risk patient for carotid endarterectomy (CEA) exist?Paris, Ile-de-France, France 2011Controversies & Updates in Vascular Surgery 2011
- Peripheral arterial disease: Diagnosis and Treatment; Cerebrovascular disease: Diagnosis and TreatmentBelo Horizonte, Minas Gerais, Brazil 2010CIPRAME (International Conference of Medical Practices) Cardiovascular Disease
- Understanding Eph-B4 Control of Vein Graft AdaptationCambridge, England, United Kingdom 20109th annual Cambridge-Yale Vascular Biology Research Program
- The Future of Bypass Surgery: Lessons from the EmbryoKyoto, Kyoto, Japan 2010Keynote Address, 11th annual congress of the Asian Society for Vascular Surgery
- La veine peut-elle devenir une artère? Do vein grafts arterialize?Paris, Ile-de-France, France 2010Controversies & Updates in Vascular Surgery 2010
- Regulation of vessel identity during vein graft adaptation - Are we closer to preventing neointimal hyperplasia?; What's Happening With Stem Cell Treatments For Lower Limb Ischemia?Gaillimh, Connaught, Ireland 20097th annual Western Vascular Institute Symposium
- Regulation of vessel identity during vein graft adaptationGaillimh, Connaught, Ireland 2008Invited lecture, 6th annual Western Vascular Institute Symposium
- Peripheral bypass strategy for infrainguinal vascular diseaseNagoya-shi, Aichi, Japan 200735th Annual Meeting of Japanese Society for Vascular Surgery
- Venous identity is lost but arterial identity is not gained during vein graft adaptationNagoya-shi, Aichi, Japan 2007Keynote address, 35th Annual Meeting of Japanese Society for Vascular Surgery
- Carotid endarterectomy: community gold standard for high risk patientsNew Delhi, NCT, India 200613th Annual National Conference of the Vascular Society of India
- U.S. update report: Carotid endarterectomy vs. carotid artery stentingTokyo, Tokyo, Japan 2006Invited lecture, Department of Cardiovascular Surgery
- Effects of aging on vascular healingNagoya-shi, Aichi, Japan 2005Invited lecture, Department of Cardiovascular Surgery
- How to build a better blood vesselOxford, England, United Kingdom 1999Invited lecture, Nuffield Department of Surgery
Honors & Recognition
| Award | Awarding Organization | Date |
|---|---|---|
| The McPhedran Lecture | The University of Calgary | 2022 |
| Distinguished keynote lecture, the 52nd Annual Meeting of the Japanese Society for Cardiovascular Surgery | Japanese Society for Cardiovascular Surgery | 2022 |
| Presidential address, New England Society for Vascular Surgery | New England Society for Vascular Surgery | 2021 |
| Presidential address, Association of VA Surgeons | Association of VA Surgeons | 2021 |
| Member, Connecticut Academy of Science and Engineering | www.ctcase.org | 2021 |
| The Conrad Jobst Lectureship | The University of Michigan and the Jobst Vascular Institute | 2018 |
| SVS Presidential Citation Award | Society for Vascular Surgery | 2018 |
| Keynote address, the 39th Annual Scientific Meeting of the Canadian Society for Vascular Surgery, Banff, Canada | the Canadian Society for Vascular Surgery | 2017 |
| Keynote address, The 2nd China Vascular Congress, Beijing, China | The 2nd China Vascular Congress CVC 2017 | 2017 |
| President’s Award | International Society for Vascular Surgery | 2016 |
| The Smithwick Visiting Professorship in Vascular Surgery | Boston University | 2016 |
| Keynote speaker; 16th Annual Meeting of the Tissue and Cell Engineering Society, London, UK | Tissue and Cell Engineering Society | 2016 |
| Presidential Address, International Society for Vascular Surgery | International Society for Vascular Surgery | 2015 |
| Keynote speaker; European Society for Vascular Surgery Spring meeting; Frankfurt, Germany | European Society for Vascular Surgery | 2015 |
| Fellow | American Surgical Association | 2015 |
| Master of Arts Degree (honorary) | Yale University, New Haven, CT | 2015 |
| Fellow (FAHA) | American Heart Association | 2014 |
| Keynote Speaker; 11th annual China National Congress of Vascular Surgery, Changsha, China | Chinese Society for Vascular Surgery | 2012 |
| Keynote speaker, 12th annual meeting; Belo Horizonte, Brazil | Encontro Mineiro De Angiologia e Cirurgia Vascular, Brazil | 2012 |
| The Litchfield Lecturership | Oxford University, Oxford, UK | 2011 |
| Keynote Speaker, 4th annual meeting; Changsha, China | Chinese National Symposium on Vascular Disease | 2011 |
| Keynote Speaker, 11th annual congress; Kyoto, Japan | Asian Society for Vascular Surgery | 2010 |
| Distinguished Fellowship (DFSVS) | Society for Vascular Surgery | 2007 |
| Keynote speaker, 35th annual meeting; Nagoya, Japan | Japanese Society for Vascular Surgery | 2007 |
| American College of Surgeons Traveling Fellowship to Japan | American College of Surgeons | 2006 |
| The William J. von Liebig Award (highest ranking vascular surgery basic science research proposal) | Lifeline Foundation/American Vascular Association | 2006 |
| C. Elton Cahow Award for Outstanding Faculty Teaching | Department of Surgery, Yale University School of Medicine, New Haven, CT | 2006 |
| Honorable Mention, C. Elton Cahow Award for Outstanding Faculty Teaching | Department of Surgery, Yale University School of Medicine, New Haven, CT | 2005 |
| The William J. von Liebig Vascular Academic Award | Peripheral Vascular Surgery Society | 2004 |
| Faculty Teaching Award | Surgical Residents of St Mary’s Hospital, Waterbury, CT | 2004 |
| Franklin Martin Faculty Research Fellowship (highest ranking faculty research proposal) | American College of Surgeons | 2002 |
| International Vascular Biology Travel Award | North American Vascular Biology Organization | 2002 |
| E.J.Wylie Traveling Fellowship | Lifeline Foundation | 2002 |
| Dennis Jahnigen Career Development Scholar Award | American Geriatrics Society | 2002 |
| Wylie Scholar in Academic Vascular Surgery Award | Vascular Cures | 2002 |
| Faculty Teaching Award | Surgical Residents of St Mary’s Hospital, Waterbury, CT | 2002 |
| First Place, Fellow and Resident Paper Competition | Chesapeake Vascular Society, Annapolis, MD | 2000 |
| Surgical Resident and Fellows Award | Baltimore Academy of Surgery, Baltimore, MD | 1997 |
| Upjohn Award for Clinical Research | Johns Hopkins University Department of Surgery, Baltimore, MD | 1997 |
| Upjohn Award for Clinical Research (for outstanding clinical research by a resident member of the Department of Surgery) | Johns Hopkins University Department of Surgery, Baltimore, MD | 1996 |
| Sandoz Surgical Student Research Award (for superior accomplishment in biomedical research) | Association for Academic Surgery | 1993 |
| Balduin Lucke Memorial Prize (for superior research in experimental medicine and biology) | University of Pennsylvania School of Medicine, Philadelphia, PA | 1992 |
| William D Carey Science Award (for an outstanding graduate student in science and engineering) | American Association for the Advancement of Science | 1991 |
| Summa Cum Laude | Yale University, New Haven, CT | 1986 |
| Distinction in the Major, Computer Science | Yale University, New Haven, CT | 1986 |
| Tau Beta Pi | Yale University, New Haven, CT | 1985 |
| Phi Beta Kappa | Yale University, New Haven, CT | 1984 |
| Valedictorian | The Frisch School, Paramus, NJ | 1982 |
Professional Service
| Organization | Role | Date |
|---|---|---|
| JVS-Vascular Science | Editor-in-Chief | 2022 - Present |
| New England Surgical Society Scholars Foundation | Connecticut Director | 2020 - Present |
| New England Society for Vascular Surgery | President | 2020 - 2021 |
| Yale Department of Surgery | Chair, Triennial Leave Committee | 2020 - Present |
| JVS-Vascular Science | Editor | 2019 - 2022 |
| Yale Department of Surgery | Research Advisory Committee | 2019 - Present |
| Yale Department of Surgery | Co-chair, Faculty Advisory Committee | 2019 - Present |
| Association of VA Surgeons (AVAS) | President | 2019 - 2021 |
| Yale School of Medicine | Term Appointments and Promotions Committee | 2019 - Present |
| Yale Department of Surgery | Chair, Appointments and Promotions Committee | 2018 - Present |
| Yale School of Medicine | Office of Student Research Leadership Search Committee | 2018 - 2019 |
| Yale School of Medicine | Appointments and Promotions Committee, Department of Surgery | 2018 - Present |
| Journal of Vascular Surgery | Associate Editor, Basic Science | 2018 - Present |
| Agence Nationale de la Recherche (Paris, France) | study section | 2017 |
| Yale University School of Medicine | Ad Hoc Committee to Review the Criteria for Appointments and Promotions in the Clinician-Educator Track | 2016 - 2017 |
| NIH NIDDK | ZRG1 DKUS-J (03) M study section | 2016 |
| American College of Surgeons | Chair, Advisory Council for Vascular Surgery | 2015 - 2019 |
| International Society for Vascular Surgery | Meeting Organizer, ISVS 2015 Annual Congress, Athens, Greece | 2015 |
| New England Surgical Society | New England Surgical Society Scholar Foundation review committee | 2015 - 2017 |
| Fondazione Cariplo (Milan, Italy) | study section | 2015 - 2017 |
| Society for Vascular Surgery | Chair, Research Council | 2015 - 2018 |
| Society for Vascular Surgery | Board of Directors | 2015 - 2018 |
| International Society for Vascular Surgery | President | 2014 - 2016 |
| International Society for Vascular Surgery | Meeting Organizer, ISVS 2014 Annual Congress, Guangzhou China | 2014 |
| Yale University School of Medicine, Dept of Surgery | review internal grant applications for the Ohse awards | 2014 - 2016 |
| Yale University School of Medicine | Senior Faculty Allotment Committee | 2013 - 2016 |
| Journal of Surgical Research | Associate Editor | 2013 - 2017 |
| Aorta | Editor for Molecular Biology and Pathophysiology | 2013 - Present |
| Society for Vascular Surgery | Course Director, Emerging Concepts of Vascular Physiology and Therapy, Vascular Research Initiatives Conference (VRIC), Lake Buena Vista, FL | 2013 |
| Association of VA Surgeons | Chairman, Local arrangements committee, AVAS 2014 New Haven meeting | 2013 - 2014 |
| Rutherford’s Textbook of Vascular Surgery (8th edition) | Editor, Basic Science | 2012 - 2013 |
| Society for Vascular Surgery | Course Director, Experimental and Applied Vascular Biology, Vascular Research Initiatives Conference (VRIC), Chicago, IL | 2012 |
| NIH NHLBI | BTSS study section | 2012 |
| NIH NHLBI | NIH NHLBI Institutional Training Mechanism (NITM) Review Committee | 2012 - Present |
| Society for Vascular Surgery | Course Director, Basic Foundations of Translational Research in Vascular Disease, Vascular Research Initiatives Conference (VRIC), Chicago, IL | 2011 |
| Association for Academic Surgery | Executive Committee; Councilor, Class of 2002 | 2010 - 2012 |
| Society for Vascular Surgery | Course Director, Research Models of Human Vascular Disease, Research Initiatives in Vascular Disease Conference, San Francisco, CA | 2010 |
| Veterans Affairs (VA) | VA Merit Study section; Chair 2011-2012 | 2010 - 2012 |
| Society for Vascular Surgery | Chair, study section for K08/K23/Wylie traveling/resident/student grants and awards | 2009 - 2013 |
| American Heart Association | Program Committee, Arteriosclerosis, Thrombosis and Vascular Biology (ATVB) Spring Conference | 2009 - 2013 |
| NIH NHLBI | VCMB study section | 2009 |
| Vascular Cures (Pacific Vascular Research Foundation) | Wylie Scholar Award Committee | 2007 - 2016 |
| American Geriatrics Society | Program Committee, Section for Surgical and Related Medical Specialties | 2007 - 2009 |
| Vascular | Editorial Board | 2007 - Present |
| Annals of Vascular Surgery | Editorial Board | 2007 - Present |
| Society for Vascular Surgery | Research and Education Committee; Chairman 2009-2013 | 2006 - 2013 |
| VA Connecticut Healthcare Systems, West Haven, CT | Compensation and Pay Committee | 2006 - Present |
| Journal of Vascular Surgery | Editorial Board | 2006 - 2012 |
| Eastern Vascular Society | Issues Committee Chairman 2009-2010 | 2006 - 2010 |
| VA Connecticut Healthcare Systems, West Haven, CT | Preservation-Amputation Care and Treatment (PACT) Committee | 2005 - Present |
| Yale University School of Medicine, Department of Surgery | Student Thesis Committee | 2002 - Present |
| VA Connecticut Healthcare Systems, West Haven, CT | Chair, Surgical Case and Other Invasive Procedure (SOIP) Committee | 2001 - 2017 |