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Daniela Tirziu, PhD

Senior Research Scientist
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Additional Titles

Associate Director of Academic Research, Yale Cardiovascular Research Group

About

Titles

Senior Research Scientist

Associate Director of Academic Research, Yale Cardiovascular Research Group

Biography

Dr. Tirziu is a Research Scientist and Associate Director of Academic Research (YCRG) who’s oversaw and served as an instrumental member of numerous, innovative advancements in the cardiovascular medicine, specifically in the fields of atherosclerosis, angiogenesis, myocardial hypertrophy, heart failure and medical devices. Dr. Tirziu’s clinical research is focused on the design, reporting and regulatory documentations for interventional cardiovascular device trials, including First-in-Human, CE Mark, IDE/IND Phase III and IV trials and post marketing studies in the US and worldwide. She has made important contributions to clinical research documents, regulatory documents (clinical trial protocols and study reports) and meta-analyses to guide clinical investigation on several novel cardiovascular devices and cerebral embolic protection devices. Dr. Tirziu's research on the basic science front contributed to the understanding of cellular crosstalk in the heart and unraveled a novel molecular mechanism of endothelium-dependent regulation of myocardial hypertrophy and metabolism.

Appointments

Other Departments & Organizations

Education & Training

Research Associate (postdoctoral training)
Dartmouth Medical School, Dartmouth-Hitchcock Medical Center (2006)
PhD
Romanian Academy of Sciences (2000)

Research

Overview

Dr. Tirziu has made substantial contributions to scientifically sound clinical research documents, regulatory documents (clinical trial protocols and study reports) and meta-analyses to guide clinical investigation on several novel cardiovascular devices and cerebral embolic protection devices during transcatheter heart procedures.

On the basic science front, findings from Dr. Tirziu's laboratory showed that stimulation of angiogenesis in the heart promotes cardiomyocyte growth and myocardial hypertrophy through a nitric oxide (NO)-dependent mechanism involving the degradation of regulator of G protein signaling type 4 (RGS4) and de-repression of the Gβγ/PI3Kγ/Akt/mTORC1 pathway with the up-regulation of miR-182 and miR-146b expression in cardiomyocytes.

Medical Subject Headings (MeSH)

Cardiovascular Diseases; Cell Communication; Clinical Trial; Endothelium, Vascular; Endothelium-Dependent Relaxing Factors; Gene Regulatory Networks; Heart Diseases; Heart Failure; MicroRNAs; Publication Characteristics

Research at a Glance

Yale Co-Authors

Frequent collaborators of Daniela Tirziu's published research.

Publications

2024

2023

Academic Achievements & Community Involvement

  • honor

    FAHA

  • honor

    “Junior Investigator Award”

  • honor

    “Magna cum laudae”

  • honor

    “Constantin Velican Award” for research in atherosclerosis and cardiovascular diseases

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