Research & Publications
Dr. Krystal is a leading expert in the areas of alcoholism, post-traumatic stress disorder, schizophrenia, and depression. His work links psychopharmacology, neuroimaging, molecular genetics, and computational neuroscience to study the neurobiology and treatment of these disorders. He is best known for leading the discovery of the rapid antidepressant effects of ketamine in depressed patients.
He is a member of the U.S. National Academy of Medicine. He also serves in a variety of advisory and review capacities for NIAAA, NIMH, Wellcome Trust, Brain and Behavior Research Foundation, the Broad Institute, the Karolinska Institutet, and the U.S. Department of Veterans Affairs.
Dr. Krystal previously served on the National Alcohol Abuse and Alcoholism Advisory Council (NIAAA), the Department of Defense Psychological Health Advisory Committee, the National Institute of Mental Health (NIMH) Advisory Council, and the NIMH Board of Scientific Counselors (chair, 2005-2007). He has led the American College of Neuropsychopharmacology (president, 2012), and International College of Neuropsychophamacology (president, 2016-2018).
Currently, he is co-chair of the Forum on Neuroscience and Nervous System Disorders (NeuroForum) of the National Academies of Sciences, Engineering, and Medicine, and he edits the journal, Biological Psychiatry (impact factor: 13.382).
Education & Training
- ResidencyYale University School of Medicine (1988)
- MDYale University (1984)
- BAUniversity of Chicago, Behavioral Sciences (1980)
- Schizophrenia TreatmentTaichung, Taiwan (2013-2014)Consulting regarding novel treatments for schizophrenia and ketamine-related psychosis.
- Neuroimaging studies of schizophrenia and related disordersChengdu, China (2012-2014)Neuroimaging studies of brain structure and function associated with psychosis
- Rapid Acting Antidepressant TreatmentTaipei, Taiwan (2012-2014)Consulting to a study conducted evaluating the antidepressant effects of ketamine, led by Dr. Tung-Ping (Tom) Su.
- Studies of the impact of sexual traumaBergen, Norway (2011-2016)I am collaborating with Iris Steine, a Ph.D. candidate at the University of Bergen, as well has her mentors and colleagues, on studies on the clinical features and neurobiology of sexual trauma and its complications, including PTSD
- Ketamine PsychosisGuangzhou, China (2010-2014)Studying the phenomenology and genetics of ketamine psychosis in relation to schizophrenia
- Clinical Archives Project Cherite HospitalBerlin, Germany (2006-2014)The Department of Psychiatry at Cherite Hospital in Berlin has long been a home to ethical and compassionate treatment of patients. However, in the period leading up to World War II, its psychiatry leadership involved the hospital in the emerging eugenics movement. This work, contributed to the emergence of the Nazi T4 Program, which introduced forced sterilization and then "euthanasia" for individuals with chronic mental illness. I serve on the External Advisory Board to a historical program, commissioned by Dr. Andreas Heinz, chair of Psychiatry at Cherite, to review the hospital clinical records and to document the participation of this hospital in these atrocities.
Honors & Recognition
|Colvin Prize for Outstanding Achievement in Mood Disorders Research||Brain and Behavior Research Foundation||2019|
|Ulf van Euler Memorial Lecturer||Karolinska Institute||2019|
|Edward H. Ahrens, Jr., Distinguished Investigator Award||Association for Clinical and Translational Science||2019|
|E.M. Jellinek Award for Alcohol Research||E.M. Jellinek Foundation||2016|
|Henri Begleiter Award for Research Excellence||Research Society on Alcoholism||2015|
|Paul Hoch Research Award||American Psychopathological Association||2014|
|Exemplary Psychiatrist Award||National Alliance on Mental Illness||2011|
|Member||U.S. National Academy of Medicine||2010|
|Jack Mendelson Award for Clinical Research||National Institute on Alcohol Abuse and Alcoholism||2010|
|Stanley Dean Award for Schizophrenia Research||American College of Psychiatry||2010|
|Anna-Monika Prize in Depression Research||Anna-Monika Foundation, Munich, Germany||2009|
|Kempf Award for Contributions to Schizophrenia Research through Research and Mentorship||American Psychiatric Association||2005|
|Joel Elkes Award||American College of Neuropsychopharmacology||2001|
|Neuroscience Forum, National Academies of Sciences, Engineering, and Medicine||Co-Director||2018 - Present|
|International College of Neuropsychopharmacology||President||2016 - 2018|
|NIMH||NIMH National Mental Health Advisory Council||2016 - Present|
|American College of Neuropsychopharmacology||President||2011 - 2012|