José Jaime Martínez-Magaña, BSc, MSc, PhD
Postdoctoral AssociateAbout
Research
Publications
Featured Publications
Clozapine Long-Term Treatment Might Reduce Epigenetic Age Through Hypomethylation of Longevity Regulatory Pathways Genes
Pérez-Aldana B, Martínez-Magaña J, Mayén-Lobo Y, de Montellano D, Aviña-Cervantes C, Ortega-Vázquez A, Genis-Mendoza A, Sarmiento E, Soto-Reyes E, Juárez-Rojop I, Tovilla-Zarate C, González-Castro T, Nicolini H, López-López M, Monroy-Jaramillo N. Clozapine Long-Term Treatment Might Reduce Epigenetic Age Through Hypomethylation of Longevity Regulatory Pathways Genes. Frontiers In Psychiatry 2022, 13: 870656. PMID: 35664466, PMCID: PMC9157596, DOI: 10.3389/fpsyt.2022.870656.Peer-Reviewed Original ResearchPathway genesDNA methylomeEpigenetic ageProtein-protein interactionsLong-term treatmentDifferential methylation sitesInfinium MethylationEPIC BeadChipMethylation sitesPsychopharmacological treatmentMethylationEPIC BeadChipContinuous clozapine treatmentDrug-naive patientsGenesMethylomeYears of treatmentLower mortality rateChronological ageCLZ treatmentClozapine treatmentMale patientsDelta agePsychiatric disordersPatientsPsychotic disordersMortality rateCentral and Peripheral Immune Dysregulation in Posttraumatic Stress Disorder: Convergent Multi-Omics Evidence
Núñez-Rios DL, Martínez-Magaña JJ, Nagamatsu ST, Andrade-Brito DE, Forero DA, Orozco-Castaño CA, Montalvo-Ortiz JL. Central and Peripheral Immune Dysregulation in Posttraumatic Stress Disorder: Convergent Multi-Omics Evidence. Biomedicines 2022, 10: 1107. PMID: 35625844, PMCID: PMC9138536, DOI: 10.3390/biomedicines10051107.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsPosttraumatic stress disorderPeripheral immune systemImmune systemInflammatory systemTrauma exposureStress disorderPeripheral immune dysregulationToll-like receptorsLifetime trauma exposurePotential novel drug targetsEtiology of PTSDImmune dysregulationInflammatory dysregulationHPA axisNovel drug targetsImmunological responseInflammatory signalingGeneral populationAnimal modelsIntegrative multi-omics approachPTSD treatmentMultifactorial disorderBrain tissueHallmark featureDysregulationGenome-Wide Analysis of Disordered Eating Behavior in the Mexican Population
Martínez-Magaña J, Hernandez S, Garcia A, Cardoso-Barajas V, Sarmiento E, Camarena B, Caballero A, Gonzalez L, Villatoro-Velazquez J, Medina-Mora M, Bustos-Gamiño M, Fleiz-Bautista C, Tovilla-Zarate C, Juárez-Rojop I, Nicolini H, Genis-Mendoza A. Genome-Wide Analysis of Disordered Eating Behavior in the Mexican Population. Nutrients 2022, 14: 394. PMID: 35057575, PMCID: PMC8778304, DOI: 10.3390/nu14020394.Peer-Reviewed Original ResearchConceptsQuantitative trait lociWide association studySingle nucleotide polymorphismsAssociation studiesTrait lociMulti-tissue expression quantitative trait lociSummary data-based Mendelian randomization analysisMethylation quantitative trait lociExpression quantitative trait lociGenome-wide association studiesGenome-wide associationGenome-wide thresholdDNA methylation levelsEnhancer marksWide analysisGenetic variationMetabolic domainsSilico function predictionFunction predictionSilico analysisMethylation levelsVariant predictionLociGenetic factorsMexican populationGenome-wide association study of psychiatric and substance use comorbidity in Mexican individuals
Martínez-Magaña JJ, Genis-Mendoza AD, Villatoro Velázquez JA, Bustos-Gamiño M, Juárez-Rojop IE, Tovilla-Zarate CA, Sarmiento E, Saucedo E, Rodríguez-Mayoral O, Fleiz-Bautista C, Camarena B, Aguilar A, Gonzalez-Castro TB, Medina-Mora ME, Nicolini H. Genome-wide association study of psychiatric and substance use comorbidity in Mexican individuals. Scientific Reports 2021, 11: 6771. PMID: 33762635, PMCID: PMC7990941, DOI: 10.1038/s41598-021-85881-4.Peer-Reviewed Original ResearchMeSH KeywordsAdultAllelesBiological Variation, PopulationComorbidityFemaleGenetic Association StudiesGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMental DisordersMiddle AgedPolymorphism, Single NucleotidePublic Health SurveillanceQuantitative Trait LociRisk AssessmentRisk FactorsSubstance-Related DisordersYoung AdultConceptsGenome-wide association studiesGenome-wide correlationSingle nucleotide polymorphismsVertical pleiotropyAssociation studiesWide association signalsGenome-wide associationPolygenic risk scoresQuantitative lociAssociation signalsPhagocytosis pathwayNominal associationTraitsPleiotropyPathwayMeQTLMendelian randomizationGenesLociHigher polygenic risk scoreMicroarrayMultiple logistic modelMexican populationCommon comorbiditiesPolymorphismThe Identification of Admixture Patterns Could Refine Pharmacogenetic Counseling: Analysis of a Population-Based Sample in Mexico
Martínez-Magaña JJ, Genis-Mendoza AD, Velázquez J, Camarena B, del Campo Sanchez R, Bautista C, Gamiño M, Reséndiz E, Aguilar A, Medina-Mora ME, Nicolini H. The Identification of Admixture Patterns Could Refine Pharmacogenetic Counseling: Analysis of a Population-Based Sample in Mexico. Frontiers In Pharmacology 2020, 11: 324. PMID: 32390825, PMCID: PMC7188951, DOI: 10.3389/fphar.2020.00324.Peer-Reviewed Original ResearchThe Prevalence of Symptomatology and Risk Factors in Mental Health in Mexico: The 2016–17 ENCODAT Cohort
Medina-Mora M, Genis-Mendoza A, Villatoro Velázquez J, Bustos-Gamiño M, Bautista C, Camarena B, Martínez-Magaña J, Nicolini H. The Prevalence of Symptomatology and Risk Factors in Mental Health in Mexico: The 2016–17 ENCODAT Cohort. International Journal Of Environmental Research And Public Health 2023, 20: 3109. PMID: 36833803, PMCID: PMC9961066, DOI: 10.3390/ijerph20043109.Peer-Reviewed Original ResearchConceptsMental healthPost-traumatic stressDrug use disordersMental health disordersSymptoms of maniaMental health symptomsRepresentative population sampleLittle recent informationIllegal drugsRisk factorsTobacco useUse disordersHealth disordersResponse rateHealth symptomsPrevalenceSymptomsInterviews of individualsComorbiditiesDrugsPopulation sampleNational surveySymptomatologyDisordersFinal sample
2024
Towards a Novel Frontier in the Use of Epigenetic Clocks in Epidemiology
Martínez-Magaña J, Hurtado-Soriano J, Rivero-Segura N, Montalvo-Ortiz J, Garcia-delaTorre P, Becerril-Rojas K, Gomez-Verjan J. Towards a Novel Frontier in the Use of Epigenetic Clocks in Epidemiology. Archives Of Medical Research 2024, 55: 103033. PMID: 38955096, DOI: 10.1016/j.arcmed.2024.103033.Peer-Reviewed Original ResearchImpact of public health interventionsHealth problems associated with agingPublic health interventionsPublic health strategiesEpigenetic clocksEfficacy of interventionsProblems associated with agingBiological agePublic health concernHealth interventionsHealth strategiesAssociated with ageDNA methylation levelsHuman phenomeHealthy agingHealth concernEpigenetic ageMultiple traitsHealthMethylation levelsInterventionAssociationAgeEpidemiological contextHealth spanExploring the relationship between admixture and genetic susceptibility to attention deficit hyperactivity disorder in two Latin American cohorts
Garzón Rodríguez N, Briceño-Balcázar I, Nicolini H, Martínez-Magaña J, Genis-Mendoza A, Flores-Lázaro J, Villatoro Velázquez J, Bustos Gamiño M, Medina-Mora M, Quiroz-Padilla M. Exploring the relationship between admixture and genetic susceptibility to attention deficit hyperactivity disorder in two Latin American cohorts. Journal Of Human Genetics 2024, 69: 373-380. PMID: 38714835, PMCID: PMC11269173, DOI: 10.1038/s10038-024-01246-5.Peer-Reviewed Original ResearchGenome-wide association analysisSingle-nucleotide polymorphismsSingle-nucleotide variantsSingle-nucleotideRisk-associated lociGenome-wide significanceRisk single-nucleotide polymorphismsAttention deficit hyperactivity disorderLocal ancestryAssociation lociIntergenic regionAdmixture proportionsAncestral componentsGenomic ancestryAssociation analysisAncestry levelsEuropean ancestryGenetic associationEuropean componentDeficit hyperactivity disorderAncestryGenomeGenesGenetic susceptibilityHyperactivity disorderA phenome-wide association and Mendelian randomisation study of alcohol use variants in a diverse cohort comprising over 3 million individuals
Jennings M, Martínez-Magaña J, Courchesne-Krak N, Cupertino R, Vilar-Ribó L, Bianchi S, Hatoum A, Atkinson E, Giusti-Rodriguez P, Montalvo-Ortiz J, Gelernter J, Artigas M, 23andMe I, Aslibekyan S, Auton A, Babalola E, Bell R, Bielenberg J, Bryc K, Bullis E, Coker D, Partida G, Dhamija D, Das S, Elson S, Eriksson N, Filshtein T, Fitch A, Fletez-Brant K, Fontanillas P, Freyman W, Granka J, Heilbron K, Hernandez A, Hicks B, Hinds D, Jewett E, Jiang Y, Kukar K, Kwong A, Lin K, Llamas B, Lowe M, McCreight J, McIntyre M, Micheletti S, Moreno M, Nandakumar P, Nguyen D, Noblin E, O'Connell J, Petrakovitz A, Poznik G, Reynoso A, Schumacher M, Shastri A, Shelton J, Shi J, Shringarpure S, Su Q, Tat S, Tchakouté C, Tran V, Tung J, Wang X, Wang W, Weldon C, Wilton P, Wong C, Elson S, Edenberg H, Fontanillas P, Palmer A, Sanchez-Roige S. A phenome-wide association and Mendelian randomisation study of alcohol use variants in a diverse cohort comprising over 3 million individuals. EBioMedicine 2024, 103: 105086. PMID: 38580523, PMCID: PMC11121167, DOI: 10.1016/j.ebiom.2024.105086.Peer-Reviewed Original ResearchConceptsMultiple domains of healthDomains of healthEffects of alcohol consumptionAlcohol consumptionHealth outcomesPhenome-wide association studyAlcohol-related behaviorsCardio-metabolic healthPotential causal effectMendelian randomisation studiesGenome-wide association studiesPhenome-wide associationMR analysisPheWAS associationsMultiple domainsHypothesis-free approachPreventive medicineDiverse cohortPheWASAssociation studiesHealthReproductive healthAlcohol behaviorConsequences of drinkingEuropean cohortNeuronal-specific methylome and hydroxymethylome analysis reveal significant loci associated with alcohol use disorder
Andrade-Brito D, Núñez-Ríos D, Martínez-Magaña J, Nagamatsu S, Rompala G, Zillich L, Witt S, Clark S, Lattig M, Montalvo-Ortiz J, Alvarez V, Benedek D, Che A, Cruz D, Davis D, Girgenti M, Hoffman E, Holtzheimer P, Huber B, Kaye A, Keane T, Krystal J, Labadorf A, Logue M, Marx B, Mash D, McKee A, Miller M, Montalvo-Ortiz J, Noller C, Schnurr P, Scott W, Stein T, Ursano R, Williamson D, Wolf E, Young K. Neuronal-specific methylome and hydroxymethylome analysis reveal significant loci associated with alcohol use disorder. Frontiers In Genetics 2024, 15: 1345410. PMID: 38633406, PMCID: PMC11021708, DOI: 10.3389/fgene.2024.1345410.Peer-Reviewed Original ResearchAssociated with alcohol use disorderAlcohol use disorderOrbitofrontal cortexEpigenome-wide association studiesUse disorderStudy of alcohol use disorderHuman orbitofrontal cortexAlcohol-related traitsHuman brainPostmortem brain samplesHuman postmortem brain samplesEnrichment analysisDifferential CpG sitesPostmortem brain tissueGenome-wide levelOxidative bisulfite sequencingAssessed 5Functional enrichment analysisBrain tissueFalse discovery rateBisulfite sequencingAssociation studiesDifferential methylationIdentified genesDNA methylation