Brenda Cabrera-Mendoza, MD/PhD
she/her/hers
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About
Titles
Postdoctoral Fellow
Biography
Dr. Cabrera-Mendoza joined Dr. Renato Polimanti's group in 2021. She completed her MD and PhD in the National Autonomous University of Mexico as part of the Plan of Combined Studies in Medicine (PECEM by its acronym in Spanish). During her PhD, she investigated genomic alterations associated with suicidal behavior. Her research focus on genetic and epigenetic changes associated with suicidal behavior and substance use disorders.
Education & Training
- MD/PhD
- National Autonomous University of Mexico (2020)
Research
Overview
Medical Subject Headings (MeSH)
Genetics; Genomics; Substance-Related Disorders; Suicide
ORCID
0000-0003-4729-9997
Research at a Glance
Yale Co-Authors
Frequent collaborators of Brenda Cabrera-Mendoza's published research.
Publications Timeline
A big-picture view of Brenda Cabrera-Mendoza's research output by year.
Research Interests
Research topics Brenda Cabrera-Mendoza is interested in exploring.
Renato Polimanti, PhD, MSc
Gita Pathak, PhD
Joel Gelernter, MD
José Jaime Martínez-Magaña, BSc, MSc, PhD
Daniel F. Levey, PhD
John Krystal, MD
36Publications
182Citations
Substance-Related Disorders
Suicide
Publications
The impact of assortative mating, participation bias and socioeconomic status on the polygenic risk of behavioural and psychiatric traits
Cabrera-Mendoza B, Wendt F, Pathak G, Yengo L, Polimanti R. The impact of assortative mating, participation bias and socioeconomic status on the polygenic risk of behavioural and psychiatric traits. Nature Human Behaviour 2024, 8: 976-987. PMID: 38366106, PMCID: PMC11161911, DOI: 10.1038/s41562-024-01828-5.Peer-Reviewed Original ResearchCitationsAltmetricConceptsSocioeconomic statusParticipation biasPsychiatric traitsPolygenic riskFrequency of drinking alcoholDepressive disorderTourette syndromeImpact of assortative matingAlcohol-related traitsAlcohol use disorderAlcohol-related phenotypesInvestigate assortative matingSocioeconomic status conditionsHabitual alcohol intakeAssortative matingAlcohol intakeDrinking alcoholBipolar disorderQuestionnaire respondentsUse disorderMeta-analysisParticipantsGametic phase disequilibriumDisordersTouretteWithin subject cross‐tissue analyzes of epigenetic clocks in substance use disorder postmortem brain and blood
Cabrera‐Mendoza B, Stertz L, Najera K, Selvaraj S, Teixeira A, Meyer T, Fries G, Walss‐Bass C. Within subject cross‐tissue analyzes of epigenetic clocks in substance use disorder postmortem brain and blood. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2022, 192: 13-27. PMID: 36056652, PMCID: PMC9742183, DOI: 10.1002/ajmg.b.32920.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSubstance use disordersStimulant use disorderUse disordersPostmortem brainsAlcohol use disorderBrains of individualsBlood tissueBiological agingSubgroup analysisBrain valuesEpigenetic clocksSUD groupPeripheral measuresAging StudyDisordersBrainPatientsBloodDNA methylation changesSame individualTissueIndividualsMethylation changesOpioidsTissue specificityEstimating the direct effects of the genetic liabilities to bipolar disorder, schizophrenia, and behavioral traits on suicide attempt using a multivariable Mendelian randomization approach
Cabrera-Mendoza B, Aydin N, Fries G, Docherty A, Walss-Bass C, Polimanti R. Estimating the direct effects of the genetic liabilities to bipolar disorder, schizophrenia, and behavioral traits on suicide attempt using a multivariable Mendelian randomization approach. Neuropsychopharmacology 2024, 49: 1383-1391. PMID: 38396255, DOI: 10.1038/s41386-024-01833-2.Peer-Reviewed Original ResearchCitationsAltmetricConceptsAssociated with higher oddsPsychiatric Genomics ConsortiumSubstance use disordersSocioeconomic factorsMendelian randomizationBipolar disorderGenetic liabilitySuicide attemptsHigher oddsTwo-sample Mendelian randomizationGenetic liability to bipolar disorderEffects of mental distressUK Biobank (UKBLiability to bipolar disorderMultivariable MR approachMendelian randomization approachComprehensive mental health assessmentGenome-wide association dataRisk of psychiatric disordersMental health assessmentBehavioral traitsAssociated with lonelinessHigh-risk individualsMental distressContext of SAThe association of obesity-related traits on COVID-19 severity and hospitalization is affected by socio-economic status: a multivariable Mendelian randomization study
Cabrera-Mendoza B, Wendt FR, Pathak GA, De Angelis F, De Lillo A, Koller D, Polimanti R. The association of obesity-related traits on COVID-19 severity and hospitalization is affected by socio-economic status: a multivariable Mendelian randomization study. International Journal Of Epidemiology 2022, 51: 1371-1383. PMID: 35751636, PMCID: PMC9278255, DOI: 10.1093/ije/dyac129.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSevere respiratory COVID-19COVID-19 severityCOVID-19 outcomesSocio-economic statusMendelian randomization studyObesity-related traitsLower oddsCOVID-19Randomization studyCoronavirus disease 2019 (COVID-19) severityBody mass indexWaist-hip ratioCOVID-19 infectionTwo-sample MR approachAssociation of incomeMultivariable Mendelian randomization studyLinking Behavior and Genetics: Psychopathology and Recognition of Anger and Other Emotions
Cabrera-Mendoza B, Koller D, Polimanti R. Linking Behavior and Genetics: Psychopathology and Recognition of Anger and Other Emotions. 2023, 1567-1584. DOI: 10.1007/978-3-031-31547-3_86.ChaptersSex differences in brain gene expression among suicide completers
Cabrera-Mendoza B, Fresno C, Monroy-Jaramillo N, Fries GR, Walss-Bass C, Glahn DC, Ostrosky-Wegman P, Mendoza-Morales RC, García-Dolores F, Díaz-Otañez CE, González-Sáenz EE, Genis-Mendoza AD, Martínez-Magaña JJ, Romero-Pimentel AL, Flores G, Vázquez-Roque RA, Nicolini H. Sex differences in brain gene expression among suicide completers. Journal Of Affective Disorders 2020, 267: 67-77. PMID: 32063575, DOI: 10.1016/j.jad.2020.01.167.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsBrain gene expressionSex-specific gene expression patternsGene expressionRibonucleic protein complexesGene expression patternsGene expression profilesProtein complexesGene setsDNA bindingExpression patternsExpression profilesGenesSuicide geneBiological levelsVesicular functionCell proliferationValuable foundationDifferentiallyMicroarrayExpressionSex-specific factorsSuicide completersSuicidal brainImmune responseSex differencesCandidate pharmacological treatments for substance use disorder and suicide identified by gene co‐expression network‐based drug repositioning
Cabrera‐Mendoza B, Martínez‐Magaña J, Monroy‐Jaramillo N, Genis‐Mendoza A, Fresno C, Fries GR, Walss‐Bass C, Armenta M, García‐Dolores F, Díaz‐Otañez C, Flores G, Vázquez‐Roque R, Nicolini H. Candidate pharmacological treatments for substance use disorder and suicide identified by gene co‐expression network‐based drug repositioning. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2021, 186: 193-206. PMID: 33403748, DOI: 10.1002/ajmg.b.32830.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSubstance use disordersUse disordersBrain gene co-expression networksHub genesPotential pharmacological targetPost-mortem samplesPharmacological treatmentHigh riskCandidate treatmentPharmacological targetsSuicidal behaviorMAOA inhibitorsPrefrontal cortexNonsuicidesDGIdb databaseGene expression profilesPatientsCo-expression networkSuicideDisordersDrugsTreatmentDrug repositioningExpression profilesIndividualsHigh polygenic burden is associated with blood DNA methylation changes in individuals with suicidal behavior
Cabrera-Mendoza B, Martínez-Magaña JJ, Genis-Mendoza AD, Sarmiento E, Ruíz-Ramos D, Tovilla-Zárate CA, González-Castro TB, Juárez-Rojop IE, García-de la Cruz DD, López-Armenta M, Real F, García-Dolores F, Flores G, Vázquez-Roque RA, Lanzagorta N, Escamilla M, Saucedo-Uribe E, Rodríguez-Mayoral O, Jiménez-Genchi J, Castañeda-González C, Roche-Bergua A, Nicolini H. High polygenic burden is associated with blood DNA methylation changes in individuals with suicidal behavior. Journal Of Psychiatric Research 2020, 123: 62-71. PMID: 32036075, DOI: 10.1016/j.jpsychires.2020.01.008.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsDNA methylation differencesMethylation differencesDiscovery samplePolygenic risk scoresDNA methylation changesSuicidal behaviorGenetic burdenPolygenic burdenPsychiatric Genomics ConsortiumEpigenetic variationATP bindingDNA methylationEnvironmental factorsMethylation changesEpigenetic changesGenomics ConsortiumPolygenic componentGenesGenetic variantsPRS analysesRisk scoreMexican individualsBurdenIntegration of approachesNeurodevelopmentBrain Gene Expression-DNA Methylation Correlation in Suicide Completers: Preliminary Results
Cabrera-Mendoza B, Martínez-Magaña J, Genis-Mendoza A, Monroy-Jaramillo N, Walss-Bass C, Fries G, García-Dolores F, López-Armenta M, Flores G, Vázquez-Roque R, Nicolini H. Brain Gene Expression-DNA Methylation Correlation in Suicide Completers: Preliminary Results. Revista De Investigación Clínica 2021, 72 DOI: 10.24875/ric.19003250.Peer-Reviewed Original ResearchCitationsAltmetricA meta-study on transcription factor networks in the suicidal brain
Cabrera-Mendoza B, de Anda-Jáuregui G, Nicolini H, Fresno C. A meta-study on transcription factor networks in the suicidal brain. Journal Of Psychiatric Research 2021, 136: 23-31. PMID: 33548827, DOI: 10.1016/j.jpsychires.2021.01.037.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsBipolar disorderSchizophrenia NetworkSuicidal brainDifferent mental disordersDisorders NetworkMajor depression disorderImmune response genesGene expression differencesHealthy controlsImmune responseDepression disorderDepression networkDisorder-specific characteristicsMental disordersPrefrontal cortexDisordersExpression differencesRegulatory mechanismsTranscription factor networkSuicideSocial stressBrainSuicide neurobiologyTranscriptional factorsFactor network
Academic Achievements and Community Involvement
activity Co-Chair
Professional OrganizationsSuicide Working Group - Latin American Genomics ConsortiumDetails09/29/2023 - Presentactivity Member
Professional OrganizationsInternational Behavioral Neuroscience SocietyDetails05/04/2021 - Presentactivity Member
Public ServiceInternational Academy of Suicide ResearchDetails09/10/2021 - PresentDescriptionJunior Memberactivity Co-Chair
Meeting Planning and ParticipationSociety of Biological Psychiatry - Early Career HourDetails04/12/2022 - Presentactivity Member
Committees International Society of Psychiatric Genetics, Inclusion, Diversity, and Equity in Action (IDEA) CommitteeDetails2022 - Present
Links & Media
News
- March 20, 2024
Yale researchers hailed as STAT 'Wunderkinds'
- September 22, 2023Source: Psychological Medicine
In Study of Veterans, Positive Personality Traits Moderate Persistent High Alcohol Consumption
- May 11, 2023
Yale-led Study Pinpoints Why Some Adults Develop Hearing Problems
- January 10, 2023
A Therapeutic Target for High Blood Pressure Control
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