Brenda Cabrera-Mendoza, MD, PhD

Featured Publications

• Genomic Studies of Suicidal Thoughts and Behaviors in Latin American Populations: A Systematic Review

  Cabrera-Mendoza B, Panzenhagen A, de Anda-Jáuregui G, He J, Magalhaes P, Martínez-Magaña J, Martínez-Levy G, Qiu D, Sotelo D, Torres D, Medrano J, Vidal G, Velásquez M, Nicolini H, Polimanti R, Kaster M, Docherty A, Kimbrel N, Genis-Mendoza A, Ito L, Shansis F, Rovaris D, Folego-Temoteo I, Fries G, Consortium S. Genomic Studies of Suicidal Thoughts and Behaviors in Latin American Populations: A Systematic Review. Biological Psychiatry 2026 PMID: 41539590, PMCID: PMC12969891, DOI: 10.1016/j.biopsych.2025.12.009.

  Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements

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• The impact of assortative mating, participation bias and socioeconomic status on the polygenic risk of behavioural and psychiatric traits

  Cabrera-Mendoza B, Wendt F, Pathak G, Yengo L, Polimanti R. The impact of assortative mating, participation bias and socioeconomic status on the polygenic risk of behavioural and psychiatric traits. Nature Human Behaviour 2024, 8: 976-987. PMID: 38366106, PMCID: PMC11161911, DOI: 10.1038/s41562-024-01828-5.

  Peer-Reviewed Original Research

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• Within subject cross‐tissue analyzes of epigenetic clocks in substance use disorder postmortem brain and blood

  Cabrera‐Mendoza B, Stertz L, Najera K, Selvaraj S, Teixeira A, Meyer T, Fries G, Walss‐Bass C. Within subject cross‐tissue analyzes of epigenetic clocks in substance use disorder postmortem brain and blood. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2022, 192: 13-27. PMID: 36056652, PMCID: PMC9742183, DOI: 10.1002/ajmg.b.32920.

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• Estimating the direct effects of the genetic liabilities to bipolar disorder, schizophrenia, and behavioral traits on suicide attempt using a multivariable Mendelian randomization approach

  Cabrera-Mendoza B, Aydin N, Fries G, Docherty A, Walss-Bass C, Polimanti R. Estimating the direct effects of the genetic liabilities to bipolar disorder, schizophrenia, and behavioral traits on suicide attempt using a multivariable Mendelian randomization approach. Neuropsychopharmacology 2024, 49: 1383-1391. PMID: 38396255, PMCID: PMC11250798, DOI: 10.1038/s41386-024-01833-2.

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• The association of obesity-related traits on COVID-19 severity and hospitalization is affected by socio-economic status: a multivariable Mendelian randomization study

  Cabrera-Mendoza B, Wendt FR, Pathak GA, De Angelis F, De Lillo A, Koller D, Polimanti R. The association of obesity-related traits on COVID-19 severity and hospitalization is affected by socio-economic status: a multivariable Mendelian randomization study. International Journal Of Epidemiology 2022, 51: 1371-1383. PMID: 35751636, PMCID: PMC9278255, DOI: 10.1093/ije/dyac129.

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• Equitable Collaboration Between LMIC and HIC Researchers, Part I: A Preliminary Framework for Capacity Building in Psychiatric Genetics Research

  Cabrera‐Mendoza B, Burmeister M, Rietschel M, Crepaz‐Keay D, Balhara Y, Seedat S, Marshe V, Hemmings S, Peterson R, Kaushik R, Viswanath B, Sud R, Haldar P, Johnstone M, Cherian A, Lencz T, Zinkstok J, Polimanti R, Mueller D, Lázaro‐Muñoz G, Liu C, John N, Nicolini H, Walss‐Bass C, Santoro M, Satapathy S, Behera C, Docherty A. Equitable Collaboration Between LMIC and HIC Researchers, Part I: A Preliminary Framework for Capacity Building in Psychiatric Genetics Research. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2025, 198: 154-167. PMID: 40635475, DOI: 10.1002/ajmg.b.33042.

  Peer-Reviewed Original Research

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• The landscape of suicide risk factors in Latin America

  Cabrera-Mendoza B, Fries G, Polimanti R, Consortium S. The landscape of suicide risk factors in Latin America. Psychiatry Research 2025, 351: 116597. PMID: 40674133, DOI: 10.1016/j.psychres.2025.116597.

  Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements

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• Sex differences in brain gene expression among suicide completers

  Cabrera-Mendoza B, Fresno C, Monroy-Jaramillo N, Fries GR, Walss-Bass C, Glahn DC, Ostrosky-Wegman P, Mendoza-Morales RC, García-Dolores F, Díaz-Otañez CE, González-Sáenz EE, Genis-Mendoza AD, Martínez-Magaña JJ, Romero-Pimentel AL, Flores G, Vázquez-Roque RA, Nicolini H. Sex differences in brain gene expression among suicide completers. Journal Of Affective Disorders 2020, 267: 67-77. PMID: 32063575, DOI: 10.1016/j.jad.2020.01.167.

  Peer-Reviewed Original Research

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• Candidate pharmacological treatments for substance use disorder and suicide identified by gene co‐expression network‐based drug repositioning

  Cabrera‐Mendoza B, Martínez‐Magaña J, Monroy‐Jaramillo N, Genis‐Mendoza A, Fresno C, Fries GR, Walss‐Bass C, Armenta M, García‐Dolores F, Díaz‐Otañez C, Flores G, Vázquez‐Roque R, Nicolini H. Candidate pharmacological treatments for substance use disorder and suicide identified by gene co‐expression network‐based drug repositioning. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2021, 186: 193-206. PMID: 33403748, DOI: 10.1002/ajmg.b.32830.

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• High polygenic burden is associated with blood DNA methylation changes in individuals with suicidal behavior

  Cabrera-Mendoza B, Martínez-Magaña JJ, Genis-Mendoza AD, Sarmiento E, Ruíz-Ramos D, Tovilla-Zárate CA, González-Castro TB, Juárez-Rojop IE, García-de la Cruz DD, López-Armenta M, Real F, García-Dolores F, Flores G, Vázquez-Roque RA, Lanzagorta N, Escamilla M, Saucedo-Uribe E, Rodríguez-Mayoral O, Jiménez-Genchi J, Castañeda-González C, Roche-Bergua A, Nicolini H. High polygenic burden is associated with blood DNA methylation changes in individuals with suicidal behavior. Journal Of Psychiatric Research 2020, 123: 62-71. PMID: 32036075, DOI: 10.1016/j.jpsychires.2020.01.008.

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