New Advanced Diagnostic Tests Lab to Perform, Interpret Clinical-grade Molecular Testing of Biomarkers
The Yale Advanced Diagnostic Tests Laboratory in the Department of Pathology, a new unit of Yale Pathology Laboratories, offers access to novel molecular tests to external users, performing and interpreting clinical grade and high-quality molecular analysis of human tissue samples.
Discovering the 'Cytokine Language' That Activates Immune Responses
Using a new computational method based on a causal inference framework, CINEMA-OT, the Yale team studied how individual immune cells react to combinations of cytokines, or small proteins released by cells that regulate inflammation. They discovered that certain cytokines have a synergistic effect, inducing unique gene activation programs compared to their individual effects. This cryptography of cytokine signals acts as a language, instructing immune cells.
Pathology Office of Research Affairs Makes an Impact
Gina Della Porta, left, Director of the Office of Research Affairs, and David Stern, Professor of Pathology and Vice Chair for Basic and Translational Sciences, who oversees the office. In just one year, the Department of Pathology’s Office of Research Affairs has made an impact.
Stephania Libreros, PhD, Receives NIH Pathway to Independence Award
Stephania Libreros, PhD, a newly appointed Assistant Professor of Pathology and a member of the Vascular Biology Therapeutics Program at Yale School of Medicine, was recently awarded a National Institute of Health (NIH) K99-R00 Award from National Heart Lung and Blood Institute, to support her independent research as she moves into a full-time tenure track faculty position.
Xuchen Zhang, MD, PhD, to Succeed Marie Robert, MD, as Director of Gastrointestinal Pathology
Xuchen Zhang, MD, PhD, Professor of Pathology, will be appointed as Director of Gastrointestinal Pathology effective July 1, succeeding Marie Robert, MD, Professor of Pathology and of Medicine (Digestive Diseases).
Angelique Levi, MD, to Succeed John Sinard, MD, PhD, as Vice Chair of Operations, CLIA Laboratory Medical Director
Angelique Levi, MD, Associate Professor of Pathology, has been appointed Vice Chair of Operations and CLIA Laboratory Medical Director for the Department of Pathology at Yale School of Medicine, effective July 1, 2023.
Study Suggests Retina Represents System for Investigating Therapeutic Approaches in Neurodegenerative Diseases
The findings provide evidence that the retina, the site of damage in advanced macular degeneration—the leading cause of blindness in elderly patients—is also a source for knowledge about treating neurodegenerative diseases.
Yale Pathology Research Highlights Challenges of Interpreting PD-L1 Expression With CPS Method
Recent studies from Marie Robert, MD, and David Rimm, MD, PhD, highlight the challenges pathologists face when interpreting PD-L1 expression using the combined positive score method of interpretation of immunohistochemistry results for patients with gastric/gastroesophageal junction/esophageal cancers.
New Data Reported From Trials of Drug Developed at Yale Pathology to Treat Rare, Often Fatal Neonatal Disorder
Clinical trial data from an enzyme-therapy drug developed at Yale Pathology to treat a rare and often fatal neonatal calcification disorder were recently reported. The drug, INZ-701, was designed and validated in the laboratory of Demetrios Braddock, MD, PhD, Associate Professor of Pathology at Yale School of Medicine.
Yale Cancer Center Study Characterizes Link Between Drug Resistance and Central Nervous System Relapse
A new study from Yale Cancer Center characterizes the functional link between drug resistance and central nervous system (CNS) relapse. The findings from a study led by Don Nguyen, PhD, BS, Associate Professor of Pathology and Medicine (Medical Oncology) and Assistant Yale Cancer Center Director for Research Development, were recently published in the journal Nature Communications.
Yale Pathologists to Collaborate with African Physicians at Inaugural PEACE Symposium
A partnership that began at Emory University to allow pathologists to collaborate and share knowledge with physicians in Africa has expanded to include Yale School of Medicine pathologists and will hold its first symposium in December.
Yale Researchers Awarded $12M NIH Grant to Study Impact of FGF21 Protein on Aging
Researchers from Yale University, and the University of Texas Southwestern Medical Center have been awarded a $12.4 million, five-year grant from the National Institute on Aging of the NIH to deploy their unique research models and expertise in a coordinated fashion to develop a novel course of gerontological research.
Dhanpat Jain, MD, Joins Pathologists Nationwide in Calling for Continued Use of Remote Work in Clinical Laboratories and Pathology
A group of pathologists and laboratory leaders from across the U.S. is urging federal officials to continue certain regulatory exemptions implemented during the COVID-19 pandemic that allow the use of remote work in clinical laboratories and pathology.