Discovering the 'Cytokine Language' That Activates Immune Responses
Using a new computational method based on a causal inference framework, CINEMA-OT, the Yale team studied how individual immune cells react to combinations of cytokines, or small proteins released by cells that regulate inflammation. They discovered that certain cytokines have a synergistic effect, inducing unique gene activation programs compared to their individual effects. This cryptography of cytokine signals acts as a language, instructing immune cells.
Can an Image-based Electrocardiographic Algorithm Improve Access to Care in Remote Settings?
Researchers at the Yale Cardiovascular Data Science (CarDS) Lab have developed an artificial intelligence (AI)-based model for clinical diagnosis that can use electrocardiogram (ECG) images, regardless of format or layout, to diagnose multiple heart rhythm and conduction disorders.
Agile Analytics & Operational Intelligence for COVID-19
The global outbreak of SARS-CoV-2 (COVID-19) has been filled with uncertainty. Who is most at risk? Which symptoms are most common? What treatments are effective? The incredibly varied presentation, from asymptomatic patients to mortality further complicates assessing the true scope of infection and drives further uncertainty in how to respond to and manage the pandemic. Rapid turnaround in research from China and other locations with some of the first cases has provided invaluable information to guide the next stage of research and treatment. However, as large-scale clinical trials are difficult to deploy rapidly, much of the next wave will rely on real-world data (RWD) and observational studies paired with basic and translational research to guide the response to and management of COVID-19.Source: Medium
"Introduction to Biomedical Data Science and Health Informatics" Summer Course, June 8-12, Will Be Online
A one-week online summer course to offer basic biomedical data science knowledge and health informatics skills. Each day will consist of office hours and labs. Lectures will be distributed in advance.
PHATED to Be: Yale Researchers Give Shape to Big Data
The lab of Yale’s Smita Krishnaswamy, associate professor of genetics and computer science, has developed a new algorithm called PHATE that overcomes many of the shortcomings of existing data visualization tools, which are more susceptible to noise and distortion in the relationship of data points.