The VA Launches Largest-Ever Trial on Screening Methods for Liver Cancer
The largest clinical trial in history related to liver cancer screening is launching in 2023, funded by the Department of Veterans Affairs. The project is scheduled to recruit 4,700 veterans with cirrhosis from 47 VA medical centers. Cirrhosis is a major risk factor for liver cancer and affects veterans disproportionally.
Bypass Surgery Has Lower Risks Than Endovascular Therapy for Limb-threatening Ischemia
Bypass surgery in artiries leading to the legs was associated with a lower risk of cardiac events among patients with peripheral arterial disease who are candidates for two types of revascularization therapy, new research suggests.
TRANSFORM-HF: Loop Diuretics Show No Difference in Mortality and Hospitalizations for Heart Failure
The results of the TRANSFORM-HF study, which explored the effects of two different therapies on heart failure outcomes, were featured during the first late-breaking session at the American Heart Association Scientific Sessions.
Fighting Breast and Ovarian Cancer With a Lupus Antibody
After discovering a specific lupus antibody that can penetrate cancer cells and, with a grant from Women's Health Research at Yale, showing it makes cancer cells vulnerable to standard treatments, Dr. Peter Glazer and his colleagues are moving a treatment to clinical trials.
Using Particles That Are Smaller Than the Head of a Pin to Treat Cancer
Thanks in part to research begun more than a decade ago with funding from Women’s Health Research at Yale, Dr. W. Mark Saltzman is working with colleagues on a way to deploy effective cancer-fighting medication safely with the help of nanoparticles.
Yale CMIPS Faculty Member Dr. Fan Li Receives PCORI Grant to Develop New Methods for Planning Cluster Randomized Trials
We as humans differ from one another in our backgrounds, genetics, and health conditions. For instance, most of us are aware that no two people are the same based on our genetic makeup and lived experiences. Yet clinical trials are often not designed to powerfully analyze how various individual differences like age, health history, and socioeconomic status impact the effect of specific interventions. Fan Li, PhD, Assistant Professor of Biostatistics and faculty member at the Center for Methods in Implementation and Prevention Science (CMIPS) at the Yale School of Public Health, has recently received an award from the Patient-Centered Outcomes Research Institute (PCORI) to develop new methods for planning cluster randomized trials that will incorporate such factors into relevant research and interventions.
Digestive Diseases Program Facilitates Research for Investigators and Study Coordinators
Investigators in the Yale School of Medicine Section of Digestive Diseases are conducting clinical trials in a variety of areas, including fatty liver disease, hepatitis, inflammatory bowel disease, and primary sclerosing cholangitis. The studies serve to help patients with complicated conditions who either have no treatment options or who would like to try novel therapies.
Researchers Are Testing Paxlovid as a Treatment for Long COVID
Long COVID currently affects millions of people in the U.S. Symptoms can include brain fog, tremors, sleep disorders, and shortness of breath. The National Institutes of Health (NIH) and other academic medical centers recently launched clinical trials aimed at finding treatments for long COVID. Researchers think that there may be different causes of long COVID symptoms in different people, which is why they are conducting different clinical trials in many centers around the country.Source: Verywell Health