Samuel Katz, MD, PhD

Associate Professor of Pathology

Research Departments & Organizations

Pathology: Katz Lab | Pathology Research

Yale Cancer Center: Genomics, Genetics, and Epigenetics

Office of Cooperative Research

Research Interests

Apoptosis; Cell Death; Endoplasmic Reticulum Stress; Genes, bcl-2; Leukemia; Lymphoma; Stem Cells

Research Summary

The goal of the Katz laboratory is to selectively control the cell death machinery for therapeutic benefit. Toward that end a multidisciplinary approach is applied to understand how mammalian cells are conditioned to expire, and how mutations in essential apoptotic regulators lead to developmental defects or malignancy. In particular, BCL-2 family proteins are vital regulators of mitochondrial integrity and have been implicated in the development, maintenance and chemoresistance of numerous cancers. While the basic mode of BCL-2 family action is established, how this pathway is integrated in the context of various cellular programs, including alternate survival and death pathways, is not nearly as well understood.

Thus, we focus on:

  1. severe apoptotic blockades in cancer stem cells;
  2. loss of pro-apoptotic BCL-2 family members in mantle cell lymphoma as well as other cancers; and
  3. the mechanism of key understudied family members.

Clinical Trials

Conditions Study Title
Melanoma, skin A Pilot Study Using Short-Term Cultured Anti-Tumor Autologous Lymphocytes Following a Lymphocyte Depleting Regimen in Metastatic Melanoma
Melanoma, skin A Phase II, Multicenter, Single-arm Study to Assess the Safety, Feasibility, and Efficacy of Cell Transfer Therapy Using Autologous Tumor Infiltrating Lymphocytes (LN-144) Followed by IL-2 for Treatment of Metastatic Melanoma

Selected Publications

See list of PubMed publications

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Contact Info

Samuel Katz, MD, PhD
Mailing Address
Pathology310 Cedar Street
PO Box 208023

New Haven, CT 06520-8023

Katz Lab