Joseph Lim, MD

Professor of Medicine; Director, Yale Viral Hepatitis Program

Research Departments & Organizations

Internal Medicine: Digestive Diseases | Liver Center

Center for Interdisciplinary Research on AIDS

Drug use, Addiction, and HIV Research Scholars (DAHRS)

Office of Cooperative Research

Research Interests

Carcinoma, Hepatocellular; Clinical Trial; Delivery of Health Care; Fatty Liver; Health Services Research; Hepatitis B; Hepatitis C; Hepatitis D; Liver Cirrhosis; Liver Neoplasms; Quality of Health Care

Research Summary

Dr. Lim's primary clinical and research interests are focused on acute and chronic liver diseases, with emphasis on: 1) Chronic hepatitis B and C infections; 2) Fatty liver disorders, including non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH); and 3) Complications of cirrhosis and portal hypertension.

Extensive Research Description

I would be pleased to work with trainees and scientists who are interested in studying health outcomes in patients with chronic liver disease, with particular attention to chronic hepatitis B and C infections, fatty liver disease, liver cirrhosis and complications of portal hypertension, and hepatocellular carcinoma. I am an investigator in several national or international multicenter cohort studies evaluating health outcomes focused on hepatitis B and hepatitis C therapy, and a VA cohort study evaluating liver disease outcomes in patients with or without HIV coinfection.

Clinical Trials

Conditions Study Title
Hepatitis An Observational Study of Patients Undergoing Therapy for Chronic Hepatitis B (HBV) Infection
Diseases of the Digestive System - Liver AURORA: Phase 3 Study for the Efficacy and Safety of CVC for the Treatment of Liver Fibrosis in Adults With NASH
Diseases of the Digestive System - Liver Procurement of Blood Samples from Subjects with NASH or NAFLD for Development of Liver Fibrosis Test
Diseases of the Digestive System - Liver Phase 3 Study to Evaluate the Efficacy and Safety of Elafibranor Versus Placebo in Patients With Nonalcoholic Steatohepatitis (NASH) (RESOLVE-IT)
Diseases Of The Digestive System, Diseases of the Digestive System - Liver Randomized Global Phase 3 Study to Evaluate the Impact on NASH With Fibrosis of Obeticholic Acid Treatment (REGENERATE)
Children's Health, Diseases of the Digestive System - Liver De Novo Autoimmune Hepatitis in Pediatric Liver Transplantation
Hepatitis, Children's Health, Diseases of the Digestive System - Liver, Immune System The Role of Sodium Chloride and the Treg/Th17 Axis in Autoimmune Hepatitis
Hepatitis, Diseases of the Digestive System - Liver HCV-TARGET- Hepatitis C Therapeutic Registry and Research Network

Selected Publications

See list of PubMed publications

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