John Hwa, MD, PhD, FRACP

Professor of Medicine (Cardiology)

Research Departments & Organizations

Internal Medicine: Cardiovascular Medicine: Hwa Lab

Vascular Biology and Therapeutics Program

Yale Cancer Center: Cancer Immunology

Office of Cooperative Research

Research Interests

Blood Platelets; Carcinoma, Non-Small-Cell Lung; Cardiology; Diabetes Mellitus; Metabolism

Research Summary

We wish to determine why patients with diabetes mellitus have increased vascular thrombosis. We use a combination of approaches including molecular signaling, biochemistry, genomics and proteomics on both human subjects and animal models. The ultimate goal is to develop novel mechanistic based therapies.

We have also been exploring the role of platelets in non-small-cell lung carcinoma (NSCLC) - both how platelets are influenced by the NSCLC, and how platelets can influence the progression of NSCLC.

Specialized Terms: Platelets; Diabetes Mellitus; Atherothrombosis; Prostacyclin; Thromboxane; NSAIDs

Extensive Research Description

The Hwa Laboratory research interests are on eicosanoids and diabetes mellitus, and include a number of large collaborative efforts within Yale and externally. All are focused in the broad areas of eicosanoids, NSAIDs and the development of thrombus on a background of atherosclerosis (atherothrombosis). Our studies extend from fundamental structure function of GPCRs, to pharmacogenetics, molecular signaling, pathophysiology, and clinical outcomes. For our studies we use a number of models including tissue culture cells, platelets, vascular smooth muscle cells, mouse knockout and transgenics, and recruited human patients. Our current studies can be broadly divided into the following major areas.

1) Pharmacogenetics of the prostanoid receptors

2) Platelet dysfunction in diabetes mellitus

3) miRNA regulation of thrombosis

4) The Yale cardiovascular tissue repository collaborative effort

Selected Publications

See list of PubMed publications

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Contact Info

John Hwa, MD, PhD, FRACP
Lab Location
Cardiovascular Research Center300 George Street, Ste 7th Floor
New Haven, CT 06511
Office Location
Cardiovascular Research Center300 George Street, Ste 759H
New Haven, CT 06511
Mailing Address
Cardiovascular MedicinePO Box 208017
New Haven, CT 06520-8017

The Hwa Lab

Research Image 1

Coronary angiogram, DNA sequence, and structural homology data for an R212C patient