Research Departments & Organizations
My translational research interests can be divided along two thematic lines: (1) clinical trials implementation and design in neurological disease, and (2) advanced imaging in cerebrovascular disease.
Specialized Terms: Translational application of advanced imaging protocols in neurovascular disease; clinical trials
Extensive Research Description
1. CLINICAL TRIALS
I am currently involved in the following national and international, multi-center clinical trials that are enrolling (or about to enroll) at Yale-New Haven Hospital.
Brain Aneurysms / Subarachnoid Hemorrhage
ASTROH Trial. A multi-center, phase II randomized clinical trial of continuous low-dose IV heparin therapy in coiled low-grade aneurysmal SAH patients with significant hemorrhage burden. [My role: site-PI.]
NEWTON Trial. A multi-center, phase 3 randomized, double-blinded, placebo-controlled efficacy and safety study comparing EG-1962 to standard of care oral nimodipine in adults with aneurysmal subarachnoid hemorrhage. [My role: site-PI.]
CONFIDENCE Trial. A prospective, multi-center, single-arm, open-label clinical study to evaluate the safety and efficacy of Roadsaver carotid stent device used in conjunction with the Nanoparasol embolic protection system for the treatment of carotid artery stenosis in patients with elevated risk for adverse events following carotid endarterectomy. [My role: site-PI.]
CREST-2. Carotid revascularization for primary prevention of stroke (CREST-2) is two independent multicenter, randomized controlled trials of carotid revascularization and intensive medical management versus medical management alone in patients with asymptomatic high-grade carotid stenosis. [My role: sub-investigator, interventionist.]
MISTIE-III. The purpose of this trial is to determine the safety of using a combination of minimally invasive surgery and clot lysis with rt-PA to remove intracerebral hemorrhage (ICH). [My role: site-co-PI, lead surgeon.]
2. ADVANCED IMAGING RESEARCH
My translational research is focused on advanced imaging of the critically ill neurovascular patient. Our overall aim is to improve the safety and quality of care rendered to patient's with cerebrovascular disease.
|Diseases of the Nervous System||An International Study to Evaluate Diagnostic Efficacy of Flurpiridaz (18F) Injection PET MPI in the Detection of Coronary Artery Disease (CAD)|
|Diseases of the Nervous System||COMPLETE: International Acute Ischemic Stroke Registry With the Penumbra System Aspiration Including the 3D Revascularization Device|
|Diseases of the Cardiovascular System||Evaluation of the Roadsaver Stent Used in Conjunction With the Nanoparasol Embolic Protection System for Carotid Artery Stenosis|
|Diseases of the Cardiovascular System||Aneurysmal Subarachnoid Hemorrhage Trial RandOmizing Heparin (ASTROH)|
Vessel wall magnetic resonance imaging identifies the site of rupture in patients with multiple intracranial aneurysms: proof of principle.
Matouk C, Mandell DM, Gunel M, Bulsara KR, Malhotra A, Hebert R, Johnson MH, Mikulis DJ, Minja FJ. Vessel wall MRI identifies the site-of-rupture in patients with multiple intracranial aneurysms: proof-of-principle. Neurosurgery. 2013 Mar;72(3):492-6; discussion 496. doi: 10.1227/NEU.0b013e31827d1012.
Carotid artery angioplasty and stenting for patients less than 70 years-of-age.
Alkins R, Matouk CC, Cruz JP, Marotta T, Montanera W, Spears J. Carotid artery angioplasty and stenting for patients less than 70 years-of-age. The Canadian Journal Of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques 2012, 39:338-42. 2012
Vessel wall MRI to differentiate between reversible cerebral vasoconstriction syndrome and central nervous system vasculitis: preliminary results.
Mandell DM, Matouk CC, Farb RI, Krings T, Agid R, terBrugge K, Willinsky RA, Swartz RH, Silver FL, Mikulis DJ. Vessel wall MRI to differentiate between reversible cerebral vasoconstriction syndrome and central nervous system vasculitis: preliminary results. Stroke; A Journal Of Cerebral Circulation 2012, 43:860-2. 2012
The pipeline flow-diverting stent for exclusion of ruptured intracranial aneurysms with difficult morphologies.
Martin AR, Cruz JP, Matouk CC, Spears J, Marotta TR. The pipeline flow-diverting stent for exclusion of ruptured intracranial aneurysms with difficult morphologies. Neurosurgery 2012, 70:21-8; discussion 28. 2012