Charles Matouk, MD

Associate Professor of Neurosurgery; Chief, Neurovascular Surgery; Director, Neurovascular/Endovascular Fellowship

Research Departments & Organizations


HHT Program

Office of Cooperative Research

Research Interests

Cerebrovascular Disorders; Clinical Trial; Diagnostic Techniques, Neurological; Endothelium, Vascular; Neurosurgery; Radiology

Research Summary

My translational research interests can be divided along two thematic lines: (1) clinical trials implementation and design in neurological disease, and (2) advanced imaging in cerebrovascular disease.

Specialized Terms: Translational application of advanced imaging protocols in neurovascular disease; clinical trials

Extensive Research Description


I am currently involved in the following national and international, multi-center clinical trials that are enrolling (or about to enroll) at Yale-New Haven Hospital.

Brain Aneurysms / Subarachnoid Hemorrhage

ASTROH Trial. A multi-center, phase II randomized clinical trial of continuous low-dose IV heparin therapy in coiled low-grade aneurysmal SAH patients with significant hemorrhage burden. [My role: site-PI.]

NEWTON Trial. A multi-center, phase 3 randomized, double-blinded, placebo-controlled efficacy and safety study comparing EG-1962 to standard of care oral nimodipine in adults with aneurysmal subarachnoid hemorrhage. [My role: site-PI.]

Carotid Revascularization

CONFIDENCE Trial. A prospective, multi-center, single-arm, open-label clinical study to evaluate the safety and efficacy of Roadsaver carotid stent device used in conjunction with the Nanoparasol embolic protection system for the treatment of carotid artery stenosis in patients with elevated risk for adverse events following carotid endarterectomy. [My role: site-PI.]

CREST-2. Carotid revascularization for primary prevention of stroke (CREST-2) is two independent multicenter, randomized controlled trials of carotid revascularization and intensive medical management versus medical management alone in patients with asymptomatic high-grade carotid stenosis. [My role: sub-investigator, interventionist.]

Intracranial Hemorrhage

MISTIE-III. The purpose of this trial is to determine the safety of using a combination of minimally invasive surgery and clot lysis with rt-PA to remove intracerebral hemorrhage (ICH). [My role: site-co-PI, lead surgeon.]


My translational research is focused on advanced imaging of the critically ill neurovascular patient. Our overall aim is to improve the safety and quality of care rendered to patient's with cerebrovascular disease.

Clinical Trials

Conditions Study Title
Diseases of the Cardiovascular System PHIL in the Treatment of Intracranial dAVF. (PHIL dAVF)
Diseases of the Nervous System An International Study to Evaluate Diagnostic Efficacy of Flurpiridaz (18F) Injection PET MPI in the Detection of Coronary Artery Disease (CAD)
Diseases of the Nervous System COMPLETE: International Acute Ischemic Stroke Registry With the Penumbra System Aspiration Including the 3D Revascularization Device
Diseases of the Cardiovascular System Evaluation of the Roadsaver Stent Used in Conjunction With the Nanoparasol Embolic Protection System for Carotid Artery Stenosis
Diseases of the Cardiovascular System Aneurysmal Subarachnoid Hemorrhage Trial RandOmizing Heparin (ASTROH)

Selected Publications

See list of PubMed publications

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