Vanessa Scanlon, PhD

• Andre Levchenko
• Betty R. Lawton
• Diane Krause
• Karin Finberg
• Larisa Lozovatsky
• Stephanie Halene
• Tarun Tyagi
• Toma Tebaldi

Blood Cells; Hematopoietic System

• Multiparameter analysis of timelapse imaging reveals kinetics of megakaryocytic erythroid progenitor clonal expansion and differentiationScanlon VM, Thompson EN, Lawton BR, Kochugaeva M, Ta K, Mayday MY, Xavier-Ferrucio J, Kang E, Eskow NM, Lu YC, Kwon N, Laumas A, Cenci M, Lawrence K, Barden K, Larsuel ST, Reed FE, Peña-Carmona G, Ubbelohde A, Lee JP, Boobalan S, Oppong Y, Anderson R, Maynard C, Sahirul K, Lajeune C, Ivathraya V, Addy T, Sanchez P, Holbrook C, Van Ho AT, Duncan JS, Blau HM, Levchenko A, Krause DS. Multiparameter analysis of timelapse imaging reveals kinetics of megakaryocytic erythroid progenitor clonal expansion and differentiation. Scientific Reports 2022, 12: 16218. PMID: 36171423, PMCID: PMC9519589, DOI: 10.1038/s41598-022-19013-x.
• Assay optimization for the objective quantification of human multilineage colony-forming unitsThompson E, Carlino M, Scanlon V, Grimes H, Krause D. Assay optimization for the objective quantification of human multilineage colony-forming units. Experimental Hematology 2023, 124: 36-44.e3. PMID: 37271449, PMCID: PMC10527702, DOI: 10.1016/j.exphem.2023.05.007.
• SATB1 Chromatin Loops Regulate Megakaryocyte/Erythroid Progenitor Expansion by Facilitating HSP70 and GATA1 Induction.Wilkes M, Chae H, Scanlon V, Cepika A, Wentworth E, Saxena M, Eskin A, Chen Z, Glader B, Grazia Roncarolo M, Nelson S, Sakamoto K. SATB1 Chromatin Loops Regulate Megakaryocyte/Erythroid Progenitor Expansion by Facilitating HSP70 and GATA1 Induction. Stem Cells 2023, 41: 560-569. PMID: 36987811, PMCID: PMC10267687, DOI: 10.1093/stmcls/sxad025.
• Structure-function analysis of the role of megakaryoblastic leukemia 1 in megakaryocyte polyploidizationReed F, Eskow N, Min E, Carlino M, Mancuso R, Kwon N, Smith E, Larsuel S, Wang L, Scanlon V, Krause D. Structure-function analysis of the role of megakaryoblastic leukemia 1 in megakaryocyte polyploidization. Haematologica 2022, 107: 2972-2976. PMID: 36453520, PMCID: PMC9713552, DOI: 10.3324/haematol.2021.280499.
• Structure-function analysis of the role of megakaryoblastic leukemia 1 in megakaryocyte polyploidization.Reed FE, Eskow NM, Min E, Carlino M, Mancuso R, Kwon N, Smith EC, Larsuel ST, Wang L, Scanlon V, Krause DS. Structure-function analysis of the role of megakaryoblastic leukemia 1 in megakaryocyte polyploidization. Haematologica 2022 PMID: 36005559.
• Downregulation of SATB1 by miRNAs reduces megakaryocyte/erythroid progenitor expansion in preclinical models of Diamond–Blackfan anemiaWilkes MC, Scanlon V, Shibuya A, Cepika AM, Eskin A, Chen Z, Narla A, Glader B, Roncarolo MG, Nelson SF, Sakamoto KM. Downregulation of SATB1 by miRNAs reduces megakaryocyte/erythroid progenitor expansion in preclinical models of Diamond–Blackfan anemia. Experimental Hematology 2022, 111: 66-78. PMID: 35460833, PMCID: PMC9255422, DOI: 10.1016/j.exphem.2022.04.005.
• 3181 – ERYTHROPOIETIN SUPPORTS SURVIVAL AND SELF-RENEWAL OF PRIMARY HUMAN MEGAKARYOCYTIC-ERYTHROID PROGENITORS, BUT DOES NOT INSTRUCT LINEAGE COMMITMENTScanlon V, Thompson E, Lawton B, Kochugaeva M, Kang E, Eskow N, Sanchez P, Bobbalan S, Cenci M, Pena-Carmona G, Laumas A, Anderson R, Reed F, Blau H, Levchenko A, Krause D. 3181 – ERYTHROPOIETIN SUPPORTS SURVIVAL AND SELF-RENEWAL OF PRIMARY HUMAN MEGAKARYOCYTIC-ERYTHROID PROGENITORS, BUT DOES NOT INSTRUCT LINEAGE COMMITMENT. Experimental Hematology 2022, 111: s135. DOI: 10.1016/j.exphem.2022.07.237.
• Single-Cell Tracking By Time Lapse Imaging Confirms Thrombopoietin Promotes Megakaryocytic-Erythroid Progenitor Self Renewal, but Does Not Instruct Lineage CommitmentScanlon V, Kochugaeva M, Lawton B, Xavier-Ferrucio J, Kang E, Eskow N, Lu Y, Kwon N, Laumas A, Cenci M, Lawrence K, Barden K, Larsuel S, Reed F, Pena-Carmona G, Ubbelohde A, Lee J, Boobalan S, Oppong Y, Anderson R, Maynard C, Sahirul K, Lajeune C, Ivathraya V, Addy T, Sanchez P, Holbrook C, Van Ho A, Tri Van Ho A, Blau H, Levchenko A, Krause D. Single-Cell Tracking By Time Lapse Imaging Confirms Thrombopoietin Promotes Megakaryocytic-Erythroid Progenitor Self Renewal, but Does Not Instruct Lineage Commitment. Blood 2021, 138: 3270-3270. DOI: 10.1182/blood-2021-154360.
• SATB1 Regulates Chromatin Organization and HSP70 Expression in Early Erythropoiesis and Is Downregulated in Models of Diamond Blackfan AnemiaWilkes M, Shibuya A, Scanlon V, Chae H, Narla A, Sakamoto K. SATB1 Regulates Chromatin Organization and HSP70 Expression in Early Erythropoiesis and Is Downregulated in Models of Diamond Blackfan Anemia. Blood 2021, 138: 2189-2189. DOI: 10.1182/blood-2021-153814.
• 1016 – INSIGHTS INTO ERYTHROPOIESIS AND MEGAKARYOPOIESIS AT THE SINGLE CELL LEVELKrause D, Lu Y, Scanlon V. 1016 – INSIGHTS INTO ERYTHROPOIESIS AND MEGAKARYOPOIESIS AT THE SINGLE CELL LEVEL. Experimental Hematology 2021, 100: s22-s23. DOI: 10.1016/j.exphem.2021.12.012.
• MRTFA: A critical protein in normal and malignant hematopoiesis and beyondReed F, Larsuel ST, Mayday MY, Scanlon V, Krause DS. MRTFA: A critical protein in normal and malignant hematopoiesis and beyond. Journal Of Biological Chemistry 2021, 296: 100543. PMID: 33722605, PMCID: PMC8079280, DOI: 10.1016/j.jbc.2021.100543.
• Current understanding of human megakaryocytic-erythroid progenitors and their fate determinants.Kwon N, Thompson EN, Mayday MY, Scanlon V, Lu YC, Krause DS. Current understanding of human megakaryocytic-erythroid progenitors and their fate determinants. Current Opinion In Hematology 2020, 28: 28-35. PMID: 33186151, PMCID: PMC7737300, DOI: 10.1097/moh.0000000000000625.
• Cell Cycle Regulates Phosphorylation of RUNX1 to Modulate Megakaryocyte-Erythroid Progenitor Fate SpecificationLu Y, Scanlon V, Xavier-Ferrucio J, Wang L, Friedman A, Cantor A, Krause D. Cell Cycle Regulates Phosphorylation of RUNX1 to Modulate Megakaryocyte-Erythroid Progenitor Fate Specification. Blood 2020, 136: 15-15. DOI: 10.1182/blood-2020-141156.
• Developing Single Cell Live Imaging Strategies to Determine MEP Fate and Predict PotentialScanlon V, Kochugaeva M, Xavier-Ferrucio J, Lu Y, Kwon N, Laumas A, Cenci M, Lawrence K, Barden K, Holbrook C, Tri Van Ho A, Van Ho A, Blau H, Levchenko A, Krause D. Developing Single Cell Live Imaging Strategies to Determine MEP Fate and Predict Potential. Blood 2019, 134: 1190-1190. DOI: 10.1182/blood-2019-131204.
• Low iron promotes megakaryocytic commitment of megakaryocytic-erythroid progenitors in humans and mice.Xavier-Ferrucio J, Scanlon V, Li X, Zhang PX, Lozovatsky L, Ayala-Lopez N, Tebaldi T, Halene S, Cao C, Fleming MD, Finberg KE, Krause DS. Low iron promotes megakaryocytic commitment of megakaryocytic-erythroid progenitors in humans and mice. Blood 2019, 134: 1547-1557. PMID: 31439541, PMCID: PMC6839952, DOI: 10.1182/blood.2019002039.
• Epithelial (E)-Cadherin is a Novel Mediator of Platelet Aggregation and Clot StabilityScanlon VM, Teixeira AM, Tyagi T, Zou S, Zhang PX, Booth CJ, Kowalska MA, Bao J, Hwa J, Hayes V, Marks MS, Poncz M, Krause DS. Epithelial (E)-Cadherin is a Novel Mediator of Platelet Aggregation and Clot Stability. Thrombosis And Haemostasis 2019, 119: 744-757. PMID: 30861547, PMCID: PMC6599679, DOI: 10.1055/s-0039-1679908.
• Low Iron Promotes Megakaryocytic Commitment of Megakaryocytic-Erythroid Progenitors in Human and MiceXavier-Ferrucio J, Li X, Scanlon V, Zhang P, Ayala-Lopez N, Tebaldi T, Halene S, Finberg K, Krause D. Low Iron Promotes Megakaryocytic Commitment of Megakaryocytic-Erythroid Progenitors in Human and Mice. Blood 2018, 132: 2-2. DOI: 10.1182/blood-2018-99-115124.
• Loss of Cbl-PI3K interaction modulates the periosteal response to fracture by enhancing osteogenic commitment and differentiationScanlon V, Walia B, Yu J, Hansen M, Drissi H, Maye P, Sanjay A. Loss of Cbl-PI3K interaction modulates the periosteal response to fracture by enhancing osteogenic commitment and differentiation. Bone 2016, 95: 124-135. PMID: 27884787, PMCID: PMC5819877, DOI: 10.1016/j.bone.2016.11.020.
• Increased periosteal expansion, Osterix expression and osteogenic potential upon bone injury during perturbed PI3K signalingWalia B, Scanlon V, Yu J, Maye P, Drissi H, Sanjay A. Increased periosteal expansion, Osterix expression and osteogenic potential upon bone injury during perturbed PI3K signaling. Bone Abstracts 2016 DOI: 10.1530/boneabs.5.p75.
• Role of Cbl-PI3K Interaction during Skeletal Remodeling in a Murine Model of Bone RepairScanlon V, Soung do Y, Adapala NS, Morgan E, Hansen MF, Drissi H, Sanjay A. Role of Cbl-PI3K Interaction during Skeletal Remodeling in a Murine Model of Bone Repair. PLOS ONE 2015, 10: e0138194. PMID: 26393915, PMCID: PMC4578922, DOI: 10.1371/journal.pone.0138194.
• Loss of Cbl–PI3K interaction in mice prevents significant bone loss following ovariectomyAdapala NS, Holland D, Scanlon V, Barbe MF, Langdon WY, Tsygankov AY, Lorenzo JA, Sanjay A. Loss of Cbl–PI3K interaction in mice prevents significant bone loss following ovariectomy. Bone 2014, 67: 1-9. PMID: 24994594, PMCID: PMC4149851, DOI: 10.1016/j.bone.2014.06.013.
• Establishment of Human cell Type-Specific iPS cells with Enhanced Chondrogenic PotentialGuzzo RM, Scanlon V, Sanjay A, Xu RH, Drissi H. Establishment of Human cell Type-Specific iPS cells with Enhanced Chondrogenic Potential. Stem Cell Reviews And Reports 2014, 10: 820-829. PMID: 24958240, DOI: 10.1007/s12015-014-9538-8.
• Retroelement demethylation associated with abnormal placentation in Mus musculus x Mus caroli hybrids.Brown JD, Piccuillo V, O'Neill RJ. Retroelement demethylation associated with abnormal placentation in Mus musculus x Mus caroli hybrids. Biology Of Reproduction 2012, 86: 88. PMID: 22116807, DOI: 10.1095/biolreprod.111.095273.