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Tejasav Sehrawat, MD

Hospital Resident

Research & Publications
Biography

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Selected Publications

Circulating Extracellular Vesicles Carrying Sphingolipid Cargo for the Diagnosis and Dynamic Risk Profiling of Alcoholic HepatitisSehrawat T, Arab J, Liu M, Amrollahi P, Wan M, Fan J, Nakao Y, Pose E, Navarro‐Corcuera A, Dasgupta D, Liao C, He L, Mauer A, Avitabile E, Ventura‐Cots M, Bataller R, Sanyal A, Chalasani N, Heimbach J, Watt K, Gores G, Gines P, Kamath P, Simonetto D, Hu T, Shah V, Malhi H. Circulating Extracellular Vesicles Carrying Sphingolipid Cargo for the Diagnosis and Dynamic Risk Profiling of Alcoholic Hepatitis. Hepatology 2021, 73: 571-585. PMID: 32246544, PMCID: PMC7541595, DOI: 10.1002/hep.31256.
The knowns and unknowns of treatment for alcoholic hepatitisSehrawat T, Liu M, Shah V. The knowns and unknowns of treatment for alcoholic hepatitis. The Lancet Gastroenterology & Hepatology 2020, 5: 494-506. PMID: 32277902, PMCID: PMC7238289, DOI: 10.1016/s2468-1253(19)30326-7.
An Open‐Label, Dose‐Escalation Study to Assess the Safety and Efficacy of IL‐22 Agonist F‐652 in Patients With Alcohol‐associated HepatitisArab J, Sehrawat T, Simonetto D, Verma V, Feng D, Tang T, Dreyer K, Yan X, Daley W, Sanyal A, Chalasani N, Radaeva S, Yang L, Vargas H, Ibacache M, Gao B, Gores G, Malhi H, Kamath P, Shah V. An Open‐Label, Dose‐Escalation Study to Assess the Safety and Efficacy of IL‐22 Agonist F‐652 in Patients With Alcohol‐associated Hepatitis. Hepatology 2020, 72: 441-453. PMID: 31774566, PMCID: PMC7250715, DOI: 10.1002/hep.31046.
Long non-coding RNA ACTA2-AS1 promotes ductular reaction by interacting with the p300/ELK1 complexNavarro-Corcuera A, Sehrawat T, Jalan-Sakrikar N, Gibbons H, Pirius N, Khanal S, Hamdan F, Aseem S, Cao S, Banales J, Kang N, Faubion W, LaRusso N, Shah V, Huebert R. Long non-coding RNA ACTA2-AS1 promotes ductular reaction by interacting with the p300/ELK1 complex. Journal Of Hepatology 2021, 76: 921-933. PMID: 34953958, PMCID: PMC8934273, DOI: 10.1016/j.jhep.2021.12.014.
Mechanical Stretch Increases Expression of CXCL1 in Liver Sinusoidal Endothelial Cells to Recruit Neutrophils, Generate Sinusoidal Microthombi, and Promote Portal HypertensionHilscher M, Sehrawat T, Arab J, Zeng Z, Gao J, Liu M, Kostallari E, Gao Y, Simonetto D, Yaqoob U, Cao S, Revzin A, Beyder A, Wang R, Kamath P, Kubes P, Shah V. Mechanical Stretch Increases Expression of CXCL1 in Liver Sinusoidal Endothelial Cells to Recruit Neutrophils, Generate Sinusoidal Microthombi, and Promote Portal Hypertension. Gastroenterology 2019, 157: 193-209.e9. PMID: 30872106, PMCID: PMC6581607, DOI: 10.1053/j.gastro.2019.03.013.
Super enhancer regulation of cytokine-induced chemokine production in alcoholic hepatitisLiu M, Cao S, He L, Gao J, Arab J, Cui H, Xuan W, Gao Y, Sehrawat T, Hamdan F, Ventura-Cots M, Argemi J, Pomerantz W, Johnsen S, Lee J, Gao F, Ordog T, Mathurin P, Revzin A, Bataller R, Yan H, Shah V. Super enhancer regulation of cytokine-induced chemokine production in alcoholic hepatitis. Nature Communications 2021, 12: 4560. PMID: 34315876, PMCID: PMC8316465, DOI: 10.1038/s41467-021-24843-w.
XIAP Knockdown in Alcohol-Associated Liver Disease Models Exhibits Divergent in vitro and in vivo Phenotypes Owing to a Potential Zonal Inhibitory Role of SMACHe L, Sehrawat T, Verma V, Navarro-Corcuera A, Sidhu G, Mauer A, Luo X, Katsumi T, Chen J, Shah S, Arab J, Cao S, Kashkar H, Gores G, Malhi H, Shah V. XIAP Knockdown in Alcohol-Associated Liver Disease Models Exhibits Divergent in vitro and in vivo Phenotypes Owing to a Potential Zonal Inhibitory Role of SMAC. Frontiers In Physiology 2021, 12: 664222. PMID: 34025452, PMCID: PMC8138467, DOI: 10.3389/fphys.2021.664222.
Quantitative assessment of portal hypertension with bi-parametric dual-frequency hepatic MR elastography in mouse modelsLi J, Sehrawat T, Chen J, Hilscher M, Glaser K, Arab J, De Assuncao T, Simonetto D, Mounajjed T, Manduca A, Ehman R, Shah V, Yin M. Quantitative assessment of portal hypertension with bi-parametric dual-frequency hepatic MR elastography in mouse models. European Radiology 2020, 31: 2303-2311. PMID: 33026502, PMCID: PMC7981248, DOI: 10.1007/s00330-020-07341-3.
Regulation and functional roles of chemokines in liver diseasesCao S, Liu M, Sehrawat T, Shah V. Regulation and functional roles of chemokines in liver diseases. Nature Reviews Gastroenterology & Hepatology 2021, 18: 630-647. PMID: 33976393, PMCID: PMC9036964, DOI: 10.1038/s41575-021-00444-2.
Post-acute COVID-19 syndromeNalbandian A, Sehgal K, Gupta A, Madhavan M, McGroder C, Stevens J, Cook J, Nordvig A, Shalev D, Sehrawat T, Ahluwalia N, Bikdeli B, Dietz D, Der-Nigoghossian C, Liyanage-Don N, Rosner G, Bernstein E, Mohan S, Beckley A, Seres D, Choueiri T, Uriel N, Ausiello J, Accili D, Freedberg D, Baldwin M, Schwartz A, Brodie D, Garcia C, Elkind M, Connors J, Bilezikian J, Landry D, Wan E. Post-acute COVID-19 syndrome. Nature Medicine 2021, 27: 601-615. PMID: 33753937, PMCID: PMC8893149, DOI: 10.1038/s41591-021-01283-z.
Extrapulmonary manifestations of COVID-19Gupta A, Madhavan MV, Sehgal K, Nair N, Mahajan S, Sehrawat TS, Bikdeli B, Ahluwalia N, Ausiello JC, Wan EY, Freedberg DE, Kirtane AJ, Parikh SA, Maurer MS, Nordvig AS, Accili D, Bathon JM, Mohan S, Bauer KA, Leon MB, Krumholz HM, Uriel N, Mehra MR, Elkind MSV, Stone GW, Schwartz A, Ho DD, Bilezikian JP, Landry DW. Extrapulmonary manifestations of COVID-19. Nature Medicine 2020, 26: 1017-1032. PMID: 32651579, DOI: 10.1038/s41591-020-0968-3.
Epigenetics of alcohol-related liver diseasesHabash N, Sehrawat T, Shah V, Cao S. Epigenetics of alcohol-related liver diseases. JHEP Reports 2022, 4: 100466. PMID: 35462859, PMCID: PMC9018389, DOI: 10.1016/j.jhepr.2022.100466.
Alcohol-Associated Liver DiseaseLiu M, Sehrawat T, Szabo G, Shah V. Alcohol-Associated Liver Disease. 2020, 309-324. DOI: 10.1007/978-3-030-51709-0_20.
Hepatic stellate cell activation promotes alcohol-induced steatohepatitis through Igfbp3 and SerpinA12Arab J, Cabrera D, Sehrawat T, Jalan-Sakrikar N, Verma V, Simonetto D, Cao S, Yaqoob U, Leon J, Freire M, Vargas J, De Assuncao T, Kwon J, Guo Y, Kostallari E, Cai Q, Kisseleva T, Oh Y, Arrese M, Huebert R, Shah V. Hepatic stellate cell activation promotes alcohol-induced steatohepatitis through Igfbp3 and SerpinA12. Journal Of Hepatology 2020, 73: 149-160. PMID: 32087348, PMCID: PMC7305991, DOI: 10.1016/j.jhep.2020.02.005.
Utility and Limitations of Glycated Hemoglobin (HbA1c) in Patients with Liver Cirrhosis as Compared with Oral Glucose Tolerance Test for Diagnosis of DiabetesSehrawat T, Jindal A, Kohli P, Thour A, Kaur J, Sachdev A, Gupta Y. Utility and Limitations of Glycated Hemoglobin (HbA1c) in Patients with Liver Cirrhosis as Compared with Oral Glucose Tolerance Test for Diagnosis of Diabetes. Diabetes Therapy 2018, 9: 243-251. PMID: 29305791, PMCID: PMC5801248, DOI: 10.1007/s13300-017-0362-4.
Modulating sphingosine 1-phosphate receptor signaling skews intrahepatic leukocytes and attenuates murine nonalcoholic steatohepatitisLiao C, Barrow F, Venkatesan N, Nakao Y, Mauer A, Fredrickson G, Song M, Sehrawat T, Dasgupta D, Graham R, Revelo X, Malhi H. Modulating sphingosine 1-phosphate receptor signaling skews intrahepatic leukocytes and attenuates murine nonalcoholic steatohepatitis. Frontiers In Immunology 2023, 14: 1130184. PMID: 37153573, PMCID: PMC10160388, DOI: 10.3389/fimmu.2023.1130184.
Loss of CEACAM1 in endothelial cells causes hepatic fibrosisMuturi H, Ghadieh H, Abdolahipour R, Stankus H, Belew G, Liu J, Jahromi M, Lee A, Singer B, Angeli-Pahim I, Sehrawat T, Malhi H, Verhulst S, van Grunsven L, Zarrinpar A, Duarte S, Najjar S. Loss of CEACAM1 in endothelial cells causes hepatic fibrosis. Metabolism 2023, 144: 155562. PMID: 37088122, PMCID: PMC10330196, DOI: 10.1016/j.metabol.2023.155562.
Adding Inflammatory Markers and Refining National Institute on Alcohol Abuse and Alcoholism Criteria Improve Diagnostic Accuracy for Alcohol-associated HepatitisAvitabile E, Díaz A, Montironi C, Pérez-Guasch M, Gratacós-Ginès J, Hernández-Évole H, Moreira R, Sehrawat T, Malhi H, Olivas P, Hernández-Gea V, Bataller R, Shah V, Kamath P, Ginès P, Pose E. Adding Inflammatory Markers and Refining National Institute on Alcohol Abuse and Alcoholism Criteria Improve Diagnostic Accuracy for Alcohol-associated Hepatitis. Clinical Gastroenterology And Hepatology 2023, 21: 3080-3088.e9. PMID: 37004974, DOI: 10.1016/j.cgh.2023.03.023.
THU033 Improving NIAAA criteria for the diagnosis of alcoholic hepatitis, role of systemic inflammationPose E, Avitabile E, Díaz A, Montironi C, Perez M, Gratacós-Gines J, Evole H, Sehrawat T, Malhi H, Olivas P, Hernandez-Gea V, Shah V, Kamath P, Ginès P. THU033 Improving NIAAA criteria for the diagnosis of alcoholic hepatitis, role of systemic inflammation. Journal Of Hepatology 2022, 77: s136-s137. DOI: 10.1016/s0168-8278(22)00653-5.
Mechanotransduction-induced glycolysis epigenetically regulates a CXCL1-dominant angiocrine signaling program in liver sinusoidal endothelial cells in vitro and in vivoGreuter T, Yaqoob U, Gan C, Jalan-Sakrikar N, Kostallari E, Lu J, Gao J, Sun L, Liu M, Sehrawat TS, Ibrahim SH, Furuta K, Nozickova K, Huang BQ, Gao B, Simons M, Cao S, Shah VH. Mechanotransduction-induced glycolysis epigenetically regulates a CXCL1-dominant angiocrine signaling program in liver sinusoidal endothelial cells in vitro and in vivo. Journal Of Hepatology 2022, 77: 723-734. PMID: 35421427, PMCID: PMC9391258, DOI: 10.1016/j.jhep.2022.03.029.
Admission Urinary and Serum Metabolites Predict Renal Outcomes in Hospitalized Patients With CirrhosisBajaj JS, Garcia‐Tsao G, Reddy KR, O’Leary J, Vargas HE, Lai JC, Kamath PS, Tandon P, Subramanian RM, Thuluvath P, Fagan A, Sehrawat T, de la Rosa Rodriguez R, Thacker LR, Wong F. Admission Urinary and Serum Metabolites Predict Renal Outcomes in Hospitalized Patients With Cirrhosis. Hepatology 2021, 74: 2699-2713. PMID: 34002868, PMCID: PMC9338693, DOI: 10.1002/hep.31907.
Hepatology HighlightsBuckholz A, Lucero C, Yang L, Lau D, Taborda C, Wedd J, Kostallari E, Schwartz R, Bamidele A, Sehrawat T, Kaplan A, Fortune B, Wahid N, Fortune B, Choi A, Brown R, Hirsova P, Jalan-Sakrikar N. Hepatology Highlights. Hepatology 2021, 74: 1-4. PMID: 34302299, DOI: 10.1002/hep.32020.
Circulating extracellular vesicles are a biomarker for NAFLD resolution and response to weight loss surgeryNakao Y, Amrollahi P, Parthasarathy G, Mauer A, Sehrawat T, Vanderboom P, Nair K, Nakao K, Allen A, Hu T, Malhi H. Circulating extracellular vesicles are a biomarker for NAFLD resolution and response to weight loss surgery. Nanomedicine Nanotechnology Biology And Medicine 2021, 36: 102430. PMID: 34174416, PMCID: PMC8418232, DOI: 10.1016/j.nano.2021.102430.
Endothelial p300 Promotes Portal Hypertension and Hepatic Fibrosis Through C‐C Motif Chemokine Ligand 2–Mediated Angiocrine SignalingGao J, Wei B, Liu M, Hirsova P, Sehrawat T, Cao S, Hu X, Xue F, Yaqoob U, Kang N, Cui H, Pomerantz W, Kostallari E, Shah V. Endothelial p300 Promotes Portal Hypertension and Hepatic Fibrosis Through C‐C Motif Chemokine Ligand 2–Mediated Angiocrine Signaling. Hepatology 2021, 73: 2468-2483. PMID: 33159815, PMCID: PMC8102654, DOI: 10.1002/hep.31617.
Hepatology HighlightsMuhammad Khan M, Alejandra Luna-Cuadros M, Lau D, Sehrawat T, Sehrawat O, Schwartz R, Choi A, Brown R, Parthasarathy G, Kostallari E, Jalan-Sakrikar N, Salerno D, Allamneni C, Vora R, Maiers J. Hepatology Highlights. Hepatology 2021, 73: 2085-2088. PMID: 34145622, DOI: 10.1002/hep.31883.
Hepatology HighlightsBuckholz A, Jesudian A, Sehrawat T, Sehrawat O, Schwartz R, Muhammad Khan M, Luna-Cuadros M, Lau D, Bamidele A, Choi A, Fortune B, Hirsova P, Kostallari E, Hang T, Reshamwala P, Wahid N, Rosenblatt R, Jalan-Sakrikar N. Hepatology Highlights. Hepatology 2021, 73: 1627-1630. PMID: 33914363, DOI: 10.1002/hep.31858.
431 SPECIFIC URINARY AND SERUM METABOLITES ON ADMISSION PREDICT THE DEVELOPMENT OF AKI AND NEED FOR DIALYSIS IN HOSPITALIZED PATIENTS WITH CIRRHOSISBajaj J, Garcia-Tsao G, Reddy R, O'Leary J, Vargas H, Lai J, Kamath P, Tandon P, Subramanian R, Thuluvath P, Fagan A, Sehrawat T, De La Rosa-Rodriguez R, Wong F. 431 SPECIFIC URINARY AND SERUM METABOLITES ON ADMISSION PREDICT THE DEVELOPMENT OF AKI AND NEED FOR DIALYSIS IN HOSPITALIZED PATIENTS WITH CIRRHOSIS. Gastroenterology 2021, 160: s-775-s-776. DOI: 10.1016/s0016-5085(21)02565-8.
Hepatology HighlightsKaur S, Trivedi H, Lau D, Bamidele A, Schwartz R, Parthasarathy G, Navarro-Corcuera A, Sehrawat T, Hans A, Roccaro G, Jalan-Sakrikar N, Hejazifar N, Brown R. Hepatology Highlights. Hepatology 2021, 73: 1245-1247. PMID: 33851455, DOI: 10.1002/hep.31813.
Perspectives of Inpatients With Cirrhosis and Caregivers on Using Health Information Technology: Cross-sectional Multicenter StudyAcharya C, Sehrawat T, McGuire D, Shaw J, Fagan A, McGeorge S, Olofson A, White M, Gavis E, Kamath P, Bergstrom L, Bajaj J. Perspectives of Inpatients With Cirrhosis and Caregivers on Using Health Information Technology: Cross-sectional Multicenter Study. Journal Of Medical Internet Research 2021, 23: e24639. PMID: 33744844, PMCID: PMC8065567, DOI: 10.2196/24639.
REPLY:Sehrawat T, Shah V, Malhi H. REPLY:. Hepatology 2021, 73: 472-473. PMID: 32673412, DOI: 10.1002/hep.31464.
Hepatology HighlightsBuckholz A, Brown R, Trivedi H, Khan M, Hanif H, Lau D, Hans A, Roccaro G, Pisa J, Jalan-Sakrikar N, Schwartz R, Russo N, Sehrawat T, Kostallari E, Bamidele A, Parthasarathy G. Hepatology Highlights. Hepatology 2020, 72: 1893-1896. PMID: 33617006, DOI: 10.1002/hep.31637.
Hepatology HighlightsRusso N, Brown R, Parthasarathy G, Schwartz R, Buckholz A, Jesudian A, Kostallari E, Taborda C, Wedd J, Sehrawat T, Hejazifar N, Yang L, Lau D, Maiers J, Jalan-Sakrikar N. Hepatology Highlights. Hepatology 2020, 72: 1505-1508. PMID: 33159409, DOI: 10.1002/hep.31591.
Serum Levels of Metabolites Produced by Intestinal Microbes and Lipid Moieties Independently Associated With Acute-on-Chronic Liver Failure and Death in Patients With CirrhosisBajaj JS, Reddy KR, O'Leary JG, Vargas HE, Lai JC, Kamath PS, Tandon P, Wong F, Subramanian RM, Thuluvath P, Fagan A, White MB, Gavis EA, Sehrawat T, de la Rosa Rodriguez R, Thacker LR, Sikaroodi M, Garcia-Tsao G, Gillevet PM. Serum Levels of Metabolites Produced by Intestinal Microbes and Lipid Moieties Independently Associated With Acute-on-Chronic Liver Failure and Death in Patients With Cirrhosis. Gastroenterology 2020, 159: 1715-1730.e12. PMID: 32687928, PMCID: PMC7680282, DOI: 10.1053/j.gastro.2020.07.019.
IRE1A Stimulates Hepatocyte-Derived Extracellular Vesicles That Promote Inflammation in Mice With SteatohepatitisDasgupta D, Nakao Y, Mauer A, Thompson J, Sehrawat T, Liao C, Krishnan A, Lucien F, Guo Q, Liu M, Xue F, Fukushima M, Katsumi T, Bansal A, Pandey M, Maiers J, DeGrado T, Ibrahim S, Revzin A, Pavelko K, Barry M, Kaufman R, Malhi H. IRE1A Stimulates Hepatocyte-Derived Extracellular Vesicles That Promote Inflammation in Mice With Steatohepatitis. Gastroenterology 2020, 159: 1487-1503.e17. PMID: 32574624, PMCID: PMC7666601, DOI: 10.1053/j.gastro.2020.06.031.
GIPC-Regulated IGFBP-3 Promotes HSC Migration In Vitro and Portal Hypertension In Vivo Through a β1-Integrin PathwayYaqoob U, Luo F, Greuter T, Sakrikar N, Sehrawat T, Lu J, Hu X, Gao J, Kostallari E, Chen J, Arab J, Martin-Mateos R, Cao S, Shah V. GIPC-Regulated IGFBP-3 Promotes HSC Migration In Vitro and Portal Hypertension In Vivo Through a β1-Integrin Pathway. Cellular And Molecular Gastroenterology And Hepatology 2020, 10: 545-559. PMID: 32447051, PMCID: PMC7399184, DOI: 10.1016/j.jcmgh.2020.05.005.
Hepatology HighlightsPisa J, Brown R, Hirsova P, Schwartz R, Sehrawat T, Russo N, Kostallari E, Tafesh Z, Fortune B, Trivedi H, Lau D, Morales-Santiago A, Wedd J, Buchl S, Maiers J. Hepatology Highlights. Hepatology 2020, 71: 1527-1529. PMID: 32347990, DOI: 10.1002/hep.31275.
462 – Circulating Extracellular Vesicles and Sphingolipids Cargo are Highly Accurate Novel Biomarkers for Diagnosis of Alcoholic HepatitisSehrawat T, Arab J, Simonetto D, Sanyal A, Chalasani N, Gores G, Kamath P, Shah V, Malhi H. 462 – Circulating Extracellular Vesicles and Sphingolipids Cargo are Highly Accurate Novel Biomarkers for Diagnosis of Alcoholic Hepatitis. Gastroenterology 2019, 156: s-98. DOI: 10.1016/s0016-5085(19)37035-0.
Anxiety among patients with diabetes mellitus evaluated using generalized anxiety disorder 7-item scaleThour A, Nagra R, Gosal A, Sehrawat T, Das S, Gupta Y. Anxiety among patients with diabetes mellitus evaluated using generalized anxiety disorder 7-item scale. Journal Of Social Health And Diabetes 2016, 04: 133-136. DOI: 10.4103/2321-0656.187988.
THU-396 Prevalence and Correlation of Diabetes with Severity of Chronic Liver Disease and Utility of HBA1C in these Patients as Compared with Oral Glucose Tolerance TestSehrawat T, Kohli P, Thour A, Nagra R, Jindal A, Kaur J, Sachdev A, Gupta Y. THU-396 Prevalence and Correlation of Diabetes with Severity of Chronic Liver Disease and Utility of HBA1C in these Patients as Compared with Oral Glucose Tolerance Test. Journal Of Hepatology 2016, 64: s289-s290. DOI: 10.1016/s0168-8278(16)00359-7.
Depression among patients with diabetes mellitus in North India evaluated using patient health questionnaire-9Thour A, Das S, Sehrawat T, Gupta Y. Depression among patients with diabetes mellitus in North India evaluated using patient health questionnaire-9. Indian Journal Of Endocrinology And Metabolism 2015, 19: 252-255. PMID: 25729687, PMCID: PMC4319265, DOI: 10.4103/2230-8210.149318.

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