Sabine Martha Lang, PhD
she/her/hers
Associate Research Scientist in Pathology
Research & Publications
Biography
Locations
Coauthors
Selected Publications
- Acquired Resistance to HER2-Targeted Therapies Creates Vulnerability to ATP Synthase InhibitionGale M, Li Y, Cao J, Liu ZZ, Holmbeck MA, Zhang M, Lang SM, Wu L, Do Carmo M, Gupta S, Aoshima K, DiGiovanna MP, Stern DF, Rimm DL, Shadel GS, Chen X, Yan Q. Acquired Resistance to HER2-Targeted Therapies Creates Vulnerability to ATP Synthase Inhibition. Cancer Research 2020, 80: 524-535. PMID: 31690671, PMCID: PMC7002225, DOI: 10.1158/0008-5472.can-18-3985.
- KDM5 histone demethylases repress immune response via suppression of STINGWu L, Cao J, Cai WL, Lang SM, Horton JR, Jansen DJ, Liu ZZ, Chen JF, Zhang M, Mott BT, Pohida K, Rai G, Kales SC, Henderson MJ, Hu X, Jadhav A, Maloney DJ, Simeonov A, Zhu S, Iwasaki A, Hall MD, Cheng X, Shadel GS, Yan Q. KDM5 histone demethylases repress immune response via suppression of STING. PLOS Biology 2018, 16: e2006134. PMID: 30080846, PMCID: PMC6095604, DOI: 10.1371/journal.pbio.2006134.
- KDM5 lysine demethylases are involved in maintenance of 3′UTR lengthBlair LP, Liu Z, Labitigan RL, Wu L, Zheng D, Xia Z, Pearson EL, Nazeer FI, Cao J, Lang SM, Rines RJ, Mackintosh SG, Moore CL, Li W, Tian B, Tackett AJ, Yan Q. KDM5 lysine demethylases are involved in maintenance of 3′UTR length. Science Advances 2016, 2: e1501662. PMID: 28138513, PMCID: PMC5262454, DOI: 10.1126/sciadv.1501662.
- Mitochondrial DNA stress primes the antiviral innate immune responseWest AP, Khoury-Hanold W, Staron M, Tal MC, Pineda CM, Lang SM, Bestwick M, Duguay BA, Raimundo N, MacDuff DA, Kaech SM, Smiley JR, Means RE, Iwasaki A, Shadel GS. Mitochondrial DNA stress primes the antiviral innate immune response. Nature 2015, 520: 553-557. PMID: 25642965, PMCID: PMC4409480, DOI: 10.1038/nature14156.
- Kaposi’s Sarcoma-Associated Herpesvirus K3 and K5 Proteins Down Regulate Both DC-SIGN and DC-SIGNRLang SM, Bynoe MO, Karki R, Tartell MA, Means RE. Kaposi’s Sarcoma-Associated Herpesvirus K3 and K5 Proteins Down Regulate Both DC-SIGN and DC-SIGNR. PLOS ONE 2013, 8: e58056. PMID: 23460925, PMCID: PMC3584050, DOI: 10.1371/journal.pone.0058056.
- CECR2 drives breast cancer metastasis by promoting NF-κB signaling and macrophage-mediated immune suppressionZhang M, Liu ZZ, Aoshima K, Cai WL, Sun H, Xu T, Zhang Y, An Y, Chen JF, Chan LH, Aoshima A, Lang SM, Tang Z, Che X, Li Y, Rutter SJ, Bossuyt V, Chen X, Morrow JS, Pusztai L, Rimm DL, Yin M, Yan Q. CECR2 drives breast cancer metastasis by promoting NF-κB signaling and macrophage-mediated immune suppression. Science Translational Medicine 2022, 14: eabf5473. PMID: 35108062, PMCID: PMC9003667, DOI: 10.1126/scitranslmed.abf5473.
- A DNAmCULTURE Epigenetic Fingerprint Recapitulates Physiological AgingMinteer C, Morselli M, Meer M, Cao J, Lang S, Pellegrini M, Yan Q, Levine M. A DNAmCULTURE Epigenetic Fingerprint Recapitulates Physiological Aging. Innovation In Aging 2021, 5: 5-6. PMCID: PMC8679434, DOI: 10.1093/geroni/igab046.018.
- Corrections: Viral Infection of the Placenta Leads to Fetal Inflammation and Sensitization to Bacterial Products Predisposing to Preterm LaborCardenas I, Means R, Aldo P, Koga K, Lang S, Booth C, Manzur A, Oyarzun E, Romero R, Mor G. Corrections: Viral Infection of the Placenta Leads to Fetal Inflammation and Sensitization to Bacterial Products Predisposing to Preterm Labor. The Journal Of Immunology 2011, 187: 2835-2835. DOI: 10.4049/jimmunol.1190048.
- The Kaposi's sarcoma-associated herpesvirus E3 ubiquitin ligase K5 acts as a novel oncogene, altering cellular metabolism and signaling: implications for tumorigenesisKarki R, Lang S, Means R. The Kaposi's sarcoma-associated herpesvirus E3 ubiquitin ligase K5 acts as a novel oncogene, altering cellular metabolism and signaling: implications for tumorigenesis. Infectious Agents And Cancer 2010, 5: a79. PMCID: PMC3002742, DOI: 10.1186/1750-9378-5-s1-a79.
- Viral infection sensitizes pregnancy to LPS leading to preterm laborCardenas I, Aldo P, Means R, Lang S, Stabach P, Mor G. Viral infection sensitizes pregnancy to LPS leading to preterm labor. Journal Of Reproductive Immunology 2010, 86: 33. DOI: 10.1016/j.jri.2010.06.061.
- Vaccine Protection by Live, Attenuated Simian Immunodeficiency Virus in the Absence of High-Titer Antibody Responses and High-Frequency Cellular Immune Responses Measurable in the Periphery▿Mansfield K, Lang S, Gauduin M, Sanford H, Lifson J, Johnson R, Desrosiers R. Vaccine Protection by Live, Attenuated Simian Immunodeficiency Virus in the Absence of High-Titer Antibody Responses and High-Frequency Cellular Immune Responses Measurable in the Periphery▿. Journal Of Virology 2008, 82: 4135-4148. PMID: 18272584, PMCID: PMC2292994, DOI: 10.1128/jvi.00015-08.
- Human gammaherpesvirus immune evasion strategiesMeans R, Lang S, Jung J. Human gammaherpesvirus immune evasion strategies. 2007, 559-586. DOI: 10.1017/cbo9780511545313.032.
- Ability of herpes simplex virus vectors to boost immune responses to DNA vectors and to protect against challenge by simian immunodeficiency virusKaur A, Sanford H, Garry D, Lang S, Klumpp S, Watanabe D, Bronson R, Lifson J, Rosati M, Pavlakis G, Felber B, Knipe D, Desrosiers R. Ability of herpes simplex virus vectors to boost immune responses to DNA vectors and to protect against challenge by simian immunodeficiency virus. Virology 2006, 357: 199-214. PMID: 16962628, PMCID: PMC1819472, DOI: 10.1016/j.virol.2006.08.007.
- Infection and Persistence of Rhesus Monkey Rhadinovirus in Immortalized B-Cell LinesBilello J, Lang S, Wang F, Aster J, Desrosiers R. Infection and Persistence of Rhesus Monkey Rhadinovirus in Immortalized B-Cell Lines. Journal Of Virology 2006, 80: 3644-3649. PMID: 16537632, PMCID: PMC1440374, DOI: 10.1128/jvi.80.7.3644-3649.2006.
- A Genetic System for Rhesus Monkey Rhadinovirus: Use of Recombinant Virus To Quantitate Antibody-Mediated NeutralizationBilello J, Morgan J, Damania B, Lang S, Desrosiers R. A Genetic System for Rhesus Monkey Rhadinovirus: Use of Recombinant Virus To Quantitate Antibody-Mediated Neutralization. Journal Of Virology 2006, 80: 1549-1562. PMID: 16415030, PMCID: PMC1346924, DOI: 10.1128/jvi.80.3.1549-1562.2006.
- Immunization of Macaques with Single-Cycle Simian Immunodeficiency Virus (SIV) Stimulates Diverse Virus-Specific Immune Responses and Reduces Viral Loads after Challenge with SIVmac239Evans D, Bricker J, Sanford H, Lang S, Carville A, Richardson B, Piatak M, Lifson J, Mansfield K, Desrosiers R. Immunization of Macaques with Single-Cycle Simian Immunodeficiency Virus (SIV) Stimulates Diverse Virus-Specific Immune Responses and Reduces Viral Loads after Challenge with SIVmac239. Journal Of Virology 2005, 79: 7707-7720. PMID: 15919923, PMCID: PMC1143664, DOI: 10.1128/jvi.79.12.7707-7720.2005.
- Impact of Nef-Mediated Downregulation of Major Histocompatibility Complex Class I on Immune Response to Simian Immunodeficiency VirusSwigut T, Alexander L, Morgan J, Lifson J, Mansfield K, Lang S, Johnson R, Skowronski J, Desrosiers R. Impact of Nef-Mediated Downregulation of Major Histocompatibility Complex Class I on Immune Response to Simian Immunodeficiency Virus. Journal Of Virology 2004, 78: 13335-13344. PMID: 15542684, PMCID: PMC525019, DOI: 10.1128/jvi.78.23.13335-13344.2004.
- Vpx proteins of SIVmac239 and HIV-2ROD interact with the cytoskeletal protein α-actinin 1Mueller S, Jung R, Weiler S, Lang S. Vpx proteins of SIVmac239 and HIV-2ROD interact with the cytoskeletal protein α-actinin 1. Journal Of General Virology 2004, 85: 3291-3303. PMID: 15483243, DOI: 10.1099/vir.0.80198-0.
- Importance of B-Cell Responses for Immunological Control of Variant Strains of Simian Immunodeficiency VirusJohnson W, Lifson J, Lang S, Johnson R, Desrosiers R. Importance of B-Cell Responses for Immunological Control of Variant Strains of Simian Immunodeficiency Virus. Journal Of Virology 2003, 77: 375-381. PMID: 12477842, PMCID: PMC140644, DOI: 10.1128/jvi.77.1.375-381.2003.
- The First HxRxG Motif in Simian Immunodeficiency Virus mac239 Vpr Is Crucial for G2/M Cell Cycle ArrestMueller S, Lang S. The First HxRxG Motif in Simian Immunodeficiency Virus mac239 Vpr Is Crucial for G2/M Cell Cycle Arrest. Journal Of Virology 2002, 76: 11704-11709. PMID: 12388729, PMCID: PMC136740, DOI: 10.1128/jvi.76.22.11704-11709.2002.
- Simian Immunodeficiency Virus Containing Mutations in N-Terminal Tyrosine Residues and in the PxxP Motif in Nef Replicates Efficiently in Rhesus MacaquesCarl S, Iafrate A, Lang S, Stolte N, Stahl-Hennig C, Mätz-Rensing K, Fuchs D, Skowronski J, Kirchhoff F. Simian Immunodeficiency Virus Containing Mutations in N-Terminal Tyrosine Residues and in the PxxP Motif in Nef Replicates Efficiently in Rhesus Macaques. Journal Of Virology 2000, 74: 4155-4164. PMID: 10756028, PMCID: PMC111930, DOI: 10.1128/jvi.74.9.4155-4164.2000.
- The Acidic Region and Conserved Putative Protein Kinase C Phosphorylation Site in Nef Are Important for SIV Replication in Rhesus MacaquesCarl S, Iafrate A, Lang S, Stahl-Hennig C, Kuhn E, Fuchs D, Mätz-Rensing K, Haaft P, Heeney J, Skowronski J, Kirchhoff F. The Acidic Region and Conserved Putative Protein Kinase C Phosphorylation Site in Nef Are Important for SIV Replication in Rhesus Macaques. Virology 1999, 257: 138-155. PMID: 10208928, DOI: 10.1006/viro.1999.9645.
- Association of simian immunodeficiency virus Nef with cellular serine/threonine kinases is dispensable for the development of AIDS in rhesus macaquesLang S, Lafrate A, Stahl-Hennig C, Kuhn E, Nisslein T, Kaup F, Haupt M, Hunsmann G, Skowronski J, Kirchhoff F. Association of simian immunodeficiency virus Nef with cellular serine/threonine kinases is dispensable for the development of AIDS in rhesus macaques. Nature Medicine 1997, 3: 860-865. PMID: 9256276, DOI: 10.1038/nm0897-860.
- Downregulation of Lck-mediated signal transduction by tip of herpesvirus saimiri.Jung J, Lang S, Jun T, Roberts T, Veillette A, Desrosiers R. Downregulation of Lck-mediated signal transduction by tip of herpesvirus saimiri. Journal Of Virology 1995, 69: 7814-22. PMID: 7494293, PMCID: PMC189725, DOI: 10.1128/jvi.69.12.7814-7822.1995.
- Identification of Lck-binding Elements in Tip of Herpesvirus Saimiri (∗)Jung J, Lang S, Friedrich U, Jun T, Roberts T, Desrosiers R, Biesinger B. Identification of Lck-binding Elements in Tip of Herpesvirus Saimiri (∗). Journal Of Biological Chemistry 1995, 270: 20660-20667. PMID: 7544793, DOI: 10.1074/jbc.270.35.20660.
- Identification of a nef allele that causes lymphocyte activation and acute disease in Macaque monkeysDu Z, Lang S, Sasseville V, Lackner A, Ilyinskii P, Daniel M, Jung J, Desrosiers R. Identification of a nef allele that causes lymphocyte activation and acute disease in Macaque monkeys. Cell 1995, 82: 665-674. PMID: 7664345, DOI: 10.1016/0092-8674(95)90038-1.
- vpr deletion mutant of simian immunodeficiency virus induces AIDS in rhesus monkeys.Hoch J, Lang S, Weeger M, Stahl-Hennig C, Coulibaly C, Dittmer U, Hunsmann G, Fuchs D, Müller J, Sopper S. vpr deletion mutant of simian immunodeficiency virus induces AIDS in rhesus monkeys. Journal Of Virology 1995, 69: 4807-13. PMID: 7609047, PMCID: PMC189293, DOI: 10.1128/jvi.69.8.4807-4813.1995.
- Progression to AIDS in the absence of a gene for vpr or vpx.Gibbs J, Lackner A, Lang S, Simon M, Sehgal P, Daniel M, Desrosiers R. Progression to AIDS in the absence of a gene for vpr or vpx. Journal Of Virology 1995, 69: 2378-83. PMID: 7884883, PMCID: PMC188910, DOI: 10.1128/jvi.69.4.2378-2383.1995.
- Importance of vpr for infection of rhesus monkeys with simian immunodeficiency virus.Lang S, Weeger M, Stahl-Hennig C, Coulibaly C, Hunsmann G, Müller J, Müller-Hermelink H, Fuchs D, Wachter H, Daniel M. Importance of vpr for infection of rhesus monkeys with simian immunodeficiency virus. Journal Of Virology 1993, 67: 902-12. PMID: 8380472, PMCID: PMC237444, DOI: 10.1128/jvi.67.2.902-912.1993.