Research & Publications
Epigenetic aberrations often lead to cancer and other human diseases. The long-term goals of our laboratory are to elucidate the roles of epigenetic regulation in cancer initiation and progression and to translate our findings to the clinic. In particular, we focus on the epigenetic regulators of cancer metastasis, immune evasion and resistance to anticancer drugs in breast cancer and melanoma. We are currently studying how epigenetic regulators including KDM5 demethylases and bromodomain protein CECR2 contribute to cancer initiation and progression using biochemical, molecular biological, cell biological and mouse genetic approaches. As these epigenetic regulators are potential drug targets, we are developing small molecule inhibitors and degraders against these regulators for cancer treatment.
Specialized Terms: Epigenetics; Gene regulation; Cancer biology
Gene Expression Regulation; Immunotherapy; Melanoma; Neoplasm Metastasis; Retroelements; Drug Resistance, Neoplasm; Jumonji Domain-Containing Histone Demethylases; Epigenomics; Epigenetic Repression
Public Health Interests