Research & Publications
We are a cancer biology lab with a research focus on brain tumors and gliomas/glioblastomas in particular. We study the processes of glioma-related tumor evolution and treatment resistance. We use high-throughput sequencing, computational analysis and functional studies in our research. We have previously identified extrachromosomal oncogene DNA amplifications as playing a particularly important role in tumor evolution of not just gliomas, but all cancers. We are developing new therapies for cancer through targeting of extrachromosomal DNA amplifications.
Astrocytoma; Glioblastoma; Oligodendroglioma; Diffuse Intrinsic Pontine Glioma
Public Health Interests
Cancer; Genetics, Genomics, Epigenetics