Research & Publications
Research on the regulation of kidney transport proteins has helped to define the mechanisms by which the kidney transports acid. Subsequently it has focused on the mechanisms by which kidney cells sense excess acid and initiate a signaling cascade that alters the expression, cellular location, and function of many proteins in the cell, resulting in enhanced acid transport and urinary excretion.
Specialized Terms: Epithelial physiology; Membrane transport; Acid-base homeostasis
Extensive Research Description
Dr. Alpern’s research has focused on the regulation of kidney transport proteins.
Acid-Base Equilibrium; Acidosis, Renal Tubular; Kidney; Nephrology; Renal Circulation; Urination; Membrane Transport Proteins; Renal Elimination