Robert Alpern, MD

• Pat Preisig
• Xuefei Tian

Acid-Base Equilibrium; Acidosis, Renal Tubular; Kidney; Nephrology; Renal Circulation; Urination; Membrane Transport Proteins; Renal Elimination

• Use of Renin Angiotensin System Blockers After Acute Kidney Injury: Balancing Tradeoffs.Alpern RJ, Peixoto AJ. Use of Renin Angiotensin System Blockers After Acute Kidney Injury: Balancing Tradeoffs. JAMA Internal Medicine 2018, 178: 1690-1692. PMID: 30422208, DOI: 10.1001/jamainternmed.2018.4757.
• Donald Seldin: A Transformative Leader in Medicine and NephrologyAlpern R, Giebisch G. Donald Seldin: A Transformative Leader in Medicine and Nephrology. Journal Of The American Society Of Nephrology 2018, 29: 2029-2030. PMID: 29986871, PMCID: PMC6065072, DOI: 10.1681/asn.2018060603.
• Acid Stimulation of the Citrate Transporter NaDC-1 Requires Pyk2 and ERK1/2 Signaling PathwaysZacchia M, Tian X, Zona E, Alpern RJ, Preisig PA. Acid Stimulation of the Citrate Transporter NaDC-1 Requires Pyk2 and ERK1/2 Signaling Pathways. Journal Of The American Society Of Nephrology 2018, 29: 1720-1730. PMID: 29678998, PMCID: PMC6054333, DOI: 10.1681/asn.2017121268.
• Randomized, Controlled Trial of TRC101 to Increase Serum Bicarbonate in Patients with CKDBushinsky DA, Hostetter T, Klaerner G, Stasiv Y, Lockey C, McNulty S, Lee A, Parsell D, Mathur V, Li E, Buysse J, Alpern R. Randomized, Controlled Trial of TRC101 to Increase Serum Bicarbonate in Patients with CKD. Clinical Journal Of The American Society Of Nephrology 2017, 13: 26-35. PMID: 29102959, PMCID: PMC5753317, DOI: 10.2215/cjn.07300717.
• Research in academic medical centers: Two threats to sustainable supportLevine AS, Alpern RJ, Andrews NC, Antman K, Balser JR, Berg JM, Davis PB, Fitz JG, Golden RN, Goldman L, Jameson JL, Lee VS, Polonsky KS, Rappley MD, Reece EA, Rothman PB, Schwinn DA, Shapiro LJ, Spiegel AM. Research in academic medical centers: Two threats to sustainable support. Science Translational Medicine 2015, 7: 289fs22-289fs22. PMID: 26019216, DOI: 10.1126/scitranslmed.aac5200.
• Treatment of Severe Metabolic Alkalosis in a Patient With Congestive Heart FailurePeixoto AJ, Alpern RJ. Treatment of Severe Metabolic Alkalosis in a Patient With Congestive Heart Failure. American Journal Of Kidney Diseases 2013, 61: 822-827. PMID: 23481366, DOI: 10.1053/j.ajkd.2012.10.028.
• Chapter 55 Cellular Mechanisms of Renal Tubular AcidificationHamm L, Alpern R, Preisig P. Chapter 55 Cellular Mechanisms of Renal Tubular Acidification. 2013, 1917-1978. DOI: 10.1016/b978-0-12-381462-3.00055-0.
• Chapter 38 Pathophysiology of Sodium Retention and WastagePalmer B, Alpern R, Seldin D. Chapter 38 Pathophysiology of Sodium Retention and Wastage. 2013, 1283-1317. DOI: 10.1016/b978-0-12-381462-3.00038-0.
• Chapter 58 Clinical Syndromes of Metabolic AlkalosisMoe O, Alpern R, Seldin D. Chapter 58 Clinical Syndromes of Metabolic Alkalosis. 2013, 2021-2047. DOI: 10.1016/b978-0-12-381462-3.00058-6.
• Chapter 59 Clinical Syndromes of Metabolic AcidosisKrapf R, Seldin D, Alpern R. Chapter 59 Clinical Syndromes of Metabolic Acidosis. 2013, 2049-2111. DOI: 10.1016/b978-0-12-381462-3.00059-8.
• Defining hypercalciuria in nephrolithiasisPak CY, Sakhaee K, Moe OW, Poindexter J, Adams-Huet B, Pearle MS, Zerwekh JE, Preminger GM, Wills MR, Breslau NA, Bartter FC, Brater DC, Heller HJ, Odvina CV, Wabner CL, Fordtran JS, Oh M, Garg A, Harvey JA, Alpern RJ, Snyder WH, Peters PC. Defining hypercalciuria in nephrolithiasis. Kidney International 2011, 80: 777-782. PMID: 21775970, PMCID: PMC4354881, DOI: 10.1038/ki.2011.227.
• Competencies in Premedical and Medical Education: The AAMC–HHMI ReportAlpern RJ, Belitsky R, Long S. Competencies in Premedical and Medical Education: The AAMC–HHMI Report. Perspectives In Biology And Medicine 2011, 54: 30-35. PMID: 21399381, DOI: 10.1353/pbm.2011.0001.
• Pre-medical education for future physicians: evolution at Yale and beyond.Segraves W, Alpern R, Salovey P. Pre-medical education for future physicians: evolution at Yale and beyond. Connecticut Medicine 2010, 74: 529-32. PMID: 21073011.
• Acid regulation of NaDC-1 requires a functional endothelin B receptorLiu L, Zacchia M, Tian X, Wan L, Sakamoto A, Yanagisawa M, Alpern RJ, Preisig PA. Acid regulation of NaDC-1 requires a functional endothelin B receptor. Kidney International 2010, 78: 895-904. PMID: 20703215, DOI: 10.1038/ki.2010.264.
• Medical Report's Static Charge Sparks Shock—ResponseAlpern R, Long S. Medical Report's Static Charge Sparks Shock—Response. Science 2009, 326: 1481-1482. DOI: 10.1126/science.326.5959.1481-b.
• An academic, apolitical approach to health care reform.Alpern R. An academic, apolitical approach to health care reform. The Journal Of Clinical Investigation 2009, 119: 2853-4. PMID: 20069711, PMCID: PMC2752101, DOI: 10.1172/jci40997.
• Science for Future PhysiciansLong S, Alpern R. Science for Future Physicians. Science 2009, 324: 1241-1241. PMID: 19498132, DOI: 10.1126/science.1176994.
• CHAPTER 54 Cellular Mechanisms of Renal Tubular AcidificationHamm L, Alpern R, Preisig P. CHAPTER 54 Cellular Mechanisms of Renal Tubular Acidification. 2008, 1539-1585. DOI: 10.1016/b978-012088488-9.50057-7.
• CHAPTER 36 Physiology and Pathophysiology of Sodium Retention and WastagePalmer B, Alpern R, Seldin D. CHAPTER 36 Physiology and Pathophysiology of Sodium Retention and Wastage. 2008, 1005-1049. DOI: 10.1016/b978-012088488-9.50039-5.
• PrefaceAlpern R, Hebert S. Preface. 2008, xxiii. DOI: 10.1016/b978-012088488-9.50003-6.
• CHAPTER 59 Clinical Syndromes of Metabolic AcidosisKrapf R, Seldin D, Alpern R. CHAPTER 59 Clinical Syndromes of Metabolic Acidosis. 2008, 1667-1720. DOI: 10.1016/b978-012088488-9.50062-0.
• CHAPTER 58 Clinical Syndromes of Metabolic AlkalosisMoe O, Seldin D, Alpern R. CHAPTER 58 Clinical Syndromes of Metabolic Alkalosis. 2008, 1645-1666. DOI: 10.1016/b978-012088488-9.50061-9.
• RhoA required for acid-induced stress fiber formation and trafficking and activation of NHE3Yang X, Huang HC, Yin H, Alpern RJ, Preisig PA. RhoA required for acid-induced stress fiber formation and trafficking and activation of NHE3. American Journal Of Physiology. Renal Physiology 2007, 293: f1054-f1064. PMID: 17686951, DOI: 10.1152/ajprenal.00295.2007.
• 招請講演3: Dietary Acid, Pyk2, Nocturnin, and Circadian Rhythm: Role in Renal Homeostasis and DiseasePreisig P, Alpern R. 招請講演3: Dietary Acid, Pyk2, Nocturnin, and Circadian Rhythm: Role in Renal Homeostasis and Disease. 日本腎臓学会誌 2006, 48: 145-145. DOI: 10.14842/jpnjnephrol1959.48.3_145.
• ISN Forefronts in Nephrology 1986–2006Alpern R, Giebisch G, Murer H. ISN Forefronts in Nephrology 1986–2006. Nature Reviews Nephrology 2006, 2: 173-173. DOI: 10.1038/ncpneph0144.
• Molecular Biology of Renal Acid–Base TransportersMoe O, Baum M, Alpern R. Molecular Biology of Renal Acid–Base Transporters. 2005, 119-176. DOI: 10.1201/b14402-6.
• Molecular Biology of Renal Acid–Base TransportersMoe O, Baum M, Alpern R. Molecular Biology of Renal Acid–Base Transporters. 2005, 141-198. DOI: 10.1201/b14402-9.
• Pyk2 activation is integral to acid stimulation of sodium/hydrogen exchanger 3Li S, Sato S, Yang X, Preisig PA, Alpern RJ. Pyk2 activation is integral to acid stimulation of sodium/hydrogen exchanger 3. Journal Of Clinical Investigation 2004, 114: 1782-1789. PMID: 15599403, PMCID: PMC535061, DOI: 10.1172/jci18046.
• A consensus sequence in the endothelin-B receptor second intracellular loop is required for NHE3 activation by endothelin-1Laghmani K, Sakamoto A, Yanagisawa M, Preisig PA, Alpern RJ. A consensus sequence in the endothelin-B receptor second intracellular loop is required for NHE3 activation by endothelin-1. American Journal Of Physiology. Renal Physiology 2004, 288: f732-f739. PMID: 15598844, DOI: 10.1152/ajprenal.00300.2004.
• An autocrine role for endothelin-1 in the regulation of proximal tubule NHE3Licht C, Laghmani K, Yanagisawa M, Preisig PA, Alpern RJ. An autocrine role for endothelin-1 in the regulation of proximal tubule NHE3. Kidney International 2004, 65: 1320-1326. PMID: 15086471, DOI: 10.1111/j.1523-1755.2004.00506.x.
• OKP cells express the Na-dicarboxylate cotransporter NaDC-1Aruga S, Pajor AM, Nakamura K, Liu L, Moe OW, Preisig PA, Alpern RJ. OKP cells express the Na-dicarboxylate cotransporter NaDC-1. American Journal Of Physiology - Cell Physiology 2004, 287: c64-c72. PMID: 14973148, DOI: 10.1152/ajpcell.00061.2003.
• Dietary acid, endothelins, and sleep.Alpern RJ, Preisig PA. Dietary acid, endothelins, and sleep. Transactions Of The American Clinical And Climatological Association 2004, 115: 385-93; discussion 393-4. PMID: 17060981, PMCID: PMC2263788.
• Treating dyslipidemia to slow the progression of chronic renal failurePalmer BF, Alpern RJ. Treating dyslipidemia to slow the progression of chronic renal failure. The American Journal Of Medicine 2003, 114: 411-412. PMID: 12714133, DOI: 10.1016/s0002-9343(03)00070-6.
• Bicarbonate reabsorption and NHE-3 expression: Abundance and activity are increased in Henle's loop of remnant ratsCapasso G, Rizzo M, Pica A, Di Maio FS, Moe OW, Alpern RJ, De Santo NG. Bicarbonate reabsorption and NHE-3 expression: Abundance and activity are increased in Henle's loop of remnant rats. Kidney International 2002, 62: 2126-2135. PMID: 12427137, DOI: 10.1046/j.1523-1755.2002.00681.x.
• Role of c-SRC and ERK in acid-induced activation of NHE3Tsuganezawa H, Sato S, Yamaji Y, Preisig PA, Moe OW, Alpern RJ. Role of c-SRC and ERK in acid-induced activation of NHE3. Kidney International 2002, 62: 41-50. PMID: 12081562, DOI: 10.1046/j.1523-1755.2002.00418.x.
• Reversible acute renal failure and nephrotic syndrome in a Type 1 diabetic patientAvilés-Santa L, Alpern R, Raskin P. Reversible acute renal failure and nephrotic syndrome in a Type 1 diabetic patient. Journal Of Diabetes And Its Complications 2002, 16: 249-254. PMID: 12015196, DOI: 10.1016/s1056-8727(01)00221-5.
• 2001 presidential address.Alpern RJ. 2001 presidential address. Journal Of The American Society Of Nephrology 2002, 13: 1119-1123. PMID: 11912274, DOI: 10.1681/asn.v1341119.
• Glucagon Acutely Inhibits but Chronically Activates Na+/H+ Antiporter 3 Activity in OKP CellsAmemiya M, Kusano E, Muto S, Tabei K, Ando Y, Alpern RJ, Asano Y. Glucagon Acutely Inhibits but Chronically Activates Na+/H+ Antiporter 3 Activity in OKP Cells. Nephron 2002, 10: 26-33. PMID: 11803202, DOI: 10.1159/000049895.
• The role of endothelin in proximal tubule proton secretion and the adaptation to a chronic metabolic acidosis.Laghmani K, Preisig PA, Alpern RJ. The role of endothelin in proximal tubule proton secretion and the adaptation to a chronic metabolic acidosis. Journal Of Nephrology 2002, 15 Suppl 5: s75-87. PMID: 12027224.
• Endothelin-1/endothelin-B receptor–mediated increases in NHE3 activity in chronic metabolic acidosisLaghmani K, Preisig P, Moe O, Yanagisawa M, Alpern R. Endothelin-1/endothelin-B receptor–mediated increases in NHE3 activity in chronic metabolic acidosis. Journal Of Clinical Investigation 2001, 107: 1563-1569. PMID: 11413164, PMCID: PMC200190, DOI: 10.1172/jci11234.
• ETB receptor activation causes exocytic insertion of NHE3 in OKP cellsPeng Y, Amemiya M, Yang X, Fan L, Moe O, Yin H, Preisig P, Yanagisawa M, Alpern R. ETB receptor activation causes exocytic insertion of NHE3 in OKP cells. American Journal Of Physiology. Renal Physiology 2001, 280: f34-f42. PMID: 11133512, DOI: 10.1152/ajprenal.2001.280.1.f34.
• Endocrine Control of Acid‐Base BalanceAlpern R. Endocrine Control of Acid‐Base Balance. 2000, 570-603. DOI: 10.1002/cphy.cp070315.
• Acid incubation causes exocytic insertion of NHE3 in OKP cellsYang X, Amemiya M, Peng Y, Moe O, Preisig P, Alpern R. Acid incubation causes exocytic insertion of NHE3 in OKP cells. American Journal Of Physiology - Cell Physiology 2000, 279: c410-c419. PMID: 10913008, DOI: 10.1152/ajpcell.2000.279.2.c410.
• Chronic metabolic acidosis increases NaDC-1 mRNA and protein abundance in rat kidneyAruga S, Wehrli S, Kaissling B, Moe O, Preisig P, Pajor A, Alpern R. Chronic metabolic acidosis increases NaDC-1 mRNA and protein abundance in rat kidney. Kidney International 2000, 58: 206-215. PMID: 10886565, DOI: 10.1046/j.1523-1755.2000.00155.x.
• Renal citrate metabolism and urinary citrate excretion in the infant ratMelnick J, Preisig P, Alpern R, Baum M. Renal citrate metabolism and urinary citrate excretion in the infant rat. Kidney International 2000, 57: 891-897. PMID: 10720942, PMCID: PMC4089854, DOI: 10.1046/j.1523-1755.2000.057003891.x.
• Authors' Reply:Ambühl P, Alpern R. Authors' Reply:. American Journal Of Kidney Diseases 1999, 34: 963-965. DOI: 10.1016/s0272-6386(99)70065-x.
• Role of glucocorticoids in acidosisHamm L, Ambühl P, Alpern R. Role of glucocorticoids in acidosis. American Journal Of Kidney Diseases 1999, 34: 960-965. PMID: 10561158, DOI: 10.1016/s0272-6386(99)70059-4.
• Cell and molecular biology of epithelial transportRossier B, Alpern R. Cell and molecular biology of epithelial transport. Current Opinion In Nephrology & Hypertension 1999, 8: 579-580. DOI: 10.1097/00041552-199909000-00008.
• ETB receptor activation leads to activation and phosphorylation of NHE3Peng Y, Moe OW, Chu T, Preisig PA, Yanagisawa M, Alpern RJ. ETB receptor activation leads to activation and phosphorylation of NHE3. American Journal Of Physiology 1999, 276: c938-c945. PMID: 10199826, DOI: 10.1152/ajpcell.1999.276.4.c938.
• Incubation of OKP cells in low-K+ media increases NHE3 activity after early decrease in intracellular pHAmemiya M, Tabei K, Kusano E, Asano Y, Alpern R. Incubation of OKP cells in low-K+ media increases NHE3 activity after early decrease in intracellular pH. American Journal Of Physiology 1999, 276: c711-c716. PMID: 10069999, DOI: 10.1152/ajpcell.1999.276.3.c711.
• Glucocorticoids enhance acid activation of the Na+/H+ exchanger 3 (NHE3)Ambühl P, Yang X, Peng Y, Preisig P, Moe O, Alpern R. Glucocorticoids enhance acid activation of the Na+/H+ exchanger 3 (NHE3). Journal Of Clinical Investigation 1999, 103: 429-435. PMID: 9927505, PMCID: PMC407891, DOI: 10.1172/jci2913.
• Converting enzyme inhibition causes hypocitraturia independent of acidosis or hypokalemiaMelnick J, Preisig P, Haynes S, Pak C, Sakhaee K, Alpern R. Converting enzyme inhibition causes hypocitraturia independent of acidosis or hypokalemia. Kidney International 1998, 54: 1670-1674. PMID: 9844143, DOI: 10.1046/j.1523-1755.1998.00150.x.
• Renal Na/H exchanger NHE-3 and Na-PO4 cotransporter NaPi-2 protein expression in glucocorticoid excess and deficient states.Loffing J, Lötscher M, Kaissling B, Biber J, Murer H, Seikaly M, Alpern RJ, Levi M, Baum M, Moe OW. Renal Na/H exchanger NHE-3 and Na-PO4 cotransporter NaPi-2 protein expression in glucocorticoid excess and deficient states. Journal Of The American Society Of Nephrology 1998, 9: 1560-7. PMID: 9727362, PMCID: PMC4131923, DOI: 10.1681/asn.v991560.
• Molcular cell biology and physiology of solute transportRossier B, Alpern R. Molcular cell biology and physiology of solute transport. Current Opinion In Nephrology & Hypertension 1998, 7: 495-496. DOI: 10.1097/00041552-199809000-00002.
• Dominant negative c-Src inhibits angiotensin II induced activation of NHE3 in OKP cellsTsuganezawa H, Preisig P, Alpern R. Dominant negative c-Src inhibits angiotensin II induced activation of NHE3 in OKP cells. Kidney International 1998, 54: 394-398. PMID: 9690205, DOI: 10.1046/j.1523-1755.1998.00029.x.
• Renal cortical mitochondrial aconitase is regulated in hypo- and hypercitraturiaMelnick J, Preisig P, Moe O, Srere P, Alpern R. Renal cortical mitochondrial aconitase is regulated in hypo- and hypercitraturia. Kidney International 1998, 54: 160-165. PMID: 9648074, DOI: 10.1046/j.1523-1755.1998.00974.x.
• Effects of thyroid hormone on the neonatal renal cortical Na+/H+ antiporterBaum M, Dwarakanath V, Alpern R, Moe O. Effects of thyroid hormone on the neonatal renal cortical Na+/H+ antiporter. Kidney International 1998, 53: 1254-1258. PMID: 9573540, PMCID: PMC4131927, DOI: 10.1046/j.1523-1755.1998.00879.x.
• Liddle’s SyndromePalmer B, Alpern R, In collaboration with The American Physiological Society T. Liddle’s Syndrome. The American Journal Of Medicine 1998, 104: 301-309. PMID: 9552093, DOI: 10.1016/s0002-9343(98)00018-7.
• Chronic hyperosmolality increases NHE3 activity in OKP cells.Ambühl P, Amemiya M, Preisig PA, Moe OW, Alpern RJ. Chronic hyperosmolality increases NHE3 activity in OKP cells. Journal Of Clinical Investigation 1998, 101: 170-177. PMID: 9421479, PMCID: PMC508553, DOI: 10.1172/jci62.
• Media acidification inhibits TGF beta-mediated growth suppression in cultured rabbit proximal tubule cells.Tovbin D, Franch HA, Alpern RJ, Preisig PA. Media acidification inhibits TGF beta-mediated growth suppression in cultured rabbit proximal tubule cells. Proceedings Of The Association Of American Physicians 1997, 109: 572-9. PMID: 9394419.
• Metabolic alkalosis.Palmer BF, Alpern RJ. Metabolic alkalosis. Journal Of The American Society Of Nephrology 1997, 8: 1462-9. PMID: 9294840, DOI: 10.1681/asn.v891462.
• Molecular mechanisms of transport protein regulationAlpern R, Rossier B. Molecular mechanisms of transport protein regulation. Current Opinion In Nephrology & Hypertension 1997, 6: 423-424. DOI: 10.1097/00041552-199709000-00002.
• Adaptation to low-K+ media increases H(+)-K(+)-ATPase but not H(+)-ATPase-mediated pHi recovery in OMCD1 cellsGuntupalli J, Onuigbo M, Wall S, Alpern RJ, DuBose TD. Adaptation to low-K+ media increases H(+)-K(+)-ATPase but not H(+)-ATPase-mediated pHi recovery in OMCD1 cells. American Journal Of Physiology 1997, 273: c558-c571. PMID: 9277353, DOI: 10.1152/ajpcell.1997.273.2.c558.
• Pathogenesis of edema formation in the nephrotic syndrome.Palmer BF, Alpern RJ. Pathogenesis of edema formation in the nephrotic syndrome. Kidney International Supplement 1997, 59: s21-7. PMID: 9185099.
• Nephrology core curriculum. The American Society of Nephrology and the American Society of Nephrology Training Program Directors Committee.Kumar R, Alpern R, Berl T, Blantz R, Chevalier R, Hostetter T, Madias N, Salant D, Wiggins R, Bennett W, Chapman A, Ekonyan G, Falk R, Gennari F, Helderman J, Hruska K, Levey A, Lindheimer M, Miller R, Nissenson A, Schwab S, Schwab T, Schwartz R, Wilcox C. Nephrology core curriculum. The American Society of Nephrology and the American Society of Nephrology Training Program Directors Committee. Journal Of The American Society Of Nephrology 1997, 8: 1018-27. PMID: 9189871, DOI: 10.1681/asn.v861018.
• Intracellular acidosis activates c-SrcYamaji Y, Tsuganezawa H, Moe OW, Alpern RJ. Intracellular acidosis activates c-Src. American Journal Of Physiology 1997, 272: c886-c893. PMID: 9124524, DOI: 10.1152/ajpcell.1997.272.3.c886.
• The clinical spectrum of chronic metabolic acidosis: Homeostatic mechanisms produce significant morbidityAlpern R, Sakhaee K. The clinical spectrum of chronic metabolic acidosis: Homeostatic mechanisms produce significant morbidity. American Journal Of Kidney Diseases 1997, 29: 291-302. PMID: 9016905, DOI: 10.1016/s0272-6386(97)90045-7.
• Does hyperphosphaturla underlle hypercalciuria?Alpern R, Sakhaee K. Does hyperphosphaturla underlle hypercalciuria? The Lancet 1997, 349: 518-519. PMID: 9048785, DOI: 10.1016/s0140-6736(97)80080-3.
• Chronic metabolic acidosis enhances NHE-3 protein abundance and transport activity in the rat thick ascending limb by increasing NHE-3 mRNA.Laghmani K, Borensztein P, Ambühl P, Froissart M, Bichara M, Moe OW, Alpern RJ, Paillard M. Chronic metabolic acidosis enhances NHE-3 protein abundance and transport activity in the rat thick ascending limb by increasing NHE-3 mRNA. Journal Of Clinical Investigation 1997, 99: 24-30. PMID: 9011571, PMCID: PMC507763, DOI: 10.1172/jci119128.
• Chapter II Renal Electrolyte Transport and Its RegulationAlpern R, Giebisch G, Seldin D. Chapter II Renal Electrolyte Transport and Its Regulation. 1997, 31-72. DOI: 10.1016/b978-012635690-8/50003-7.
• Adenosine triphosphate citrate lyase mediates hypocitraturia in rats.Melnick JZ, Srere PA, Elshourbagy NA, Moe OW, Preisig PA, Alpern RJ. Adenosine triphosphate citrate lyase mediates hypocitraturia in rats. Journal Of Clinical Investigation 1996, 98: 2381-2387. PMID: 8941657, PMCID: PMC507690, DOI: 10.1172/jci119051.
• Hensin: a matrix protein determinant of epithelial polarity.Alpern RJ. Hensin: a matrix protein determinant of epithelial polarity. The Journal Of Clinical Investigation 1996, 98: 2189-90. PMID: 8941631, PMCID: PMC507664, DOI: 10.1172/JCI119025.
• Chronic metabolic acidosis increases NHE3 protein abundance in rat kidneyAmbuhl P, Amemiya M, Danczkay M, Lotscher M, Kaissling B, Moe OW, Preisig PA, Alpern RJ. Chronic metabolic acidosis increases NHE3 protein abundance in rat kidney. American Journal Of Physiology 1996, 271: f917-f925. PMID: 8898023, DOI: 10.1152/ajprenal.1996.271.4.f917.
• Role of tyrosine kinase pathways in ETB receptor activation of NHE3Chu TS, Tsuganezawa H, Peng Y, Cano A, Yanagisawa M, Alpern RJ. Role of tyrosine kinase pathways in ETB receptor activation of NHE3. American Journal Of Physiology 1996, 271: c763-c771. PMID: 8843705, DOI: 10.1152/ajpcell.1996.271.3.c763.
• Endothelin(B) receptor activates NHE-3 by a Ca2+-dependent pathway in OKP cells.Chu TS, Peng Y, Cano A, Yanagisawa M, Alpern RJ. Endothelin(B) receptor activates NHE-3 by a Ca2+-dependent pathway in OKP cells. Journal Of Clinical Investigation 1996, 97: 1454-1462. PMID: 8617878, PMCID: PMC507205, DOI: 10.1172/jci118567.
• Glucocorticoids regulate NHE-3 transcription in OKP cellsBaum M, Amemiya M, Dwarakanath V, Alpern RJ, Moe OW. Glucocorticoids regulate NHE-3 transcription in OKP cells. American Journal Of Physiology 1996, 270: f164-f169. PMID: 8769835, DOI: 10.1152/ajprenal.1996.270.1.f164.
• Regulation of Cell pHMoe O, Alpern R. Regulation of Cell pH. 1996, 407-425. DOI: 10.1007/978-1-4613-1143-0_20.
• Presentation of the 1995 Jean Hamburger Award to Donald W. Seldin.Alpern RJ. Presentation of the 1995 Jean Hamburger Award to Donald W. Seldin. Kidney International 1995, 48: 2036-9. PMID: 8587267.
• Chronic regulation of the proximal tubular Na/H antiporter: From HCO3 to SRCAlpern R, Moe O, Preisig P. Chronic regulation of the proximal tubular Na/H antiporter: From HCO3 to SRC. Kidney International 1995, 48: 1386-1396. PMID: 8544394, DOI: 10.1038/ki.1995.427.
• Expression of NHE-3 in the apical membrane of rat renal proximal tubule and thick ascending limbAmemiya M, Loffing J, Lötscher M, Kaissling B, Alpern R, Moe O. Expression of NHE-3 in the apical membrane of rat renal proximal tubule and thick ascending limb. Kidney International 1995, 48: 1206-1215. PMID: 8569082, DOI: 10.1038/ki.1995.404.
• Overexpression of csk inhibits acid-induced activation of NHE-3.Yamaji Y, Amemiya M, Cano A, Preisig PA, Miller RT, Moe OW, Alpern RJ. Overexpression of csk inhibits acid-induced activation of NHE-3. Proceedings Of The National Academy Of Sciences Of The United States Of America 1995, 92: 6274-6278. PMID: 7541536, PMCID: PMC41500, DOI: 10.1073/pnas.92.14.6274.
• Acid incubation increases NHE-3 mRNA abundance in OKP cellsAmemiya M, Yamaji Y, Cano A, Moe OW, Alpern RJ. Acid incubation increases NHE-3 mRNA abundance in OKP cells. American Journal Of Physiology 1995, 269: c126-c133. PMID: 7631739, DOI: 10.1152/ajpcell.1995.269.1.c126.
• Involvement of pRB family in TGF beta-dependent epithelial cell hypertrophy.Franch HA, Shay JW, Alpern RJ, Preisig PA. Involvement of pRB family in TGF beta-dependent epithelial cell hypertrophy. Journal Of Cell Biology 1995, 129: 245-254. PMID: 7698989, PMCID: PMC2120382, DOI: 10.1083/jcb.129.1.245.
• Southwestern Internal Medicine Conference: Vasculitis—It’s Time To ReclassifyAlpern R. Southwestern Internal Medicine Conference: Vasculitis—It’s Time To Reclassify. The American Journal Of The Medical Sciences 1995, 309: 235-248. PMID: 7900748, DOI: 10.1097/00000441-199504000-00010.
• Renal Proximal Tubule Response to AcidAlpern R, Yamaji Y, Amemiya M, Cano A, Preisig P, Miller, Moe O. Renal Proximal Tubule Response to Acid. Physiology 1995, 10: 77-81. DOI: 10.1152/physiologyonline.1995.10.2.77.
• Na+/H+ antiporter (NHE-1 isoform) in cultured vascular smooth muscle from the spontaneously hypertensive ratLaPointe M, Ye M, Moe O, Alpern R, Batlle D. Na+/H+ antiporter (NHE-1 isoform) in cultured vascular smooth muscle from the spontaneously hypertensive rat. Kidney International 1995, 47: 78-87. PMID: 7731174, DOI: 10.1038/ki.1995.9.
• Molecular cloning of ion transporters: potential clinical implications.Cano A, Alpern R. Molecular cloning of ion transporters: potential clinical implications. Seminars In Nephrology 1995, 15: 2-8. PMID: 7754253.
• Acid activation of immediate early genes in renal epithelial cells.Yamaji Y, Moe OW, Miller RT, Alpern RJ. Acid activation of immediate early genes in renal epithelial cells. Journal Of Clinical Investigation 1994, 94: 1297-1303. PMID: 8083371, PMCID: PMC295215, DOI: 10.1172/jci117448.
• Effect of glucocorticoids on renal cortical NHE-3 and NHE-1 mRNABaum M, Moe OW, Gentry DL, Alpern RJ. Effect of glucocorticoids on renal cortical NHE-3 and NHE-1 mRNA. American Journal Of Physiology 1994, 267: f437-f442. PMID: 8092257, DOI: 10.1152/ajprenal.1994.267.3.f437.
• Angiotensin II stimulation of Na-H antiporter activity is cAMP independent in OKP cellsCano A, Miller RT, Alpern RJ, Preisig PA. Angiotensin II stimulation of Na-H antiporter activity is cAMP independent in OKP cells. American Journal Of Physiology 1994, 266: c1603-c1608. PMID: 8023891, DOI: 10.1152/ajpcell.1994.266.6.c1603.
• The renal proximal tubule renin-angiotensin system.Moe O, Alpern R, Henrich W. The renal proximal tubule renin-angiotensin system. Seminars In Nephrology 1993, 13: 552-7. PMID: 8278688.
• Cyclic adenosine monophosphate acutely inhibits and chronically stimulates Na/H antiporter in OKP cells.Cano A, Preisig P, Alpern RJ. Cyclic adenosine monophosphate acutely inhibits and chronically stimulates Na/H antiporter in OKP cells. Journal Of Clinical Investigation 1993, 92: 1632-1638. PMID: 7691881, PMCID: PMC288321, DOI: 10.1172/jci116748.
• Chronic regulation of the Na/H antiporter.Alpern RJ, Yamaji Y, Cano A, Horie S, Miller RT, Moe OW, Preisig PA. Chronic regulation of the Na/H antiporter. Translational Research 1993, 122: 137-40. PMID: 8393472.
• Glucocorticoids stimulate Na+/H+ antiporter in OKP cellsBaum M, Cano A, Alpern RJ. Glucocorticoids stimulate Na+/H+ antiporter in OKP cells. American Journal Of Physiology 1993, 264: f1027-f1031. PMID: 8391752, DOI: 10.1152/ajprenal.1993.264.6.f1027.
• Renin expression in renal proximal tubule.Moe OW, Ujiie K, Star RA, Miller RT, Widell J, Alpern RJ, Henrich WL. Renin expression in renal proximal tubule. Journal Of Clinical Investigation 1993, 91: 774-779. PMID: 7680667, PMCID: PMC288027, DOI: 10.1172/jci116296.
• Cell pH and transepithelial H/HCO3 transport in the renal proximal tubuleKrapf R, Alpern R. Cell pH and transepithelial H/HCO3 transport in the renal proximal tubule. The Journal Of Membrane Biology 1993, 131: 1-10. PMID: 8381871, DOI: 10.1007/bf02258529.
• Renal Acidification: Cellular Mechanisms of Tubular Transport and RegulationAlpern R, Rector F. Renal Acidification: Cellular Mechanisms of Tubular Transport and Regulation. 1992, 767-812. DOI: 10.1002/cphy.cp080118.
• Role of protein kinase C and transcription factor AP-1 in the acid-induced increase in Na/H antiporter activity.Horie S, Moe O, Yamaji Y, Cano A, Miller RT, Alpern RJ. Role of protein kinase C and transcription factor AP-1 in the acid-induced increase in Na/H antiporter activity. Proceedings Of The National Academy Of Sciences Of The United States Of America 1992, 89: 5236-5240. PMID: 1319056, PMCID: PMC49266, DOI: 10.1073/pnas.89.12.5236.
• Induction of stress proteins in cultured myogenic cells. Molecular signals for the activation of heat shock transcription factor during ischemia.Benjamin IJ, Horie S, Greenberg ML, Alpern RJ, Williams RS. Induction of stress proteins in cultured myogenic cells. Molecular signals for the activation of heat shock transcription factor during ischemia. Journal Of Clinical Investigation 1992, 89: 1685-1689. PMID: 1569208, PMCID: PMC443048, DOI: 10.1172/jci115768.
• Citraturic Response to Oral Citric Acid LoadSakhaee K, Alpern R, Poindexter J, Pak C. Citraturic Response to Oral Citric Acid Load. Investigative Urology 1992, 147: 975-976. PMID: 1552616, DOI: 10.1016/s0022-5347(17)37437-2.
• Long-term activation of protein kinase c causes chronic Na/H antiporter stimulation in cultured proximal tubule cells.Horie S, Moe O, Miller RT, Alpern RJ. Long-term activation of protein kinase c causes chronic Na/H antiporter stimulation in cultured proximal tubule cells. Journal Of Clinical Investigation 1992, 89: 365-372. PMID: 1310692, PMCID: PMC442861, DOI: 10.1172/jci115594.
• Differential regulation of Na/H antiporter by acid in renal epithelial cells and fibroblasts.Moe OW, Miller RT, Horie S, Cano A, Preisig PA, Alpern RJ. Differential regulation of Na/H antiporter by acid in renal epithelial cells and fibroblasts. Journal Of Clinical Investigation 1991, 88: 1703-1708. PMID: 1658050, PMCID: PMC295708, DOI: 10.1172/jci115487.
• Chronic K depletion stimulates rat renal brush-border membrane Na-citrate cotransporterLevi M, McDonald LA, Preisig PA, Alpern RJ. Chronic K depletion stimulates rat renal brush-border membrane Na-citrate cotransporter. American Journal Of Physiology 1991, 261: f767-f773. PMID: 1683169, DOI: 10.1152/ajprenal.1991.261.5.f767.
• Inhibition of Na(+)-independent H+ pump by Na(+)-induced changes in cell Ca2+.Hays SR, Alpern RJ. Inhibition of Na(+)-independent H+ pump by Na(+)-induced changes in cell Ca2+. The Journal Of General Physiology 1991, 98: 791-813. PMID: 1660062, PMCID: PMC2229082, DOI: 10.1085/jgp.98.4.791.
• Chronic adaptations in proximal tubular H/HCO3 transporters.Alpern RJ, Horie S, Moe O, Tejedor A, Miller RT, Preisig PA. Chronic adaptations in proximal tubular H/HCO3 transporters. Kidney International Supplement 1991, 33: s29-32. PMID: 1653870.
• Basolateral membrane H/HCO3 transport in renal tubulesPreisig P, Alpern R. Basolateral membrane H/HCO3 transport in renal tubules. Kidney International 1991, 39: 1077-1086. PMID: 1895662, DOI: 10.1038/ki.1991.137.
• Effects of endothelin on in vitro renin secretionMoe O, Tejedor A, Campbell WB, Alpern RJ, Henrich WL. Effects of endothelin on in vitro renin secretion. American Journal Of Physiology 1991, 260: e521-e525. PMID: 2018117, DOI: 10.1152/ajpendo.1991.260.4.e521.
• Regulation of proximal reabsorption by effective arterial blood volume.Seldin DW, Preisig PA, Alpern RJ. Regulation of proximal reabsorption by effective arterial blood volume. Seminars In Nephrology 1991, 11: 212-9. PMID: 2034926.
• Increased Na/H antiporter and Na/3HCO3 symporter activities in chronic hyperfiltration. A model of cell hypertrophy.Preisig PA, Alpern RJ. Increased Na/H antiporter and Na/3HCO3 symporter activities in chronic hyperfiltration. A model of cell hypertrophy. The Journal Of General Physiology 1991, 97: 195-217. PMID: 1849958, PMCID: PMC2216475, DOI: 10.1085/jgp.97.2.195.
• Contrasting effects of various potassium salts on renal citrate excretion.Sakhaee K, Alpern R, Jacobson HR, Pak CY. Contrasting effects of various potassium salts on renal citrate excretion. The Journal Of Clinical Endocrinology & Metabolism 1991, 72: 396-400. PMID: 1899422, DOI: 10.1210/jcem-72-2-396.
• Dietary NaCl modulates Na(+)-H+ antiporter activity in renal cortical apical membrane vesiclesMoe OW, Tejedor A, Levi M, Seldin DW, Preisig PA, Alpern RJ. Dietary NaCl modulates Na(+)-H+ antiporter activity in renal cortical apical membrane vesicles. American Journal Of Physiology 1991, 260: f130-f137. PMID: 1847012, DOI: 10.1152/ajprenal.1991.260.1.f130.
• Mechanism of Distal Acidification: Relevance to Distal RTAAlpern R. Mechanism of Distal Acidification: Relevance to Distal RTA. 1991, 1184-1188. DOI: 10.1007/978-3-662-35158-1_119.
• Apical and basolateral membrane H+ extrusion mechanisms in inner stripe of rabbit outer medullary collecting ductHays SR, Alpern RJ. Apical and basolateral membrane H+ extrusion mechanisms in inner stripe of rabbit outer medullary collecting duct. American Journal Of Physiology 1990, 259: f628-f635. PMID: 2171359, DOI: 10.1152/ajprenal.1990.259.4.f628.
• Cellular model of proximal tubule NaCl and NaHCO3 absorptionMoe O, Preisig P, Alpern R. Cellular model of proximal tubule NaCl and NaHCO3 absorption. Kidney International 1990, 38: 605-611. PMID: 2172616, DOI: 10.1038/ki.1990.249.
• Pathways for apical and basolateral membrane NH3 and NH4+ movement in rat proximal tubulePreisig PA, Alpern RJ. Pathways for apical and basolateral membrane NH3 and NH4+ movement in rat proximal tubule. American Journal Of Physiology 1990, 259: f587-f593. PMID: 2221097, DOI: 10.1152/ajprenal.1990.259.4.f587.
• Preincubation in acid medium increases Na/H antiporter activity in cultured renal proximal tubule cells.Horie S, Moe O, Tejedor A, Alpern RJ. Preincubation in acid medium increases Na/H antiporter activity in cultured renal proximal tubule cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 1990, 87: 4742-4745. PMID: 2162055, PMCID: PMC54193, DOI: 10.1073/pnas.87.12.4742.
• Basolateral membrane H/OH/HCO3 transport mechanisms along the nephron: role in control of pHi and transepithelial bicarbonate transport.Preisig PA, Hays SR, Alpern RJ. Basolateral membrane H/OH/HCO3 transport mechanisms along the nephron: role in control of pHi and transepithelial bicarbonate transport. Seminars In Nephrology 1990, 10: 104-14. PMID: 2156327.
• Hypokalemic Nephropathy — A Clue to Cystogenesis?Alpern R, Toto R. Hypokalemic Nephropathy — A Clue to Cystogenesis? New England Journal Of Medicine 1990, 322: 398-399. PMID: 2300091, DOI: 10.1056/nejm199002083220609.
• Basolateral membrane Na(+)-independent Cl-/HCO3- exchange in the inner stripe of the rabbit outer medullary collecting tubule.Hays SR, Alpern RJ. Basolateral membrane Na(+)-independent Cl-/HCO3- exchange in the inner stripe of the rabbit outer medullary collecting tubule. The Journal Of General Physiology 1990, 95: 347-367. PMID: 2307960, PMCID: PMC2216319, DOI: 10.1085/jgp.95.2.347.
• Cell mechanisms of proximal tubule acidification.Alpern RJ. Cell mechanisms of proximal tubule acidification. Physiological Reviews 1990, 70: 79-114. PMID: 2404291, DOI: 10.1152/physrev.1990.70.1.79.
• Contributions of cellular leak pathways to net NaHCO3 and NaCl absorption.Preisig PA, Alpern RJ. Contributions of cellular leak pathways to net NaHCO3 and NaCl absorption. Journal Of Clinical Investigation 1989, 83: 1859-1867. PMID: 2542374, PMCID: PMC303906, DOI: 10.1172/jci114092.
• Basolateral membrane H-OH-HCO3 transport in the proximal tubulePreisig P, Alpern R. Basolateral membrane H-OH-HCO3 transport in the proximal tubule. American Journal Of Physiology 1989, 256: f751-f765. PMID: 2541627, DOI: 10.1152/ajprenal.1989.256.5.f751.
• Complications of diuretic use.Nader PC, Thompson JR, Alpern RJ. Complications of diuretic use. Seminars In Nephrology 1988, 8: 365-87. PMID: 3068757.
• Chronic metabolic acidosis causes an adaptation in the apical membrane Na/H antiporter and basolateral membrane Na(HCO3)3 symporter in the rat proximal convoluted tubule.Preisig PA, Alpern RJ. Chronic metabolic acidosis causes an adaptation in the apical membrane Na/H antiporter and basolateral membrane Na(HCO3)3 symporter in the rat proximal convoluted tubule. Journal Of Clinical Investigation 1988, 82: 1445-1453. PMID: 2844858, PMCID: PMC442703, DOI: 10.1172/jci113750.
• Hepatic renal interrelations in acid-base regulationAlpern RJ, Star R, Seldin DW. Hepatic renal interrelations in acid-base regulation. American Journal Of Physiology 1988, 255: f807-f809. PMID: 3177661, DOI: 10.1152/ajprenal.1988.255.4.f807.
• Regulation of cell pH by ambient bicarbonate, carbon dioxide tension, and pH in the rabbit proximal convoluted tubule.Krapf R, Berry CA, Alpern RJ, Rector FC. Regulation of cell pH by ambient bicarbonate, carbon dioxide tension, and pH in the rabbit proximal convoluted tubule. Journal Of Clinical Investigation 1988, 81: 381-389. PMID: 3123519, PMCID: PMC329580, DOI: 10.1172/jci113330.
• Basolateral membrane Na/base cotransport is dependent on CO2/HCO3 in the proximal convoluted tubule.Krapf R, Alpern RJ, Rector FC, Berry CA. Basolateral membrane Na/base cotransport is dependent on CO2/HCO3 in the proximal convoluted tubule. The Journal Of General Physiology 1987, 90: 833-853. PMID: 2831294, PMCID: PMC2228880, DOI: 10.1085/jgp.90.6.833.
• Role of the Na+/H+ antiporter in rat proximal tubule bicarbonate absorption.Preisig PA, Ives HE, Cragoe EJ, Alpern RJ, Rector FC. Role of the Na+/H+ antiporter in rat proximal tubule bicarbonate absorption. Journal Of Clinical Investigation 1987, 80: 970-978. PMID: 2888788, PMCID: PMC442334, DOI: 10.1172/jci113190.
• Basolateral membrane Cl/HCO3 exchange in the rat proximal convoluted tubule. Na-dependent and -independent modes.Alpern RJ, Chambers M. Basolateral membrane Cl/HCO3 exchange in the rat proximal convoluted tubule. Na-dependent and -independent modes. The Journal Of General Physiology 1987, 89: 581-598. PMID: 2953859, PMCID: PMC2215917, DOI: 10.1085/jgp.89.4.581.
• Apical membrane chloride/base exchange in the rat proximal convoluted tubule.Alpern RJ. Apical membrane chloride/base exchange in the rat proximal convoluted tubule. Journal Of Clinical Investigation 1987, 79: 1026-1030. PMID: 3558814, PMCID: PMC424279, DOI: 10.1172/jci112914.
• Kinetic transport model for cellular regulation of pH and solute concentration in the renal proximal tubuleVerkman AS, Alpern RJ. Kinetic transport model for cellular regulation of pH and solute concentration in the renal proximal tubule. Biophysical Journal 1987, 51: 533-546. PMID: 3580482, PMCID: PMC1329926, DOI: 10.1016/s0006-3495(87)83379-9.
• Carbonic Anhydrase InhibitorsPreisig PA, Toto RD, Alpern RJ. Carbonic Anhydrase Inhibitors. Renal Physiology 1987, 10: 136-159. PMID: 3133728, DOI: 10.1159/000173126.
• Electrogenic sodium/bicarbonate cotransport in rabbit renal cortical basolateral membrane vesicles.Akiba T, Alpern RJ, Eveloff J, Calamina J, Warnock DG. Electrogenic sodium/bicarbonate cotransport in rabbit renal cortical basolateral membrane vesicles. Journal Of Clinical Investigation 1986, 78: 1472-1478. PMID: 3782468, PMCID: PMC423898, DOI: 10.1172/jci112738.
• Cell pH in the rat proximal convoluted tubule. Regulation by luminal and peritubular pH and sodium concentration.Alpern RJ, Chambers M. Cell pH in the rat proximal convoluted tubule. Regulation by luminal and peritubular pH and sodium concentration. Journal Of Clinical Investigation 1986, 78: 502-510. PMID: 3016029, PMCID: PMC423587, DOI: 10.1172/jci112602.
• Evidence for electroneutral sodium chloride transport in rat proximal convoluted tubuleHowlin KJ, Alpern RJ, Berry CA, Rector FC. Evidence for electroneutral sodium chloride transport in rat proximal convoluted tubule. American Journal Of Physiology 1986, 250: f644-f648. PMID: 3963204, DOI: 10.1152/ajprenal.1986.250.4.f644.
• Mechanism of basolateral membrane H+/OH-/HCO-3 transport in the rat proximal convoluted tubule. A sodium-coupled electrogenic process.Alpern RJ. Mechanism of basolateral membrane H+/OH-/HCO-3 transport in the rat proximal convoluted tubule. A sodium-coupled electrogenic process. The Journal Of General Physiology 1985, 86: 613-636. PMID: 2999293, PMCID: PMC2228817, DOI: 10.1085/jgp.86.5.613.
• Active and passive components of chloride transport in the rat proximal convoluted tubule.Alpern RJ, Howlin KJ, Preisig PA. Active and passive components of chloride transport in the rat proximal convoluted tubule. Journal Of Clinical Investigation 1985, 76: 1360-1366. PMID: 4056034, PMCID: PMC424076, DOI: 10.1172/jci112111.
• Amiloride inhibition of proximal tubular acidificationHowlin KJ, Alpern RJ, Rector FC. Amiloride inhibition of proximal tubular acidification. American Journal Of Physiology 1985, 248: f773-f778. PMID: 2988347, DOI: 10.1152/ajprenal.1985.248.6.f773.
• A model of proximal tubular bicarbonate absorptionAlpern RJ, Rector FC. A model of proximal tubular bicarbonate absorption. American Journal Of Physiology 1985, 248: f272-f281. PMID: 3970216, DOI: 10.1152/ajprenal.1985.248.2.f272.
• Bicarbonate-water interactions in the rat proximal convoluted tubule. An effect of volume flux on active proton secretion.Alpern RJ. Bicarbonate-water interactions in the rat proximal convoluted tubule. An effect of volume flux on active proton secretion. The Journal Of General Physiology 1984, 84: 753-770. PMID: 6096481, PMCID: PMC2228763, DOI: 10.1085/jgp.84.5.753.
• Regulation of proximal bicarbonate reabsorptionCogan MG, Alpern RJ. Regulation of proximal bicarbonate reabsorption. American Journal Of Physiology 1984, 247: f387-f395. PMID: 6148019, DOI: 10.1152/ajprenal.1984.247.3.f387.
• Increased Vmax for Na+/H+ antiporter activity in proximal tubule brush border vesicles from rabbits with metabolic acidosisTsai CJ, Ives HE, Alpern RJ, Yee VJ, Warnock DG, Rector FC. Increased Vmax for Na+/H+ antiporter activity in proximal tubule brush border vesicles from rabbits with metabolic acidosis. American Journal Of Physiology 1984, 247: f339-f343. PMID: 6087681, DOI: 10.1152/ajprenal.1984.247.2.f339.
• Acidification MechanismsDuBose T, Paillard M, Frömter E, Alpern R, Good D, Stone D. Acidification Mechanisms. 1984, 251-256. DOI: 10.1007/978-1-4612-5284-9_23.
• Flow dependence of proximal tubular bicarbonate absorptionAlpern RJ, Cogan MG, Rector FC. Flow dependence of proximal tubular bicarbonate absorption. American Journal Of Physiology 1983, 245: f478-f484. PMID: 6414312, DOI: 10.1152/ajprenal.1983.245.4.f478.
• Effects of extracellular fluid volume and plasma bicarbonate concentration on proximal acidification in the rat.Alpern RJ, Cogan MG, Rector FC. Effects of extracellular fluid volume and plasma bicarbonate concentration on proximal acidification in the rat. Journal Of Clinical Investigation 1983, 71: 736-746. PMID: 6826733, PMCID: PMC436924, DOI: 10.1172/jci110821.
• Effect of luminal bicarbonate concentration on proximal acidification in the ratAlpern RJ, Cogan MG, Rector FC. Effect of luminal bicarbonate concentration on proximal acidification in the rat. American Journal Of Physiology 1982, 243: f53-f59. PMID: 7091367, DOI: 10.1152/ajprenal.1982.243.1.f53.