Pat Preisig, PhD
Professor of Medicine (Nephrology) and of Cellular And Molecular Physiology
Research & Publications
Biography
News
Research Summary
Elucidation of the acid-activated pathway that mediates the physiological response of the renal proximal tubule to the need for the kidney to excrete acid
Coauthors
Research Interests
Kidney; Kidney Tubules, Proximal; Nephrology; Physiology
Selected Publications
- Acid Stimulation of the Citrate Transporter NaDC-1 Requires Pyk2 and ERK1/2 Signaling PathwaysZacchia M, Tian X, Zona E, Alpern RJ, Preisig PA. Acid Stimulation of the Citrate Transporter NaDC-1 Requires Pyk2 and ERK1/2 Signaling Pathways Journal Of The American Society Of Nephrology 2018, 29: 1720-1730. PMID: 29678998, PMCID: PMC6054333, DOI: 10.1681/asn.2017121268.
- Tough decisions about protocol reviewPreisig PA, Silverman J, Brown P, Petervary N. Tough decisions about protocol review Lab Animal 2017, 46: 290-294. PMID: 28644450, DOI: 10.1038/laban.1300.
- The role of the IACUC in ensuring research reproducibilitySilverman J, Macy J, Preisig PA. The role of the IACUC in ensuring research reproducibility Lab Animal 2017, 46: 129-135. PMID: 28328872, DOI: 10.1038/laban.1213.
- Response to Protocol Review Scenario: One wrong, one rightPreisig PA, Macy JD. Response to Protocol Review Scenario: One wrong, one right Lab Animal 2015, 44: 87-88. PMID: 25693102, DOI: 10.1038/laban.705.
- Response to Protocol Review Scenario: Not so fast.Preisig PA, Fusco KA. Response to Protocol Review Scenario: Not so fast. Lab Animal 2014, 43: 81. PMID: 24552907, DOI: 10.1038/laban.478.
- Chapter 55 Cellular Mechanisms of Renal Tubular AcidificationHamm L, Alpern R, Preisig P. Chapter 55 Cellular Mechanisms of Renal Tubular Acidification 2013, 1917-1978. DOI: 10.1016/b978-0-12-381462-3.00055-0.
- Drosophila: a fruitful model for calcium oxalate nephrolithiasis?Knauf F, Preisig PA. Drosophila: a fruitful model for calcium oxalate nephrolithiasis? Kidney International 2011, 80: 327-329. PMID: 21799502, DOI: 10.1038/ki.2011.166.
- Acid regulation of NaDC-1 requires a functional endothelin B receptorLiu L, Zacchia M, Tian X, Wan L, Sakamoto A, Yanagisawa M, Alpern RJ, Preisig PA. Acid regulation of NaDC-1 requires a functional endothelin B receptor Kidney International 2010, 78: 895-904. PMID: 20703215, DOI: 10.1038/ki.2010.264.
- Low urinary citrate: an overview.Zacchia M, Preisig P. Low urinary citrate: an overview. Journal Of Nephrology 2010, 23 Suppl 16: s49-56. PMID: 21170889.
- Biochemical and histological assessment of Alkali therapy during high animal protein intake in the ratZerwekh JE, Zou L, Pak CY, Moe OW, Preisig PA. Biochemical and histological assessment of Alkali therapy during high animal protein intake in the rat Bone 2009, 45: 1004-1009. PMID: 19651255, PMCID: PMC2753741, DOI: 10.1016/j.bone.2009.07.077.
- CHAPTER 54 Cellular Mechanisms of Renal Tubular AcidificationHamm L, Alpern R, Preisig P. CHAPTER 54 Cellular Mechanisms of Renal Tubular Acidification 2008, 1539-1585. DOI: 10.1016/b978-012088488-9.50057-7.
- The acid-activated signaling pathway: Starting with Pyk2 and ending with increased NHE3 activityPreisig PA. The acid-activated signaling pathway: Starting with Pyk2 and ending with increased NHE3 activity Kidney International 2007, 72: 1324-1329. PMID: 17882150, DOI: 10.1038/sj.ki.5002543.
- RhoA required for acid-induced stress fiber formation and trafficking and activation of NHE3Yang X, Huang HC, Yin H, Alpern RJ, Preisig PA. RhoA required for acid-induced stress fiber formation and trafficking and activation of NHE3 American Journal Of Physiology. Renal Physiology 2007, 293: f1054-f1064. PMID: 17686951, DOI: 10.1152/ajprenal.00295.2007.
- Dual role of citrate in mammalian urineMoe OW, Preisig PA. Dual role of citrate in mammalian urine Current Opinion In Nephrology & Hypertension 2006, 15: 419-424. PMID: 16775456, DOI: 10.1097/01.mnh.0000232882.35469.72.
- 招請講演3: Dietary Acid, Pyk2, Nocturnin, and Circadian Rhythm: Role in Renal Homeostasis and DiseasePreisig P, Alpern R. 招請講演3: Dietary Acid, Pyk2, Nocturnin, and Circadian Rhythm: Role in Renal Homeostasis and Disease 日本腎臓å¦ä¼šèªŒ 2006, 48: 145-145. DOI: 10.14842/jpnjnephrol1959.48.3_145.
- Hypothesizing on the evolutionary origins of salt-induced hypercalciuriaMoe OW, Preisig PA. Hypothesizing on the evolutionary origins of salt-induced hypercalciuria Current Opinion In Nephrology & Hypertension 2005, 14: 368-372. PMID: 15931006, DOI: 10.1097/01.mnh.0000172724.29628.73.
- Pyk2 activation is integral to acid stimulation of sodium/hydrogen exchanger 3Li S, Sato S, Yang X, Preisig PA, Alpern RJ. Pyk2 activation is integral to acid stimulation of sodium/hydrogen exchanger 3 Journal Of Clinical Investigation 2004, 114: 1782-1789. PMID: 15599403, PMCID: PMC535061, DOI: 10.1172/jci18046.
- A consensus sequence in the endothelin-B receptor second intracellular loop is required for NHE3 activation by endothelin-1Laghmani K, Sakamoto A, Yanagisawa M, Preisig PA, Alpern RJ. A consensus sequence in the endothelin-B receptor second intracellular loop is required for NHE3 activation by endothelin-1 American Journal Of Physiology. Renal Physiology 2004, 288: f732-f739. PMID: 15598844, DOI: 10.1152/ajprenal.00300.2004.
- An autocrine role for endothelin-1 in the regulation of proximal tubule NHE3Licht C, Laghmani K, Yanagisawa M, Preisig PA, Alpern RJ. An autocrine role for endothelin-1 in the regulation of proximal tubule NHE3 Kidney International 2004, 65: 1320-1326. PMID: 15086471, DOI: 10.1111/j.1523-1755.2004.00506.x.
- OKP cells express the Na-dicarboxylate cotransporter NaDC-1Aruga S, Pajor AM, Nakamura K, Liu L, Moe OW, Preisig PA, Alpern RJ. OKP cells express the Na-dicarboxylate cotransporter NaDC-1 American Journal Of Physiology - Cell Physiology 2004, 287: c64-c72. PMID: 14973148, DOI: 10.1152/ajpcell.00061.2003.
- Dietary acid, endothelins, and sleep.Alpern RJ, Preisig PA. Dietary acid, endothelins, and sleep. Transactions Of The American Clinical And Climatological Association 2004, 115: 385-93; discussion 393-4. PMID: 17060981, PMCID: PMC2263788.
- Effect of high protein diet on stone-forming propensity and bone loss in ratsAmanzadeh J, Gitomer WL, Zerwekh JE, Preisig PA, Moe OW, Pak CY, Levi M. Effect of high protein diet on stone-forming propensity and bone loss in rats Kidney International 2003, 64: 2142-2149. PMID: 14633136, DOI: 10.1046/j.1523-1755.2003.00309.x.
- Renal pathophysiology: understanding the technique before acquiring the dataPreisig P, Moe O. Renal pathophysiology: understanding the technique before acquiring the data Current Opinion In Nephrology & Hypertension 2003, 12: 405. DOI: 10.1097/00041552-200307000-00008.
- Compensatory renal hypertrophy is mediated by a cell cycle-dependent mechanismLiu B, Preisig PA. Compensatory renal hypertrophy is mediated by a cell cycle-dependent mechanism Kidney International 2002, 62: 1650-1658. PMID: 12371965, DOI: 10.1046/j.1523-1755.2002.00620.x.
- Role of c-SRC and ERK in acid-induced activation of NHE3Tsuganezawa H, Sato S, Yamaji Y, Preisig PA, Moe OW, Alpern RJ. Role of c-SRC and ERK in acid-induced activation of NHE3 Kidney International 2002, 62: 41-50. PMID: 12081562, DOI: 10.1046/j.1523-1755.2002.00418.x.
- The role of endothelin in proximal tubule proton secretion and the adaptation to a chronic metabolic acidosis.Laghmani K, Preisig PA, Alpern RJ. The role of endothelin in proximal tubule proton secretion and the adaptation to a chronic metabolic acidosis. Journal Of Nephrology 2002, 15 Suppl 5: s75-87. PMID: 12027224.
- Endothelin-1/endothelin-B receptor–mediated increases in NHE3 activity in chronic metabolic acidosisLaghmani K, Preisig P, Moe O, Yanagisawa M, Alpern R. Endothelin-1/endothelin-B receptor–mediated increases in NHE3 activity in chronic metabolic acidosis Journal Of Clinical Investigation 2001, 107: 1563-1569. PMID: 11413164, PMCID: PMC200190, DOI: 10.1172/jci11234.
- Bouncing the question from the whole animal to the test tube and backPreisig P, Moe O. Bouncing the question from the whole animal to the test tube and back Current Opinion In Nephrology & Hypertension 2001, 10: 405-407. PMID: 11342805, DOI: 10.1097/00041552-200105000-00017.
- ETB receptor activation causes exocytic insertion of NHE3 in OKP cellsPeng Y, Amemiya M, Yang X, Fan L, Moe O, Yin H, Preisig P, Yanagisawa M, Alpern R. ETB receptor activation causes exocytic insertion of NHE3 in OKP cells American Journal Of Physiology. Renal Physiology 2001, 280: f34-f42. PMID: 11133512, DOI: 10.1152/ajprenal.2001.280.1.f34.
- Acid incubation causes exocytic insertion of NHE3 in OKP cellsYang X, Amemiya M, Peng Y, Moe O, Preisig P, Alpern R. Acid incubation causes exocytic insertion of NHE3 in OKP cells American Journal Of Physiology - Cell Physiology 2000, 279: c410-c419. PMID: 10913008, DOI: 10.1152/ajpcell.2000.279.2.c410.
- Chronic metabolic acidosis increases NaDC-1 mRNA and protein abundance in rat kidneyAruga S, Wehrli S, Kaissling B, Moe O, Preisig P, Pajor A, Alpern R. Chronic metabolic acidosis increases NaDC-1 mRNA and protein abundance in rat kidney Kidney International 2000, 58: 206-215. PMID: 10886565, DOI: 10.1046/j.1523-1755.2000.00155.x.
- G1 kinases and transforming growth factor-β; signaling are associated with a growth pattern switch in diabetes-induced renal growthHuang H, Preisig P. G1 kinases and transforming growth factor-β; signaling are associated with a growth pattern switch in diabetes-induced renal growth Kidney International 2000, 58: 162-172. PMID: 10886561, DOI: 10.1046/j.1523-1755.2000.00151.x.
- A better understanding of the kidney in health and disease: what will it take?Moe O, Preisig P. A better understanding of the kidney in health and disease: what will it take? Current Opinion In Nephrology & Hypertension 2000, 9: 381-384. PMID: 10926174, DOI: 10.1097/00041552-200007000-00009.
- Renal citrate metabolism and urinary citrate excretion in the infant ratMelnick J, Preisig P, Alpern R, Baum M. Renal citrate metabolism and urinary citrate excretion in the infant rat Kidney International 2000, 57: 891-897. PMID: 10720942, PMCID: PMC4089854, DOI: 10.1046/j.1523-1755.2000.057003891.x.
- A cell cycle-dependent mechanism of renal tubule epithelial cell hypertrophyPreisig P. A cell cycle-dependent mechanism of renal tubule epithelial cell hypertrophy Kidney International 1999, 56: 1193-1198. PMID: 10610409, DOI: 10.1046/j.1523-1755.1999.00708.x.
- Size does matter: Will knockout of p21WAF1/CIP1 save the kidney by limiting compensatory renal growth?Al-Awqati Q, Preisig P. Size does matter: Will knockout of p21WAF1/CIP1 save the kidney by limiting compensatory renal growth? Proceedings Of The National Academy Of Sciences Of The United States Of America 1999, 96: 10551-10553. PMID: 10485857, PMCID: PMC33735, DOI: 10.1073/pnas.96.19.10551.
- TGF-β1-mediated hypertrophy involves inhibiting pRB phosphorylation by blocking activation of cyclin E kinaseLiu B, Preisig P. TGF-β1-mediated hypertrophy involves inhibiting pRB phosphorylation by blocking activation of cyclin E kinase American Journal Of Physiology 1999, 277: f186-f194. PMID: 10444572, DOI: 10.1152/ajprenal.1999.277.2.f186.
- What Makes Cells Grow Larger and How Do They Do It? Renal Hypertrophy RevisitedPreisig P. What Makes Cells Grow Larger and How Do They Do It? Renal Hypertrophy Revisited Nephron 1999, 7: 273-283. PMID: 10450014, DOI: 10.1159/000020614.
- ETB receptor activation leads to activation and phosphorylation of NHE3Peng Y, Moe OW, Chu T, Preisig PA, Yanagisawa M, Alpern RJ. ETB receptor activation leads to activation and phosphorylation of NHE3 American Journal Of Physiology 1999, 276: c938-c945. PMID: 10199826, DOI: 10.1152/ajpcell.1999.276.4.c938.
- Glucocorticoids enhance acid activation of the Na+/H+ exchanger 3 (NHE3)Ambühl P, Yang X, Peng Y, Preisig P, Moe O, Alpern R. Glucocorticoids enhance acid activation of the Na+/H+ exchanger 3 (NHE3) Journal Of Clinical Investigation 1999, 103: 429-435. PMID: 9927505, PMCID: PMC407891, DOI: 10.1172/jci2913.
- Converting enzyme inhibition causes hypocitraturia independent of acidosis or hypokalemiaMelnick J, Preisig P, Haynes S, Pak C, Sakhaee K, Alpern R. Converting enzyme inhibition causes hypocitraturia independent of acidosis or hypokalemia Kidney International 1998, 54: 1670-1674. PMID: 9844143, DOI: 10.1046/j.1523-1755.1998.00150.x.
- Dominant negative c-Src inhibits angiotensin II induced activation of NHE3 in OKP cellsTsuganezawa H, Preisig P, Alpern R. Dominant negative c-Src inhibits angiotensin II induced activation of NHE3 in OKP cells Kidney International 1998, 54: 394-398. PMID: 9690205, DOI: 10.1046/j.1523-1755.1998.00029.x.
- Renal cortical mitochondrial aconitase is regulated in hypo- and hypercitraturiaMelnick J, Preisig P, Moe O, Srere P, Alpern R. Renal cortical mitochondrial aconitase is regulated in hypo- and hypercitraturia Kidney International 1998, 54: 160-165. PMID: 9648074, DOI: 10.1046/j.1523-1755.1998.00974.x.
- Development of a Patient Classification System for Chronic Hemodialysis PatientsFreund L, Burrows-Hudson S, Preisig P. Development of a Patient Classification System for Chronic Hemodialysis Patients American Journal Of Kidney Diseases 1998, 31: 818-829. PMID: 9590192, DOI: 10.1016/s0272-6386(98)70051-4.
- Chronic hyperosmolality increases NHE3 activity in OKP cells.Ambühl P, Amemiya M, Preisig PA, Moe OW, Alpern RJ. Chronic hyperosmolality increases NHE3 activity in OKP cells. Journal Of Clinical Investigation 1998, 101: 170-177. PMID: 9421479, PMCID: PMC508553, DOI: 10.1172/jci62.
- Media acidification inhibits TGF beta-mediated growth suppression in cultured rabbit proximal tubule cells.Tovbin D, Franch HA, Alpern RJ, Preisig PA. Media acidification inhibits TGF beta-mediated growth suppression in cultured rabbit proximal tubule cells. Proceedings Of The Association Of American Physicians 1997, 109: 572-9. PMID: 9394419.
- Adenosine triphosphate citrate lyase mediates hypocitraturia in rats.Melnick JZ, Srere PA, Elshourbagy NA, Moe OW, Preisig PA, Alpern RJ. Adenosine triphosphate citrate lyase mediates hypocitraturia in rats. Journal Of Clinical Investigation 1996, 98: 2381-2387. PMID: 8941657, PMCID: PMC507690, DOI: 10.1172/jci119051.
- Chronic metabolic acidosis increases NHE3 protein abundance in rat kidneyAmbuhl P, Amemiya M, Danczkay M, Lotscher M, Kaissling B, Moe OW, Preisig PA, Alpern RJ. Chronic metabolic acidosis increases NHE3 protein abundance in rat kidney American Journal Of Physiology 1996, 271: f917-f925. PMID: 8898023, DOI: 10.1152/ajprenal.1996.271.4.f917.
- NH4Cl-induced hypertrophy is mediated by weak base effects and is independent of cell cycle processesFranch H, Preisig P. NH4Cl-induced hypertrophy is mediated by weak base effects and is independent of cell cycle processes American Journal Of Physiology 1996, 270: c932-c938. PMID: 8638677, DOI: 10.1152/ajpcell.1996.270.3.c932.
- Chronic regulation of the proximal tubular Na/H antiporter: From HCO3 to SRCAlpern R, Moe O, Preisig P. Chronic regulation of the proximal tubular Na/H antiporter: From HCO3 to SRC Kidney International 1995, 48: 1386-1396. PMID: 8544394, DOI: 10.1038/ki.1995.427.
- Overexpression of csk inhibits acid-induced activation of NHE-3.Yamaji Y, Amemiya M, Cano A, Preisig PA, Miller RT, Moe OW, Alpern RJ. Overexpression of csk inhibits acid-induced activation of NHE-3. Proceedings Of The National Academy Of Sciences Of The United States Of America 1995, 92: 6274-6278. PMID: 7541536, PMCID: PMC41500, DOI: 10.1073/pnas.92.14.6274.
- Renal epithelial cell hyperplasia and hypertrophy.Preisig P, Franch H. Renal epithelial cell hyperplasia and hypertrophy. Seminars In Nephrology 1995, 15: 327-40. PMID: 7569412.
- Involvement of pRB family in TGF beta-dependent epithelial cell hypertrophy.Franch HA, Shay JW, Alpern RJ, Preisig PA. Involvement of pRB family in TGF beta-dependent epithelial cell hypertrophy. Journal Of Cell Biology 1995, 129: 245-254. PMID: 7698989, PMCID: PMC2120382, DOI: 10.1083/jcb.129.1.245.
- Renal Proximal Tubule Response to AcidAlpern R, Yamaji Y, Amemiya M, Cano A, Preisig P, Miller, Moe O. Renal Proximal Tubule Response to Acid Physiology 1995, 10: 77-81. DOI: 10.1152/physiologyonline.1995.10.2.77.
- Angiotensin II stimulation of Na-H antiporter activity is cAMP independent in OKP cellsCano A, Miller RT, Alpern RJ, Preisig PA. Angiotensin II stimulation of Na-H antiporter activity is cAMP independent in OKP cells American Journal Of Physiology 1994, 266: c1603-c1608. PMID: 8023891, DOI: 10.1152/ajpcell.1994.266.6.c1603.
- Cyclic adenosine monophosphate acutely inhibits and chronically stimulates Na/H antiporter in OKP cells.Cano A, Preisig P, Alpern RJ. Cyclic adenosine monophosphate acutely inhibits and chronically stimulates Na/H antiporter in OKP cells. Journal Of Clinical Investigation 1993, 92: 1632-1638. PMID: 7691881, PMCID: PMC288321, DOI: 10.1172/jci116748.
- Chronic regulation of the Na/H antiporter.Alpern RJ, Yamaji Y, Cano A, Horie S, Miller RT, Moe OW, Preisig PA. Chronic regulation of the Na/H antiporter. Translational Research 1993, 122: 137-40. PMID: 8393472.
- Luminal flow rate regulates proximal tubule H-HCO3 transportersPreisig P. Luminal flow rate regulates proximal tubule H-HCO3 transporters American Journal Of Physiology 1992, 262: f47-f54. PMID: 1310229, DOI: 10.1152/ajprenal.1992.262.1.f47.
- Differential regulation of Na/H antiporter by acid in renal epithelial cells and fibroblasts.Moe OW, Miller RT, Horie S, Cano A, Preisig PA, Alpern RJ. Differential regulation of Na/H antiporter by acid in renal epithelial cells and fibroblasts. Journal Of Clinical Investigation 1991, 88: 1703-1708. PMID: 1658050, PMCID: PMC295708, DOI: 10.1172/jci115487.
- Chronic K depletion stimulates rat renal brush-border membrane Na-citrate cotransporterLevi M, McDonald LA, Preisig PA, Alpern RJ. Chronic K depletion stimulates rat renal brush-border membrane Na-citrate cotransporter American Journal Of Physiology 1991, 261: f767-f773. PMID: 1683169, DOI: 10.1152/ajprenal.1991.261.5.f767.
- Chronic adaptations in proximal tubular H/HCO3 transporters.Alpern RJ, Horie S, Moe O, Tejedor A, Miller RT, Preisig PA. Chronic adaptations in proximal tubular H/HCO3 transporters. Kidney International Supplement 1991, 33: s29-32. PMID: 1653870.
- Basolateral membrane H/HCO3 transport in renal tubulesPreisig P, Alpern R. Basolateral membrane H/HCO3 transport in renal tubules Kidney International 1991, 39: 1077-1086. PMID: 1895662, DOI: 10.1038/ki.1991.137.
- Regulation of proximal reabsorption by effective arterial blood volume.Seldin DW, Preisig PA, Alpern RJ. Regulation of proximal reabsorption by effective arterial blood volume. Seminars In Nephrology 1991, 11: 212-9. PMID: 2034926.
- Increased Na/H antiporter and Na/3HCO3 symporter activities in chronic hyperfiltration. A model of cell hypertrophy.Preisig PA, Alpern RJ. Increased Na/H antiporter and Na/3HCO3 symporter activities in chronic hyperfiltration. A model of cell hypertrophy. The Journal Of General Physiology 1991, 97: 195-217. PMID: 1849958, PMCID: PMC2216475, DOI: 10.1085/jgp.97.2.195.
- Dietary NaCl modulates Na(+)-H+ antiporter activity in renal cortical apical membrane vesiclesMoe OW, Tejedor A, Levi M, Seldin DW, Preisig PA, Alpern RJ. Dietary NaCl modulates Na(+)-H+ antiporter activity in renal cortical apical membrane vesicles American Journal Of Physiology 1991, 260: f130-f137. PMID: 1847012, DOI: 10.1152/ajprenal.1991.260.1.f130.
- Cellular model of proximal tubule NaCl and NaHCO3 absorptionMoe O, Preisig P, Alpern R. Cellular model of proximal tubule NaCl and NaHCO3 absorption Kidney International 1990, 38: 605-611. PMID: 2172616, DOI: 10.1038/ki.1990.249.
- Pathways for apical and basolateral membrane NH3 and NH4+ movement in rat proximal tubulePreisig PA, Alpern RJ. Pathways for apical and basolateral membrane NH3 and NH4+ movement in rat proximal tubule American Journal Of Physiology 1990, 259: f587-f593. PMID: 2221097, DOI: 10.1152/ajprenal.1990.259.4.f587.
- Basolateral membrane H/OH/HCO3 transport mechanisms along the nephron: role in control of pHi and transepithelial bicarbonate transport.Preisig PA, Hays SR, Alpern RJ. Basolateral membrane H/OH/HCO3 transport mechanisms along the nephron: role in control of pHi and transepithelial bicarbonate transport. Seminars In Nephrology 1990, 10: 104-14. PMID: 2156327.
- Contributions of cellular leak pathways to net NaHCO3 and NaCl absorption.Preisig PA, Alpern RJ. Contributions of cellular leak pathways to net NaHCO3 and NaCl absorption. Journal Of Clinical Investigation 1989, 83: 1859-1867. PMID: 2542374, PMCID: PMC303906, DOI: 10.1172/jci114092.
- Basolateral membrane H-OH-HCO3 transport in the proximal tubulePreisig P, Alpern R. Basolateral membrane H-OH-HCO3 transport in the proximal tubule American Journal Of Physiology 1989, 256: f751-f765. PMID: 2541627, DOI: 10.1152/ajprenal.1989.256.5.f751.
- Chronic metabolic acidosis causes an adaptation in the apical membrane Na/H antiporter and basolateral membrane Na(HCO3)3 symporter in the rat proximal convoluted tubule.Preisig PA, Alpern RJ. Chronic metabolic acidosis causes an adaptation in the apical membrane Na/H antiporter and basolateral membrane Na(HCO3)3 symporter in the rat proximal convoluted tubule. Journal Of Clinical Investigation 1988, 82: 1445-1453. PMID: 2844858, PMCID: PMC442703, DOI: 10.1172/jci113750.
- Role of Na+-H+ antiport in rat proximal tubule NaCl absorptionPreisig P, Rector F. Role of Na+-H+ antiport in rat proximal tubule NaCl absorption American Journal Of Physiology 1988, 255: f461-f465. PMID: 2843052, DOI: 10.1152/ajprenal.1988.255.3.f461.
- Role of the Na+/H+ antiporter in rat proximal tubule bicarbonate absorption.Preisig PA, Ives HE, Cragoe EJ, Alpern RJ, Rector FC. Role of the Na+/H+ antiporter in rat proximal tubule bicarbonate absorption. Journal Of Clinical Investigation 1987, 80: 970-978. PMID: 2888788, PMCID: PMC442334, DOI: 10.1172/jci113190.
- Carbonic Anhydrase InhibitorsPreisig PA, Toto RD, Alpern RJ. Carbonic Anhydrase Inhibitors Renal Physiology 1987, 10: 136-159. PMID: 3133728, DOI: 10.1159/000173126.
- Active and passive components of chloride transport in the rat proximal convoluted tubule.Alpern RJ, Howlin KJ, Preisig PA. Active and passive components of chloride transport in the rat proximal convoluted tubule. Journal Of Clinical Investigation 1985, 76: 1360-1366. PMID: 4056034, PMCID: PMC424076, DOI: 10.1172/jci112111.
- Evidence for transcellular osmotic water flow in rat proximal tubulesPreisig P, Berry C. Evidence for transcellular osmotic water flow in rat proximal tubules American Journal Of Physiology 1985, 249: f124-f131. PMID: 4014469, DOI: 10.1152/ajprenal.1985.249.1.f124.
- Alpern, R.J. and P.A. Preisig. Renal acid-base transport. In: Diseases of the Kidney, Schrier RW, CW Gottschalk, eds. 8th Edition. Boston: Little, Brown and Company, 2007: Chapter 6: 183-195.Alpern, R.J. and P.A. Preisig. Renal acid-base transport. In: Diseases of the Kidney, Schrier RW, CW Gottschalk, eds. 8th Edition. Boston: Little, Brown and Company, 2007: Chapter 6: 183-195.