Rajeev Kumar
Research & Publications
Biography
Research Summary
Dr. Kumar earned his Ph.D. in Life Science and Biotechnology from the Indian Institute of Chemical Biology at Jadavpur University. His work in the Liu Lab at Yale focuses on the molecular mechanisms underlying host-pathogen interactions. Motor proteins play a crucial role in the assembly and function of bacterial secretion machinery and are highly conserved in various secretion systems, including type III (T3SS) and type IV (T4SS). Specifically, Dr. Kumar investigates the ATPase complex, a key motor protein in T3SS. His research aims to reveal the structure and exact function of this dynamic protein complex, providing valuable insights for the development of novel antibiotics.
Research Interests
Cryoelectron Microscopy; Electron Microscope Tomography; Bacterial Structures; Bacterial Secretion Systems
Selected Publications
- Delineating specific regions of N- terminal domain of T3SS ATPase YsaN of Yersinia enterocolitica governing its different oligomerization states.Kumar R, Roy C, Datta S. Delineating specific regions of N- terminal domain of T3SS ATPase YsaN of Yersinia enterocolitica governing its different oligomerization states. Front Mol Biosci 2022, 9: 967974. PMID: 36158578, DOI: 10.3389/fmolb.2022.967974.
- Biophysical and Computational Approaches to Unravel pH-Dependent Conformational Change of PspA Assist PspA-PspF Complex Formation in Yersinia enterocolitica.Roy C, Kumar R, Hossain MM, Das A, Datta S. Biophysical and Computational Approaches to Unravel pH-Dependent Conformational Change of PspA Assist PspA-PspF Complex Formation in Yersinia enterocolitica. Protein J 2022, 41: 403-413. PMID: 35708879, DOI: 10.1007/s10930-022-10061-w.
- Comparative studies on ion-pair energetic, distribution among three domains of life: Archaea, eubacteria, and eukarya.Roy C, Kumar R, Datta S. Comparative studies on ion-pair energetic, distribution among three domains of life: Archaea, eubacteria, and eukarya. Proteins 2020, 88: 865-873. PMID: 31999377, DOI: 10.1002/prot.25878.