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Visualizing Molecular Machines In Cells

The Liu laboratory is dedicated to developing a high-throughput cryo-electron tomography (cryo-ET) pipeline for high-resolution structure determination of molecular machines in cells. Our state-of-the-art imaging system has been utilized to gain molecular insights into fundamental biochemical processes: bacterial motility, chemotactic signaling, protein secretion, and DNA translocation.

Cryo-electron tomography reveals cellular architecture of Treponema pallidum

Video by Jun Liu