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Visualizing Molecular Machines In Cells

The Liu laboratory is dedicated to developing a high-throughput cryo-electron tomography (cryo-ET) pipeline for high-resolution structure determination of molecular machines in cells. Our state-of-the-art imaging system has been utilized to gain molecular insights into fundamental biochemical processes: bacterial motility, chemotactic signaling, protein secretion, and DNA translocation.

Cryo-electron tomography reveals cellular architecture of Treponema pallidum

Video by Jun Liu
Molecular mechanism for rotational switching of the bacterial flagellar motor

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Molecular mechanism for rotational switching of the bacterial flagellar motor

Video by Yunjie Chang, Kai Zhang, Brittany L. Carroll, Xiaowei Zhao, Nyles W. Charon, Steven J. Norris, Md A. Motaleb, Chunhao Li & Jun Liu