Visualizing Molecular Machines In Cells
The Liu laboratory is dedicated to developing a high-throughput cryo-electron tomography (cryo-ET) pipeline for high-resolution structure determination of molecular machines in cells. Our state-of-the-art imaging system has been utilized to gain molecular insights into fundamental biochemical processes: bacterial motility, chemotactic signaling, protein secretion, and DNA translocation.
Cryo-electron tomography reveals cellular architecture of Treponema pallidum
Video by Jun Liu
00:00:37
Molecular mechanism for rotational switching of the bacterial flagellar motor
Video by Yunjie Chang, Kai Zhang, Brittany L. Carroll, Xiaowei Zhao, Nyles W. Charon, Steven J. Norris, Md A. Motaleb, Chunhao Li & Jun Liu
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...and we are thankful to be together apart with you! https://t.co/MHcnQXJRlT #thankfulforscience @YaleMed https://t.co/5spDRbIUnm4 DAYS AGO
Congratulations to the @Hatzios_Lab, who have received a Concern Foundation grant to target cancer-causing infections https://t.co/sJliFK1VOm @ConcernFdn @Yale @MCDB_Yale https://t.co/mDWVQTWdQ515 DAYS AGO
#STEMdiversity https://t.co/Rue7yBYdGi16 DAYS AGO
🦠Many bacteria require flagella for the ability to move, survive, and cause infection. Check out @BritCarroll2 's review on recent structural studies that have led to a mechanistic understanding of flagellar assembly, function, and evolution.
https://t.co/CKxWa7NzXS https://t.co/iu8vUSQD0L23 DAYS AGO
The flagellar motor of Vibrio alginolyticus undergoes major structural remodeling during rotational switching https://t.co/hk6LCdaOKl @JunLiuLab @BritCarroll2 #cryoETA MONTH AGO