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INFORMATION FOR

Petr Protiva, MD, MPH

Associate Professor of Medicine (Digestive Diseases); Adjunct Faculty at Breslow Lab, Rockefeller University, New York, NY

Contact Information

Petr Protiva, MD, MPH

Mailing Address

  • Yale School of Medicine

    Department of Medicine (Digestive Diseases), PO Box 208019

    New Haven, CT 06520-8019

    United States

Research Summary

Major goal of our research is to identify molecular pathways that modulate the risk of colon cancer.

Extensive Research Description

Colonoscopy Versus Fecal Immunochemical Test in Reducing Mortality From Colorectal Cancer (CONFIRM)

This is a VA Multisite Study. The purpose of this study is to compare two types of colon cancer screening tests and determine which is more effective in preventing death from colon and rectal cancer. These tests have not been compared in a large study and it is not clear which test is more effective Role: Site Principal Investigator/Local Site Investigator

Effect of Dietary Folate Supplementation and Depletion on Human Colonic Mucosa

Adequate folate status is important for optimal one carbon metabolic processes including the synthesis and methylation of DNA and genomic stability. This may impact the risk of cancer. The purpose of this study was to examine the effect of folate depletion-repletion and supplementation on gene expression and genomic stability in human colorectal mucosa. Multiple additional biomarkers were measured.

Calcium and 1,25-dihydroxyvitamin D3 modulate genes of immune and inflammatory pathways in the human colon: a human crossover trial

Inadequate calcium and vitamin D levels/intake are implicated in colorectal carcinogenesis. The purpose of this study was to examine the effect of Western style diet +/- calcium and/or vitamin D on gene expression in human colorectal mucosa.

Coauthors

Research Interests

Colorectal Neoplasms; Molecular Epidemiology; Endpoint Determination; Nontherapeutic Human Experimentation; Therapeutic Human Experimentation

Public Health Interests

Biomarkers; Cancer; Clinical Trials; Genetics, Genomics, Epigenetics; Nutrition

Selected Publications

  • S220 High Intratumoral Hepatovirus Abundance in Colon Adenocarcinoma Is Associated With Worse Overall Survival and Increased Intratumoral CD8+ T-Cell InfiltrationChen G, Chen G, Zaman S, Segarra D, Patel A, Protiva P. S220 High Intratumoral Hepatovirus Abundance in Colon Adenocarcinoma Is Associated With Worse Overall Survival and Increased Intratumoral CD8+ T-Cell Infiltration The American Journal Of Gastroenterology 2022, 117: e158-e158. DOI: 10.14309/01.ajg.0000857520.28843.4b.
  • S209 Appendiceal Adenocarcinomas Are Associated With Better Prognosis Than Cecal Adenocarcinomas: A Population-Based Comparative Survival StudyChen G, Chen G, Chen K, Rotundo L, Zaman S, Protiva P. S209 Appendiceal Adenocarcinomas Are Associated With Better Prognosis Than Cecal Adenocarcinomas: A Population-Based Comparative Survival Study The American Journal Of Gastroenterology 2022, 117: e151-e152. DOI: 10.14309/01.ajg.0000857476.13762.f0.
  • S208 Increased Primary Tumor Sutterella Bacterial RNAseq Signatures Are Associated With Increased M2 Macrophage Abundance and Worse Overall Survival in Rectal AdenocarcinomaZaman S, Zaman S, Chen G, Segarra D, Patel A, Protiva P. S208 Increased Primary Tumor Sutterella Bacterial RNAseq Signatures Are Associated With Increased M2 Macrophage Abundance and Worse Overall Survival in Rectal Adenocarcinoma The American Journal Of Gastroenterology 2022, 117: e150-e151. DOI: 10.14309/01.ajg.0000857472.84764.69.
  • S213 Intratumoral Human Cytomegalovirus Abundance in Colon Adenocarcinoma Is Associated With Poor Survival Outcomes and Increased Intratumoral Regulatory T-cell Infiltrate in Elderly PatientsZaman S, Zaman S, Chen G, Patel A, Segarra D, Protiva P. S213 Intratumoral Human Cytomegalovirus Abundance in Colon Adenocarcinoma Is Associated With Poor Survival Outcomes and Increased Intratumoral Regulatory T-cell Infiltrate in Elderly Patients The American Journal Of Gastroenterology 2022, 117: e153-e154. DOI: 10.14309/01.ajg.0000857492.57792.96.
  • Su1106: SOCIOECONOMIC AND DEMOGRAPHIC CHARACTERISTICS ARE ASSOCIATED WITH SURVIVAL EXPERIENCE IN MALIGNANT APPENDICEAL TUMORSChen G, Rotundo L, Chen K, Protiva P. Su1106: SOCIOECONOMIC AND DEMOGRAPHIC CHARACTERISTICS ARE ASSOCIATED WITH SURVIVAL EXPERIENCE IN MALIGNANT APPENDICEAL TUMORS Gastroenterology 2022, 162: s-505. DOI: 10.1016/s0016-5085(22)61195-8.
  • S80 Clinical and Socioeconomic Determinants of Survival in Gallbladder and Biliary AdenocarcinomaRotundo L, Tsay C, Protiva P. S80 Clinical and Socioeconomic Determinants of Survival in Gallbladder and Biliary Adenocarcinoma The American Journal Of Gastroenterology 2021, 116: s34-s34. DOI: 10.14309/01.ajg.0000772300.66447.a1.
  • S1410 Gastric Adenocarcinoma Involving the Pylorus: A Comparative Survival Analysis of Distal and Proximal TumorsTsay C, Rotundo L, Protiva P. S1410 Gastric Adenocarcinoma Involving the Pylorus: A Comparative Survival Analysis of Distal and Proximal Tumors The American Journal Of Gastroenterology 2021, 116: s647-s648. DOI: 10.14309/01.ajg.0000779172.37232.37.
  • S2141 Acute on Chronic Mesenteric Ischemia With Peristaltic BlanchingTsay C, Protiva P. S2141 Acute on Chronic Mesenteric Ischemia With Peristaltic Blanching The American Journal Of Gastroenterology 2020, 115: s1130-s1130. DOI: 10.14309/01.ajg.0000710612.40428.51.
  • Sa1354 – Sex and Age Disparities in Pancreatic Cancer SurvivalChung S, Nagar A, Kolodecik T, Shugrue C, Desir G, Gorelick F, Protiva P. Sa1354 – Sex and Age Disparities in Pancreatic Cancer Survival Gastroenterology 2019, 156: s-324. DOI: 10.1016/s0016-5085(19)37641-3.
  • 871 – Transcriptional Signatures of Western-Style and Prudent Diets in Human ColonProtiva P, Khaliqdina S, Pendyala S, Holt P. 871 – Transcriptional Signatures of Western-Style and Prudent Diets in Human Colon Gastroenterology 2019, 156: s-196. DOI: 10.1016/s0016-5085(19)37280-4.
  • Vitamin D and Colorectal CancerDo A, Protiva P. Vitamin D and Colorectal Cancer 2018, 103-114. DOI: 10.1007/978-3-319-73742-3_5.
  • Mo1484 Endoscopic Ultrasound (EUS) Is Superior to Esophagogastroduodenoscopy (EGD) and Esophageal Capsule Endoscopy (ECE) for Varices ScreeningAbdi T, Marino D, Imaeda A, Chung C, Protiva P, Nagar A. Mo1484 Endoscopic Ultrasound (EUS) Is Superior to Esophagogastroduodenoscopy (EGD) and Esophageal Capsule Endoscopy (ECE) for Varices Screening Gastrointestinal Endoscopy 2015, 81: ab437. DOI: 10.1016/j.gie.2015.03.814.
  • Abstract LB-182: Effects of methyl donor status on intestinal tumorigenesis in ApcMin/+ miceKadaveru K, Protiva P, Greenspan E, Kim Y, Rosenberg D. Abstract LB-182: Effects of methyl donor status on intestinal tumorigenesis in ApcMin/+ mice Cancer Research 2012, 72: lb-182-lb-182. DOI: 10.1158/1538-7445.am2012-lb-182.
  • Colorectal Cancer PathwaysProtiva P. Colorectal Cancer Pathways 2011, 1-6. DOI: 10.1007/978-1-60761-398-5_1.
  • ChemopreventionSingerman J, Protiva P. Chemoprevention 2011, 187-200. DOI: 10.1007/978-1-60761-398-5_12.
  • T1178 Folic Acid Supplementation Alters Expression of Genes Regulating 1-Carbon Metabolism and Inflammation in the Human Rectosigmoid MucosaProtiva P, Mason J, Liu Z, Hopkins M, Nelson C, Lambrecht R, Marshall J, Kopelovich L, Lipkin M, Holt P. T1178 Folic Acid Supplementation Alters Expression of Genes Regulating 1-Carbon Metabolism and Inflammation in the Human Rectosigmoid Mucosa Gastroenterology 2010, 138: s-505. DOI: 10.1016/s0016-5085(10)62333-5.
  • M1183 Modulation by Calcium of Vitamin D Induced Molecular Changes in the Human Rectosigmoid ColonHolt P, Pendyala S, Protiva P, Augenlicht L. M1183 Modulation by Calcium of Vitamin D Induced Molecular Changes in the Human Rectosigmoid Colon Gastroenterology 2010, 138: s-349. DOI: 10.1016/s0016-5085(10)61609-5.
  • Aberrant Crypt Foci and Tobacco Use: The Smoking Gun For Serrated Adenomas?Anderson J, Pleau D, Protiva P, Rajan T, Brenner B, Rosenberg D. Aberrant Crypt Foci and Tobacco Use: The Smoking Gun For Serrated Adenomas? The American Journal Of Gastroenterology 2009, 104: s559. DOI: 10.14309/00000434-200910003-01486.
  • S1590 Immuno-Allergic (I-a) Manifestations of Drug-Induced Liver Injury (DILI) in the USA. Results from the Prospective Study of the DILI NetworkBonkovsky H, Agrawal S, Fontana R, Chalasani N, Watkins P, Davern T, Serrano J, Protiva P, Boling J, Rochon J, Kleiner D. S1590 Immuno-Allergic (I-a) Manifestations of Drug-Induced Liver Injury (DILI) in the USA. Results from the Prospective Study of the DILI Network Gastroenterology 2009, 136: a-820. DOI: 10.1016/s0016-5085(09)63780-x.
  • Mechanistic studies on anticancer benzophenones from Clusiaceae fruitsKennelly E, Protiva P, Yang H, Baggett S, Weinstein B. Mechanistic studies on anticancer benzophenones from Clusiaceae fruits Planta Medica 2008, 74 DOI: 10.1055/s-0028-1083968.
  • T1781 N-Acetyl-L-Cysteine (NAC) Abrogates Changes in Cell Viability, Mitochondrial Potential and Gene Expression Caused By (-)-Epigallocatechin Gallate (EGCG) in a Human Liver (Huh7) Cell LineGrupka M, Lambrecht R, Protiva P. T1781 N-Acetyl-L-Cysteine (NAC) Abrogates Changes in Cell Viability, Mitochondrial Potential and Gene Expression Caused By (-)-Epigallocatechin Gallate (EGCG) in a Human Liver (Huh7) Cell Line Gastroenterology 2008, 134: a-821. DOI: 10.1016/s0016-5085(08)63836-6.
  • Phenylacetate induces G1/S arrest and apoptosis in colon cancer cells but antagonizes S-phase specific chemotherapyProtiva P, Agarwal B, Shimizu M, Weinstein I, Holt P. Phenylacetate induces G1/S arrest and apoptosis in colon cancer cells but antagonizes S-phase specific chemotherapy Gastroenterology 2003, 124: a463. DOI: 10.1016/s0016-5085(03)82342-9.
  • Phenylacetate enhances the effect of chemotherapy on colon cancer cellsProtiva P, Agarwal B, Holt P. Phenylacetate enhances the effect of chemotherapy on colon cancer cells Gastroenterology 2001, 120: a616. DOI: 10.1016/s0016-5085(08)83063-6.
  • Lovastatin augments apoptosis induced by COX-2 selective inhibitors in colon cancer cellsAgarwal B, Protiva P, Swaroop P, Chuttani R, Ramey W, Holt P. Lovastatin augments apoptosis induced by COX-2 selective inhibitors in colon cancer cells Gastroenterology 2000, 118: a681. DOI: 10.1016/s0016-5085(00)84860-x.
  • Cox-2 selective inhibitors induce apoptosis by both Cox-2 dependent and Cox-2 independent mechanismsAgarwal B, Swaroop P, Protiva P, Chuttani R, Ramey W, Holt P. Cox-2 selective inhibitors induce apoptosis by both Cox-2 dependent and Cox-2 independent mechanisms Gastroenterology 2000, 118: a52. DOI: 10.1016/s0016-5085(00)82279-9.