Pawel Licznerski, PhD
Associate Research Scientist in Medicine (Endocrinology)
Research & Publications
Biography
News
Coauthors
Selected Publications
- ATP Synthase c-Subunit Leak Causes Aberrant Cellular Metabolism in Fragile X SyndromeLicznerski P, Park HA, Rolyan H, Chen R, Mnatsakanyan N, Miranda P, Graham M, Wu J, Cruz-Reyes N, Mehta N, Sohail S, Salcedo J, Song E, Effman C, Effman S, Brandao L, Xu GN, Braker A, Gribkoff VK, Levy RJ, Jonas EA. ATP Synthase c-Subunit Leak Causes Aberrant Cellular Metabolism in Fragile X Syndrome. Cell 2020, 182: 1170-1185.e9. PMID: 32795412, PMCID: PMC7484101, DOI: 10.1016/j.cell.2020.07.008.
- Inefficient thermogenic mitochondrial respiration due to futile proton leak in a mouse model of fragile X syndromeGriffiths KK, Wang A, Wang L, Tracey M, Kleiner G, Quinzii CM, Sun L, Yang G, Perez‐Zoghbi J, Licznerski P, Yang M, Jonas EA, Levy RJ. Inefficient thermogenic mitochondrial respiration due to futile proton leak in a mouse model of fragile X syndrome. The FASEB Journal 2020, 34: 7404-7426. PMID: 32307754, PMCID: PMC7692004, DOI: 10.1096/fj.202000283rr.
- Alpha-tocotrienol enhances arborization of primary hippocampal neurons via upregulation of Bcl-xLPark HA, Crowe-White KM, Ciesla L, Scott M, Bannerman S, Davis AU, Adhikari B, Burnett G, Broman K, Ferdous KA, Lackey KH, Licznerski P, Jonas EA. Alpha-tocotrienol enhances arborization of primary hippocampal neurons via upregulation of Bcl-xL. Nutrition Research 2022, 101: 31-42. PMID: 35366596, PMCID: PMC9081260, DOI: 10.1016/j.nutres.2022.02.007.
- Alpha-Tocotrienol Prevents Oxidative Stress-Mediated Post-Translational Cleavage of Bcl-xL in Primary Hippocampal NeuronsPark HA, Mnatsakanyan N, Broman K, Davis AU, May J, Licznerski P, Crowe-White KM, Lackey KH, Jonas EA. Alpha-Tocotrienol Prevents Oxidative Stress-Mediated Post-Translational Cleavage of Bcl-xL in Primary Hippocampal Neurons. International Journal Of Molecular Sciences 2019, 21: 220. PMID: 31905614, PMCID: PMC6982044, DOI: 10.3390/ijms21010220.
- Parkinson’s disease protein DJ-1 regulates ATP synthase protein components to increase neuronal process outgrowthChen R, Park HA, Mnatsakanyan N, Niu Y, Licznerski P, Wu J, Miranda P, Graham M, Tang J, Boon AJW, Cossu G, Mandemakers W, Bonifati V, Smith PJS, Alavian KN, Jonas EA. Parkinson’s disease protein DJ-1 regulates ATP synthase protein components to increase neuronal process outgrowth. Cell Death & Disease 2019, 10: 469. PMID: 31197129, PMCID: PMC6565618, DOI: 10.1038/s41419-019-1679-x.
- Remodeling of axo-spinous synapses in the pathophysiology and treatment of depressionLicznerski P, Duman RS. Remodeling of axo-spinous synapses in the pathophysiology and treatment of depression. Neuroscience 2012, 251: 33-50. PMID: 23036622, PMCID: PMC3566360, DOI: 10.1016/j.neuroscience.2012.09.057.
- A Bcl-xL–Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosisLi H, Alavian KN, Lazrove E, Mehta N, Jones A, Zhang P, Licznerski P, Graham M, Uo T, Guo J, Rahner C, Duman RS, Morrison RS, Jonas EA. A Bcl-xL–Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis. Nature Cell Biology 2013, 15: 773-785. PMID: 23792689, PMCID: PMC3725990, DOI: 10.1038/ncb2791.
- An uncoupling channel within the c-subunit ring of the F1FO ATP synthase is the mitochondrial permeability transition poreAlavian KN, Beutner G, Lazrove E, Sacchetti S, Park HA, Licznerski P, Li H, Nabili P, Hockensmith K, Graham M, Porter GA, Jonas EA. An uncoupling channel within the c-subunit ring of the F1FO ATP synthase is the mitochondrial permeability transition pore. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 10580-10585. PMID: 24979777, PMCID: PMC4115574, DOI: 10.1073/pnas.1401591111.
- Bcl-xL Is Necessary for Neurite Outgrowth in Hippocampal NeuronsPark HA, Licznerski P, Alavian KN, Shanabrough M, Jonas EA. Bcl-xL Is Necessary for Neurite Outgrowth in Hippocampal Neurons. Antioxidants & Redox Signaling 2015, 22: 93-108. PMID: 24787232, PMCID: PMC4281845, DOI: 10.1089/ars.2013.5570.
- Decreased SGK1 Expression and Function Contributes to Behavioral Deficits Induced by Traumatic StressLicznerski P, Duric V, Banasr M, Alavian KN, Ota KT, Kang HJ, Jonas EA, Ursano R, Krystal JH, Duman RS, . Decreased SGK1 Expression and Function Contributes to Behavioral Deficits Induced by Traumatic Stress. PLOS Biology 2015, 13: e1002282. PMID: 26506154, PMCID: PMC4623974, DOI: 10.1371/journal.pbio.1002282.
- Decreased expression of synapse-related genes and loss of synapses in major depressive disorderKang HJ, Voleti B, Hajszan T, Rajkowska G, Stockmeier CA, Licznerski P, Lepack A, Majik MS, Jeong LS, Banasr M, Son H, Duman RS. Decreased expression of synapse-related genes and loss of synapses in major depressive disorder. Nature Medicine 2012, 18: 1413-1417. PMID: 22885997, PMCID: PMC3491115, DOI: 10.1038/nm.2886.
- Neuritin produces antidepressant actions and blocks the neuronal and behavioral deficits caused by chronic stressSon H, Banasr M, Choi M, Chae SY, Licznerski P, Lee B, Voleti B, Li N, Lepack A, Fournier NM, Lee KR, Lee IY, Kim J, Kim JH, Kim YH, Jung SJ, Duman RS. Neuritin produces antidepressant actions and blocks the neuronal and behavioral deficits caused by chronic stress. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 11378-11383. PMID: 22733766, PMCID: PMC3396528, DOI: 10.1073/pnas.1201191109.
- Actin/α-Actinin-Dependent Transport of AMPA Receptors in Dendritic Spines: Role of the PDZ-LIM Protein RILSchulz TW, Nakagawa T, Licznerski P, Pawlak V, Kolleker A, Rozov A, Kim J, Dittgen T, Köhr G, Sheng M, Seeburg PH, Osten P. Actin/α-Actinin-Dependent Transport of AMPA Receptors in Dendritic Spines: Role of the PDZ-LIM Protein RIL. Journal Of Neuroscience 2004, 24: 8584-8594. PMID: 15456832, PMCID: PMC6729893, DOI: 10.1523/jneurosci.2100-04.2004.
- Lentivirus-based genetic manipulations of cortical neurons and their optical and electrophysiological monitoring in vivoDittgen T, Nimmerjahn A, Komai S, Licznerski P, Waters J, Margrie TW, Helmchen F, Denk W, Brecht M, Osten P. Lentivirus-based genetic manipulations of cortical neurons and their optical and electrophysiological monitoring in vivo. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 18206-18211. PMID: 15608064, PMCID: PMC539748, DOI: 10.1073/pnas.0407976101.
- Postsynaptic excitability is necessary for strengthening of cortical sensory responses during experience-dependent developmentKomai S, Licznerski P, Cetin A, Waters J, Denk W, Brecht M, Osten P. Postsynaptic excitability is necessary for strengthening of cortical sensory responses during experience-dependent development. Nature Neuroscience 2006, 9: 1125-1133. PMID: 16921372, DOI: 10.1038/nn1752.
- Select Overexpression of Homer1a in Dorsal Hippocampus Impairs Spatial Working MemoryCelikel T, Marx V, Freudenberg F, Zivkovic A, Resnik E, Hasan MT, Licznerski P, Osten P, Rozov A, Seeburg PH, Schwarz MK. Select Overexpression of Homer1a in Dorsal Hippocampus Impairs Spatial Working Memory. Frontiers In Neuroscience 2007, 1: 97-110. PMID: 18982121, PMCID: PMC2518050, DOI: 10.3389/neuro.01.1.1.007.2007.
- Incomplete and Inaccurate Vocal Imitation after Knockdown of FoxP2 in Songbird Basal Ganglia Nucleus Area XHaesler S, Rochefort C, Georgi B, Licznerski P, Osten P, Scharff C. Incomplete and Inaccurate Vocal Imitation after Knockdown of FoxP2 in Songbird Basal Ganglia Nucleus Area X. PLOS Biology 2007, 5: e321. PMID: 18052609, PMCID: PMC2100148, DOI: 10.1371/journal.pbio.0050321.
- The transcription factor orthodenticle homeobox 2 influences axonal projections and vulnerability of midbrain dopaminergic neuronsChung CY, Licznerski P, Alavian KN, Simeone A, Lin Z, Martin E, Vance J, Isacson O. The transcription factor orthodenticle homeobox 2 influences axonal projections and vulnerability of midbrain dopaminergic neurons. Brain 2010, 133: 2022-2031. PMID: 20573704, PMCID: PMC2892944, DOI: 10.1093/brain/awq142.
- A negative regulator of MAP kinase causes depressive behaviorDuric V, Banasr M, Licznerski P, Schmidt HD, Stockmeier CA, Simen AA, Newton SS, Duman RS. A negative regulator of MAP kinase causes depressive behavior. Nature Medicine 2010, 16: 1328-1332. PMID: 20953200, PMCID: PMC3066515, DOI: 10.1038/nm.2219.
- BDNF signaling: Harnessing stress to battle mood disorderLicznerski P, Jonas EA. BDNF signaling: Harnessing stress to battle mood disorder. Proceedings Of The National Academy Of Sciences Of The United States Of America 2018, 115: 3742-3744. PMID: 29592951, PMCID: PMC5899500, DOI: 10.1073/pnas.1803645115.
- Prefrontal cortex astroglia modulate anhedonia-like behaviorCodeluppi S, Xu M, Bansal Y, Lepack A, Duric V, Chow M, Muir J, Bagot R, Licznerski P, Wilber S, Sanacora G, Sibille E, Duman R, Pittenger C, Banasr M. Prefrontal cortex astroglia modulate anhedonia-like behavior. Molecular Psychiatry 2023, 28: 4632-4641. PMID: 37696873, PMCID: PMC10914619, DOI: 10.1038/s41380-023-02246-1.
- Vitamin E Improves Neurite Complexity by Enhancing Mitochondrial FunctionPark H, Crowe-White K, Davis A, Bannerman S, Burnett G, Scott M, Broman K, Lackey K, Licznerski P, Jonas E. Vitamin E Improves Neurite Complexity by Enhancing Mitochondrial Function. Current Developments In Nutrition 2021, 5: 5140915. PMCID: PMC8181647, DOI: 10.1093/cdn/nzab049_028.
- Activation of Slack Potassium Channels (KCNT1) Triggers an Increase in mRNA TranslationMalone T, Licznerski P, Jonas E, Kaczmarek L. Activation of Slack Potassium Channels (KCNT1) Triggers an Increase in mRNA Translation. Biophysical Journal 2019, 116: 306a. DOI: 10.1016/j.bpj.2018.11.1658.
- ATP synthase in neuronal development, neurodegeneration and plasticityJonas E, Licznerski P, Chen R, Rolyan H, Gribkoff V, Mnatsakanyan N. ATP synthase in neuronal development, neurodegeneration and plasticity. Biochimica Et Biophysica Acta (BBA) - Bioenergetics 2018, 1859: e30. DOI: 10.1016/j.bbabio.2018.09.095.
- Mitochondria and Memory: Bioenergetics, Synaptic Plasticity and NeurodegenerationJonas E, Mnatsakanyan N, Miranda P, Park H, Chen R, Licznerski P, Weinert M, Smith P, Chavez A, Zukin R, Gribkoff V, Alavian K. Mitochondria and Memory: Bioenergetics, Synaptic Plasticity and Neurodegeneration. Biophysical Journal 2017, 112: 180a. DOI: 10.1016/j.bpj.2016.11.996.
- ABT‐737 Inhibits Full Length And Cleaved Pro‐Apoptotic Bcl‐xL, Resulting in Differential Effects on Death And SurvivalPark H, Licznerski P, Niu Y, Alavian K, Jonas E. ABT‐737 Inhibits Full Length And Cleaved Pro‐Apoptotic Bcl‐xL, Resulting in Differential Effects on Death And Survival. The FASEB Journal 2015, 29 DOI: 10.1096/fasebj.29.1_supplement.777.4.
- The lifelong maintenance of mesencephalic dopaminergic neurons by Nurr1 and engrailedAlavian KN, Jeddi S, Naghipour SI, Nabili P, Licznerski P, Tierney TS. The lifelong maintenance of mesencephalic dopaminergic neurons by Nurr1 and engrailed. Journal Of Biomedical Science 2014, 21: 27. PMID: 24685177, PMCID: PMC3998737, DOI: 10.1186/1423-0127-21-27.
- [P1.61]: Studies to examine the neuroprotective effect of ALDH1a1 in midbrain dopamine neuronsBlak A, Licznerski P, Isacson O. [P1.61]: Studies to examine the neuroprotective effect of ALDH1a1 in midbrain dopamine neurons. International Journal Of Developmental Neuroscience 2008, 26: 861-862. DOI: 10.1016/j.ijdevneu.2008.09.111.
- HPV detection in cervical cancer patients in northern Poland.Dybikowska A, Licznerski P, Podhajska A. HPV detection in cervical cancer patients in northern Poland. Oncology Reports 2002, 9: 871-4. PMID: 12066224, DOI: 10.3892/or.9.4.871.