Cobalamin Deficiency in Children with Sickle Cell Disease
Hatabah D, Kreiger R, Brown L, Harris F, Korman R, Benedit L, Rees C, Bakshi N, Dampier C, Morris C. Cobalamin Deficiency in Children with Sickle Cell Disease. 2024, 1 DOI: 10.1093/jscdis/yoae002.011.Peer-Reviewed Original ResearchPrevalence of B12 deficiencyDiagnosis of B12 deficiencyPlasma methylmalonic acidSickle cell diseaseB12 deficiencyMethylmalonic acidCobalamin deficiencyB12 supplementationEffects of B12 supplementationSecondary analysis of samplesTreatment of acute painCell diseaseMarker of B12 deficiencyElevated plasma methylmalonic acidEmergency departmentNon-deficient groupPhase II randomized controlled trialIrreversible neurological impairmentIncreased nutritional requirementsStudent's t-testPediatric emergency departmentRandomized controlled trialsIV opioidsPearson chi-squareRenal impairment