Miguel Coca-Prados, PhD
Research & Publications
Biography
News
Locations
Research Summary
Major research projects being conducted in my laboratory:
Project # 1 The ciliary epithelium as a novel endocrine secretory epithelium:
The secretion of aqueous humor and the regulation of intraocular pressure are fundamental physiologic processes for the integrity and normal function of the mammalian eye. The ciliary epithelium, a bilayer of secretory neuroepithelial cells, is the site of synthesis of aqueous humor (inflow system), and it regulates its secretion by the coordinated action of a complex transport system that involves ion channels and active transporters. The aqueous humor fluid leaves the eye through the trabecular meshwork and the Schlemm channel (outflow system). A balance between the rates of secretion and drainage of the aqueous humor determines the level of intraocular pressure.
In Primary Open Angle Glaucoma, the most prevalent form of glaucoma, an obstruction of the outflow system leads to an abnormal increase in eye pressure, and with time, to blindness. The most effective way to lower intraocular pressure is by targeting the inflow system with drugs that reduce the rate of secretion of aqueous humor. Thus, an understanding of the biology of the ciliary epithelium, at the cellular and molecular levels, is essential in our knowledge of how intraocular pressure is regulated in normal and disease processes.
Specialized Terms: Chloride Channels of the ClC Family; Construction of Subtractive Libraries; Gene Expression and Regulation of Neuropeptides and Hormones; Gene Expression and Regulation of TIGR; Regulatory Peptides With Hypertensive And/or Hypotensive Act; Steroid Metabolism and Regulation of Gene Expression of 17bH
Extensive Research Description
Current work in our laboratory focuses on the hypotensive function of natriuretic peptides in the eye. We found that natriuretic peptides acting on natriuretic peptide receptors type B in the nonpigmented ciliary epithelium, blocked the activity of the Na+/H+-exchanger, a cellular sensor of cell volume and intracellular pH. The predicted net result of the Na+/H+-exchanger inhibition is the reduction of aqueous humor secretion and IOP. This interpretation is consistent with two sets of independent studies indicating that: 1) inhibitors of the Na+/H+-exchanger; and 2) natriuretic peptides, elicit ocular hypotensive effect by lowering IOP in experimental animals. We do not preclude that this mechanism might be similar in the outflow system where NP receptors are also present (Figure?.) These studies open a great opportunity to consider inhibitors of the Na+/H+-exchanger in the inflow and outflow systems as a key gene target to lower IOP in glaucoma.
Additional studies are under way to elucidate the intracellular signaling pathway of the natriuretic peptide receptors and other neuropeptide receptors including somatostatin receptors that lead to the attenuation of the Na+/H+-exchanger. Glaucoma genes: structure-function relationship Seven chromosomal loci (GLC1A-GLC1G) have so far been implicated in Primary Open Angle Glaucoma, of which three genes, Myocilin (MYOC) on GLC1A (1q23), Optineurin (OPTN) on GLC1E (10qp14) and WDR36 on GLC1G (5q22.1) have been identified.
At present our work focus on myocilin a 55-57kDa glycoprotein of unknown function, originally identified in cultured trabecular meshwork cells upon induction with glucocorticoids. MYOC was independently cloned from the human ciliary body and the retina. MYOC is mutated in certain forms of glaucoma, including Juvenile open angle glaucoma and Primary-open angle glaucoma.
The gene consists of three exons. Exon I, encodes the amino-terminal region of myocilin and contains a cleavable signal peptide at position 32, and a leucine-zipper like domain with leucine and arginine repeats along in an alpha-helix conformation. Exon II, encodes the central region of the protein a linker between the N- and C-terminal regions. Finally, exon III is homologous to olfactomedin, an extracellular matrix protein rich in the olfactory neuroepithelium. The leucine-zipper-like domain of myocilin shares low homology (20-28%) with the ezrin/radixin/moesin (ERM) family of proteins, contractile proteins (smooth muscle myosin), and transcription factors lacking the basic DNA binding region. The ERM proteins crosslink actin filaments with plasma membrane. So far, the majority of the mutations identified in MYOC, in glaucoma patients, have been found along the olfactomedin-like domain (Figure ). Recent studies, in collaboration with Dr. Julio Escribano (Universidad de Castilla-La Mancha, Albacete, Spain), have revealed that myocilin undergoes an intracellular endoproteolytic cleavage between amino acids Arg226 and Ile227 . This processing predicts the production of two fragments which are co-secreted with the nonprocessed myocilin protein. We proposed that inhibition of the normal processing by myocilin when is mutated may explain in part the pathogenesis of glaucoma.
Our work on MYOC focuses on the structural motifs present in myocilin, and on their involvement on multiple molecular interactions with other proteins. Furthermore, we are interested in determining how specific mutations in myocilin leading to glaucoma can affect the interaction with other interacting proteins. Recent studies have shown that myocilin interacts in vitro with extracellular matrix (ECM) proteins, including fibronectin and type I collagen. Ongoing work in our laboratory, at Yale, is searching for proteins that interact with myocilin using the GAL-4 based yeast two-hybrid system. We have identified and initially characterized one gene encoding the half-carboxyl terminus of the protein hevin, a secretory glycoprotein and a member of the SPARC/BM-40/ Osteonectin family of extracellular proteins as an interacting protein with myocilin. Interestingly we have found that a specific mutation in myocilin (P370L) inhibits the normal secretion of the half-carboxyl terminus of the protein hevin, suggesting that myocilin establish a regulatory effect on the normal function of other key proteins (Li et al. 2006).
Further studies are underway to determine the exact inhibitory mechanism exerted by distinct myocilin mutations causing glaucoma. These studies open a great opportunity to explore in what extent mutations causing glaucoma alter the normal function of the cell where is expressed. We are interested in finding this in two specific eye-cell types: in the ciliary epithelium, and in the trabecular meshwork. Both cell types are involved in the regulation of IOP. These studies ultimately will lead us to learn the function of myocilin in glaucoma, and therefore to design strategies to revert the abnormal function of the protein when mutated.
1.Molecular interaction between Myocilin and members of the SPARC family of matricellular proteins and the mechanism for mutant myocilin causing glaucoma.
2. Proteomics analysis of the core of myocilin-interacting proteins
Coauthors
Research Interests
Epithelium; Neuropeptides; Ophthalmology; Trabecular Meshwork; Chloride Channels
Selected Publications
- Candidate Glaucoma Biomarkers: From Proteins to Metabolites, and the Pitfalls to Clinical ApplicationsCueto A, Álvarez L, García M, Álvarez-Barrios A, Artime E, Cueto L, Coca-Prados M, González-Iglesias H. Candidate Glaucoma Biomarkers: From Proteins to Metabolites, and the Pitfalls to Clinical Applications. Biology 2021, 10: 763. PMID: 34439995, PMCID: PMC8389649, DOI: 10.3390/biology10080763.
- Association of Rare CYP39A1 Variants With Exfoliation Syndrome Involving the Anterior Chamber of the EyePartnership T, Li Z, Wang Z, Lee M, Zenkel M, Peh E, Ozaki M, Topouzis F, Nakano S, Chan A, Chen S, Williams S, Orr A, Nakano M, Kobakhidze N, Zarnowski T, Popa-Cherecheanu A, Mizoguchi T, Manabe S, Hayashi K, Kazama S, Inoue K, Mori Y, Miyata K, Sugiyama K, Higashide T, Chihara E, Ideta R, Ishiko S, Yoshida A, Tokumo K, Kiuchi Y, Ohashi T, Sakurai T, Sugimoto T, Chuman H, Aihara M, Inatani M, Mori K, Ikeda Y, Ueno M, Gaston D, Rafuse P, Shuba L, Saunders J, Nicolela M, Chichua G, Tabagari S, Founti P, Sim K, Meah W, Soo H, Chen X, Chatzikyriakidou A, Keskini C, Pappas T, Anastasopoulos E, Lambropoulos A, Panagiotou E, Mikropoulos D, Kosior-Jarecka E, Cheong A, Li Y, Lukasik U, Nongpiur M, Husain R, Perera S, Álvarez L, García M, González-Iglesias H, Cueto A, Cueto L, Martinón-Torres F, Salas A, Oguz Ç, Tamcelik N, Atalay E, Batu B, Irkec M, Aktas D, Kasım B, Astakhov Y, Astakhov S, Akopov E, Giessl A, Mardin C, Hellerbrand C, Bailey J, Igo R, Haines J, Edward D, Heegaard S, Davila S, Tan P, Kang J, Pasquale L, Kruse F, Reis A, Carmichael T, Hauser M, Ramsay M, Mossböck G, Yildirim N, Tashiro K, Konstas A, Coca-Prados M, Foo J, Kinoshita S, Sotozono C, Kubota T, Dubina M, Ritch R, Wiggs J, Pasutto F, Schlötzer-Schrehardt U, Ho Y, Aung T, Tam W, Khor C. Association of Rare CYP39A1 Variants With Exfoliation Syndrome Involving the Anterior Chamber of the Eye. JAMA 2021, 325: 753-764. PMID: 33620406, PMCID: PMC7903258, DOI: 10.1001/jama.2021.0507.
- Systemic Alterations of Immune Response-Related Proteins during Glaucoma Development in the Murine Model DBA/2JCueto A, Álvarez L, García M, Artime E, Barrios A, Rodríguez-Uña I, Coca-Prados M, González-Iglesias H. Systemic Alterations of Immune Response-Related Proteins during Glaucoma Development in the Murine Model DBA/2J. Diagnostics 2020, 10: 425. PMID: 32585848, PMCID: PMC7345206, DOI: 10.3390/diagnostics10060425.
- Role of GUCA1C in Primary Congenital Glaucoma and in the Retina: Functional Evaluation in ZebrafishMorales-Cámara S, Alexandre-Moreno S, Bonet-Fernández J, Atienzar-Aroca R, Aroca-Aguilar J, Ferre-Fernández J, Méndez C, Morales L, Fernández-Sánchez L, Cuenca N, Coca-Prados M, Martínez-de-la-Casa J, Garcia-Feijoo J, Escribano J. Role of GUCA1C in Primary Congenital Glaucoma and in the Retina: Functional Evaluation in Zebrafish. Genes 2020, 11: 550. PMID: 32422965, PMCID: PMC7288452, DOI: 10.3390/genes11050550.
- CPAMD8 loss-of-function underlies non-dominant congenital glaucoma with variable anterior segment dysgenesis and abnormal extracellular matrixBonet-Fernández J, Aroca-Aguilar J, Corton M, Ramírez A, Alexandre-Moreno S, García-Antón M, Salazar J, Ferre-Fernández J, Atienzar-Aroca R, Villaverde C, Iancu I, Tamayo A, Méndez-Hernández C, Morales-Fernández L, Rojas B, Ayuso C, Coca-Prados M, Martinez-de-la-Casa J, García-Feijoo J, Escribano J. CPAMD8 loss-of-function underlies non-dominant congenital glaucoma with variable anterior segment dysgenesis and abnormal extracellular matrix. Human Genetics 2020, 139: 1209-1231. PMID: 32274568, DOI: 10.1007/s00439-020-02164-0.
- The association study of lipid metabolism gene polymorphisms with AMD identifies a protective role for APOE‐E2 allele in the wet form in a Northern Spanish populationFernández‐Vega B, García M, Olivares L, Álvarez L, González‐Fernández A, Artime E, Cueto A, Cobo T, Coca‐Prados M, Vega J, González‐Iglesias H. The association study of lipid metabolism gene polymorphisms with AMD identifies a protective role for APOE‐E2 allele in the wet form in a Northern Spanish population. Acta Ophthalmologica 2019, 98: e282-e291. PMID: 31654486, DOI: 10.1111/aos.14280.
- Identification of myocilin as a blood plasma protein and analysis of its role in leukocyte adhesion to endothelial cell monolayersAroca-Aguilar JD, Fernández-Navarro A, Ontañón J, Coca-Prados M, Escribano J. Identification of myocilin as a blood plasma protein and analysis of its role in leukocyte adhesion to endothelial cell monolayers. PLOS ONE 2018, 13: e0209364. PMID: 30557320, PMCID: PMC6296516, DOI: 10.1371/journal.pone.0209364.
- The Zinc-Metallothionein Redox System Reduces Oxidative Stress in Retinal Pigment Epithelial CellsRodríguez-Menéndez S, García M, Fernández B, Álvarez L, Fernández-Vega-Cueto A, Coca-Prados M, Pereiro R, González-Iglesias H. The Zinc-Metallothionein Redox System Reduces Oxidative Stress in Retinal Pigment Epithelial Cells. Nutrients 2018, 10: 1874. PMID: 30513827, PMCID: PMC6315569, DOI: 10.3390/nu10121874.
- Quantitative study of zinc and metallothioneins in the human retina and RPE cells by mass spectrometry-based methodologiesRodríguez-Menéndez S, Fernández B, García M, Álvarez L, Fernández M, Sanz-Medel A, Coca-Prados M, Pereiro R, González-Iglesias H. Quantitative study of zinc and metallothioneins in the human retina and RPE cells by mass spectrometry-based methodologies. Talanta 2017, 178: 222-230. PMID: 29136815, DOI: 10.1016/j.talanta.2017.09.024.
- Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility lociAung T, Ozaki M, Lee MC, Schlötzer-Schrehardt U, Thorleifsson G, Mizoguchi T, Igo RP, Haripriya A, Williams SE, Astakhov YS, Orr AC, Burdon KP, Nakano S, Mori K, Abu-Amero K, Hauser M, Li Z, Prakadeeswari G, Bailey JNC, Cherecheanu AP, Kang JH, Nelson S, Hayashi K, Manabe SI, Kazama S, Zarnowski T, Inoue K, Irkec M, Coca-Prados M, Sugiyama K, Järvelä I, Schlottmann P, Lerner SF, Lamari H, Nilgün Y, Bikbov M, Park KH, Cha SC, Yamashiro K, Zenteno JC, Jonas JB, Kumar RS, Perera SA, Chan ASY, Kobakhidze N, George R, Vijaya L, Do T, Edward DP, de Juan Marcos L, Pakravan M, Moghimi S, Ideta R, Bach-Holm D, Kappelgaard P, Wirostko B, Thomas S, Gaston D, Bedard K, Greer WL, Yang Z, Chen X, Huang L, Sang J, Jia H, Jia L, Qiao C, Zhang H, Liu X, Zhao B, Wang YX, Xu L, Leruez S, Reynier P, Chichua G, Tabagari S, Uebe S, Zenkel M, Berner D, Mossböck G, Weisschuh N, Hoja U, Welge-Luessen UC, Mardin C, Founti P, Chatzikyriakidou A, Pappas T, Anastasopoulos E, Lambropoulos A, Ghosh A, Shetty R, Porporato N, Saravanan V, Venkatesh R, Shivkumar C, Kalpana N, Sarangapani S, Kanavi MR, Beni AN, Yazdani S, lashay A, Naderifar H, Khatibi N, Fea A, Lavia C, Dallorto L, Rolle T, Frezzotti P, Paoli D, Salvi E, Manunta P, Mori Y, Miyata K, Higashide T, Chihara E, Ishiko S, Yoshida A, Yanagi M, Kiuchi Y, Ohashi T, Sakurai T, Sugimoto T, Chuman H, Aihara M, Inatani M, Miyake M, Gotoh N, Matsuda F, Yoshimura N, Ikeda Y, Ueno M, Sotozono C, Jeoung JW, Sagong M, Park KH, Ahn J, Cruz-Aguilar M, Ezzouhairi SM, Rafei A, Chong YF, Ng XY, Goh SR, Chen Y, Yong VHK, Khan MI, Olawoye OO, Ashaye AO, Ugbede I, Onakoya A, Kizor-Akaraiwe N, Teekhasaenee C, Suwan Y, Supakontanasan W, Okeke S, Uche NJ, Asimadu I, Ayub H, Akhtar F, Kosior-Jarecka E, Lukasik U, Lischinsky I, Castro V, Grossmann RP, Megevand GS, Roy S, Dervan E, Silke E, Rao A, Sahay P, Fornero P, Cuello O, Sivori D, Zompa T, Mills RA, Souzeau E, Mitchell P, Wang JJ, Hewitt AW, Coote M, Crowston JG, Astakhov SY, Akopov EL, Emelyanov A, Vysochinskaya V, Kazakbaeva G, Fayzrakhmanov R, Al-Obeidan SA, Owaidhah O, Aljasim LA, Chowbay B, Foo JN, Soh RQ, Sim KS, Xie Z, Cheong AWO, Mok SQ, Soo HM, Chen XY, Peh SQ, Heng KK, Husain R, Ho SL, Hillmer AM, Cheng CY, Escudero-Domínguez FA, González-Sarmiento R, Martinon-Torres F, Salas A, Pathanapitoon K, Hansapinyo L, Wanichwecharugruang B, Kitnarong N, Sakuntabhai A, Nguyn HX, Nguyn GTT, Nguyn TV, Zenz W, Binder A, Klobassa DS, Hibberd ML, Davila S, Herms S, Nöthen MM, Moebus S, Rautenbach RM, Ziskind A, Carmichael TR, Ramsay M, Álvarez L, García M, González-Iglesias H, Rodríguez-Calvo PP, Fernández-Vega Cueto L, Oguz Ç, Tamcelik N, Atalay E, Batu B, Aktas D, Kasım B, Wilson MR, Coleman AL, Liu Y, Challa P, Herndon L, Kuchtey RW, Kuchtey J, Curtin K, Chaya CJ, Crandall A, Zangwill LM, Wong TY, Nakano M, Kinoshita S, den Hollander AI, Vesti E, Fingert JH, Lee RK, Sit AJ, Shingleton BJ, Wang N, Cusi D, Qamar R, Kraft P, Pericak-Vance MA, Raychaudhuri S, Heegaard S, Kivelä T, Reis A, Kruse FE, Weinreb RN, Pasquale LR, Haines JL, Thorsteinsdottir U, Jonasson F, Allingham RR, Milea D, Ritch R, Kubota T, Tashiro K, Vithana EN, Micheal S, Topouzis F, Craig JE, Dubina M, Sundaresan P, Stefansson K, Wiggs JL, Pasutto F, Khor CC. Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci. Nature Genetics 2017, 49: 993-1004. PMID: 28553957, PMCID: PMC6685441, DOI: 10.1038/ng.3875.
- Whole-Exome Sequencing of Congenital Glaucoma Patients Reveals Hypermorphic Variants in GPATCH3, a New Gene Involved in Ocular and Craniofacial DevelopmentFerre-Fernández JJ, Aroca-Aguilar JD, Medina-Trillo C, Bonet-Fernández JM, Méndez-Hernández CD, Morales-Fernández L, Corton M, Cabañero-Valera MJ, Gut M, Tonda R, Ayuso C, Coca-Prados M, García-Feijoo J, Escribano J. Whole-Exome Sequencing of Congenital Glaucoma Patients Reveals Hypermorphic Variants in GPATCH3, a New Gene Involved in Ocular and Craniofacial Development. Scientific Reports 2017, 7: 46175. PMID: 28397860, PMCID: PMC5387416, DOI: 10.1038/srep46175.
- Metallothionein polymorphisms in a Northern Spanish population with neovascular and dry forms of age-related macular degenerationGarcía M, Álvarez L, Fernández Á, González-Iglesias H, Escribano J, Fernández-Vega B, Villota E, Cueto L, Fernández-Vega Á, Coca-Prados M. Metallothionein polymorphisms in a Northern Spanish population with neovascular and dry forms of age-related macular degeneration. Ophthalmic Genetics 2017, 38: 451-458. PMID: 28635422, DOI: 10.1080/13816810.2017.1288825.
- Quantitative distribution of Zn, Fe and Cu in the human lens and study of the Zn–metallothionein redox system in cultured lens epithelial cells by elemental MSGonzález-Iglesias H, Petrash C, Rodríguez-Menéndez S, García M, Álvarez L, Fernández-Vega Cueto L, Fernández B, Pereiro R, Sanz-Medel A, Coca-Prados M. Quantitative distribution of Zn, Fe and Cu in the human lens and study of the Zn–metallothionein redox system in cultured lens epithelial cells by elemental MS. Journal Of Analytical Atomic Spectrometry 2017, 32: 1746-1756. DOI: 10.1039/c6ja00431h.
- Metallothionein polymorphisms in a Northern Spanish population with Age‐Related Macular Degeneration (AMD)Garcia M, Álvarez L, Fernandez Á, Gonzalez‐Iglesias H, Escribano J, Fernandez‐Vega B, Fernandez‐Vega Á, Villota E, Fernandez‐Vega L, Coca‐Prados M. Metallothionein polymorphisms in a Northern Spanish population with Age‐Related Macular Degeneration (AMD). Acta Ophthalmologica 2016, 94 DOI: 10.1111/j.1755-3768.2016.0531.
- The zinc‐metallothionein redox system in human retina and RPEAlvarez L, García M, Rodríguez S, Fernández B, Pereiro R, Sanz‐Medel A, Coca‐Prados M, González‐Iglesias H. The zinc‐metallothionein redox system in human retina and RPE. Acta Ophthalmologica 2016, 94 DOI: 10.1111/j.1755-3768.2016.0560.
- LOXL1 gene variants and their association with pseudoexfoliation glaucoma (XFG) in Spanish patientsÁlvarez L, García M, González-Iglesias H, Escribano J, Rodríguez-Calvo PP, Fernández-Vega L, Coca-Prados M. LOXL1 gene variants and their association with pseudoexfoliation glaucoma (XFG) in Spanish patients. BMC Medical Genomics 2015, 16: 72. PMID: 26319397, PMCID: PMC4593192, DOI: 10.1186/s12881-015-0221-y.
- CFH polymorphisms in a Northern Spanish population with neovascular and dry forms of age‐related macular degenerationGarcía M, Álvarez L, Nogacka AM, González-Iglesias H, Escribano J, Fernández-Vega B, Fernández-Vega Á, Fernández-Vega L, Coca-Prados M. CFH polymorphisms in a Northern Spanish population with neovascular and dry forms of age‐related macular degeneration. Acta Ophthalmologica 2015, 93: e658-e666. PMID: 26152901, DOI: 10.1111/aos.12790.
- Sensitive targeted multiple protein quantification based on elemental detection of Quantum DotsBustos A, Garcia-Cortes M, González-Iglesias H, Encinar J, Costa-Fernández JM, Coca-Prados M, Sanz-Medel A. Sensitive targeted multiple protein quantification based on elemental detection of Quantum Dots. Analytica Chimica Acta 2015, 879: 77-84. PMID: 26002480, DOI: 10.1016/j.aca.2015.03.015.
- A Renal-Like Organic Anion Transport System in the Ciliary Epithelium of the Bovine and Human EyeLee J, Shahidullah M, Hotchkiss A, Coca-Prados M, Delamere NA, Pelis RM. A Renal-Like Organic Anion Transport System in the Ciliary Epithelium of the Bovine and Human Eye. Molecular Pharmacology 2015, 87: 697-705. PMID: 25661037, PMCID: PMC6067639, DOI: 10.1124/mol.114.096578.
- Quantitative selenium speciation by HPLC-ICP-MS(IDA) and simultaneous activity measurements in human vitreous humorGonzález de Vega R, Fernández-Sánchez ML, González Iglesias H, Coca Prados M, Sanz-Medel A. Quantitative selenium speciation by HPLC-ICP-MS(IDA) and simultaneous activity measurements in human vitreous humor. Analytical And Bioanalytical Chemistry 2014, 407: 2405-2413. PMID: 25344931, DOI: 10.1007/s00216-014-8241-6.
- Lysyl Oxidase‐Like 1 gene haplotypes and their association with pseudoexfoliation glaucoma in the Spanish populationALVAREZ L, GARCIA M, GONZALEZ‐IGLESIAS H, ESCRIBANO J, RODRIGUEZ‐CALVO P, FERNANDEZ‐VEGA L, COCA‐PRADOS M. Lysyl Oxidase‐Like 1 gene haplotypes and their association with pseudoexfoliation glaucoma in the Spanish population. Acta Ophthalmologica 2014, 92: 0-0. DOI: 10.1111/j.1755-3768.2014.t075.x.
- Characterization of Vitamin D Production by Human Ocular Barrier CellsVitamin D Production by Human Ocular Barrier CellsAlsalem JA, Patel D, Susarla R, Coca-Prados M, Bland R, Walker EA, Rauz S, Wallace GR. Characterization of Vitamin D Production by Human Ocular Barrier CellsVitamin D Production by Human Ocular Barrier Cells. Investigative Ophthalmology & Visual Science 2014, 55: 2140-2147. PMID: 24576880, DOI: 10.1167/iovs.13-13019.
- Quantitative bioimaging of trace elements in the human lens by LA-ICP-MSKonz I, Fernández B, Fernández ML, Pereiro R, González-Iglesias H, Coca-Prados M, Sanz-Medel A. Quantitative bioimaging of trace elements in the human lens by LA-ICP-MS. Analytical And Bioanalytical Chemistry 2014, 406: 2343-2348. PMID: 24500754, DOI: 10.1007/s00216-014-7617-y.
- The Blood-Aqueous Barrier in Health and DiseaseCoca-Prados M. The Blood-Aqueous Barrier in Health and Disease. Journal Of Glaucoma 2014, 23: s36-s38. PMID: 25275903, DOI: 10.1097/ijg.0000000000000107.
- Metallothioneins (MTs) in the human eye: a perspective article on the zinc–MT redox cycleGonzalez-Iglesias H, Alvarez L, García M, Petrash C, Sanz-Medel A, Coca-Prados M. Metallothioneins (MTs) in the human eye: a perspective article on the zinc–MT redox cycle. Metallomics 2014, 6: 201-208. PMID: 24419560, DOI: 10.1039/c3mt00298e.
- Comparative proteomic study in serum of patients with primary open-angle glaucoma and pseudoexfoliation glaucomaGonzález-Iglesias H, Álvarez L, García M, Escribano J, Rodríguez-Calvo PP, Fernández-Vega L, Coca-Prados M. Comparative proteomic study in serum of patients with primary open-angle glaucoma and pseudoexfoliation glaucoma. Journal Of Proteomics 2013, 98: 65-78. PMID: 24355480, DOI: 10.1016/j.jprot.2013.12.006.
- MRP4 and MRP5 in the ciliary epithelium of the eye and their potential role in regulating extracellular cAMP levelsHotchkiss A, Pasumarthi K, Coca‐Prados M, Pelis R. MRP4 and MRP5 in the ciliary epithelium of the eye and their potential role in regulating extracellular cAMP levels. The FASEB Journal 2013, 27: 732.3-732.3. DOI: 10.1096/fasebj.27.1_supplement.732.3.
- Gold internal standard correction for elemental imaging of soft tissue sections by LA-ICP-MS: element distribution in eye microstructuresKonz I, Fernández B, Fernández ML, Pereiro R, González H, Álvarez L, Coca-Prados M, Sanz-Medel A. Gold internal standard correction for elemental imaging of soft tissue sections by LA-ICP-MS: element distribution in eye microstructures. Analytical And Bioanalytical Chemistry 2013, 405: 3091-3096. PMID: 23380953, DOI: 10.1007/s00216-013-6778-4.
- Bicarbonate-Dependent Secretion and Proteolytic Processing of Recombinant MyocilinAroca-Aguilar JD, Martínez-Redondo F, Martín-Gil A, Pintor J, Coca-Prados M, Escribano J. Bicarbonate-Dependent Secretion and Proteolytic Processing of Recombinant Myocilin. PLOS ONE 2013, 8: e54385. PMID: 23342144, PMCID: PMC3547000, DOI: 10.1371/journal.pone.0054385.
- The Stoichiometric Transition from Zn6Cu1-Metallothionein to Zn7-Metallothionein Underlies the Up-regulation of Metallothionein (MT) Expression QUANTITATIVE ANALYSIS OF MT-METAL LOAD IN EYE CELLS*Alvarez L, Gonzalez-Iglesias H, Garcia M, Ghosh S, Sanz-Medel A, Coca-Prados M. The Stoichiometric Transition from Zn6Cu1-Metallothionein to Zn7-Metallothionein Underlies the Up-regulation of Metallothionein (MT) Expression QUANTITATIVE ANALYSIS OF MT-METAL LOAD IN EYE CELLS*. Journal Of Biological Chemistry 2012, 287: 28456-28469. PMID: 22722935, PMCID: PMC3436589, DOI: 10.1074/jbc.m112.365015.
- Functional Expression of MRP4 in the Ciliary Epithelium of the EyePelis R, Coca-Prados M. Functional Expression of MRP4 in the Ciliary Epithelium of the Eye. The FASEB Journal 2012, 26: 694.10-694.10. DOI: 10.1096/fasebj.26.1_supplement.694.10.
- WDR36 and P53 Gene Variants and Susceptibility to Primary Open-Angle Glaucoma: Analysis of Gene-Gene InteractionsBlanco-Marchite C, Sánchez-Sánchez F, López-Garrido MP, Iñigez-de-Onzoño M, López-Martínez F, López-Sánchez E, Alvarez L, Rodríguez-Calvo PP, Méndez-Hernández C, Fernández-Vega L, García-Sánchez J, Coca-Prados M, García-Feijoo J, Escribano J. WDR36 and P53 Gene Variants and Susceptibility to Primary Open-Angle Glaucoma: Analysis of Gene-Gene Interactions. Investigative Ophthalmology & Visual Science 2011, 52: 8467-8478. PMID: 21931130, PMCID: PMC3208188, DOI: 10.1167/iovs.11-7489.
- Interaction of Recombinant Myocilin with the Matricellular Protein SPARC: Functional ImplicationsAroca-Aguilar JD, Sánchez-Sánchez F, Ghosh S, Fernández-Navarro A, Coca-Prados M, Escribano J. Interaction of Recombinant Myocilin with the Matricellular Protein SPARC: Functional Implications. Investigative Ophthalmology & Visual Science 2011, 52: 179-189. PMID: 20926826, PMCID: PMC3053273, DOI: 10.1167/iovs.09-4866.
- Neuroendocrine Properties of the Ciliary EpitheliumCoca-Prados M. Neuroendocrine Properties of the Ciliary Epithelium. 2010, 107-112. DOI: 10.1016/b978-0-12-374203-2.00088-9.
- Functional Role of Proteolytic Processing of Recombinant Myocilin in Self-AggregationAroca-Aguilar JD, Martínez-Redondo F, Sánchez-Sánchez F, Coca-Prados M, Escribano J. Functional Role of Proteolytic Processing of Recombinant Myocilin in Self-Aggregation. Investigative Ophthalmology & Visual Science 2009, 51: 72-78. PMID: 19696176, PMCID: PMC2869055, DOI: 10.1167/iovs.09-4118.
- Localization of Multidrug Resistance-Associated Protein 2 in the Nonpigmented Ciliary Epithelium of the EyePelis RM, Shahidullah M, Ghosh S, Coca-Prados M, Wright SH, Delamere NA. Localization of Multidrug Resistance-Associated Protein 2 in the Nonpigmented Ciliary Epithelium of the Eye. Journal Of Pharmacology And Experimental Therapeutics 2009, 329: 479-485. PMID: 19201990, PMCID: PMC2672870, DOI: 10.1124/jpet.108.149625.
- Heterozygous expression of myocilin glaucoma mutants increases secretion of the mutant forms and reduces extracellular processed myocilin.Aroca-Aguilar JD, Sánchez-Sánchez F, Martínez-Redondo F, Coca-Prados M, Escribano J. Heterozygous expression of myocilin glaucoma mutants increases secretion of the mutant forms and reduces extracellular processed myocilin. Molecular Vision 2008, 14: 2097-108. PMID: 19023451, PMCID: PMC2585175.
- Expression and purification of functional recombinant human pigment epithelium-derived factor (PEDF) secreted by the yeast Pichia pastorisSánchez-Sánchez F, Aroca-Aguilar JD, Segura I, Ramírez-Castillejo C, Riese HH, Coca-Prados M, Escribano J. Expression and purification of functional recombinant human pigment epithelium-derived factor (PEDF) secreted by the yeast Pichia pastoris. Journal Of Biotechnology 2008, 134: 193-201. PMID: 18282627, DOI: 10.1016/j.jbiotec.2008.01.005.
- Chapter 5 Functional Modulators Linking Inflow with Outflow of Aqueous HumorCoca‐Prados M, Ghosh S. Chapter 5 Functional Modulators Linking Inflow with Outflow of Aqueous Humor. 2008, 62: 123-160. DOI: 10.1016/s1063-5823(08)00405-5.
- Chapter 4 The Ciliary Body: A Potential Multifaceted Functional Neuroendocrine UnitYorio T, Prasanna G, Coca-Prados M. Chapter 4 The Ciliary Body: A Potential Multifaceted Functional Neuroendocrine Unit. 2008, 69-85. DOI: 10.1016/b978-012370585-3.50006-6.
- Characterization of the Intracellular Proteolytic Cleavage of Myocilin and Identification of Calpain II as a Myocilin-processing Protease*Sánchez-Sánchez F, Martínez-Redondo F, Aroca-Aguilar JD, Coca-Prados M, Escribano J. Characterization of the Intracellular Proteolytic Cleavage of Myocilin and Identification of Calpain II as a Myocilin-processing Protease*. Journal Of Biological Chemistry 2007, 282: 27810-27824. PMID: 17650508, DOI: 10.1074/jbc.m609608200.
- Role of MYOC and OPTN sequence variations in Spanish patients with primary open-angle glaucoma.López-Martínez F, López-Garrido M, Sánchez-Sánchez F, Campos-Mollo E, Coca-Prados M, Escribano J. Role of MYOC and OPTN sequence variations in Spanish patients with primary open-angle glaucoma. Molecular Vision 2007, 13: 862-72. PMID: 17615537, PMCID: PMC2770203.
- New perspectives in aqueous humor secretion and in glaucoma: The ciliary body as a multifunctional neuroendocrine glandCoca-Prados M, Escribano J. New perspectives in aqueous humor secretion and in glaucoma: The ciliary body as a multifunctional neuroendocrine gland. Progress In Retinal And Eye Research 2007, 26: 239-262. PMID: 17321191, DOI: 10.1016/j.preteyeres.2007.01.002.
- Molecular Analysis of Neurolysin Expression in the Rat and Bovine Ciliary BodyBertazolli-Filho R, Coca-Prados M, Haddad A, Laicine EM. Molecular Analysis of Neurolysin Expression in the Rat and Bovine Ciliary Body. Current Eye Research 2007, 32: 751-756. PMID: 17882707, DOI: 10.1080/02713680701573381.
- Heterozygous CYP1B1 gene mutations in Spanish patients with primary open-angle glaucoma.López-Garrido MP, Sánchez-Sánchez F, López-Martínez F, Aroca-Aguilar JD, Blanco-Marchite C, Coca-Prados M, Escribano J. Heterozygous CYP1B1 gene mutations in Spanish patients with primary open-angle glaucoma. Molecular Vision 2006, 12: 748-55. PMID: 16862072.
- Somatostatin modulates PI3K-Akt, eNOS and NHE activity in the ciliary epitheliumGhosh S, Choritz L, Geibel J, Coca-Prados M. Somatostatin modulates PI3K-Akt, eNOS and NHE activity in the ciliary epithelium. Molecular And Cellular Endocrinology 2006, 253: 63-75. PMID: 16764985, DOI: 10.1016/j.mce.2006.05.002.
- Interaction of myocilin with the C-terminal region of hevinLi Y, Aroca-Aguilar JD, Ghosh S, Sánchez-Sánchez F, Escribano J, Coca-Prados M. Interaction of myocilin with the C-terminal region of hevin. Biochemical And Biophysical Research Communications 2005, 339: 797-804. PMID: 16316624, DOI: 10.1016/j.bbrc.2005.11.082.
- Selective Upregulation of the A3 Adenosine Receptor in Eyes with Pseudoexfoliation Syndrome and GlaucomaSchlötzer-Schrehardt U, Zenkel M, Decking U, Haubs D, Kruse FE, Jünemann A, Coca-Prados M, Naumann GO. Selective Upregulation of the A3 Adenosine Receptor in Eyes with Pseudoexfoliation Syndrome and Glaucoma. Investigative Ophthalmology & Visual Science 2005, 46: 2023-2034. PMID: 15914619, DOI: 10.1167/iovs.04-0915.
- Retinoid processing proteins in the ocular ciliary epithelium.Salvador-Silva M, Ghosh S, Bertazolli-Filho R, Boatright JH, Nickerson JM, Garwin GG, Saari JC, Coca-Prados M. Retinoid processing proteins in the ocular ciliary epithelium. Molecular Vision 2005, 11: 356-65. PMID: 15928609.
- Myocilin Mutations Causing Glaucoma Inhibit the Intracellular Endoproteolytic Cleavage of Myocilin between Amino Acids Arg226 and Ile227 *Aroca-Aguilar JD, Sánchez-Sánchez F, Ghosh S, Coca-Prados M, Escribano J. Myocilin Mutations Causing Glaucoma Inhibit the Intracellular Endoproteolytic Cleavage of Myocilin between Amino Acids Arg226 and Ile227 *. Journal Of Biological Chemistry 2005, 280: 21043-21051. PMID: 15795224, DOI: 10.1074/jbc.m501340200.
- FOXC1 Transcriptional Regulatory Activity Is Impaired by PBX1 in a Filamin A-Mediated MannerBerry FB, O'Neill MA, Coca-Prados M, Walter MA. FOXC1 Transcriptional Regulatory Activity Is Impaired by PBX1 in a Filamin A-Mediated Manner. Molecular And Cellular Biology 2005, 25: 1415-1424. PMID: 15684392, PMCID: PMC548007, DOI: 10.1128/mcb.25.4.1415-1424.2005.
- The Cross-Species A3 Adenosine-Receptor Antagonist MRS 1292 Inhibits Adenosine-Triggered Human Nonpigmented Ciliary Epithelial Cell Fluid Release and Reduces Mouse Intraocular PressureYang H, Avila MY, Peterson-Yantorno K, Coca-Prados M, Stone RA, Jacobson KA, Civan MM. The Cross-Species A3 Adenosine-Receptor Antagonist MRS 1292 Inhibits Adenosine-Triggered Human Nonpigmented Ciliary Epithelial Cell Fluid Release and Reduces Mouse Intraocular Pressure. Current Eye Research 2005, 30: 747-754. PMID: 16146920, PMCID: PMC3471215, DOI: 10.1080/02713680590953147.
- Hyposmotic activation of ICl,swell in rabbit nonpigmented ciliary epithelial cells involves increased ClC-3 trafficking to the plasma membraneVessey JP, Shi C, Jollimore CA, Stevens KT, Coca-Prados M, Barnes S, Kelly ME. Hyposmotic activation of ICl,swell in rabbit nonpigmented ciliary epithelial cells involves increased ClC-3 trafficking to the plasma membrane. Biochemistry And Cell Biology 2004, 82: 708-718. PMID: 15674438, DOI: 10.1139/o04-107.
- The bovine iris–ciliary epithelium expresses components of rod phototransductionGhosh S, Salvador-Silva M, Coca-Prados M. The bovine iris–ciliary epithelium expresses components of rod phototransduction. Neuroscience Letters 2004, 370: 7-12. PMID: 15489008, DOI: 10.1016/j.neulet.2004.07.026.
- Identification of Target Genes Regulated by FOXC1 Using Nickel Agarose–Based Chromatin EnrichmentTamimi Y, Lines M, Coca-Prados M, Walter MA. Identification of Target Genes Regulated by FOXC1 Using Nickel Agarose–Based Chromatin Enrichment. Investigative Ophthalmology & Visual Science 2004, 45: 3904-3913. PMID: 15505035, DOI: 10.1167/iovs.04-0628.
- Functional and Molecular Characterization of a Volume-activated Chloride Channel in Rabbit Corneal Epithelial CellsAl-Nakkash L, Iserovich P, Coca-Prados M, Yang H, Reinach P. Functional and Molecular Characterization of a Volume-activated Chloride Channel in Rabbit Corneal Epithelial Cells. The Journal Of Membrane Biology 2004, 201: 41-49. PMID: 15635811, DOI: 10.1007/s00232-004-0706-5.
- Inhibition of NHE-1 Na+/H+ exchanger by natriuretic peptides in ocular nonpigmented ciliary epitheliumFidzinski P, Salvador-Silva M, Choritz L, Geibel J, Coca-Prados M. Inhibition of NHE-1 Na+/H+ exchanger by natriuretic peptides in ocular nonpigmented ciliary epithelium. American Journal Of Physiology - Cell Physiology 2004, 287: c655-c663. PMID: 15140751, DOI: 10.1152/ajpcell.00552.2003.
- Sex steroid hormone metabolism takes place in human ocular cellsCoca-Prados M, Ghosh S, Wang Y, Escribano J, Herrala A, Vihko P. Sex steroid hormone metabolism takes place in human ocular cells. The Journal Of Steroid Biochemistry And Molecular Biology 2003, 86: 207-216. PMID: 14568574, DOI: 10.1016/j.jsbmb.2003.08.001.
- Inhibition of 11β-hydroxysteroid dehydrogenase type 1 lowers intraocular pressure in patients with ocular hypertensionRauz S, Cheung C, Wood P, Coca-Prados M, Walker E, Murray P, Stewart P. Inhibition of 11β-hydroxysteroid dehydrogenase type 1 lowers intraocular pressure in patients with ocular hypertension. QJM 2003, 96: 481-490. PMID: 12881590, DOI: 10.1093/qjmed/hcg085.
- A3 adenosine and CB1 receptors activate a PKC‐sensitive Cl− current in human nonpigmented ciliary epithelial cells via a Gβγ‐coupled MAPK signaling pathwayShi C, Szczesniak A, Mao L, Jollimore C, Coca‐Prados M, Hung O, Kelly ME. A3 adenosine and CB1 receptors activate a PKC‐sensitive Cl− current in human nonpigmented ciliary epithelial cells via a Gβγ‐coupled MAPK signaling pathway. British Journal Of Pharmacology 2003, 139: 475-486. PMID: 12788807, PMCID: PMC1573867, DOI: 10.1038/sj.bjp.0705266.
- Production, purification, and functional analysis of recombinant human and mouse 17β-hydroxysteroid dehydrogenase type 7Törn S, Nokelainen P, Kurkela R, Pulkka A, Menjivar M, Ghosh S, Coca-Prados M, Peltoketo H, Isomaa V, Vihko P. Production, purification, and functional analysis of recombinant human and mouse 17β-hydroxysteroid dehydrogenase type 7. Biochemical And Biophysical Research Communications 2003, 305: 37-45. PMID: 12732193, DOI: 10.1016/s0006-291x(03)00694-6.
- Serum- and Glucocorticoid-Regulated Kinase Isoform-1 and Epithelial Sodium Channel Subunits in Human Ocular Ciliary EpitheliumRauz S, Walker EA, Hughes SV, Coca-Prados M, Hewison M, Murray PI, Stewart PM. Serum- and Glucocorticoid-Regulated Kinase Isoform-1 and Epithelial Sodium Channel Subunits in Human Ocular Ciliary Epithelium. Investigative Ophthalmology & Visual Science 2003, 44: 1643-1651. PMID: 12657604, DOI: 10.1167/iovs.02-0514.
- Expression of cell surface transmembrane carbonic anhydrase genes CA9 and CA12 in the human eye: overexpression of CA12 (CAXII) in glaucomaLiao S, Ivanov S, Ivanova A, Ghosh S, Cote M, Keefe K, Coca-Prados M, Stanbridge E, Lerman M. Expression of cell surface transmembrane carbonic anhydrase genes CA9 and CA12 in the human eye: overexpression of CA12 (CAXII) in glaucoma. Journal Of Medical Genetics 2003, 40: 257. PMID: 12676895, PMCID: PMC1735430, DOI: 10.1136/jmg.40.4.257.
- CRALBP transcriptional regulation in ciliary epithelial, retinal Müller and retinal pigment epithelial cellsKennedy BN, Li C, Ortego J, Coca-Prados M, Sarthy VP, Crabb JW. CRALBP transcriptional regulation in ciliary epithelial, retinal Müller and retinal pigment epithelial cells. Experimental Eye Research 2003, 76: 257-260. PMID: 12565814, DOI: 10.1016/s0014-4835(02)00308-1.
- Differential regulation of gene expression of neurotensin and prohormone convertases PC1 and PC2 in the bovine ocular ciliary epithelium: possible implications on neurotensin processingOrtego J, Wollmann G, Coca-Prados M. Differential regulation of gene expression of neurotensin and prohormone convertases PC1 and PC2 in the bovine ocular ciliary epithelium: possible implications on neurotensin processing. Neuroscience Letters 2002, 333: 49-53. PMID: 12401558, DOI: 10.1016/s0304-3940(02)00028-9.
- Bioinformatics and reanalysis of subtracted expressed sequence tags from the human ciliary body: Identification of novel biological functions.Escribano J, Coca-Prados M. Bioinformatics and reanalysis of subtracted expressed sequence tags from the human ciliary body: Identification of novel biological functions. Molecular Vision 2002, 8: 315-32. PMID: 12355061.
- Renin-angiotensin system expression and secretory function in cultured human ciliary body non-pigmented epitheliumCullinane A, Leung P, Ortego J, Coca-Prados M, Harvey B. Renin-angiotensin system expression and secretory function in cultured human ciliary body non-pigmented epithelium. British Journal Of Ophthalmology 2002, 86: 676. PMID: 12034692, PMCID: PMC1771149, DOI: 10.1136/bjo.86.6.676.
- Protein tyrosine kinase and protein phosphatase signaling pathways regulate volume-sensitive chloride currents in a nonpigmented ciliary epithelial cell line.Shi C, Barnes S, Coca-Prados M, Kelly ME. Protein tyrosine kinase and protein phosphatase signaling pathways regulate volume-sensitive chloride currents in a nonpigmented ciliary epithelial cell line. Investigative Ophthalmology & Visual Science 2002, 43: 1525-32. PMID: 11980870.
- Adult-Onset Primary Open-Angle Glaucoma Caused by Mutations in OptineurinRezaie T, Child A, Hitchings R, Brice G, Miller L, Coca-Prados M, Héon E, Krupin T, Ritch R, Kreutzer D, Crick RP, Sarfarazi M. Adult-Onset Primary Open-Angle Glaucoma Caused by Mutations in Optineurin. Science 2002, 295: 1077-1079. PMID: 11834836, DOI: 10.1126/science.1066901.
- PGE2, Ca2+, and cAMP mediate ATP activation of Cl− channels in pigmented ciliary epithelial cellsFleischhauer J, Mitchell C, Peterson-Yantorno K, Coca-Prados M, Civan M. PGE2, Ca2+, and cAMP mediate ATP activation of Cl− channels in pigmented ciliary epithelial cells. American Journal Of Physiology - Cell Physiology 2001, 281: c1614-c1623. PMID: 11600425, DOI: 10.1152/ajpcell.2001.281.5.c1614.
- Molecular Evidence That Human Ocular Ciliary Epithelium Expresses Components Involved in PhototransductionBertazolli-Filho R, Ghosh S, Huang W, Wollmann G, Coca-Prados M. Molecular Evidence That Human Ocular Ciliary Epithelium Expresses Components Involved in Phototransduction. Biochemical And Biophysical Research Communications 2001, 284: 317-325. PMID: 11394879, DOI: 10.1006/bbrc.2001.4970.
- Chloride dependent intracellular pH effects of external ATP in cultured human non-pigmented ciliary body epitheliumCullinane A, Coca-Prados M, Harvey B. Chloride dependent intracellular pH effects of external ATP in cultured human non-pigmented ciliary body epithelium. Current Eye Research 2001, 23: 443-447. PMID: 12045894, DOI: 10.1076/ceyr.23.6.443.6967.
- Extracellular ATP effects on calcium signaling in cultured human non-pigmented ciliary body epitheliumCullinane A, Coca-Prados M, Harvey B. Extracellular ATP effects on calcium signaling in cultured human non-pigmented ciliary body epithelium. Current Eye Research 2001, 23: 448-454. PMID: 12045895, DOI: 10.1076/ceyr.23.6.448.6964.
- Expression of the TIGR gene in the iris, ciliary body, and trabecular meshwork of the human eye.Huang W, Jaroszewski J, Ortego J, Escribano J, Coca-Prados M. Expression of the TIGR gene in the iris, ciliary body, and trabecular meshwork of the human eye. Ophthalmic Genetics 2000, 21: 155-69. PMID: 11035548, DOI: 10.1076/1381-6810(200009)21:3;1-z;ft155.
- Similarity of A3-adenosine and swelling-activated Cl− channels in nonpigmented ciliary epithelial cellsCarré D, Mitchell C, Peterson-Yantorno K, Coca-Prados M, Civan M. Similarity of A3-adenosine and swelling-activated Cl− channels in nonpigmented ciliary epithelial cells. American Journal Of Physiology - Cell Physiology 2000, 279: c440-c451. PMID: 10913011, DOI: 10.1152/ajpcell.2000.279.2.c440.
- Na+/H+ and Cl–/HCO3–-antiporters of bovine pigmented ciliary epithelial cellsCounillon L, Touret N, Bidet M, Peterson-Yantorno K, Coca-Prados M, Stuart-Tilley A, Wilhelm S, Alper S, Civan M. Na+/H+ and Cl–/HCO3–-antiporters of bovine pigmented ciliary epithelial cells. Pflügers Archiv - European Journal Of Physiology 2000, 440: 667-678. PMID: 11007305, DOI: 10.1007/s004240000302.
- Tamoxifen and ATP synergistically activate Cl− release by cultured bovine pigmented ciliary epithelial cellsMitchell C, Peterson‐Yantorno K, Coca‐Prados M, Civan M. Tamoxifen and ATP synergistically activate Cl− release by cultured bovine pigmented ciliary epithelial cells. The Journal Of Physiology 2000, 525: 183-193. PMID: 10811736, PMCID: PMC2269939, DOI: 10.1111/j.1469-7793.2000.00183.x.
- Expression of the TIGR gene in the iris, ciliary body, and trabecular meshwork of the human eyeHuang W, Jaroszewski J, Ortego J, Escribano J, Coca-Prados M. Expression of the TIGR gene in the iris, ciliary body, and trabecular meshwork of the human eye. Ophthalmic Genetics 2000, 21: 155-169. DOI: 10.1076/1381-6810(200009)2131-zft155.
- Hyposmotically activated chloride channels in cultured rabbit non‐pigmented ciliary epithelial cellsShi C, Ryan J, French A, Coca‐Prados M, Kelly M. Hyposmotically activated chloride channels in cultured rabbit non‐pigmented ciliary epithelial cells. The Journal Of Physiology 1999, 521: 57-67. PMID: 10562334, PMCID: PMC2269649, DOI: 10.1111/j.1469-7793.1999.00057.x.
- Functional Expression of Components of the Natriuretic Peptide System in Human Ocular Nonpigmented Ciliary Epithelial Cells Volume 258, Number 1 (1999), pages 21–28:Ortego J, Coca-Prados M. Functional Expression of Components of the Natriuretic Peptide System in Human Ocular Nonpigmented Ciliary Epithelial Cells Volume 258, Number 1 (1999), pages 21–28:. Biochemical And Biophysical Research Communications 1999, 264: 1007. DOI: 10.1006/bbrc.1999.1530.
- Differential gene expression in the human ciliary epitheliumCoca-Prados M, Escribano J, Ortego J. Differential gene expression in the human ciliary epithelium. Progress In Retinal And Eye Research 1999, 18: 403-429. PMID: 10192520, DOI: 10.1016/s1350-9462(98)00026-3.
- Identification, expression and chromosome localization of a human gene encoding a novel protein with similarity to the pilB family of transcriptional factors (pilin) and to bacterial peptide methionine sulfoxide reductasesHuang W, Escribano J, Sarfarazi M, Coca-Prados M. Identification, expression and chromosome localization of a human gene encoding a novel protein with similarity to the pilB family of transcriptional factors (pilin) and to bacterial peptide methionine sulfoxide reductases. Gene 1999, 233: 233-240. PMID: 10375640, DOI: 10.1016/s0378-1119(99)00131-6.
- Functional Expression of Components of the Natriuretic Peptide System in Human Ocular Nonpigmented Ciliary Epithelial CellsOrtego J, Coca-Prados M. Functional Expression of Components of the Natriuretic Peptide System in Human Ocular Nonpigmented Ciliary Epithelial Cells. Biochemical And Biophysical Research Communications 1999, 258: 21-28. PMID: 10222228, DOI: 10.1006/bbrc.1999.0573.
- A3 adenosine receptors regulate Cl−channels of nonpigmented ciliary epithelial cellsMitchell C, Peterson-Yantorno K, Carré D, McGlinn A, Coca-Prados M, Stone R, Civan M. A3 adenosine receptors regulate Cl−channels of nonpigmented ciliary epithelial cells. American Journal Of Physiology 1999, 276: c659-c666. PMID: 10069993, DOI: 10.1152/ajpcell.1999.276.3.c659.
- Effects of hypotonic swelling on the cellular distribution and expression of pICln in human nonpigmented ciliary epithelial cellsSánchez-Torres J, Huang W, Civan M, Coca-Prados M. Effects of hypotonic swelling on the cellular distribution and expression of pICln in human nonpigmented ciliary epithelial cells. Current Eye Research 1999, 18: 408-416. PMID: 10435827, DOI: 10.1076/ceyr.18.6.408.5266.
- Identification ofPKD2L,a HumanPKD2-Related Gene: Tissue-Specific Expression and Mapping to Chromosome 10q25Wu G, Hayashi T, Park J, Dixit M, Reynolds D, Li L, Maeda Y, Cai Y, Coca-Prados M, Somlo S. Identification ofPKD2L,a HumanPKD2-Related Gene: Tissue-Specific Expression and Mapping to Chromosome 10q25. Genomics 1998, 54: 564-568. PMID: 9878261, DOI: 10.1006/geno.1998.5618.
- Molecular Identification and Coexpression of Galanin and GalR‐1 Galanin Receptor in the Human Ocular Ciliary Epithelium: Differential Modulation of Their Expression by the Activation of α2‐ and β2‐Adrenergic Receptors in Cultured Ciliary Epithelial CellsOrtego J, Coca‐Prados M. Molecular Identification and Coexpression of Galanin and GalR‐1 Galanin Receptor in the Human Ocular Ciliary Epithelium: Differential Modulation of Their Expression by the Activation of α2‐ and β2‐Adrenergic Receptors in Cultured Ciliary Epithelial Cells. Journal Of Neurochemistry 1998, 71: 2260-2270. PMID: 9832123, DOI: 10.1046/j.1471-4159.1998.71062260.x.
- Sequence Analysis and Homology Modeling Suggest That Primary Congenital Glaucoma on 2p21 Results from Mutations Disrupting Either the Hinge Region or the Conserved Core Structures of Cytochrome P4501B1Stoilov I, Akarsu A, Alozie I, Child A, Barsoum-Homsy M, Turacli M, Or M, Lewis R, Ozdemir N, Brice G, Aktan S, Chevrette L, Coca-Prados M, Sarfarazi M. Sequence Analysis and Homology Modeling Suggest That Primary Congenital Glaucoma on 2p21 Results from Mutations Disrupting Either the Hinge Region or the Conserved Core Structures of Cytochrome P4501B1. American Journal Of Human Genetics 1998, 62: 573-584. PMID: 9497261, PMCID: PMC1376958, DOI: 10.1086/301764.
- Expression of pICln mRNA in cultured bovine lens epithelial cells: response to changes in cell volumeReeves R, Sanchez-Torres J, Coca-Prados M, Cammarata P. Expression of pICln mRNA in cultured bovine lens epithelial cells: response to changes in cell volume. Current Eye Research 1998, 17: 861-869. PMID: 9746432, DOI: 10.1076/ceyr.17.9.861.5140.
- Potential contribution of epithelial Na+ channel to net secretion of aqueous humorCivan M, Peterson‐Yantorno K, Sánchez‐Torres J, Coca‐Prados M. Potential contribution of epithelial Na+ channel to net secretion of aqueous humor. Journal Of Experimental Zoology 1997, 279: 498-503. PMID: 9392872, DOI: 10.1002/(sici)1097-010x(19971201)279:5<498::aid-jez13>3.0.co;2-4.
- Molecular Characterization and Differential Gene Induction of the Neuroendocrine‐Specific Genes Neurotensin, Neurotensin Receptor, PC1, PC2, and 7B2 in the Human Ocular Ciliary EpitheliumOrtego J, Coca‐Prados M. Molecular Characterization and Differential Gene Induction of the Neuroendocrine‐Specific Genes Neurotensin, Neurotensin Receptor, PC1, PC2, and 7B2 in the Human Ocular Ciliary Epithelium. Journal Of Neurochemistry 1997, 69: 1829-1839. PMID: 9349525, DOI: 10.1046/j.1471-4159.1997.69051829.x.
- Adenosine stimulates Cl− channels of nonpigmented ciliary epithelial cellsCarré D, Mitchell C, Peterson-Yantorno K, Coca-Prados M, Civan M. Adenosine stimulates Cl− channels of nonpigmented ciliary epithelial cells. American Journal Of Physiology 1997, 273: c1354-c1361. PMID: 9357781, DOI: 10.1152/ajpcell.1997.273.4.c1354.
- Cloning and characterization of subtracted cDNAs from a human ciliary body library encoding TIGR, a protein involved in juvenile open angle glaucoma with homology to myosin and olfactomedinOrtego J, Escribano J, Coca-Prados M. Cloning and characterization of subtracted cDNAs from a human ciliary body library encoding TIGR, a protein involved in juvenile open angle glaucoma with homology to myosin and olfactomedin. FEBS Letters 1997, 413: 349-353. PMID: 9280311, DOI: 10.1016/s0014-5793(97)00934-4.
- Gene Expression of Proteases and Protease Inhibitors in the Human Ciliary Epithelium and ODM-2 CellsORTEGO J, ESCRIBANO J, COCA-PRADOS M. Gene Expression of Proteases and Protease Inhibitors in the Human Ciliary Epithelium and ODM-2 Cells. Experimental Eye Research 1997, 65: 289-299. PMID: 9268597, DOI: 10.1006/exer.1997.0333.
- The prostaglandin transporter is widely expressed in ocular tissuesSchuster V, Lu R, Coca-Prados M. The prostaglandin transporter is widely expressed in ocular tissues. Survey Of Ophthalmology 1997, 41: s41-s45. PMID: 9154275, DOI: 10.1016/s0039-6257(97)80006-9.
- Chapter 2 Molecular Approaches to the Study of the Na+,K+ -ATPase and Chloride Channels in the Ocular Ciliary EpitheliumCoca-Prados M, Sánchez-Torres J. Chapter 2 Molecular Approaches to the Study of the Na+,K+ -ATPase and Chloride Channels in the Ocular Ciliary Epithelium. 1997, 45: 25-53. DOI: 10.1016/s0070-2161(08)60242-7.
- Gene expression of the neurotrophic pigment epithelium-derived factor in the human ciliary epithelium. Synthesis and secretion into the aqueous humor.Ortego J, Escribano J, Becerra S, Coca-Prados M. Gene expression of the neurotrophic pigment epithelium-derived factor in the human ciliary epithelium. Synthesis and secretion into the aqueous humor. Investigative Ophthalmology & Visual Science 1996, 37: 2759-67. PMID: 8977492.
- Regulatory Volume Increase of Human Non-pigmented Ciliary Epithelial CellsCIVAN M, COCA-PRADOS M, PETERSON-YANTORNO K. Regulatory Volume Increase of Human Non-pigmented Ciliary Epithelial Cells. Experimental Eye Research 1996, 62: 627-640. PMID: 8983945, DOI: 10.1006/exer.1996.0074.
- Identification of Prostanoid Receptors in Rabbit Non-pigmented Ciliary Epithelial CellsBHATTACHERJEE P, JACOBS N, COCA-PRADOS M, PATERSON C. Identification of Prostanoid Receptors in Rabbit Non-pigmented Ciliary Epithelial Cells. Experimental Eye Research 1996, 62: 491-498. PMID: 8759517, DOI: 10.1006/exer.1996.0059.
- Association of ClC-3 Channel with Cl− Transport by Human Nonpigmented Ciliary Epithelial CellsCoca-Prados M, Sánchez-Torres J, Peterson-Yantorno K, Civan M. Association of ClC-3 Channel with Cl− Transport by Human Nonpigmented Ciliary Epithelial Cells. The Journal Of Membrane Biology 1996, 150: 197-208. PMID: 8661780, DOI: 10.1007/s002329900044.
- Crocin, safranal and picrocrocin from saffron (Crocus sativus L.) inhibit the growth of human cancer cells in vitroEscribano J, Alonso G, Coca-Prados M, Fernández J. Crocin, safranal and picrocrocin from saffron (Crocus sativus L.) inhibit the growth of human cancer cells in vitro. Cancer Letters 1996, 100: 23-30. PMID: 8620447, DOI: 10.1016/0304-3835(95)04067-6.
- Identification of a Neuropeptide and Neuropeptide‐Processing Enzymes in Aqueous Humor Confers Neuroendocrine Features to the Human Ocular Ciliary EpitheliumOrtego J, Escribano J, Crabb J, Coca‐Prados M. Identification of a Neuropeptide and Neuropeptide‐Processing Enzymes in Aqueous Humor Confers Neuroendocrine Features to the Human Ocular Ciliary Epithelium. Journal Of Neurochemistry 1996, 66: 787-796. PMID: 8592153, DOI: 10.1046/j.1471-4159.1996.66020787.x.
- Cell-attached patch clamping of the intact rabbit ciliary epitheliumCarré D, Anguíta J, Coca-Prados M, Civan M. Cell-attached patch clamping of the intact rabbit ciliary epithelium. Current Eye Research 1996, 15: 193-201. PMID: 8670728, DOI: 10.3109/02713689608997413.
- Cell-specific expression of the human Na+,K(+)-ATPase beta 2 subunit isoform in the nonpigmented ciliary epithelium.Coca-Prados M, Fernández-Cabezudo M, Sánchez-Torres J, Crabb J, Ghosh S. Cell-specific expression of the human Na+,K(+)-ATPase beta 2 subunit isoform in the nonpigmented ciliary epithelium. Investigative Ophthalmology & Visual Science 1995, 36: 2717-28. PMID: 7499094.
- Immortalization of cat iris sphincter smooth muscle cells by SV40 virus: Growth, morphological, biochemical and pharmacological characteristicsOcklind A, Yousufzai S, Ghosh S, Coca-Prados M, St Jernschantz J, Abdel-Latif A. Immortalization of cat iris sphincter smooth muscle cells by SV40 virus: Growth, morphological, biochemical and pharmacological characteristics. Experimental Eye Research 1995, 61: 535-545. PMID: 8654496, DOI: 10.1016/s0014-4835(05)80047-8.
- Isolation and characterization of cell-specific cDNA clones from a subtractive library of the ocular ciliary body of a single normal human donor: transcription and synthesis of plasma proteins.Escribano J, Ortego J, Coca-Prados M. Isolation and characterization of cell-specific cDNA clones from a subtractive library of the ocular ciliary body of a single normal human donor: transcription and synthesis of plasma proteins. The Journal Of Biochemistry 1995, 118: 921-31. PMID: 8749308, DOI: 10.1093/jb/118.5.921.
- PKC-sensitive Cl- channels associated with ciliary epithelial homologue of pIClnCoca-Prados M, Anguita J, Chalfant M, Civan M. PKC-sensitive Cl- channels associated with ciliary epithelial homologue of pICln. American Journal Of Physiology 1995, 268: c572-c579. PMID: 7534980, DOI: 10.1152/ajpcell.1995.268.3.c572.
- Royal academy of medicine in Ireland section of biomedical sciences Proceedings of Summer Meeting held June, 1994Cullinane A, Coca-Prados M, Harvey B, O’Reilly C, Ryan M, Maguire D, O’Sullivan G, Harvey B, Gebruers E, Hall W, Harris A, O’Halloran K, Curran A, Bradford A, Bunting H, McConaghy P, McLoughlin C, Sweeney D, Hardiman O, Grealy M, Sreenan J, Gilmartin L, O’Cuinn G, Lawlor M, O’Boyle K, Farrell C, Foster N, Walsh D, Baxter G, Allen J, Cawley T, Breslin E, Docherty J, Hynes A, Kane M, Duffy C, Mohd Nor A, Johnson A, Tomkin G, Collins P, Crónín D, McCloskey S, Thornbury K, O’Rourke M, Kearns S, Campion D, Leek B, Curran A, Curran A, O’Regan R, McLaughlin N, Curran A, Gaffney J, Edgell T, Walker J, MacSweeney C, Faherty C, Kelly J, Leonard B, Earley B, O’Neill M, Reymann J, Allain H, Caldwell M, Jennings M, Prosser E, Urbach V, Horwitz E, Horwitz E, Presser E, Raffin J, Thomas S, Egan D, O’Farrell A. Royal academy of medicine in Ireland section of biomedical sciences Proceedings of Summer Meeting held June, 1994. Irish Journal Of Medical Science 1995, 164: 79. DOI: 10.1007/bf02968123.
- Isolation of cDNA clones encoding the 80-kd subunit protein of the human autoantigen Ku (p70/p80) by antisera raised against ciliary processes of human eye donors.Hong T, Escribano J, Coca-Prados M. Isolation of cDNA clones encoding the 80-kd subunit protein of the human autoantigen Ku (p70/p80) by antisera raised against ciliary processes of human eye donors. Investigative Ophthalmology & Visual Science 1994, 35: 4023-30. PMID: 7960584.
- National Scientific Medical Meeting 1994 AbstractsCarson K, Grimes S, McGinley J, Thornton M, Mulhall J, Bourke A, McCrory C, Marsh B, Hone R, Phelan D, White M, Fabry J, Hughes D, Carson K, Donnelly M, Shanahan E, Fitzpatrick G, Bourke M, Warde D, Buggy D, Hughes N, Taylor A, Dowd N, Markham T, Blunnie W, Nicholson G, O’Leary E, Cunningham A, Dwyer R, McMechan S, Cullen C, Dempsey G, Wright G, MacKenzie G, Anderson J, Adgey J, Walsh M, O’Callaghan P, Graham I, O’Hare J, Geoghegan M, Iman N, Shah P, Chander R, Lavin F, Daly K, Johnston P, Imam Z, Adgey A, Rusk R, Richardson S, Hale A, Kinsella B, FitzGerald G, King G, Crean P, Gearty G, Cawley T, Docherty J, Geraghty J, Osborne H, Upton J, D’Arcy G, Stinson J, Cooke T, Colgan M, Hall M, Tyrrell J, Gaffney K, Grouden M, Moore D, Shanik G, Feely J, Delanty N, Reilly M, Lawson J, Fitzgerald D, Reilly M, McAdam B, Bergin C, Walshe M, Herity N, Allen J, Silke B, Singh H, O’Neill S, Hargrove M, Coleman E, Shorten E, Aherne T, Kelly B, Hill D, McIlrath E, Morrow B, Lavery G, Blackwood B, Fee J, Kevin L, Doran M, Tansey D, Boylan I, McShane A, O’Reilly G, Tuohy B, Grainger P, Larkin T, Mahady J, Malone J, Condon C, Donoghue T, O’Leary J, Lyons J, Tay Y, Tham S, Khoo Tan H, Gibson G, O’Grady A, Leader M, Walshe J, Carmody M, Donohoe J, Murphy G, O’Connor W, Barnes L, Watson R, Darby C, O’Moore R, Mulcahy F, O’Toole E, O’Briain D, Young M, Buckley D, Healy E, Rogers S, Ni Scannlain N, McKenna M, McBrinn Y, Murray B, Freaney R, Barrett E, Razza Q, Abuaisha F, Powell D, Murray T, Powell A, O’Mongain E, O’Neill J, Kernan R, O’Connor P, Clarke D, Fearon U, Cunningham S, McKenna T, Hayes F, Heffernan A, Sheahan K, Harper R, Johnston G, Atkinson A, Sheridan B, Bell P, Heaney A, Loughrey G, McCance D, Hadden D, Kennedy A, McNamara P, O’Shaughnessy C, Loughrey H, Reid I, Teahan S, Caldwell M, Walsh T, McSweeney J, Hennessy T, Caldwell M, Byrne P, Hennessy T, El-Magbri A, Stevens F, O’Sullivan R, McCarthy C, Laundon J, Heneghan M, Kearns M, Goulding J, Egan E, McMahon B, Hegarty F, Malone J, Merriman R, MacMathuna P, Crowe J, Lennon J, White P, Clarke E, Prabhakar M, Ryan E, Graham D, Yeoh P, Kelly P, McKeogh D, O’Keane C, Kitching A, Mulligan E, Gorey T, Mahmud N, O’Connell M, Goggins M, Keeling P, Weir D, Kelleher D, McDonald G, Maguire D, O’Sullivan G, Harvey B, Cherukuri A, McGrath J, Timon C, Lawlor P, O’Shea J, Buckley M, English L, Walsh T, O’Morain C, Lavelle S, Kanagaratnam B, Harding B, Murphy B, Kavanagh J, Kerr D, Lavelle E, O’Gorman T, Liston S, Fitzpatrick C, Fitzpatrick P, Turner M, Murphy A, Cafferty D, Dowling J, Bury G, Kaf Al-Ghazal S, Zimmermann E, O’Donoghue J, McCann J, Sheehan C, Boissel L, Lynch M, Cryan B, Fanning S, O’Meara D, Fennell J, Byrne P, Lyons D, Mulcahy R, Pooransingh A, Walsh J, Coakley D, O’Neill D, Ryall N, Connolly P, Namushi R, Lawler M, Locasciulli A, Bacigalupo A, Humphries P, McCann S, Pamphilon D, Reidy M, Madden M, Finch T, Borton M, Barnes C, Lawlor S, Gardiner N, Egan L, Orren A, Doherty J, Curran C, O’Hanlon D, Kent P, Kerin M, Maher D, Given H, Lynch S, McManus R, O’Farrelly C, Madrigal L, Feighery C, O’Donoghue D, Whelan C, Rea I, Stewart M, Campbell P, Alexander H, Crockard A, Morris T, Maguire H, Davidson F, Kaminski G, Butler K, Hillary I, Parfrey N, Crowley B, McCreary C, Keane C, O’Reilly M, Goh J, Kennedy M, Fitzgerald M, Scott T, Murphy S, Hildebrand J, Holliman R, Smith C, Kengasu K, Riain U, Cormican M, Flynn J, Glennon M, Smith T, Whyte D, Keane C, Barry T, Noone D, Maher M, Dawson M, Gilmartin J, Gannon F, Eljamel M, Allcut D, Pidgeon C, Phillips J, Rawluk D, Young S, Toland J, Deveney A, Waddington J, O’Brien D, Hickey A, Maguire E, Phillips J, Al-Ansari N, Cunney R, Smyth E, Sharif S, Eljamel M, Pidgeon C, Maguire E, Burke E, Staunton H, O’Riordan J, Hutchinson M, Norton M, McGeeney B, O’Connor M, Redmond J, Feely S, Boyle G, McAuliffe F, Foley M, Kelehan P, Murphy J, Greene R, Higgins J, Darling M, Byrne P, Kondaveeti U, Gordon A, Hennelly B, Woods T, Harrison R, Geary M, Sutherst J, Turner M, DeLancey J, Donnelly V, O’Connell P, O’Herlihy C, Barry-Kinsella C, Sharma S, Drury L, Lewis S, Stratton J, Ni Scanaill S, Stuart B, Hickey K, Coulter-Smith S, Moloney A, Robson M, Murphy M, Keane D, Stronge J, Boylan P, Gonsalves R, Blankson S, McGuinness E, Sheppard B, Bonnar J, MacDonagh-White C, Kelleher C, Newell J, White O, Young Y, Hallahan C, Carroll K, Tipton K, McDermott E, Reynolds J, Nolan N, McCann A, Rafferty R, Sweeney P, Carney D, O’Higgins N, Duffy M, Grimes H, Gallagher S, O’Hanlon D, Strattan J, Lenehan P, Robson M, Cusack Y, O’Riordain D, Mercer P, Smyth P, Gallagher H, Moule B, Cooke T, McArdle C, Burke C, Vance A, Saidtéar C, Early A, Eustace P, Maguire L, Cullinane A, Prosser E, Coca-Prados M, Harvey B, Saidléar C, Orwa S, Fitzsimons R, Bradley O, Hogan M, Zimmerman L, Wang J, Kuliszewski M, Liu J, Post M, Premkumar, Conran M, Nolan G, Duff D, Oslizlok P, Denham B, O’Connell P, Birthistle K, Hitchcock R, Carrington D, Calvert S, Holmes K, Smith D, Hetherton A, Mott M, Oakhill A, Foreman N, Foot A, Dixon J, Walsh S, Mortimer G, O’Sullivan C, Kilgallen C, Sweeney E, Brayden D, Kelly J, McCormack P, Hayes C, Johnson Z, Dack P, Hosseini J, O’Connell T, Hemeryck L, Condren L, McCormack P, McAdam B, Lawson J, Keimowitz R, O’Leary A, Pilkington R, Adebayo G, Gaffney P, McGettigan P, McManus J, O’Shea B, Wen Y, Killalea S, Golden J, Swanwick G, Clare A, Mulvany F, Byrne M, O’Callaghan E, Byrne H, Cannon N, Kinsella T, Cassidy B, Shepard N, Horgan R, Larkin C, Cotter D, Coffey V, Sham P, Murray L, Lane A, Kinsella A, Murphy P, Colgan K, Sloan D, Gilligan P, McEnri J, Ennis J, Stack J, Corcoran E, Walsh D, Thornton L, Temperley I, Lawlor E, Tobin A, Hillary I, Nelson H, Martin M, Ryan F, Christie M, Murray D, Keane E, Holmes E, Hollyer J, Strangeways J, Foster P, Stanwell-Smith R, Griffin E, Conlon T, Hayes E, Clarke T, Fogarty J, Moloney A, Killeen P, Farrell S, Clancy L, Hynes M, Conlon C, Foley-Nolan C, Shelley E, Collins C, McNamara E, Hayes B, Creamer E, LaFoy M, Costigan P, Al fnAnsari N, Cunney R, Smyth E, Johnson H, McQuoid G, Gilmer B, Browne G, Keogh J, Jefferson A, Smith M, Hennessy S, Burke C, Sreenan S, Power C, Pathmakanthan S, Poulter L, Chan A, Sheehan M, Maguire M, O’Connor C, FitzGerald M, Southey A, Costello C, McQuaid K, Urbach V, Thomas S, Horwitz E, Mulherin D, FitzGerald O, Bresnihan B, Kirk G, Veale D, Belch J, Mofidi A, Mofidi R, Quigley C, McLaren M, Veale D, D’Arrigo C, Couto J, Woof J, Greer M, Cree I, Belch J, Hone S, Fenton J, Hamilton S, McShane D. National Scientific Medical Meeting 1994 Abstracts. Irish Journal Of Medical Science 1994, 163: 1-50. DOI: 10.1007/bf02943102.
- cDNA from human ocular ciliary epithelium homologous to βig‐h3 is preferentially expressed as an extracellular protein in the corneal epitheliumEscribano J, Hernando N, Ghosh S, Coca‐Prados M, Crabb J. cDNA from human ocular ciliary epithelium homologous to βig‐h3 is preferentially expressed as an extracellular protein in the corneal epithelium. Journal Of Cellular Physiology 1994, 160: 511-521. PMID: 8077289, DOI: 10.1002/jcp.1041600314.
- EP2-receptor Stimulated Cyclic Amp Synthesis in Cultured Human Non-pigmented Ciliary EpitheliumJumblatt M, Neltner A, Coca-Prados M, Paterson C. EP2-receptor Stimulated Cyclic Amp Synthesis in Cultured Human Non-pigmented Ciliary Epithelium. Experimental Eye Research 1994, 58: 563-566. PMID: 7925693, DOI: 10.1006/exer.1994.1050.
- Pathways signaling the regulatory volume decrease of cultured nonpigmented ciliary epithelial cells.Civan M, Coca-Prados M, Peterson-Yantorno K. Pathways signaling the regulatory volume decrease of cultured nonpigmented ciliary epithelial cells. Investigative Ophthalmology & Visual Science 1994, 35: 2876-86. PMID: 8188483.
- Nucleotide sequence of a cDNA for the β2 subunit isoform of Na+, K+-ATPase from human retinaHernando N, Martin-Vasallo P, Ghosh S, Ghosh P, Swaroop A, Coca-Prados M. Nucleotide sequence of a cDNA for the β2 subunit isoform of Na+, K+-ATPase from human retina. Biochimica Et Biophysica Acta 1994, 1189: 109-111. PMID: 8305453, DOI: 10.1016/0005-2736(94)90287-9.
- Inhibition of Na(+)-K(+)-ATPase activates Na(+)-K(+)-2Cl- cotransporter activity in cultured ciliary epitheliumDong J, Delamere N, Coca-Prados M. Inhibition of Na(+)-K(+)-ATPase activates Na(+)-K(+)-2Cl- cotransporter activity in cultured ciliary epithelium. American Journal Of Physiology 1994, 266: c198-c205. PMID: 8304416, DOI: 10.1152/ajpcell.1994.266.1.c198.
- Cloning of the bovine plasma selenium-dependent glutathione peroxidase (GP) cDNA from the ocular ciliary epithelium: expression of the plasma and cellular forms within the mammalian eye.Martín-Alonso J, Ghosh S, Coca-Prados M. Cloning of the bovine plasma selenium-dependent glutathione peroxidase (GP) cDNA from the ocular ciliary epithelium: expression of the plasma and cellular forms within the mammalian eye. The Journal Of Biochemistry 1993, 114: 284-91. PMID: 8262911, DOI: 10.1093/oxfordjournals.jbchem.a124168.
- Differential Expression of the Cellular Retinaldehyde-binding Protein in Bovine Ciliary EpitheliumMartı̀n-Alonso J, Ghosh S, Hernando N, Crabb J, Coca-Prados M. Differential Expression of the Cellular Retinaldehyde-binding Protein in Bovine Ciliary Epithelium. Experimental Eye Research 1993, 56: 659-669. PMID: 8595808, DOI: 10.1006/exer.1993.1083.
- Studies on regulation of the ascorbic acid transporter in a cell line derived from rabbit non-pigmented ciliary epitheliumDelamere N, Coca-Prados M, Aggarwal S. Studies on regulation of the ascorbic acid transporter in a cell line derived from rabbit non-pigmented ciliary epithelium. Biochimica Et Biophysica Acta 1993, 1149: 102-108. PMID: 8391316, DOI: 10.1016/0005-2736(93)90030-4.
- Calcium-dependent regulation of cation transport in cultured human nonpigmented ciliary epithelial cellsMito T, Delamere N, Coca-Prados M. Calcium-dependent regulation of cation transport in cultured human nonpigmented ciliary epithelial cells. American Journal Of Physiology 1993, 264: c519-c526. PMID: 8384781, DOI: 10.1152/ajpcell.1993.264.3.c519.
- Isolation of a cDNA encoding a glutathione S-transferase (GST) class-π from the bovine ocular ciliary epitheliumHernando N, Martin-Alonso J, Ghosh S, Coca-Prados M. Isolation of a cDNA encoding a glutathione S-transferase (GST) class-π from the bovine ocular ciliary epithelium. Experimental Eye Research 1992, 55: 711-718. PMID: 1478280, DOI: 10.1016/0014-4835(92)90175-r.
- Expression of a group of genes define regional and functional boundaries in the ciliary epitheliumCoca-Prados M, Ghosh S, Martin-Alonso J. Expression of a group of genes define regional and functional boundaries in the ciliary epithelium. Experimental Eye Research 1992, 55: 168. DOI: 10.1016/0014-4835(92)90784-p.
- Regulation of ICAM-1 expression on human non-pigmented ciliary body epithelial (NPE) and trabecular meshwork (HTM) cellsAoki K, Kropp M, Bullington R, Gil D, Coca-Prados M, WoldeMussie E, Wheeler L. Regulation of ICAM-1 expression on human non-pigmented ciliary body epithelial (NPE) and trabecular meshwork (HTM) cells. Experimental Eye Research 1992, 55: 10. DOI: 10.1016/0014-4835(92)90248-q.
- Molecular Cloning of the Bovine CD9 Antigen from Ocular Ciliary Epithelial CellsMartín-Alonso J, Hernando N, Ghosh S, Coca-Prados M. Molecular Cloning of the Bovine CD9 Antigen from Ocular Ciliary Epithelial Cells. The Journal Of Biochemistry 1992, 112: 63-67. PMID: 1339429, DOI: 10.1093/oxfordjournals.jbchem.a123866.
- Regulatory volume decrease by cultured non-pigmented ciliary epithelial cellsCivan M, Peterson-Yantorno K, Coca-Prados M, E.Yantorno R. Regulatory volume decrease by cultured non-pigmented ciliary epithelial cells. Experimental Eye Research 1992, 54: 181-191. PMID: 1559547, DOI: 10.1016/s0014-4835(05)80207-6.
- Whole cell patch clamping of ciliary epithelial cells during anisosmotic swellingYantorno R, Carre D, Coca-Prados M, Krupin T, Civan M. Whole cell patch clamping of ciliary epithelial cells during anisosmotic swelling. American Journal Of Physiology 1992, 262: c501-c509. PMID: 1539636, DOI: 10.1152/ajpcell.1992.262.2.c501.
- Comparative Studies of Furosemide Effects on Membrane Potential and Intracellular Chloride Activity in Human and Rabbit Ciliary EpitheliumChu T, Socci R, Coca-Prados M, Green K. Comparative Studies of Furosemide Effects on Membrane Potential and Intracellular Chloride Activity in Human and Rabbit Ciliary Epithelium. Ophthalmic Research 1992, 24: 83-91. PMID: 1608601, DOI: 10.1159/000267151.
- Expression and cellular distribution of the al gap junction gene product in the ocular pigmented ciliary epitheliumCoca-Prados M, Ghosh S, Gilula N, Kumar N. Expression and cellular distribution of the al gap junction gene product in the ocular pigmented ciliary epithelium. Current Eye Research 1992, 11: 113-122. PMID: 1374005, DOI: 10.3109/02713689209000061.
- Expression of multiple Na+,K+‐ATPase genes reveals a gradient of isoforms along the nonpigmented ciliary epithelium: Functional implications in aqueous humor secretionGhosh S, Hernando N, Martín‐Alonso J, Martin‐Vasallo P, Coca‐Prados M. Expression of multiple Na+,K+‐ATPase genes reveals a gradient of isoforms along the nonpigmented ciliary epithelium: Functional implications in aqueous humor secretion. Journal Of Cellular Physiology 1991, 149: 184-194. PMID: 1660898, DOI: 10.1002/jcp.1041490203.
- Gamma-interferon induces differential expression of HLA-DR, -DP and -DQ in human ciliary epithelial cellsHelbig H, Kittredge K, Palestine A, Coca-Prados M, Nussenblatt R. Gamma-interferon induces differential expression of HLA-DR, -DP and -DQ in human ciliary epithelial cells. Graefe's Archive For Clinical And Experimental Ophthalmology 1991, 229: 191-194. PMID: 1904385, DOI: 10.1007/bf00170556.
- Detection and characterization of Ca2+-activated K+ channels in transformed cells of human non-pigmented ciliary epitheliumBarros F, Lòpez-Briones L, Coca-Prados M, Belmonte C. Detection and characterization of Ca2+-activated K+ channels in transformed cells of human non-pigmented ciliary epithelium. Current Eye Research 1991, 10: 731-738. PMID: 1914505, DOI: 10.3109/02713689109013867.
- Mammalian ciliary-body epithelial cells in culture produce transforming growth factor-betaHelbig H, Kittredge K, Coca-Prados M, Davis J, Palestine A, Nussenblatt R. Mammalian ciliary-body epithelial cells in culture produce transforming growth factor-beta. Graefe's Archive For Clinical And Experimental Ophthalmology 1991, 229: 84-87. PMID: 2004731, DOI: 10.1007/bf00172268.
- Differential expression of HLA DR, DP and DQ in cultivated, human ciliary body epithelial cells.Helbig H, Kittredge K, Coca-Prados M, Nussenblatt R. Differential expression of HLA DR, DP and DQ in cultivated, human ciliary body epithelial cells. Die Ophthalmologie 1991, 88: 295-8. PMID: 1889783.
- Regulation of protein phosphorylation in ocular ciliary epithelial cells by A, C and Ca2+calmodulin-dependent protein kinasesLopez-Briones L, Wax M, Coca-Prados M. Regulation of protein phosphorylation in ocular ciliary epithelial cells by A, C and Ca2+calmodulin-dependent protein kinases. Experimental Eye Research 1990, 51: 277-286. PMID: 2119313, DOI: 10.1016/0014-4835(90)90024-o.
- Cellular distribution and differential gene expression of the three alpha subunit isoforms of the Na,K-ATPase in the ocular ciliary epithelium.Ghosh S, Freitag A, Martin-Vasallo P, Coca-Prados M. Cellular distribution and differential gene expression of the three alpha subunit isoforms of the Na,K-ATPase in the ocular ciliary epithelium. Journal Of Biological Chemistry 1990, 265: 2935-2940. PMID: 1689295, DOI: 10.1016/s0021-9258(19)39891-6.
- Expression of Na,K‐ATPase alpha subunit isoforms in the human ciliary body and cultured ciliary epithelial cellsMartin‐Vasallo P, Ghosh S, Coca‐Prados M. Expression of Na,K‐ATPase alpha subunit isoforms in the human ciliary body and cultured ciliary epithelial cells. Journal Of Cellular Physiology 1989, 141: 243-252. PMID: 2553750, DOI: 10.1002/jcp.1041410203.
- Role of HCO3- in regulation of cytoplasmic pH in ciliary epithelial cellsHelbig H, Korbmacher C, Stumpff F, Coca-Prados M, Wiederholt M. Role of HCO3- in regulation of cytoplasmic pH in ciliary epithelial cells. American Journal Of Physiology 1989, 257: c696-c705. PMID: 2801920, DOI: 10.1152/ajpcell.1989.257.4.c696.
- Volume regulation of cultured, transformed, non-pigmented epithelial cells from human ciliary bodyYantorno R, Coca-Prados M, Krupin T, Civan M. Volume regulation of cultured, transformed, non-pigmented epithelial cells from human ciliary body. Experimental Eye Research 1989, 49: 423-437. PMID: 2477268, DOI: 10.1016/0014-4835(89)90051-1.
- Receptor-mediated phosphoinositide hydrolysis in human ocular ciliary epithelial cells.Wax M, Coca-Prados M. Receptor-mediated phosphoinositide hydrolysis in human ocular ciliary epithelial cells. Investigative Ophthalmology & Visual Science 1989, 30: 1675-9. PMID: 2545648.
- Electrical membrane properties of a cell clone derived from human nonpigmented ciliary epithelium.Helbig H, Korbmacher C, Wohlfarth J, Coca-Prados M, Wiederholt M. Electrical membrane properties of a cell clone derived from human nonpigmented ciliary epithelium. Investigative Ophthalmology & Visual Science 1989, 30: 882-9. PMID: 2470692.
- Effect of acetylcholine on membrane potential of cultured human nonpigmented ciliary epithelial cells.Helbig H, Korbmacher C, Wohlfarth J, Coroneo M, Lindschau C, Quass P, Haller H, Coca-Prados M, Wiederholt M. Effect of acetylcholine on membrane potential of cultured human nonpigmented ciliary epithelial cells. Investigative Ophthalmology & Visual Science 1989, 30: 890-6. PMID: 2722445.
- Intracellular voltage recordings in bovine non-pigmented ciliary epithelial cells in primary cultureHelbig H, Korbmacher C, Wohlfarth J, Coca-Prados M, Wiederholt M. Intracellular voltage recordings in bovine non-pigmented ciliary epithelial cells in primary culture. Current Eye Research 1989, 8: 793-800. PMID: 2791626, DOI: 10.3109/02713688909000869.
- Na+/H+ exchange regulates intracellular pH in a cell clone derived from bovine pigmented ciliary epitheliumHelbig H, Korbmacher C, Stumpff F, Coca‐Prados M, Wiederholt M. Na+/H+ exchange regulates intracellular pH in a cell clone derived from bovine pigmented ciliary epithelium. Journal Of Cellular Physiology 1988, 137: 384-389. PMID: 2848042, DOI: 10.1002/jcp.1041370225.
- Evidence that the α and α(+) isoforms of the catalytic subunit of (Na+,K+)-ATPase reside in distinct ciliary epithelial cells of the mammalian eyeCoca-Prados M, López-Briones L. Evidence that the α and α(+) isoforms of the catalytic subunit of (Na+,K+)-ATPase reside in distinct ciliary epithelial cells of the mammalian eye. Biochemical And Biophysical Research Communications 1987, 145: 460-466. PMID: 3036129, DOI: 10.1016/0006-291x(87)91343-x.
- Transformation of human ciliary epithelial cells by simian virus 40: induction of cell proliferation and retention of beta 2-adrenergic receptors.Coca-Prados M, Wax M. Transformation of human ciliary epithelial cells by simian virus 40: induction of cell proliferation and retention of beta 2-adrenergic receptors. Proceedings Of The National Academy Of Sciences Of The United States Of America 1986, 83: 8754-8758. PMID: 3022303, PMCID: PMC387010, DOI: 10.1073/pnas.83.22.8754.
- Growth of non-pigmented ciliary epithelial cells in serum-free hormone-supplemented mediaCoca-Prados M, Chatt G. Growth of non-pigmented ciliary epithelial cells in serum-free hormone-supplemented media. Experimental Eye Research 1986, 43: 617-629. PMID: 3792464, DOI: 10.1016/s0014-4835(86)80028-8.
- Hormonal Regulation of Vimentin in the Ciliary Epithelium of the Mammalian EyeCOCA‐PRADOS M. Hormonal Regulation of Vimentin in the Ciliary Epithelium of the Mammalian Eye. Annals Of The New York Academy Of Sciences 1985, 455: 682-685. DOI: 10.1111/j.1749-6632.1985.tb50444.x.
- Regulation of protein phosphorylation of the intermediate-sized filament vimentin in the ciliary epithelium of the mammalian eye.Coca-Prados M. Regulation of protein phosphorylation of the intermediate-sized filament vimentin in the ciliary epithelium of the mammalian eye. Journal Of Biological Chemistry 1985, 260: 10332-10338. PMID: 4019517, DOI: 10.1016/s0021-9258(17)39252-9.
- Separation of bovine pigmented ciliary epithelial cells by density gradient and further characterization in cultureCoca-Prados M, Kondo K. Separation of bovine pigmented ciliary epithelial cells by density gradient and further characterization in culture. Experimental Eye Research 1985, 40: 731-739. PMID: 3891394, DOI: 10.1016/0014-4835(85)90142-3.
- Human ciliary epithelia in monolayer cultureKondo K, Coca-Prados M, Sears M. Human ciliary epithelia in monolayer culture. Experimental Eye Research 1984, 38: 423-433. PMID: 6373335, DOI: 10.1016/0014-4835(84)90197-0.
- Ciliary epithelia of the mammalian eye in cultured explantsKondo K, Coca-Prados M, Sears M. Ciliary epithelia of the mammalian eye in cultured explants. Cell And Tissue Research 1983, 233: 629-638. PMID: 6627352, DOI: 10.1007/bf00212230.
- Protein Phosphorylation in Cultured Human Ciliary Epithelia in Response to Activators of Adenylate Cyclase, Cyclic AMP and AnaloguesCoca-Prados M, Kondo K, Sears M. Protein Phosphorylation in Cultured Human Ciliary Epithelia in Response to Activators of Adenylate Cyclase, Cyclic AMP and Analogues. 1983, 1-6. DOI: 10.1007/978-3-642-69096-9_1.
- Intracellular forms of simian virus 40 nucleoprotein complexes. IV. Micrococcal nuclease digestion.Coca-Prados M, Yu H, Hsu M. Intracellular forms of simian virus 40 nucleoprotein complexes. IV. Micrococcal nuclease digestion. Journal Of Virology 1982, 44: 603-9. PMID: 6292520, PMCID: PMC256304, DOI: 10.1128/jvi.44.2.603-609.1982.
- Intracellular forms of simian virus 40 nucleoprotein complexes. III. Study of histone modifications.Coca-Prados M, Vidali G, Hsu M. Intracellular forms of simian virus 40 nucleoprotein complexes. III. Study of histone modifications. Journal Of Virology 1980, 36: 353-60. PMID: 6253661, PMCID: PMC353651, DOI: 10.1128/jvi.36.2.353-360.1980.
- Enzymatic analysis of 5-methylcytosine content in eukaryotic DNA. Study of intracellular Simian Virus 40 DNA.Ford J, Coca-Prados M, Hsu M. Enzymatic analysis of 5-methylcytosine content in eukaryotic DNA. Study of intracellular Simian Virus 40 DNA. Journal Of Biological Chemistry 1980, 255: 7544-7547. PMID: 6249806, DOI: 10.1016/s0021-9258(19)43861-1.
- Electron microscopic evidence for the circular form of RNA in the cytoplasm of eukaryotic cellsHSU M, COCA-PRADOS M. Electron microscopic evidence for the circular form of RNA in the cytoplasm of eukaryotic cells. Nature 1979, 280: 339-340. PMID: 460409, DOI: 10.1038/280339a0.
- Intracellular forms of simian virus 40 nucleoprotein complexes. II. Biochemical and electron microscopic analysis of simian virus 40 virion assembly.Coca-Prados M, Hsu M. Intracellular forms of simian virus 40 nucleoprotein complexes. II. Biochemical and electron microscopic analysis of simian virus 40 virion assembly. Journal Of Virology 1979, 31: 199-208. PMID: 228054, PMCID: PMC353436, DOI: 10.1128/jvi.31.1.199-208.1979.
- Intracellular forms of simian virus 40 nucleoprotein complexes. I. Methods of isolation and characterization in CV-1 cells.Fernandez-Munoz R, Coca-Prados M, Hsu M. Intracellular forms of simian virus 40 nucleoprotein complexes. I. Methods of isolation and characterization in CV-1 cells. Journal Of Virology 1979, 29: 612-23. PMID: 219250, PMCID: PMC353194, DOI: 10.1128/jvi.29.2.612-623.1979.