Michael Krauthammer, MD, PhD
Research & Publications
Biography
News
Research Summary
I conduct research in translational bioinformatics to analyze functional and clinical data linked to human diseases, with a particular focus on skin cancer. Text and image-mining algorithms are used for extracting molecular and phenotypic data from the research literature to generate models of molecular and clinical processes. Such models guide the identification of disease-related genes or pathways from high-throughput functional data.
Specialized Terms: Molecular interaction networks, computational analysis, pathway discovery, knowledge representation; Statistical modeling and analysis; Text mining in biomedicine, term identification, information extraction
Coauthors
Research Interests
Medical Informatics; Pathology; Skin Neoplasms; Models, Statistical; Computational Biology
Selected Publications
- RASopathy Gene Mutations in MelanomaHalaban R, Krauthammer M. RASopathy Gene Mutations in Melanoma. Journal Of Investigative Dermatology 2016, 136: 1755-1759. PMID: 27236105, PMCID: PMC4992636, DOI: 10.1016/j.jid.2016.05.095.
- Exome sequencing identifies recurrent mutations in NF1 and RASopathy genes in sun-exposed melanomasKrauthammer M, Kong Y, Bacchiocchi A, Evans P, Pornputtapong N, Wu C, McCusker JP, Ma S, Cheng E, Straub R, Serin M, Bosenberg M, Ariyan S, Narayan D, Sznol M, Kluger HM, Mane S, Schlessinger J, Lifton RP, Halaban R. Exome sequencing identifies recurrent mutations in NF1 and RASopathy genes in sun-exposed melanomas. Nature Genetics 2015, 47: 996-1002. PMID: 26214590, PMCID: PMC4916843, DOI: 10.1038/ng.3361.
- Exome sequencing identifies recurrent somatic RAC1 mutations in melanomaKrauthammer M, Kong Y, Ha BH, Evans P, Bacchiocchi A, McCusker J, Cheng E, Davis MJ, Goh G, Choi M, Ariyan S, Narayan D, Dutton-Regester K, Capatana A, Holman EC, Bosenberg M, Sznol M, Kluger HM, Brash DE, Stern DF, Materin MA, Lo RS, Mane S, Ma S, Kidd KK, Hayward NK, Lifton RP, Schlessinger J, Boggon TJ, Halaban R. Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma. Nature Genetics 2012, 44: 1006-1014. PMID: 22842228, PMCID: PMC3432702, DOI: 10.1038/ng.2359.
- A semantic web framework to integrate cancer omics data with biological knowledgeHolford ME, McCusker JP, Cheung KH, Krauthammer M. A semantic web framework to integrate cancer omics data with biological knowledge. BMC Bioinformatics 2012, 13: s10. PMID: 22373303, PMCID: PMC3471346, DOI: 10.1186/1471-2105-13-s1-s10.
- Yale Image Finder (YIF): a new search engine for retrieving biomedical imagesXu S, McCusker J, Krauthammer M. Yale Image Finder (YIF): a new search engine for retrieving biomedical images. Bioinformatics 2008, 24: 1968-1970. PMID: 18614584, PMCID: PMC2732221, DOI: 10.1093/bioinformatics/btn340.