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Ruth Halaban, PhD

Senior Research Scientist

Research & Publications
Biography
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Research Summary

Dr. Halaban's research is focused on melanoma and the main interests are: 1) novel mutations that promote melanoma initiations and metastasis; 2) molecular mechanism that leads to melanoma resistance to therapy; 3) new targets for therapy; and 4) the application molecular diagnosis of melanoma in the clinic. Most recently Dr. Halaban has been engaged in sequencing the melanoma exome and transcriptome and relating the mutations to melanoma cell uncontrolled growth and drug response. These studies were facilitated by the Yale SPORE in Skin Cancer (YSPORE), a program funded over the past 19 years by the NCI/NIH. The Tissue Resource Core of the YSPORE, managed by Ms. Antonella Bacchiocchi, has accumulated a large collection of tumor tissues, PBL, serum/plasma, normal skin, and cultured normal melanocytes and melanoma cells. The Core routinely performs targeted sequencing of melanoma oncogenes and validation of exome-capture sequencing data. In addition, the Core records each patient detailed clinical information and treatment outcome. These resources are shared with investigators at Yale, other Skin Cancer SPOREs, nationally and around the world and have been the subject of multiple publications.

Coauthors

Research Interests

Dermatology; Malignant Catarrh; Melanocytes; Melanoma; Pigmentation; Transformation, Genetic; Signal Transduction; Gene Expression; Hyperpigmentation; Cell Proliferation; Histiocytoma, Malignant Fibrous

Selected Publications

Unannotated microprotein EMBOW regulates the interactome and chromatin and mitotic functions of WDR5Chen Y, Su H, Zhao J, Na Z, Jiang K, Bacchiocchi A, Loh K, Halaban R, Wang Z, Cao X, Slavoff S. Unannotated microprotein EMBOW regulates the interactome and chromatin and mitotic functions of WDR5. Cell Reports 2023, 42: 113145. PMID: 37725512, PMCID: PMC10629662, DOI: 10.1016/j.celrep.2023.113145.
CD4 T cells and toxicity from immune checkpoint blockadeEarland N, Zhang W, Usmani A, Nene A, Bacchiocchi A, Chen D, Sznol M, Halaban R, Chaudhuri A, Newman A. CD4 T cells and toxicity from immune checkpoint blockade. Immunological Reviews 2023, 318: 96-109. PMID: 37491734, PMCID: PMC10838135, DOI: 10.1111/imr.13248.
A subset of neutrophils as a predictive biomarker for immunotherapy response in patients with non–small-cell lung cancer and melanoma.Shaked Y, Benguigui M, Halaban R, Bacchiocchi A, Kamer I, Bar J, Lotem M, Shen-Orr S, Sznol M, Cooper T. A subset of neutrophils as a predictive biomarker for immunotherapy response in patients with non–small-cell lung cancer and melanoma. Journal Of Clinical Oncology 2023, 41: 2557-2557. DOI: 10.1200/jco.2023.41.16_suppl.2557.
Abstract 6670: Association between circulating CD4 memory T cell levels and severe immune-related adverse events in melanoma patients treated with immune checkpoint blockadeUsmani A, Earland N, Zhang W, Harris P, Bacchiocchi A, Nene A, Chen D, Sznol M, Halaban R, Newman A, Chaudhuri A. Abstract 6670: Association between circulating CD4 memory T cell levels and severe immune-related adverse events in melanoma patients treated with immune checkpoint blockade. Cancer Research 2023, 83: 6670-6670. DOI: 10.1158/1538-7445.am2023-6670.
Dynamic changes of circulating soluble PD-1/PD-L1 and its association with patient survival in immune checkpoint blockade-treated melanomaLu L, Risch E, Halaban R, Zhen P, Bacchiocchi A, Risch H. Dynamic changes of circulating soluble PD-1/PD-L1 and its association with patient survival in immune checkpoint blockade-treated melanoma. International Immunopharmacology 2023, 118: 110092. PMID: 37004344, DOI: 10.1016/j.intimp.2023.110092.
Abstract 1179: Rational combinations with the dual RAF/MEK inhibitor VS-6766 for treatment of cutaneous melanoma harboring BRAF, NRAS, NF1 or CRAF mutationsBacchiocchi A, Coma S, Chowdhury S, Sznol M, Halaban R, Pachter J. Abstract 1179: Rational combinations with the dual RAF/MEK inhibitor VS-6766 for treatment of cutaneous melanoma harboring BRAF, NRAS, NF1 or CRAF mutations. Cancer Research 2022, 82: 1179-1179. DOI: 10.1158/1538-7445.am2022-1179.
Author Correction: Integrative molecular and clinical profiling of acral melanoma links focal amplification of 22q11.21 to metastasisFarshidfar F, Rhrissorrakrai K, Levovitz C, Peng C, Knight J, Bacchiocchi A, Su J, Yin M, Sznol M, Ariyan S, Clune J, Olino K, Parida L, Nikolaus J, Zhang M, Zhao S, Wang Y, Huang G, Wan M, Li X, Cao J, Yan Q, Chen X, Newman AM, Halaban R. Author Correction: Integrative molecular and clinical profiling of acral melanoma links focal amplification of 22q11.21 to metastasis. Nature Communications 2022, 13: 2704. PMID: 35538087, PMCID: PMC9090916, DOI: 10.1038/s41467-022-30446-w.
Integrative molecular and clinical profiling of acral melanoma links focal amplification of 22q11.21 to metastasisFarshidfar F, Rhrissorrakrai K, Levovitz C, Peng C, Knight J, Bacchiocchi A, Su J, Yin M, Sznol M, Ariyan S, Clune J, Olino K, Parida L, Nikolaus J, Zhang M, Zhao S, Wang Y, Huang G, Wan M, Li X, Cao J, Yan Q, Chen X, Newman AM, Halaban R. Integrative molecular and clinical profiling of acral melanoma links focal amplification of 22q11.21 to metastasis. Nature Communications 2022, 13: 898. PMID: 35197475, PMCID: PMC8866401, DOI: 10.1038/s41467-022-28566-4.
T cell characteristics associated with toxicity to immune checkpoint blockade in patients with melanomaLozano AX, Chaudhuri AA, Nene A, Bacchiocchi A, Earland N, Vesely MD, Usmani A, Turner BE, Steen CB, Luca BA, Badri T, Gulati GS, Vahid MR, Khameneh F, Harris PK, Chen DY, Dhodapkar K, Sznol M, Halaban R, Newman AM. T cell characteristics associated with toxicity to immune checkpoint blockade in patients with melanoma. Nature Medicine 2022, 28: 353-362. PMID: 35027754, PMCID: PMC8866214, DOI: 10.1038/s41591-021-01623-z.
Retrospective cell lineage reconstruction in humans by using short tandem repeatsTao L, Raz O, Marx Z, Ghosh MS, Huber S, Greindl-Junghans J, Biezuner T, Amir S, Milo L, Adar R, Levy R, Onn A, Chapal-Ilani N, Berman V, Arie A, Rom G, Oron B, Halaban R, Czyz ZT, Werner-Klein M, Klein CA, Shapiro E. Retrospective cell lineage reconstruction in humans by using short tandem repeats. Cell Reports Methods 2021, 1: 100054. PMID: 34341783, PMCID: PMC8313865, DOI: 10.1016/j.crmeth.2021.100054.
21 Plasma-based proteomic profiling as a tool for predicting response to immunotherapy in melanoma patientsHarel M, Lahav C, Jacob E, Issler E, Bar H, Dicker A, Sharon O, Bacchiocchi A, Halaban R, Sznol M, Shaked Y. 21 Plasma-based proteomic profiling as a tool for predicting response to immunotherapy in melanoma patients. Journal For ImmunoTherapy Of Cancer 2020, 8: a11-a12. DOI: 10.1136/jitc-2020-sitc2020.0021.
Abstract PR01: Genomic UV-hypersensitive sites as sentinels for personal UV exposurePremi S, Han L, Mehta S, Knight J, Zhao D, Bacchiocchi A, Halaban R, Palmatier M, Kornacker K, Brash D. Abstract PR01: Genomic UV-hypersensitive sites as sentinels for personal UV exposure. Cancer Prevention Research 2020, 13: pr01-pr01. DOI: 10.1158/1940-6215.envcaprev19-pr01.
A proteomic biomarker discovery platform for predicting clinical benefit of immunotherapy in advanced melanoma.Shaked Y, Harel M, Issler E, Fremder E, Jacob E, Dahan N, Bar H, Halaban R, Sznol M, Sharon O. A proteomic biomarker discovery platform for predicting clinical benefit of immunotherapy in advanced melanoma. Journal Of Clinical Oncology 2020, 38: 10037-10037. DOI: 10.1200/jco.2020.38.15_suppl.10037.
A novel anti-melanoma SRC-family kinase inhibitorHalaban R, Bacchiocchi A, Straub R, Cao J, Sznol M, Narayan D, Allam A, Krauthammer M, Mansour TS. A novel anti-melanoma SRC-family kinase inhibitor. Oncotarget 2019, 10: 2237-2251. PMID: 31040916, PMCID: PMC6481345, DOI: 10.18632/oncotarget.26787.
Early B cell changes predict autoimmunity following combination immune checkpoint blockadeDas R, Bar N, Ferreira M, Newman AM, Zhang L, Bailur JK, Bacchiocchi A, Kluger H, Wei W, Halaban R, Sznol M, Dhodapkar MV, Dhodapkar KM. Early B cell changes predict autoimmunity following combination immune checkpoint blockade. Journal Of Clinical Investigation 2018, 128: 715-720. PMID: 29309048, PMCID: PMC5785243, DOI: 10.1172/jci96798.
A Serum Protein Signature Associated with Outcome after Anti–PD-1 Therapy in Metastatic MelanomaWeber JS, Sznol M, Sullivan RJ, Blackmon S, Boland G, Kluger HM, Halaban R, Bacchiocchi A, Ascierto PA, Capone M, Oliveira C, Meyer K, Grigorieva J, Asmellash SG, Roder J, Roder H. A Serum Protein Signature Associated with Outcome after Anti–PD-1 Therapy in Metastatic Melanoma. Cancer Immunology Research 2018, 6: 79-86. PMID: 29208646, DOI: 10.1158/2326-6066.cir-17-0412.
Future perspectives in melanoma research “Melanoma Bridge”, Napoli, November 30th–3rd December 2016Ascierto PA, Agarwala SS, Ciliberto G, Demaria S, Dummer R, Duong CPM, Ferrone S, Formenti SC, Garbe C, Halaban R, Khleif S, Luke JJ, Mir LM, Overwijk WW, Postow M, Puzanov I, Sondel P, Taube JM, Thor Straten P, Stroncek DF, Wargo JA, Zarour H, Thurin M. Future perspectives in melanoma research “Melanoma Bridge”, Napoli, November 30th–3rd December 2016. Journal Of Translational Medicine 2017, 15: 236. PMID: 29145885, PMCID: PMC5691855, DOI: 10.1186/s12967-017-1341-2.
ISY9-3 Proteomic and T cell biomarkers identify sensitivity and resistance to immunotherapy in cancer patientsWeber J, Woods D, Laino A, Kluger H, Halaban R, Sznol M, Roder H, Roder J, Blackmon K, Sullivan R. ISY9-3 Proteomic and T cell biomarkers identify sensitivity and resistance to immunotherapy in cancer patients. Annals Of Oncology 2017, 28: ix21. DOI: 10.1093/annonc/mdx553.001.
Changes in serum interleukin-8 (IL-8) levels reflect and predict response to anti-PD-1 treatment in melanoma and non-small-cell lung cancer patientsSanmamed MF, Perez-Gracia JL, Schalper KA, Fusco JP, Gonzalez A, Rodriguez-Ruiz ME, Oñate C, Perez G, Alfaro C, Martín-Algarra S, Andueza MP, Gurpide A, Morgado M, Wang J, Bacchiocchi A, Halaban R, Kluger H, Chen L, Sznol M, Melero I. Changes in serum interleukin-8 (IL-8) levels reflect and predict response to anti-PD-1 treatment in melanoma and non-small-cell lung cancer patients. Annals Of Oncology 2017, 28: 1988-1995. PMID: 28595336, PMCID: PMC5834104, DOI: 10.1093/annonc/mdx190.
513 GNA14 somatic mutation causes congenital and sporadic vascular tumors by MAPK activationLim Y, Bacchiocchi A, Qiu J, Bruckner A, Bercovitch L, Narayan D, McNiff J, Ko C, Robinson-Bostom L, Antaya R, Halaban R, Choate K. 513 GNA14 somatic mutation causes congenital and sporadic vascular tumors by MAPK activation. Journal Of Investigative Dermatology 2017, 137: s88. DOI: 10.1016/j.jid.2017.02.533.
Abstracts from the 4th ImmunoTherapy of Cancer ConferenceŽenka J, Caisová V, Uher O, Nedbalová P, Kvardová K, Masáková K, Krejčová G, Paďouková L, Jochmanová I, Wolf K, Chmelař J, Kopecký J, Loumagne L, Mestadier J, D’agostino S, Rohaut A, Ruffin Y, Croize V, Lemaître O, Sidhu S, Althammer S, Steele K, Rebelatto M, Tan T, Wiestler T, Spitzmueller A, Korn R, Schmidt G, Higgs B, Li X, Shi L, Jin X, Ranade K, Koeck S, Amann A, Gamerith G, Zwierzina M, Lorenz E, Zwierzina H, Kern J, Riva M, Baert T, Coosemans A, Giovannoni R, Radaelli E, Gsell W, Himmelreich U, Van Ranst M, Xing F, Qian W, Dong C, Xu X, Guo S, Shi Q, Quandt D, Seliger B, Plett C, Amberger D, Rabe A, Deen D, Stankova Z, Hirn A, Vokac Y, Werner J, Krämer D, Rank A, Schmid C, Schmetzer H, Guerin M, Weiss J, Regnier F, Renault G, Vimeux L, Peranzoni E, Feuillet V, Thoreau M, Guilbert T, Trautmann A, Bercovici N, Amberger D, Doraneh-Gard F, Boeck C, Plett C, Gunsilius C, Kugler C, Werner J, Schmohl J, Kraemer D, Ismann B, Rank A, Schmid C, Schmetzer H, Markota A, Ochs C, May P, Gottschlich A, Gosálvez J, Karches C, Wenk D, Endres S, Kobold S, Hilmenyuk T, Klar R, Jaschinski F, Gamerith G, Augustin F, Lorenz E, Manzl C, Hoflehner E, Moser P, Zelger B, Köck S, Amann A, Kern J, Schäfer G, Öfner D, Maier H, Zwierzina H, Sopper S, Prado-Garcia H, Romero-Garcia S, Sandoval-Martínez R, Puerto-Aquino A, Lopez-Gonzalez J, Rumbo-Nava U, Klar R, Hilmenyuk T, Jaschinski F, Coosemans A, Baert T, Van Hoylandt A, Busschaert P, Vergote I, Baert T, Van Hoylandt A, Busschaert P, Vergote I, Coosemans A, Laengle J, Pilatova K, Budinska E, Bencsikova B, Sefr R, Nenutil R, Brychtova V, Fedorova L, Hanakova B, Zdrazilova-Dubska L, Allen C, Ku Y, Tom W, Sun Y, Pankov A, Looney T, Hyland F, Au-Young J, Mongan A, Becker A, Tan J, Chen A, Lawson K, Lindsey E, Powers J, Walters M, Schindler U, Young S, Jaen J, Yin S, Chen Y, Gullo I, Gonçalves G, Pinto M, Athelogou M, Almeida G, Huss R, Oliveira C, Carneiro F, Merz C, Sykora J, Hermann K, Hussong R, Richards D, Fricke H, Hill O, Gieffers C, Pinho M, Barbuto J, McArdle S, Foulds G, Vadakekolathu J, Abdel-Fatah T, Johnson C, Hood S, Moseley P, Rees R, Chan S, Pockley A, Rutella S, Geppert C, Hartmann A, Kumar K, Gokilavani M, Wang S, Merz C, Richards D, Sykora J, Redondo-Müller M, Heinonen K, Marschall V, Thiemann M, Fricke H, Gieffers C, Hill O, Zhang L, Mao B, Jin Y, Zhai G, Li Z, Wang Z, Qian W, An X, Qiao M, Zhang J, Shi Q, Weber J, Kluger H, Halaban R, Sznol M, Roder H, Roder J, Grigorieva J, Asmellash S, Oliveira C, Meyer K, Steingrimsson A, Blackmon S, Sullivan R, Boeck C, Amberger D, Doraneh-Gard F, Sutanto W, Guenther T, Schmohl J, Schuster F, Salih H, Babor F, Borkhardt A, Schmetzer H, Kim Y, Oh I, Park C, Ahn S, Na K, Song S, Choi Y, Fedorova L, Poprach A, Lakomy R, Selingerova I, Demlova R, Pilatova K, Kozakova S, Valik D, Petrakova K, Vyzula R, Zdrazilova-Dubska L, Aguilar-Cazares D, Galicia-Velasco M, Camacho-Mendoza C, Islas-Vazquez L, Chavez-Dominguez R, Gonzalez-Gonzalez C, Prado-Garcia H, Lopez-Gonzalez J, Yang S, Moynihan K, Noh M, Bekdemir A, Stellacci F, Irvine D, Volz B, Kapp K, Oswald D, Wittig B, Schmidt M, Chavez-Dominguez R, Aguilar-Cazares D, Prado-Garcia H, Islas-Vazquez L, Lopez-Gonzalez J, Kleef R, Bohdjalian A, McKee D, Moss R, Saeed M, Zalba S, Debets R, ten Hagen T, Javed S, Becher J, Koch-Nolte F, Haag F, Gordon E, Sankhala K, Stumpf N, Tseng W, Chawla S, Suárez N, Báez G, Rodríguez M, Pérez A, García L, Fernández D, Pous J, Ramírez B, Jacoberger-Foissac C, Saliba H, Seguin C, Brion A, Frisch B, Fournel S, Heurtault B, Otterhaug T, Håkerud M, Nedberg A, Edwards V, Selbo P, Høgset A, Jaitly T, Dörrie J, Schaft N, Gross S, Schuler-Thurner B, Gupta S, Taher L, Schuler G, Vera J, Rataj F, Kraus F, Grassmann S, Chaloupka M, Lesch S, Heise C, Endres S, Kobold S, Cadilha B, Dorman K, Heise C, Rataj F, Endres S, Kobold S. Abstracts from the 4th ImmunoTherapy of Cancer Conference. Journal For ImmunoTherapy Of Cancer 2017, 5: 12. PMCID: PMC5374589, DOI: 10.1186/s40425-017-0219-4.
Single-cell cytokine profiling of tumor-infiltrating T cells to measure patient responses to anti-PD-1 therapy.Mackay S, Flynn B, Morse K, Paczkowski P, Bacchiocchi A, Fan R, Halaban R, Zhou J. Single-cell cytokine profiling of tumor-infiltrating T cells to measure patient responses to anti-PD-1 therapy. Journal Of Clinical Oncology 2017, 35: 49-49. DOI: 10.1200/jco.2017.35.7_suppl.49.
Distinct dominant T-cell receptors with a tissue resident memory phenotype in individual melanoma metastases.Dhodapkar K, Boddupalli C, Bar N, Kadaveru K, Krauthammer M, Pornputtapong N, Mai Z, Ariyan S, Narayan D, Kluger H, Deng Y, Verma R, Das R, Bacchiocchi A, Halaban R, Sznol M, Dhodapkar M. Distinct dominant T-cell receptors with a tissue resident memory phenotype in individual melanoma metastases. Journal Of Clinical Oncology 2017, 35: 3-3. DOI: 10.1200/jco.2017.35.7_suppl.3.
Spitz nevi and Spitzoid melanomas: exome sequencing and comparison with conventional melanocytic nevi and melanomasLazova R, Pornputtapong N, Halaban R, Bosenberg M, Bai Y, Chai H, Krauthammer M. Spitz nevi and Spitzoid melanomas: exome sequencing and comparison with conventional melanocytic nevi and melanomas. Modern Pathology 2017, 30: 640-649. PMID: 28186096, PMCID: PMC5413430, DOI: 10.1038/modpathol.2016.237.
Interlesional diversity of T cell receptors in melanoma with immune checkpoints enriched in tissue-resident memory T cellsBoddupalli CS, Bar N, Kadaveru K, Krauthammer M, Pornputtapong N, Mai Z, Ariyan S, Narayan D, Kluger H, Deng Y, Verma R, Das R, Bacchiocchi A, Halaban R, Sznol M, Dhodapkar MV, Dhodapkar KM. Interlesional diversity of T cell receptors in melanoma with immune checkpoints enriched in tissue-resident memory T cells. JCI Insight 2016, 1: e88955. PMID: 28018970, PMCID: PMC5161225, DOI: 10.1172/jci.insight.88955.
La perte d’expression de l’adénylate cyclase soluble facilite la transformation tumorale des mélanocytesNardin C, Saviola A, Park M, Bacchiocchi A, Halaban R, Zippin J. La perte d’expression de l’adénylate cyclase soluble facilite la transformation tumorale des mélanocytes. Annales De Dermatologie Et De Vénéréologie 2016, 143: s427. DOI: 10.1016/j.annder.2016.09.068.
31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part oneLundqvist A, van Hoef V, Zhang X, Wennerberg E, Lorent J, Witt K, Sanz L, Liang S, Murray S, Larsson O, Kiessling R, Mao Y, Sidhom J, Bessell C, Havel J, Schneck J, Chan T, Sachsenmeier E, Woods D, Berglund A, Ramakrishnan R, Sodre A, Weber J, Zappasodi R, Li Y, Qi J, Wong P, Sirard C, Postow M, Newman W, Koon H, Velcheti V, Callahan M, Wolchok J, Merghoub T, Lum L, Choi M, Thakur A, Deol A, Dyson G, Shields A, Haymaker C, Uemura M, Murthy R, James M, Wang D, Brevard J, Monaghan C, Swann S, Geib J, Cornfeld M, Chunduru S, Agrawal S, Yee C, Wargo J, Patel S, Amaria R, Tawbi H, Glitza I, Woodman S, Hwu W, Davies M, Hwu P, Overwijk W, Bernatchez C, Diab A, Massarelli E, Segal N, Ribrag V, Melero I, Gangadhar T, Urba W, Schadendorf D, Ferris R, Houot R, Morschhauser F, Logan T, Luke J, Sharfman W, Barlesi F, Ott P, Mansi L, Kummar S, Salles G, Carpio C, Meier R, Krishnan S, McDonald D, Maurer M, Gu X, Neely J, Suryawanshi S, Levy R, Khushalani N, Wu J, Zhang J, Basher F, Rubinstein M, Bucsek M, Qiao G, MacDonald C, Hylander B, Repasky E, Chatterjee S, Daenthanasanmak A, Chakraborty P, Toth K, Meek M, Garrett-Mayer E, Nishimura M, Paulos C, Beeson C, Yu X, Mehrotra S, Zhao F, Evans K, Xiao C, Holtzhausen A, Hanks B, Scharping N, Menk A, Moreci R, Whetstone R, Dadey R, Watkins S, Ferris R, Delgoffe G, Peled J, Devlin S, Staffas A, Lumish M, Rodriguez K, Ahr K, Perales M, Giralt S, Taur Y, Pamer E, van den Brink M, Jenq R, Annels N, Pandha H, Simpson G, Mostafid H, Harrington K, Melcher A, Grose M, Davies B, Au G, Karpathy R, Shafren D, Ricca J, Merghoub T, Wolchok J, Zamarin D, Batista L, Marliot F, Vasaturo A, Carpentier S, Poggionovo C, Frayssinet V, Fieschi J, Van den Eynde M, Pagès F, Galon J, Hermitte F, Smith S, Nguyen K, Ravindranathan S, Koppolu B, Zaharoff D, Schvartsman G, Bassett R, McQuade J, Haydu L, Davies M, Tawbi H, Glitza I, Kline D, Chen X, Fosco D, Kline J, Overacre A, Chikina M, Brunazzi E, Shayan G, Horne W, Kolls J, Ferris R, Delgoffe G, Bruno T, Workman C, Vignali D, Adusumilli P, Ansa-Addo E, Li Z, Gerry A, Sanderson J, Howe K, Docta R, Gao Q, Bagg E, Tribble N, Maroto M, Betts G, Bath N, Melchiori L, Lowther D, Ramachandran I, Kari G, Basu S, Binder-Scholl G, Chagin K, Pandite L, Holdich T, Amado R, Zhang H, Glod J, Bernstein D, Jakobsen B, Mackall C, Wong R, Silk J, Adams K, Hamilton G, Bennett A, Brett S, Jing J, Quattrini A, Saini M, Wiedermann G, Gerry A, Jakobsen B, Binder-Scholl G, Brewer J, Duong M, Lu A, Chang P, Mahendravada A, Shinners N, Slawin K, Spencer D, Foster A, Bayle J, Bergamaschi C, Ng S, Nagy B, Jensen S, Hu X, Alicea C, Fox B, Felber B, Pavlakis G, Chacon J, Yamamoto T, Garrabrant T, Cortina L, Powell D, Donia M, Kjeldsen J, Andersen R, Westergaard M, Bianchi V, Legut M, Attaf M, Dolton G, Szomolay B, Ott S, Lyngaa R, Hadrup S, Sewell A, Svane I, Fan A, Kumai T, Celis E, Frank I, Stramer A, Blaskovich M, Wardell S, Fardis M, Bender J, Lotze M, Goff S, Zacharakis N, Assadipour Y, Prickett T, Gartner J, Somerville R, Black M, Xu H, Chinnasamy H, Kriley I, Lu L, Wunderlich J, Robbins P, Rosenberg S, Feldman S, Trebska-McGowan K, Kriley I, Malekzadeh P, Payabyab E, Sherry R, Rosenberg S, Goff S, Gokuldass A, Blaskovich M, Kopits C, Rabinovich B, Lotze M, Green D, Kamenyeva O, Zoon K, Annunziata C, Hammill J, Helsen C, Aarts C, Bramson J, Harada Y, Yonemitsu Y, Helsen C, Hammill J, Mwawasi K, Denisova G, Bramson J, Giri R, Jin B, Campbell T, Draper L, Stevanovic S, Yu Z, Weissbrich B, Restifo N, Trimble C, Rosenberg S, Hinrichs C, Tsang K, Fantini M, Hodge J, Fujii R, Fernando I, Jochems C, Heery C, Gulley J, Soon-Shiong P, Schlom J, Jing W, Gershan J, Blitzer G, Weber J, McOlash L, Johnson B, Kiany S, Gangxiong H, Kleinerman E, Klichinsky M, Ruella M, Shestova O, Kenderian S, Kim M, Scholler J, June C, Gill S, Moogk D, Zhong S, Yu Z, Liadi I, Rittase W, Fang V, Dougherty J, Perez-Garcia A, Osman I, Zhu C, Varadarajan N, Restifo N, Frey A, Krogsgaard M, Landi D, Fousek K, Mukherjee M, Shree A, Joseph S, Bielamowicz K, Byrd T, Ahmed N, Hegde M, Lee S, Byrd D, Thompson J, Bhatia S, Tykodi S, Delismon J, Chu L, Abdul-Alim S, Ohanian A, DeVito A, Riddell S, Margolin K, Magalhaes I, Mattsson J, Uhlin M, Nemoto S, Villarroel P, Nakagawa R, Mule J, Mailloux A, Mata M, Nguyen P, Gerken C, DeRenzo C, Spencer D, Gottschalk S, Mathieu M, Pelletier S, Stagg J, Turcotte S, Minutolo N, Sharma P, Tsourkas A, Powell D, Mockel-Tenbrinck N, Mauer D, Drechsel K, Barth C, Freese K, Kolrep U, Schult S, Assenmacher M, Kaiser A, Mullinax J, Hall M, Le J, Kodumudi K, Royster E, Richards A, Gonzalez R, Sarnaik A, Pilon-Thomas S, Nielsen M, Krarup-Hansen A, Hovgaard D, Petersen M, Loya A, Junker N, Svane I, Rivas C, Parihar R, Gottschalk S, Rooney C, Qin H, Nguyen S, Su P, Burk C, Duncan B, Kim B, Kohler M, Fry T, Rao A, Teyssier N, Pfeil J, Sgourakis N, Salama S, Haussler D, Richman S, Nunez-Cruz S, Gershenson Z, Mourelatos Z, Barrett D, Grupp S, Milone M, Rodriguez-Garcia A, Robinson M, Adams G, Powell D, Santos J, Havunen R, Siurala M, Cervera-Carrascón V, Parviainen S, Antilla M, Hemminki A, Sethuraman J, Santiago L, Chen J, Dai Z, Wardell S, Bender J, Lotze M, Sha H, Su S, Ding N, Liu B, Stevanovic S, Pasetto A, Helman S, Gartner J, Prickett T, Robbins P, Rosenberg S, Hinrichs C, Bhatia S, Burgess M, Zhang H, Lee T, Klingemann H, Soon-Shiong P, Nghiem P, Kirkwood J, Rossi J, Sherman M, Xue A, Shen Y, Navale L, Rosenberg S, Kochenderfer J, Bot A, Veerapathran A, Gokuldass A, Stramer A, Sethuraman J, Blaskovich M, Wiener D, Frank I, Santiago L, Rabinovich B, Fardis M, Bender J, Lotze M, Waller E, Li J, Petersen C, Blazar B, Li J, Giver C, Wang Z, Grossenbacher S, Sturgill I, Canter R, Murphy W, Zhang C, Burger M, Jennewein L, Waldmann A, Mittelbronn M, Tonn T, Steinbach J, Wels W, Williams J, Zha Y, Gajewski T, Williams L, Krenciute G, Kalra M, Louis C, 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Journal For ImmunoTherapy Of Cancer 2016, 4: 82. PMCID: PMC5123387, DOI: 10.1186/s40425-016-0172-7.
1055O Changes in serum IL8 levels reflect and predict response to anti-PD-1 treatment in melanoma and non-small cell lung cancer patientsSanmamed M, Perez-Gracia J, Fusco J, Oñate C, Perez G, Alfaro C, Martín-Algarra S, González A, Rodriguez-Ruiz M, Andueza M, Wang J, Bacchiocchi A, Halaban R, Kluger H, Sznol M, Melero I. 1055O Changes in serum IL8 levels reflect and predict response to anti-PD-1 treatment in melanoma and non-small cell lung cancer patients. Annals Of Oncology 2016, 27: vi359. DOI: 10.1093/annonc/mdw378.03.
A generic, cost-effective, and scalable cell lineage analysis platformBiezuner T, Spiro A, Raz O, Amir S, Milo L, Adar R, Chapal-Ilani N, Berman V, Fried Y, Ainbinder E, Cohen G, Barr H, Halaban R, Shapiro E. A generic, cost-effective, and scalable cell lineage analysis platform. Genome Research 2016, 26: 1588-1599. PMID: 27558250, PMCID: PMC5088600, DOI: 10.1101/gr.202903.115.
GNA14 Somatic Mutation Causes Congenital and Sporadic Vascular Tumors by MAPK ActivationLim YH, Bacchiocchi A, Qiu J, Straub R, Bruckner A, Bercovitch L, Narayan D, Genomics Y, McNiff J, Ko C, Robinson-Bostom L, Antaya R, Halaban R, Choate KA. GNA14 Somatic Mutation Causes Congenital and Sporadic Vascular Tumors by MAPK Activation. American Journal Of Human Genetics 2016, 99: 443-450. PMID: 27476652, PMCID: PMC4974082, DOI: 10.1016/j.ajhg.2016.06.010.
Germline MC1R status influences somatic mutation burden in melanomaRobles-Espinoza CD, Roberts ND, Chen S, Leacy FP, Alexandrov LB, Pornputtapong N, Halaban R, Krauthammer M, Cui R, Timothy Bishop D, Adams DJ. Germline MC1R status influences somatic mutation burden in melanoma. Nature Communications 2016, 7: 12064. PMID: 27403562, PMCID: PMC4945874, DOI: 10.1038/ncomms12064.
RASopathy Gene Mutations in MelanomaHalaban R, Krauthammer M. RASopathy Gene Mutations in Melanoma. Journal Of Investigative Dermatology 2016, 136: 1755-1759. PMID: 27236105, PMCID: PMC4992636, DOI: 10.1016/j.jid.2016.05.095.
625 Loss of soluble adenylyl cyclase is a marker of invasive melanoma and facilitates melanomagenesisLevy J, Saviola A, Halaban R, Bacchiocchi A, Magro C, Saab J, Merghoub T, Zhou D, Zippin J. 625 Loss of soluble adenylyl cyclase is a marker of invasive melanoma and facilitates melanomagenesis. Journal Of Investigative Dermatology 2016, 136: s111. DOI: 10.1016/j.jid.2016.02.665.
606 The pH sensor soluble adenylyl cyclase regulates melanogenesisZhou D, Halaban R, Bacchiocchi A, Nardin C, Zippin J. 606 The pH sensor soluble adenylyl cyclase regulates melanogenesis. Journal Of Investigative Dermatology 2016, 136: s108. DOI: 10.1016/j.jid.2016.02.646.
AMPK promotes tolerance to Ras pathway inhibition by activating autophagySanduja S, Feng Y, Mathis RA, Sokol ES, Reinhardt F, Halaban R, Gupta PB. AMPK promotes tolerance to Ras pathway inhibition by activating autophagy. Oncogene 2016, 35: 5295-5303. PMID: 27041569, PMCID: PMC6086350, DOI: 10.1038/onc.2016.70.
Pre-treatment patient selection for nivolumab benefit based on serum mass spectraWeber J, Martinez A, Roder H, Roder J, Meyer K, Asmellash S, Grigorieva J, Tsypin M, Oliveira C, Steingrimsson A, Sayers K, Bacchiocchi A, Sznol M, Halaban R, Kluger H. Pre-treatment patient selection for nivolumab benefit based on serum mass spectra. Journal For ImmunoTherapy Of Cancer 2015, 3: p103. PMCID: PMC4645498, DOI: 10.1186/2051-1426-3-s2-p103.
Abstract LB-104: Excited electrons in melanin induce cyclobutane dimers in the darkPremi S, Wallisch S, Mano C, Weiner A, Bacchiocchi A, Wakamatsu K, Bechara E, Halaban R, Douki T, Brash D. Abstract LB-104: Excited electrons in melanin induce cyclobutane dimers in the dark. 2015, lb-104-lb-104. DOI: 10.1158/1538-7445.am2015-lb-104.
Exome sequencing identifies recurrent mutations in NF1 and RASopathy genes in sun-exposed melanomasKrauthammer M, Kong Y, Bacchiocchi A, Evans P, Pornputtapong N, Wu C, McCusker JP, Ma S, Cheng E, Straub R, Serin M, Bosenberg M, Ariyan S, Narayan D, Sznol M, Kluger HM, Mane S, Schlessinger J, Lifton RP, Halaban R. Exome sequencing identifies recurrent mutations in NF1 and RASopathy genes in sun-exposed melanomas. Nature Genetics 2015, 47: 996-1002. PMID: 26214590, PMCID: PMC4916843, DOI: 10.1038/ng.3361.
Rôle de l’adénylate cyclase soluble dans la mélanomagenèseNardin C, Park M, Bacchiocchi A, Halaban R. Rôle de l’adénylate cyclase soluble dans la mélanomagenèse. Annales De Dermatologie Et De Vénéréologie 2015, 142: s283. DOI: 10.1016/j.annder.2015.04.021.
Genomic Classification of Cutaneous MelanomaNetwork T, Akbani R, Akdemir K, Aksoy B, Albert M, Ally A, Amin S, Arachchi H, Arora A, Auman J, Ayala B, Baboud J, Balasundaram M, Balu S, Barnabas N, Bartlett J, Bartlett P, Bastian B, Baylin S, Behera M, Belyaev D, Benz C, Bernard B, Beroukhim R, Bir N, Black A, Bodenheimer T, Boice L, Boland G, Bono R, Bootwalla M, Bosenberg M, Bowen J, Bowlby R, Bristow C, Brockway-Lunardi L, Brooks D, Brzezinski J, Bshara W, Buda E, Burns W, Butterfield Y, Button M, Calderone T, Cappellini G, Carter C, Carter S, Cherney L, Cherniack A, Chevalier A, Chin L, Cho J, Cho R, Choi Y, Chu A, Chudamani S, Cibulskis K, Ciriello G, Clarke A, Coons S, Cope L, Crain D, Curley E, Danilova L, D’Atri S, Davidsen T, Davies M, Delman K, Demchok J, Deng Q, Deribe Y, Dhalla N, Dhir R, DiCara D, Dinikin M, Dubina M, Ebrom J, Egea S, Eley G, Engel J, Eschbacher J, Fedosenko K, Felau I, Fennell T, Ferguson M, Fisher S, Flaherty K, Frazer S, Frick J, Fulidou V, Gabriel S, Gao J, Gardner J, Garraway L, Gastier-Foster J, Gaudioso C, Gehlenborg N, Genovese G, Gerken M, Gershenwald J, Getz G, Gomez-Fernandez C, Gribbin T, Grimsby J, Gross B, Guin R, Gutschner T, Hadjipanayis A, Halaban R, Hanf B, Haussler D, Haydu L, Hayes D, Hayward N, Heiman D, Herbert L, Herman J, Hersey P, Hoadley K, Hodis E, Holt R, Hoon D, Hoppough S, Hoyle A, Huang F, Huang M, Huang S, Hutter C, Ibbs M, Iype L, Jacobsen A, Jakrot V, Janning A, Jeck W, Jefferys S, Jensen M, Jones C, Jones S, Ju Z, Kakavand H, Kang H, Kefford R, Khuri F, Kim J, Kirkwood J, Klode J, Korkut A, Korski K, Krauthammer M, Kucherlapati R, Kwong L, Kycler W, Ladanyi M, Lai P, Laird P, Lander E, Lawrence M, Lazar A, Łaźniak R, Lee D, Lee J, Lee J, Lee K, Lee S, Lee W, Leporowska E, Leraas K, Li H, Lichtenberg T, Lichtenstein L, Lin P, Ling S, Liu J, Liu O, Liu W, Long G, Lu Y, Ma, Ma Y, Mackiewicz A, Mahadeshwar H, Malke J, Mallery D, Manikhas G, Mann G, Marra M, Matejka B, Mayo M, Mehrabi S, Meng S, Meyerson M, Mieczkowski P, Miller J, Miller M, Mills G, Moiseenko F, Moore R, Morris S, Morrison C, Morton D, Moschos S, Mose L, Muller F, Mungall A, Murawa D, Murawa P, Murray B, Nezi L, Ng S, Nicholson D, Noble M, Osunkoya A, Owonikoko T, Ozenberger B, Pagani E, Paklina O, Pantazi A, Parfenov M, Parfitt J, Park P, Park W, Parker J, Passarelli F, Penny R, Perou C, Pihl T, Potapova O, Prieto V, Protopopov A, Quinn M, Radenbaugh A, Rai K, Ramalingam S, Raman A, Ramirez N, Ramirez R, Rao U, Rathmell W, Ren X, Reynolds S, Roach J, Robertson A, Ross M, Roszik J, Russo G, Saksena G, Saller C, Samuels Y, Sander C, Sander C, Sandusky G, Santoso N, Saul M, Saw R, Schadendorf D, Schein J, Schultz N, Schumacher S, Schwallier C, Scolyer R, Seidman J, Sekhar P, Sekhon H, Senbabaoglu Y, Seth S, Shannon K, Sharpe S, Sharpless N, Shaw K, Shelton C, Shelton T, Shen R, Sheth M, Shi Y, Shiau C, Shmulevich I, Sica G, Simons J, Sinha R, Sipahimalani P, Sofia H, Soloway M, Song X, Sougnez C, Spillane A, Spychała A, Stretch J, Stuart J, Suchorska W, Sucker A, Sumer S, Sun Y, Synott M, Tabak B, Tabler T, Tam A, Tan D, Tang J, Tarnuzzer R, Tarvin K, Tatka H, Taylor B, Teresiak M, Thiessen N, Thompson J, Thorne L, Thorsson V, Trent J, Triche T, Tsai K, Tsou P, Van Den Berg D, Van Allen E, Veluvolu U, Verhaak R, Voet D, Voronina O, Walter V, Walton J, Wan Y, Wang Y, Wang Z, Waring S, Watson I, Weinhold N, Weinstein J, Weisenberger D, White P, Wilkerson M, Wilmott J, Wise L, Wiznerowicz M, Woodman S, Wu C, Wu C, Wu J, Wu Y, Xi R, Xu A, Yang D, Yang L, Yang L, Zack T, Zenklusen J, Zhang H, Zhang J, Zhang W, Zhao X, Zhu J, Zhu K, Zimmer L, Zmuda E, Zou L. Genomic Classification of Cutaneous Melanoma. Cell 2015, 161: 1681-1696. PMID: 26091043, PMCID: PMC4580370, DOI: 10.1016/j.cell.2015.05.044.
Downregulation of the Ubiquitin Ligase RNF125 Underlies Resistance of Melanoma Cells to BRAF Inhibitors via JAK1 DeregulationKim H, Frederick DT, Levesque MP, Cooper ZA, Feng Y, Krepler C, Brill L, Samuels Y, Hayward NK, Perlina A, Piris A, Zhang T, Halaban R, Herlyn MM, Brown KM, Wargo JA, Dummer R, Flaherty KT, Ronai Z. Downregulation of the Ubiquitin Ligase RNF125 Underlies Resistance of Melanoma Cells to BRAF Inhibitors via JAK1 Deregulation. Cell Reports 2015, 11: 1458-1473. PMID: 26027934, PMCID: PMC4681438, DOI: 10.1016/j.celrep.2015.04.049.
PLEKHA5 as a Biomarker and Potential Mediator of Melanoma Brain MetastasisJilaveanu LB, Parisi F, Barr ML, Zito CR, Cruz-Munoz W, Kerbel RS, Rimm DL, Bosenberg MW, Halaban R, Kluger Y, Kluger HM. PLEKHA5 as a Biomarker and Potential Mediator of Melanoma Brain Metastasis. Clinical Cancer Research 2015, 21: 2138-2147. PMID: 25316811, PMCID: PMC4397107, DOI: 10.1158/1078-0432.ccr-14-0861.
PDK1 and SGK3 Contribute to the Growth of BRAF-Mutant Melanomas and Are Potential Therapeutic TargetsScortegagna M, Lau E, Zhang T, Feng Y, Sereduk C, Yin H, De SK, Meeth K, Platt JT, Langdon CG, Halaban R, Pellecchia M, Davies MA, Brown K, Stern DF, Bosenberg M, Ronai ZA. PDK1 and SGK3 Contribute to the Growth of BRAF-Mutant Melanomas and Are Potential Therapeutic Targets. Cancer Research 2015, 75: 1399-1412. PMID: 25712345, PMCID: PMC4383687, DOI: 10.1158/0008-5472.can-14-2785.
Chemiexcitation of melanin derivatives induces DNA photoproducts long after UV exposurePremi S, Wallisch S, Mano CM, Weiner AB, Bacchiocchi A, Wakamatsu K, Bechara EJ, Halaban R, Douki T, Brash DE. Chemiexcitation of melanin derivatives induces DNA photoproducts long after UV exposure. Science 2015, 347: 842-847. PMID: 25700512, PMCID: PMC4432913, DOI: 10.1126/science.1256022.
Combination Therapy with Anti–CTLA-4 and Anti–PD-1 Leads to Distinct Immunologic Changes In VivoDas R, Verma R, Sznol M, Boddupalli CS, Gettinger SN, Kluger H, Callahan M, Wolchok JD, Halaban R, Dhodapkar MV, Dhodapkar KM. Combination Therapy with Anti–CTLA-4 and Anti–PD-1 Leads to Distinct Immunologic Changes In Vivo. The Journal Of Immunology 2015, 194: 950-959. PMID: 25539810, PMCID: PMC4380504, DOI: 10.4049/jimmunol.1401686.
RAC1 and MelanomaHalaban R. RAC1 and Melanoma. Clinical Therapeutics 2014, 37: 682-685. PMID: 25465943, PMCID: PMC4415501, DOI: 10.1016/j.clinthera.2014.10.027.
Future perspectives in melanoma research: meeting report from the "Melanoma Bridge", Napoli, December 5th-8th 2013Ascierto PA, Grimaldi AM, Anderson AC, Bifulco C, Cochran A, Garbe C, Eggermont AM, Faries M, Ferrone S, Gershenwald JE, Gajewski TF, Halaban R, Hodi FS, Kefford R, Kirkwood JM, Larkin J, Leachman S, Maio M, Marais R, Masucci G, Melero I, Palmieri G, Puzanov I, Ribas A, Saenger Y, Schilling B, Seliger B, Stroncek D, Sullivan R, Testori A, Wang E, Ciliberto G, Mozzillo N, Marincola FM, Thurin M. Future perspectives in melanoma research: meeting report from the "Melanoma Bridge", Napoli, December 5th-8th 2013. Journal Of Translational Medicine 2014, 12: 277. PMID: 25348889, PMCID: PMC4232645, DOI: 10.1186/s12967-014-0277-z.
Rare SF3B1 R625 mutations in cutaneous melanomaKong Y, Krauthammer M, Halaban R. Rare SF3B1 R625 mutations in cutaneous melanoma. Melanoma Research 2014, 24: 332-334. PMID: 24709888, PMCID: PMC4101881, DOI: 10.1097/cmr.0000000000000071.
Identification of PLX4032‐resistance mechanisms and implications for novel RAF inhibitorsChoi J, Landrette SF, Wang T, Evans P, Bacchiocchi A, Bjornson R, Cheng E, Stiegler AL, Gathiaka S, Acevedo O, Boggon TJ, Krauthammer M, Halaban R, Xu T. Identification of PLX4032‐resistance mechanisms and implications for novel RAF inhibitors. Pigment Cell & Melanoma Research 2014, 27: 253-262. PMID: 24283590, PMCID: PMC4065135, DOI: 10.1111/pcmr.12197.
Clonal growth of human melanocytes using cell‐free extracellular matrixZhang R, Premi S, Kilic SS, Bacchiocchi A, Halaban R, Brash DE. Clonal growth of human melanocytes using cell‐free extracellular matrix. Pigment Cell & Melanoma Research 2013, 26: 925-927. PMID: 24034857, PMCID: PMC4086752, DOI: 10.1111/pcmr.12159.
RAC1P29S is a spontaneously activating cancer-associated GTPaseDavis MJ, Ha BH, Holman EC, Halaban R, Schlessinger J, Boggon TJ. RAC1P29S is a spontaneously activating cancer-associated GTPase. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 912-917. PMID: 23284172, PMCID: PMC3549122, DOI: 10.1073/pnas.1220895110.
Integrated analysis of tumor samples sheds light on tumor heterogeneity.Parisi F, Micsinai M, Strino F, Ariyan S, Narayan D, Bacchiocchi A, Cheng E, Xu F, Li P, Kluger H, Halaban R, Kluger Y. Integrated analysis of tumor samples sheds light on tumor heterogeneity. The Yale Journal Of Biology And Medicine 2012, 85: 347-61. PMID: 23012583, PMCID: PMC3447199.
Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrateHa BH, Davis MJ, Chen C, Lou HJ, Gao J, Zhang R, Krauthammer M, Halaban R, Schlessinger J, Turk BE, Boggon TJ. Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 16107-16112. PMID: 22988085, PMCID: PMC3479536, DOI: 10.1073/pnas.1214447109.
Exome sequencing identifies recurrent somatic RAC1 mutations in melanomaKrauthammer M, Kong Y, Ha BH, Evans P, Bacchiocchi A, McCusker J, Cheng E, Davis MJ, Goh G, Choi M, Ariyan S, Narayan D, Dutton-Regester K, Capatana A, Holman EC, Bosenberg M, Sznol M, Kluger HM, Brash DE, Stern DF, Materin MA, Lo RS, Mane S, Ma S, Kidd KK, Hayward NK, Lifton RP, Schlessinger J, Boggon TJ, Halaban R. Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma. Nature Genetics 2012, 44: 1006-1014. PMID: 22842228, PMCID: PMC3432702, DOI: 10.1038/ng.2359.
Chitinase-like Proteins in Lung Injury, Repair, and MetastasisLee CG, Dela Cruz CS, Ma B, Ahangari F, Zhou Y, Halaban R, Sznol M, Elias JA. Chitinase-like Proteins in Lung Injury, Repair, and Metastasis. Annals Of The American Thoracic Society 2012, 9: 57-61. PMID: 22550243, PMCID: PMC3359113, DOI: 10.1513/pats.201112-056ms.
Preexisting MEK1 Exon 3 Mutations in V600E/KBRAF Melanomas Do Not Confer Resistance to BRAF InhibitorsShi H, Moriceau G, Kong X, Koya RC, Nazarian R, Pupo GM, Bacchiocchi A, Dahlman KB, Chmielowski B, Sosman JA, Halaban R, Kefford RF, Long GV, Ribas A, Lo RS. Preexisting MEK1 Exon 3 Mutations in V600E/KBRAF Melanomas Do Not Confer Resistance to BRAF Inhibitors. Cancer Discovery 2012, 2: 414-424. PMID: 22588879, PMCID: PMC3594852, DOI: 10.1158/2159-8290.cd-12-0022.
In Vivo Identification of Tumor- Suppressive PTEN ceRNAs in an Oncogenic BRAF-Induced Mouse Model of MelanomaKarreth F, Tay Y, Perna D, Ala U, Tan S, Rust A, DeNicola G, Webster K, Weiss D, Perez-Mancera P, Krauthammer M, Halaban R, Provero P, Adams D, Tuveson D, Pandolfi P. In Vivo Identification of Tumor- Suppressive PTEN ceRNAs in an Oncogenic BRAF-Induced Mouse Model of Melanoma. Cell 2011, 147: 948. DOI: 10.1016/j.cell.2011.10.032.
In Vivo Identification of Tumor- Suppressive PTEN ceRNAs in an Oncogenic BRAF-Induced Mouse Model of MelanomaKarreth FA, Tay Y, Perna D, Ala U, Tan SM, Rust AG, DeNicola G, Webster KA, Weiss D, Perez-Mancera PA, Krauthammer M, Halaban R, Provero P, Adams DJ, Tuveson DA, Pandolfi PP. In Vivo Identification of Tumor- Suppressive PTEN ceRNAs in an Oncogenic BRAF-Induced Mouse Model of Melanoma. Cell 2011, 147: 382-395. PMID: 22000016, PMCID: PMC3236086, DOI: 10.1016/j.cell.2011.09.032.
Integrated NY-ESO-1 antibody and CD8+ T-cell responses correlate with clinical benefit in advanced melanoma patients treated with ipilimumabYuan J, Adamow M, Ginsberg BA, Rasalan TS, Ritter E, Gallardo HF, Xu Y, Pogoriler E, Terzulli SL, Kuk D, Panageas KS, Ritter G, Sznol M, Halaban R, Jungbluth AA, Allison JP, Old LJ, Wolchok JD, Gnjatic S. Integrated NY-ESO-1 antibody and CD8+ T-cell responses correlate with clinical benefit in advanced melanoma patients treated with ipilimumab. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 16723-16728. PMID: 21933959, PMCID: PMC3189057, DOI: 10.1073/pnas.1110814108.
MicroRNA signatures differentiate melanoma subtypesChan E, Patel R, Nallur S, Ratner E, Bacchiocchi A, Hoyt K, Szpakowski S, Godshalk S, Ariyan S, Sznol M, Halaban R, Krauthammer M, Tuck D, Slack FJ, Weidhaas JB. MicroRNA signatures differentiate melanoma subtypes. Cell Cycle 2011, 10: 1845-1852. PMID: 21543894, PMCID: PMC3233487, DOI: 10.4161/cc.10.11.15777.
Phosphoproteomic Screen Identifies Potential Therapeutic Targets in MelanomaTworkoski K, Singhal G, Szpakowski S, Zito CI, Bacchiocchi A, Muthusamy V, Bosenberg M, Krauthammer M, Halaban R, Stern DF. Phosphoproteomic Screen Identifies Potential Therapeutic Targets in Melanoma. Molecular Cancer Research 2011, 9: 801-812. PMID: 21521745, PMCID: PMC3117976, DOI: 10.1158/1541-7786.mcr-10-0512.
Detecting copy number status and uncovering subclonal markers in heterogeneous tumor biopsiesParisi F, Ariyan S, Narayan D, Bacchiocchi A, Hoyt K, Cheng E, Xu F, Li P, Halaban R, Kluger Y. Detecting copy number status and uncovering subclonal markers in heterogeneous tumor biopsies. BMC Genomics 2011, 12: 230. PMID: 21569352, PMCID: PMC3114747, DOI: 10.1186/1471-2164-12-230.
Plasma Markers for Identifying Patients with Metastatic MelanomaKluger HM, Hoyt K, Bacchiocchi A, Mayer T, Kirsch J, Kluger Y, Sznol M, Ariyan S, Molinaro A, Halaban R. Plasma Markers for Identifying Patients with Metastatic Melanoma. Clinical Cancer Research 2011, 17: 2417-2425. PMID: 21487066, PMCID: PMC3415234, DOI: 10.1158/1078-0432.ccr-10-2402.
Future perspectives in melanoma research. Meeting report from the "Melanoma Research: a bridge Naples-USA. Naples, December 6th-7th2010"Ascierto PA, De Maio E, Bertuzzi S, Palmieri G, Halaban R, Hendrix M, Kashani-sabet M, Ferrone S, Wang E, Cochran A, Rivoltini L, Lee PP, Fox BA, Kirkwood JM, Ullmann CD, Lehmann FF, Sznol M, Schwartzentruber DJ, Maio M, Flaherty K, Galon J, Ribas A, Yang J, Stroncek DF, Mozzillo N, Marincola FM. Future perspectives in melanoma research. Meeting report from the "Melanoma Research: a bridge Naples-USA. Naples, December 6th-7th2010". Journal Of Translational Medicine 2011, 9: 32. PMID: 21439082, PMCID: PMC3078100, DOI: 10.1186/1479-5876-9-32.
A Variant in a MicroRNA complementary site in the 3′ UTR of the KIT oncogene increases risk of acral melanomaGodshalk SE, Paranjape T, Nallur S, Speed W, Chan E, Molinaro AM, Bacchiocchi A, Hoyt K, Tworkoski K, Stern DF, Sznol M, Ariyan S, Lazova R, Halaban R, Kidd KK, Weidhaas JB, Slack FJ. A Variant in a MicroRNA complementary site in the 3′ UTR of the KIT oncogene increases risk of acral melanoma. Oncogene 2010, 30: 1542-1550. PMID: 21119596, PMCID: PMC3069149, DOI: 10.1038/onc.2010.536.
Incidence of the V600K mutation among melanoma patients with BRAF mutations, and potential therapeutic response to the specific BRAF inhibitor PLX4032Rubinstein JC, Sznol M, Pavlick AC, Ariyan S, Cheng E, Bacchiocchi A, Kluger HM, Narayan D, Halaban R. Incidence of the V600K mutation among melanoma patients with BRAF mutations, and potential therapeutic response to the specific BRAF inhibitor PLX4032. Journal Of Translational Medicine 2010, 8: 67. PMID: 20630094, PMCID: PMC2917408, DOI: 10.1186/1479-5876-8-67.
PLX4032, a selective BRAFV600E kinase inhibitor, activates the ERK pathway and enhances cell migration and proliferation of BRAFWT melanoma cellsHalaban R, Zhang W, Bacchiocchi A, Cheng E, Parisi F, Ariyan S, Krauthammer M, McCusker JP, Kluger Y, Sznol M. PLX4032, a selective BRAFV600E kinase inhibitor, activates the ERK pathway and enhances cell migration and proliferation of BRAFWT melanoma cells. Pigment Cell & Melanoma Research 2010, 23: 190-200. PMID: 20149136, PMCID: PMC2848976, DOI: 10.1111/j.1755-148x.2010.00685.x.
Meenhard HerlynHalaban R. Meenhard Herlyn. Pigment Cell & Melanoma Research 2010, 23: 287-287. PMID: 20394680, DOI: 10.1111/j.1755-148x.2010.00683.x.
Genome-wide methylation and expression profiling identifies promoter characteristics affecting demethylation-induced gene up-regulation in melanomaRubinstein JC, Tran N, Ma S, Halaban R, Krauthammer M. Genome-wide methylation and expression profiling identifies promoter characteristics affecting demethylation-induced gene up-regulation in melanoma. BMC Medical Genomics 2010, 3: 4. PMID: 20144234, PMCID: PMC2843643, DOI: 10.1186/1755-8794-3-4.
Genome-wide screen of promoter methylation identifies novel markers in melanomaKoga Y, Pelizzola M, Cheng E, Krauthammer M, Sznol M, Ariyan S, Narayan D, Molinaro AM, Halaban R, Weissman SM. Genome-wide screen of promoter methylation identifies novel markers in melanoma. Genome Research 2009, 19: 1462-1470. PMID: 19491193, PMCID: PMC2720187, DOI: 10.1101/gr.091447.109.
Integrative Analysis of Epigenetic Modulation in Melanoma Cell Response to Decitabine: Clinical ImplicationsHalaban R, Krauthammer M, Pelizzola M, Cheng E, Kovacs D, Sznol M, Ariyan S, Narayan D, Bacchiocchi A, Molinaro A, Kluger Y, Deng M, Tran N, Zhang W, Picardo M, Enghild JJ. Integrative Analysis of Epigenetic Modulation in Melanoma Cell Response to Decitabine: Clinical Implications. PLOS ONE 2009, 4: e4563. PMID: 19234609, PMCID: PMC2642998, DOI: 10.1371/journal.pone.0004563.
MEDME: An experimental and analytical methodology for the estimation of DNA methylation levels based on microarray derived MeDIP-enrichmentPelizzola M, Koga Y, Urban AE, Krauthammer M, Weissman S, Halaban R, Molinaro AM. MEDME: An experimental and analytical methodology for the estimation of DNA methylation levels based on microarray derived MeDIP-enrichment. Genome Research 2008, 18: 1652-1659. PMID: 18765822, PMCID: PMC2556264, DOI: 10.1101/gr.080721.108.
Nuclear to non-nuclear Pmel17/gp100 expression (HMB45 staining) as a discriminator between benign and malignant melanocytic lesionsRothberg BE, Moeder CB, Kluger H, Halaban R, Elder DE, Murphy GF, Lazar A, Prieto V, Duncan LM, Rimm DL. Nuclear to non-nuclear Pmel17/gp100 expression (HMB45 staining) as a discriminator between benign and malignant melanocytic lesions. Modern Pathology 2008, 21: 1121-1129. PMID: 18552823, PMCID: PMC2570478, DOI: 10.1038/modpathol.2008.100.
Metastatic Peritoneal Neurocutaneous MelanocytosisCajaiba MM, Benjamin D, Halaban R, Reyes-Múgica M. Metastatic Peritoneal Neurocutaneous Melanocytosis. The American Journal Of Surgical Pathology 2008, 32: 156-161. PMID: 18162783, DOI: 10.1097/pas.0b013e3181238cd2.
Roadmap for New Opportunities in Melanoma ResearchHerlyn M, Halaban R, Ronai Z, Schuchter L, Berwick M, Pinkel D. Roadmap for New Opportunities in Melanoma Research. Seminars In Oncology 2007, 34: 566-576. PMID: 18083380, DOI: 10.1053/j.seminoncol.2007.09.004.
XAF1 Mediates Tumor Necrosis Factor-α-induced Apoptosis and X-linked Inhibitor of Apoptosis Cleavage by Acting through the Mitochondrial Pathway*Straszewski-Chavez SL, Visintin IP, Karassina N, Los G, Liston P, Halaban R, Fadiel A, Mor G. XAF1 Mediates Tumor Necrosis Factor-α-induced Apoptosis and X-linked Inhibitor of Apoptosis Cleavage by Acting through the Mitochondrial Pathway*. Journal Of Biological Chemistry 2007, 282: 13059-13072. PMID: 17329253, DOI: 10.1074/jbc.m609038200.
Rab33A: Characterization, Expression, and Suppression by Epigenetic ModificationCheng E, Trombetta SE, Kovacs D, Beech RD, Ariyan S, Reyes-Mugica M, McNiff JM, Narayan D, Kluger HM, Picardo M, Halaban R. Rab33A: Characterization, Expression, and Suppression by Epigenetic Modification. Journal Of Investigative Dermatology 2006, 126: 2257-2271. PMID: 16810302, DOI: 10.1038/sj.jid.5700386.
Expression of Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand Receptors 1 and 2 in MelanomaMcCarthy MM, DiVito KA, Sznol M, Kovacs D, Halaban R, Berger AJ, Flaherty KT, Camp RL, Lazova R, Rimm DL, Kluger HM. Expression of Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand Receptors 1 and 2 in Melanoma. Clinical Cancer Research 2006, 12: 3856-3863. PMID: 16778114, PMCID: PMC1839847, DOI: 10.1158/1078-0432.ccr-06-0190.
Growth Factor Receptors and Signal Transduction Regulating the Proliferation and Differentiation of MelanocytesHalaban R, Moellmann G. Growth Factor Receptors and Signal Transduction Regulating the Proliferation and Differentiation of Melanocytes. 2006, 445-463. DOI: 10.1002/9780470987100.ch22.
RB/E2F Regulation and Dual Activity in the Melanocytic SystemHalaban R. RB/E2F Regulation and Dual Activity in the Melanocytic System. 2006, 223-245. DOI: 10.1007/978-1-59259-994-3_13.
OR.65. Melanoma Biomarker Discovery Through Serum Antibody Profiling On Protein MicroarraysMattoon D, Love B, Kluger Y, Michaud G, Schweitzer B, Predki P, Ritter G, Halaban R. OR.65. Melanoma Biomarker Discovery Through Serum Antibody Profiling On Protein Microarrays. Clinical Immunology 2006, 119: s28. DOI: 10.1016/j.clim.2006.04.221.
Melanocyte and Keratinocyte Carcinogenesis: p53 Family Protein Activities and Intersecting mRNA Expression ProfilesKulesz-Martin M, Lagowski J, Fei S, Pelz C, Sears R, Powell MB, Halaban R, Johnson J. Melanocyte and Keratinocyte Carcinogenesis: p53 Family Protein Activities and Intersecting mRNA Expression Profiles. Journal Of Investigative Dermatology Symposium Proceedings 2005, 10: 142-152. PMID: 16363065, DOI: 10.1111/j.1087-0024.2005.200405.x.
Rb/E2F: A two-edged sword in the melanocytic systemHalaban R. Rb/E2F: A two-edged sword in the melanocytic system. Cancer And Metastasis Reviews 2005, 24: 339-356. PMID: 15986142, DOI: 10.1007/s10555-005-1582-z.
Automated Quantitative Analysis of HDM2 Expression in Malignant Melanoma Shows Association with Early-Stage Disease and Improved OutcomeBerger AJ, Camp RL, DiVito KA, Kluger HM, Halaban R, Rimm DL. Automated Quantitative Analysis of HDM2 Expression in Malignant Melanoma Shows Association with Early-Stage Disease and Improved Outcome. Cancer Research 2004, 64: 8767-8772. PMID: 15574789, DOI: 10.1158/0008-5472.can-04-1384.
Expression Profiling Reveals Novel Pathways in the Transformation of Melanocytes to MelanomasHoek K, Rimm DL, Williams KR, Zhao H, Ariyan S, Lin A, Kluger HM, Berger AJ, Cheng E, Trombetta ES, Wu T, Niinobe M, Yoshikawa K, Hannigan GE, Halaban R. Expression Profiling Reveals Novel Pathways in the Transformation of Melanocytes to Melanomas. Cancer Research 2004, 64: 5270-5282. PMID: 15289333, DOI: 10.1158/0008-5472.can-04-0731.
Expression profiling reveals novel pathways in the transformation of Melanocytes to Melanomas.Hoek K, Rimm D, Williams K, Zhao H, Ariyan S, Lin A, Kluger H, Berger A, Cheng E, Trombetta E, Wu T, Halaban R, Niinobe M, Yoshikawa K, Hannigan G. Expression profiling reveals novel pathways in the transformation of Melanocytes to Melanomas. Pigment Cell & Melanoma Research 2004, 17: 430-430. DOI: 10.1111/j.1600-0749.2004.00175_12.x.
Novel tyramide‐based tyrosinase assay for the detection of melanoma cells in cytological preparationsAngeletti C, Khomitch V, Halaban R, Rimm DL. Novel tyramide‐based tyrosinase assay for the detection of melanoma cells in cytological preparations. Diagnostic Cytopathology 2004, 31: 33-37. PMID: 15236262, DOI: 10.1002/dc.20051.
Her2/neu is not a commonly expressed therapeutic target in melanoma – a large cohort tissue microarray studyKluger HM, DiVito K, Berger AJ, Halaban R, Ariyan S, Camp RL, Rimm DL. Her2/neu is not a commonly expressed therapeutic target in melanoma – a large cohort tissue microarray study. Melanoma Research 2004, 14: 207-210. PMID: 15179190, DOI: 10.1097/01.cmr.0000130874.33504.2f.
Carbohydrates act as sorting determinants in ER-associated degradation of tyrosinaseSvedine S, Wang T, Halaban R, Hebert DN. Carbohydrates act as sorting determinants in ER-associated degradation of tyrosinase. Journal Of Cell Science 2004, 117: 2937-2949. PMID: 15161941, DOI: 10.1242/jcs.01154.
Subcellular localization of activating transcription factor 2 in melanoma specimens predicts patient survival.Berger AJ, Kluger HM, Li N, Kielhorn E, Halaban R, Ronai Z, Rimm DL. Subcellular localization of activating transcription factor 2 in melanoma specimens predicts patient survival. Cancer Research 2003, 63: 8103-7. PMID: 14678960.
Tyrosinase Maturation and Oligomerization in the Endoplasmic Reticulum Require a Melanocyte-specific Factor*Francis E, Wang N, Parag H, Halaban R, Hebert DN. Tyrosinase Maturation and Oligomerization in the Endoplasmic Reticulum Require a Melanocyte-specific Factor*. Journal Of Biological Chemistry 2003, 278: 25607-25617. PMID: 12724309, DOI: 10.1074/jbc.m303411200.
The tyrphostin AG1024 accelerates the degradation of phosphorylated forms of retinoblastoma protein (pRb) and restores pRb tumor suppressive function in melanoma cells.von Willebrand M, Zacksenhaus E, Cheng E, Glazer P, Halaban R. The tyrphostin AG1024 accelerates the degradation of phosphorylated forms of retinoblastoma protein (pRb) and restores pRb tumor suppressive function in melanoma cells. Cancer Research 2003, 63: 1420-9. PMID: 12649208.
Coexpression of Wild-Type Tyrosinase Enhances Maturation of Temperature-Sensitive Tyrosinase MutantsHalaban R, Cheng E, Hebert DN. Coexpression of Wild-Type Tyrosinase Enhances Maturation of Temperature-Sensitive Tyrosinase Mutants. Journal Of Investigative Dermatology 2002, 119: 481-488. PMID: 12190874, DOI: 10.1046/j.1523-1747.2002.01824.x.
Signal Transduction Abnormalities as Therapeutic TargetsHalaban R, Von Willebrand M. Signal Transduction Abnormalities as Therapeutic Targets. 2002, 0: 287-323. DOI: 10.1385/1-59259-159-0:287.
Abnormal Acidification of Melanoma Cells Induces Tyrosinase Retention in the Early Secretory Pathway*Halaban R, Patton RS, Cheng E, Svedine S, Trombetta ES, Wahl ML, Ariyan S, Hebert DN. Abnormal Acidification of Melanoma Cells Induces Tyrosinase Retention in the Early Secretory Pathway*. Journal Of Biological Chemistry 2002, 277: 14821-14828. PMID: 11812790, DOI: 10.1074/jbc.m111497200.
Signal Transduction Abnormalities as Therapeutic TargetsHalaban R, von Willebrand M. Signal Transduction Abnormalities as Therapeutic Targets. 2002, 287-323. DOI: 10.1007/978-1-59259-159-6_11.
COMMENTARY Pigmentation in Melanomas: Changes Manifesting Underlying Oncogenic and Metabolic ActivitiesHalaban R. COMMENTARY Pigmentation in Melanomas: Changes Manifesting Underlying Oncogenic and Metabolic Activities. Oncology Research Featuring Preclinical And Clinical Cancer Therapeutics 2002, 13: 3-8. PMID: 12201672, DOI: 10.3727/096504002108747908.
Proper Folding and Endoplasmic Reticulum to Golgi Transport of Tyrosinase Are Induced by Its Substrates, DOPA and Tyrosine*Halaban R, Cheng E, Svedine S, Aron R, Hebert D. Proper Folding and Endoplasmic Reticulum to Golgi Transport of Tyrosinase Are Induced by Its Substrates, DOPA and Tyrosine*. Journal Of Biological Chemistry 2000, 276: 11933-11938. PMID: 11124258, DOI: 10.1074/jbc.m008703200.
Translation Rate of Human Tyrosinase Determines ItsN-Linked Glycosylation Level*Újvári A, Aron R, Eisenhaure T, Cheng E, Parag H, Smicun Y, Halaban R, Hebert D. Translation Rate of Human Tyrosinase Determines ItsN-Linked Glycosylation Level*. Journal Of Biological Chemistry 2000, 276: 5924-5931. PMID: 11069924, DOI: 10.1074/jbc.m009203200.
Endoplasmic reticulum retention is a common defect associated with tyrosinase-negative albinismHalaban R, Svedine S, Cheng E, Smicun Y, Aron R, Hebert D. Endoplasmic reticulum retention is a common defect associated with tyrosinase-negative albinism. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 5889-5894. PMID: 10823941, PMCID: PMC18529, DOI: 10.1073/pnas.97.11.5889.
Deregulated E2f Transcriptional Activity in Autonomously Growing Melanoma CellsHalaban R, Cheng E, Smicun Y, Germino J. Deregulated E2f Transcriptional Activity in Autonomously Growing Melanoma Cells. Journal Of Experimental Medicine 2000, 191: 1005-1016. PMID: 10727462, PMCID: PMC2193116, DOI: 10.1084/jem.191.6.1005.
The Regulation of Normal Melanocyte ProliferationHalaban R. The Regulation of Normal Melanocyte Proliferation. Pigment Cell & Melanoma Research 2000, 13: 4-14. PMID: 10761990, DOI: 10.1034/j.1600-0749.2000.130103.x.
Melanoma Cell Autonomous Growth: The Rb/E2F PathwayHalaban R. Melanoma Cell Autonomous Growth: The Rb/E2F Pathway. Cancer And Metastasis Reviews 1999, 18: 333-343. PMID: 10721488, DOI: 10.1023/a:1006396104073.
Identification of morc (microrchidia), a mutation that results in arrest of spermatogenesis at an early meiotic stage in the mouseWatson M, Zinn A, Inoue N, Hess K, Cobb J, Handel M, Halaban R, Duchene C, Albright G, Moreadith R. Identification of morc (microrchidia), a mutation that results in arrest of spermatogenesis at an early meiotic stage in the mouse. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 14361-14366. PMID: 9826705, PMCID: PMC24378, DOI: 10.1073/pnas.95.24.14361.
Release of cell cycle constraints in mouse melanocytes by overexpressed mutant E2F1E132, but not by deletion of p16INK4A or p21WAF1/CIP1Halaban R, Cheng E, Zhang Y, Mandigo C, Miglarese M. Release of cell cycle constraints in mouse melanocytes by overexpressed mutant E2F1E132, but not by deletion of p16INK4A or p21WAF1/CIP1. Oncogene 1998, 16: 2489-2501. PMID: 9627115, DOI: 10.1038/sj.onc.1201773.
Release of melanocytes from external growth inhibitory signals by overexpressed mutant transcription factor E2F1E132, but not by disruption of p16INK4A, p21WAF1/CIP1 or p27KIP1 genesHalaban R, Cheng E, Zhang Y, Mandigo C, Miglarese M. Release of melanocytes from external growth inhibitory signals by overexpressed mutant transcription factor E2F1E132, but not by disruption of p16INK4A, p21WAF1/CIP1 or p27KIP1 genes. Journal Of Dermatological Science 1998, 16: s6. DOI: 10.1016/s0923-1811(98)83031-4.
Melanomas, from the cell cycle point of view (Review).Halaban R, Miglarese M, Smicun Y, Puig S. Melanomas, from the cell cycle point of view (Review). International Journal Of Molecular Medicine 1998, 1: 419-25. PMID: 9852245, DOI: 10.3892/ijmm.1.2.419.
Regulation of fibroblast growth factor 2 expression in melanoma cells by the c-MYB proto-oncoprotein.Miglarese M, Halaban R, Gibson N. Regulation of fibroblast growth factor 2 expression in melanoma cells by the c-MYB proto-oncoprotein. Molecular Cancer Research 1997, 8: 1199-210. PMID: 9372243.
Chymase cleavage of stem cell factor yields a bioactive, soluble productLongley B, Tyrrell L, Ma Y, Williams D, Halaban R, Langley K, Lu H, Schechter N. Chymase cleavage of stem cell factor yields a bioactive, soluble product. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 9017-9021. PMID: 9256427, PMCID: PMC23007, DOI: 10.1073/pnas.94.17.9017.
Diminished TCR signaling in cutaneous T cell lymphoma is associated with decreased activities of Zap70, Syk and membrane-associated CskFargnoli M, Edelson R, Berger C, Chimenti S, Couture C, Mustelin T, Halaban R. Diminished TCR signaling in cutaneous T cell lymphoma is associated with decreased activities of Zap70, Syk and membrane-associated Csk. Leukemia 1997, 11: 1338-1346. PMID: 9264390, DOI: 10.1038/sj.leu.2400745.
Suppression of autocrine cell proliferation and tumorigenesis of human melanoma cells and fibroblast growth factor transformed fibroblasts by a kinase-deficient FGF receptor 1: evidence for the involvement of Src-family kinasesYayon A, Ma Y, Safran M, Klagsbrun M, Halaban R. Suppression of autocrine cell proliferation and tumorigenesis of human melanoma cells and fibroblast growth factor transformed fibroblasts by a kinase-deficient FGF receptor 1: evidence for the involvement of Src-family kinases. Oncogene 1997, 14: 2999-3009. PMID: 9223663, DOI: 10.1038/sj.onc.1201159.
Aberrant retention of tyrosinase in the endoplasmic reticulum mediates accelerated degradation of the enzyme and contributes to the dedifferentiated phenotype of amelanotic melanoma cellsHalaban R, Cheng E, Zhang Y, Moellmann G, Hanlon D, Michalak M, Setaluri V, Hebert D. Aberrant retention of tyrosinase in the endoplasmic reticulum mediates accelerated degradation of the enzyme and contributes to the dedifferentiated phenotype of amelanotic melanoma cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 6210-6215. PMID: 9177196, PMCID: PMC21028, DOI: 10.1073/pnas.94.12.6210.
Recognition of activated CSF-1 receptor in breast carcinomas by a tyrosine 723 phosphospecific antibodyFlick M, Sapi E, Perrotta P, Maher M, Halaban R, Carter D, Kacinski B. Recognition of activated CSF-1 receptor in breast carcinomas by a tyrosine 723 phosphospecific antibody. Oncogene 1997, 14: 2553-2561. PMID: 9191055, DOI: 10.1038/sj.onc.1201092.
Growth factors and melanomas.Halaban R. Growth factors and melanomas. Seminars In Oncology 1996, 23: 673-81. PMID: 8970586.
UV-induced ubiquitination of RNA polymerase II: a novel modification deficient in Cockayne syndrome cells.Bregman D, Halaban R, van Gool A, Henning K, Friedberg E, Warren S. UV-induced ubiquitination of RNA polymerase II: a novel modification deficient in Cockayne syndrome cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 1996, 93: 11586-11590. PMID: 8876179, PMCID: PMC38101, DOI: 10.1073/pnas.93.21.11586.
Growth Regulatory Proteins that Repress Differentiation Markers in Melanocytes Also Downregulate the Transcription Factor MicrophthalmiaHalaban R, Böhm M, Dotto P, Moellmann G, Cheng E, Zhang Y. Growth Regulatory Proteins that Repress Differentiation Markers in Melanocytes Also Downregulate the Transcription Factor Microphthalmia. Journal Of Investigative Dermatology 1996, 106: 1266-1272. PMID: 8752668, DOI: 10.1111/1523-1747.ep12348972.
Characterization and Subcellular Localization of Human Pmel 17/silver, a 100-kDa (Pre)Melanosomal Membrane Protein Associated With 5,6,-Dihydroxyindole-2-Carboxylic Acid (DHICA) Converting ActivityLee Z, Hou L, Moellmann G, Kuklinska E, Antol K, Fraser M, Halaban R, Kwon B. Characterization and Subcellular Localization of Human Pmel 17/silver, a 100-kDa (Pre)Melanosomal Membrane Protein Associated With 5,6,-Dihydroxyindole-2-Carboxylic Acid (DHICA) Converting Activity. Journal Of Investigative Dermatology 1996, 106: 605-610. PMID: 8617992, DOI: 10.1111/1523-1747.ep12345163.
VEGF121, a Vascular Endothelial Growth Factor (VEGF) Isoform Lacking Heparin Binding Ability, Requires Cell-surface Heparan Sulfates for Efficient Binding to the VEGF Receptors of Human Melanoma Cells*Cohen T, Gitay-Goren H, Sharon R, Shibuya M, Halaban R, Levi B, Neufeld G. VEGF121, a Vascular Endothelial Growth Factor (VEGF) Isoform Lacking Heparin Binding Ability, Requires Cell-surface Heparan Sulfates for Efficient Binding to the VEGF Receptors of Human Melanoma Cells*. Journal Of Biological Chemistry 1995, 270: 11322-11326. PMID: 7744769, DOI: 10.1074/jbc.270.19.11322.
Identification of p90RSK as the probable CREB-Ser133 kinase in human melanocytes.Böhm M, Moellmann G, Cheng E, Alvarez-Franco M, Wagner S, Sassone-Corsi P, Halaban R. Identification of p90RSK as the probable CREB-Ser133 kinase in human melanocytes. Molecular Cancer Research 1995, 6: 291-302. PMID: 7540859.
Mouse silver. mutation is caused by a single base insertion in the putative cytoplasmic domain of Pmel 17Kwon B, Halaban R, Ponnazhagan S, Kim K, Chintamaneni C, Bennett D, Pickard R. Mouse silver. mutation is caused by a single base insertion in the putative cytoplasmic domain of Pmel 17. Nucleic Acids Research 1995, 23: 154-158. PMID: 7870580, PMCID: PMC306643, DOI: 10.1093/nar/23.1.154.
Characterization of Mouse Pmel 17 Gene and Silver LocusKWON B, KIM K, HALABAN R, PICKARD R. Characterization of Mouse Pmel 17 Gene and Silver Locus. Pigment Cell & Melanoma Research 1994, 7: 394-397. PMID: 7761347, DOI: 10.1111/j.1600-0749.1994.tb00067.x.
Signal Transduction in Normal and Malignant MelanocytesHALABAN R. Signal Transduction in Normal and Malignant Melanocytes. Pigment Cell & Melanoma Research 1994, 7: 89-95. PMID: 8066025, DOI: 10.1111/j.1600-0749.1994.tb00026.x.
Molbcular analysis of a tyrosinase-negative albinismPark K, Chintamaneni C, Halaban R, Witkop C, Kwon B. Molbcular analysis of a tyrosinase-negative albinism. Journal Of Dermatological Science 1993, 6: 37. DOI: 10.1016/0923-1811(93)90935-i.
KIT ligand (mast cell growth factor) inhibits the growth of KIT-expressing melanoma cells.Zakut R, Perlis R, Eliyahu S, Yarden Y, Givol D, Lyman S, Halaban R. KIT ligand (mast cell growth factor) inhibits the growth of KIT-expressing melanoma cells. Oncogene 1993, 8: 2221-9. PMID: 7687762.
A transcriptional inhibitor induced in human melanoma cells upon ultraviolet irradiation.Yang Y, Rutberg S, Luo F, Spratt T, Halaban R, Ferrone S, Ronai Z. A transcriptional inhibitor induced in human melanoma cells upon ultraviolet irradiation. Molecular Cancer Research 1993, 4: 595-602. PMID: 8398900.
Molecular correlates in the progression of normal melanocytes to melanomas.Halaban R. Molecular correlates in the progression of normal melanocytes to melanomas. Seminars In Cancer Biology 1993, 4: 171-81. PMID: 8318693.
Altered Metabolism of Mast-Cell Growth Factor (c-kit Ligand) in Cutaneous MastocytosisLongley B, Morganroth G, Tyrrell L, Ding T, Anderson D, Williams D, Halaban R. Altered Metabolism of Mast-Cell Growth Factor (c-kit Ligand) in Cutaneous Mastocytosis. New England Journal Of Medicine 1993, 328: 1302-1307. PMID: 7682288, DOI: 10.1056/nejm199305063281803.
Pigmentation and Proliferation of Human Melanocytes and the Effects of Melanocyte‐Stimulating Hormone and Ultraviolet B LightaHALABAN R, TYRRELL L, LONGLEY J, YARDEN Y, RUBIN J. Pigmentation and Proliferation of Human Melanocytes and the Effects of Melanocyte‐Stimulating Hormone and Ultraviolet B Lighta. Annals Of The New York Academy Of Sciences 1993, 680: 290-301. PMID: 7685575, DOI: 10.1111/j.1749-6632.1993.tb19691.x.
Growth factors/receptors in normal and malignant human melanocytesHalaban R. Growth factors/receptors in normal and malignant human melanocytes. Melanoma Research 1993, 3: 19. DOI: 10.1097/00008390-199303000-00064.
White Mutants in Mice Shedding Light on Humans.Halaban R, Moellmann G. White Mutants in Mice Shedding Light on Humans. Journal Of Investigative Dermatology 1993, 100: 176s-185s. DOI: 10.1111/1523-1747.ep12465140.
Human Melanoma Cells but Not Normal Melanocytes Express Vascular Endothelial Growth Factor ReceptorsGitaygoren H, Halaban R, Neufeld G. Human Melanoma Cells but Not Normal Melanocytes Express Vascular Endothelial Growth Factor Receptors. Biochemical And Biophysical Research Communications 1993, 190: 702-709. PMID: 8439321, DOI: 10.1006/bbrc.1993.1106.
Molecular analyses of a tyrosinase-negative albino family.Park K, Chintamaneni C, Halaban R, Witkop C, Kwon B. Molecular analyses of a tyrosinase-negative albino family. American Journal Of Human Genetics 1993, 52: 406-13. PMID: 8430701, PMCID: PMC1682201.
White mutants in mice shedding light on humans.Halaban R, Moellmann G. White mutants in mice shedding light on humans. Journal Of Investigative Dermatology 1993, 100: 176s-185s. PMID: 8433006, DOI: 10.1038/jid.1993.10.
White Mutants in Mice Shedding Light on HumansHalaban R, Moellmann G. White Mutants in Mice Shedding Light on Humans. Journal Of Investigative Dermatology 1993, 100: s176-s185. DOI: 10.1038/jid.1993.73.
met and HGF-SF in normal melanocytes and melanoma cells.Halaban R, Rubin J, White W. met and HGF-SF in normal melanocytes and melanoma cells. 1993, 65: 329-39. PMID: 8380740.
Growth Regulation in Normal and Malignant MelanocytesHalaban R. Growth Regulation in Normal and Malignant Melanocytes. 1993, 128: 133-150. PMID: 8356315, DOI: 10.1007/978-3-642-84881-0_10.
Met and hepatocyte growth factor/scatter factor signal transduction in normal melanocytes and melanoma cells.Halaban R, Rubin J, Funasaka Y, Cobb M, Boulton T, Faletto D, Rosen E, Chan A, Yoko K, White W. Met and hepatocyte growth factor/scatter factor signal transduction in normal melanocytes and melanoma cells. Oncogene 1992, 7: 2195-206. PMID: 1331934.
Growth Factors, Receptor Kinases, and Protein Tyro sine Phosphatases in Normal and Malignant MelanocytesHalaban R, Fan B, Ahn J, Funasaka Y, Gitay-Goren H, Neufeld G. Growth Factors, Receptor Kinases, and Protein Tyro sine Phosphatases in Normal and Malignant Melanocytes. Journal Of Immunotherapy 1992, 12: 154-161. PMID: 1445804, DOI: 10.1097/00002371-199210000-00002.
Scatter factor and hepatocyte growth factor: activities, properties, and mechanism.Bhargava M, Joseph A, Knesel J, Halaban R, Li Y, Pang S, Goldberg I, Setter E, Donovan M, Zarnegar R. Scatter factor and hepatocyte growth factor: activities, properties, and mechanism. Molecular Cancer Research 1992, 3: 11-20. PMID: 1534687.
Fibroblast Growth Factors in Normal and Malignant MelanocytesaHalaban R, Funasaka Y, Lee P, Rubin J, Ron D, Birnbaum D. Fibroblast Growth Factors in Normal and Malignant Melanocytesa. Annals Of The New York Academy Of Sciences 1991, 638: 232-243. PMID: 1723854, DOI: 10.1111/j.1749-6632.1991.tb49034.x.
Supplement II: Abstracts of the international symposium on Skin Carcinogenesis in man and in experimental models. Heidelberg, 29–31 October 1991 (pp S61–S88)Barrett J, Afshari C, Annab L, Burkhart B, Boyd J, Owen R, Futreal P, Richter K, Moses H, Lavker R, Miller S, Sun T, Stingl G, Bianchi A, Navone N, Conti C, Spencer J, Kahn S, Weinstein I, Silvers D, DeLeo V, Larcher F, Bauluz C, Quintanilla M, Ballestin C, Jorcano J, Schön M, Haas M, Klein C, Weber L, Cerri A, Tadini G, Gitto R, Berti E, Cano A, Caulín C, Gómez M, Gandarillas A, Martín M, Montes A, Navarro P, Bastian B, Van der Piepen U, Römisch J, Pâques E, Hartmann A, Krieg P, Schnapke R, Feil S, Fürstenberger G, Marks F, Missero C, Cajal S, Filvaroff E, Dotto G, Sherman J, Albert R, Baxter C, Bauer G, Höfler P, Götschl M, Viesel E, Jürgensmeier J, Schaefer D, Picht G, Grande T, Real A, Rünqer T, Möller K, Fuchs P, Bauer C, Epe' B, Gruner S, Diezel W, Macejewski J, Weber H, Eckert R, Volk H, Sönnichsen N, Bavinck J, Vermeer B, Van Der Woude F, Vandenbroucke J, Claas F, Griffin E, Harris H, Tilgen W, Garbe C, Østerlind A, Weiss J, Jung E, Ruiter D, Danen E, Broecker E, Johnson J, van Muijen G, Halaban R, Krüger-Krasagakes S, Orfanos C, Newton J, Bataille V, Cuzick J, Bishop T, Schwaaf A, Azizi E, Bröcker E, Eberlein B, Froschermaier S, Gollhausen R, Przybilla B, Krasagakis K, Abdel-Naser M, Lopez-Bran E, Robledo A, Lopez-Bran E, Heine H, Hennig B, Graf G, Nährig J, Niedner R, Schöpf E, Mailhammer R, Reisbach G, Kempkes B, Hültner L, Thalmeier K, Anders F, Zechel C, Schleenbecker U, Leers J, Smith A, Wagner E, Burcin U, Hug H, Fiebich B, Anders A, Gröger H, Schlatterer B, Moll I, Wollina U, Leigh I, Purkis P, Markey A, Neill S, Proby C, Glover M, Lane E, Klein-Szanto A, Yaar M, Garmyn M, Gilani A, Gilchrest B, Bowden G, Nelson M, Levy J, Tanooka H, Ootsuyama A, Urbach F, van der Leun J, de Gruijl F, Kripke M, Yuspa S, Glick A, Lee E, Diugosz A, Balmain A, Bums P, Kemp C, Stoler A, Harks F, Boukamp P, Pascheberg U, Breitkreutz D, Hülsen A, Altmeier S, Tomakidi P, Fusenig N, Lowy D, Sedman S, Cohen B, Schiller J, Kricker A, Armstrong B, English D, Heenan P, Randell P, de Gruijl F, Kelfkens G, van Weelden H, van der Leun J, Grabbe S, Bruvers S, Granstein R, Albert R, Miller M, Cody T, Baxter C, Shukla R, Ueda M, Ichihashi M, Yamamura K, Hayashibe K, Funasaka Y, Mishima Y, Fujiwara Y, Ichihashi M, Jimbo T, Mishima Y, Popanda O, Thielmann H, Jahrens D, Edler L, Ootsuyama A, Tanooka H, Sutter C, Mukhtar H, Strickland P, Winter H, Schweizer J, Schmidt R, Weber E, Rippmann F, Hecker E, Kopp-Schneider A, Lehmann W, Stephan M, Troll W, Wei H, Fujiki H, Garte S, Frenkel K, Svetek J, Schara M, Pečar S, Hergenhahn M, Kinzel V, Richards J, Plein P, Schiess K, Kaszkin M, Yamamoto S, Wang J, Kato R, Kuroki T, Hashimoto Y, Osada S, Ohno S, Gilles C, Piette M, Foidart J, Ranki A, Lassus J, Lehmus A, Niemi K, Friesel H, Schneider T, Steinbauer B, Sorg B, Winter A, Krauter G, Krauß R, Roeser H, Unger S, Janiaud P, Rueß D, Mechler B, Stanbridge E, Gross M, Buček M, Klein-Bauernschmitt P, Schlehofer J, Kosters R, Stark H, Okulov V, Elgjo K, Ushmorov A, Danilov A, Zubova S, Furstenberger G, Faissner A. Supplement II: Abstracts of the international symposium on Skin Carcinogenesis in man and in experimental models. Heidelberg, 29–31 October 1991 (pp S61–S88). Journal Of Cancer Research And Clinical Oncology 1991, 117: s61-s83. DOI: 10.1007/bf01613300.
A single base insertion in the putative transmembrane domain of the tyrosinase gene as a cause for tyrosinase-negative oculocutaneous albinism.Chintamaneni C, Halaban R, Kobayashi Y, Witkop C, Kwon B. A single base insertion in the putative transmembrane domain of the tyrosinase gene as a cause for tyrosinase-negative oculocutaneous albinism. Proceedings Of The National Academy Of Sciences Of The United States Of America 1991, 88: 5272-5276. PMID: 1711223, PMCID: PMC51854, DOI: 10.1073/pnas.88.12.5272.
Growth factors and tyrosine protein kinases in normal and malignant melanocytesHalaban R. Growth factors and tyrosine protein kinases in normal and malignant melanocytes. Cancer And Metastasis Reviews 1991, 10: 129-140. PMID: 1873853, DOI: 10.1007/bf00049410.
Localization of Basic Fibroblast Growth Factor mRNA in Melanocytic Lesions by In Situ HybridizationScott G, Stoler M, Sarkar S, Halaban R. Localization of Basic Fibroblast Growth Factor mRNA in Melanocytic Lesions by In Situ Hybridization. Journal Of Investigative Dermatology 1991, 96: 318-322. PMID: 2002252, DOI: 10.1111/1523-1747.ep12465203.
Induction of different morphologic features of malignant melanoma and pigmented lesions after transformation of murine melanocytes with bFGF-cDNA and H-ras, myc, neu, and E1a oncogenes.Ramon y Cajal S, Suster S, Halaban R, Filvaroff E, Dotto G. Induction of different morphologic features of malignant melanoma and pigmented lesions after transformation of murine melanocytes with bFGF-cDNA and H-ras, myc, neu, and E1a oncogenes. American Journal Of Pathology 1991, 138: 349-58. PMID: 1992762, PMCID: PMC1886204.
Proliferation and malignant transformation of melanocytes.Halaban R, Moellmann G. Proliferation and malignant transformation of melanocytes. Critical Reviews™ In Oncogenesis 1991, 2: 247-58. PMID: 1958709.
Growth factors regulating normal and malignant melanocytesHalaban R. Growth factors regulating normal and malignant melanocytes. 1991, 54: 19-40. PMID: 1673857, DOI: 10.1007/978-1-4615-3938-4_2.
Murine and human b locus pigmentation genes encode a glycoprotein (gp75) with catalase activity.Halaban R, Moellmann G. Murine and human b locus pigmentation genes encode a glycoprotein (gp75) with catalase activity. Proceedings Of The National Academy Of Sciences Of The United States Of America 1990, 87: 4809-4813. PMID: 1693779, PMCID: PMC54207, DOI: 10.1073/pnas.87.12.4809.
Recent Advances in the Molecular Biology of Pigmentation: Mouse ModelsHalaban R, Moellmann G. Recent Advances in the Molecular Biology of Pigmentation: Mouse Models. Pigment Cell & Melanoma Research 1990, 3: 67-78. PMID: 1409441, DOI: 10.1111/j.1600-0749.1990.tb00352.x.
Growth Regulation in Normal and Malignant MelanocytesHalaban R. Growth Regulation in Normal and Malignant Melanocytes. 1990, 3-14. DOI: 10.1007/978-3-642-74496-9_1.
Transformation of murine melanocytes by basic fibroblast growth factor cDNA and oncogenes and selective suppression of the transformed phenotype in a reconstituted cutaneous environment.Dotto G, Moellmann G, Ghosh S, Edwards M, Halaban R. Transformation of murine melanocytes by basic fibroblast growth factor cDNA and oncogenes and selective suppression of the transformed phenotype in a reconstituted cutaneous environment. Journal Of Cell Biology 1989, 109: 3115-3128. PMID: 2556408, PMCID: PMC2115972, DOI: 10.1083/jcb.109.6.3115.
Isolation, Chromosomal Mapping, and Expression of the Mouse Tyrosinase GeneKwon B, Haq A, Wakulchik M, Kestler D, Barton D, Francke U, Lamoreux M, Whitney J, Halaban R. Isolation, Chromosomal Mapping, and Expression of the Mouse Tyrosinase Gene. Journal Of Investigative Dermatology 1989, 93: 589-594. PMID: 2507645, DOI: 10.1111/1523-1747.ep12319693.
Molecular basis of mouse Himalayan mutationKwon B, Halaban R, Chintamaneni C. Molecular basis of mouse Himalayan mutation. Biochemical And Biophysical Research Communications 1989, 161: 252-260. PMID: 2567165, DOI: 10.1016/0006-291x(89)91588-x.
Paracrine Stimulation of Melanocytes by Keratinocytes through Basic Fibroblast Growth FactoraHALABAN R, LANGDON R, BIRCHALL N, CCUONO C, BAIRD A, SCOTT G, MOELLOMANN G, MCGUIRE J. Paracrine Stimulation of Melanocytes by Keratinocytes through Basic Fibroblast Growth Factora. Annals Of The New York Academy Of Sciences 1988, 548: 180-190. PMID: 2470294, DOI: 10.1111/j.1749-6632.1988.tb18805.x.
Responses of Cultured Melanocytes to Defined Growth FactorsHALABAN R. Responses of Cultured Melanocytes to Defined Growth Factors. Pigment Cell & Melanoma Research 1988, 1: 18-26. DOI: 10.1111/j.1600-0749.1988.tb00790.x.
The BULT Melanoma: A Spontaneous Transplantable Tumor in MiceQUEVEDO W, DYCKMAN J, HALABAN R, MOELLMANN G, COWAN J, HOLSTEIN T. The BULT Melanoma: A Spontaneous Transplantable Tumor in Mice. Pigment Cell & Melanoma Research 1988, 1: 124-131. DOI: 10.1111/j.1600-0749.1988.tb00802.x.
Basic fibroblast growth factor from human keratinocytes is a natural mitogen for melanocytes.Halaban R, Langdon R, Birchall N, Cuono C, Baird A, Scott G, Moellmann G, McGuire J. Basic fibroblast growth factor from human keratinocytes is a natural mitogen for melanocytes. Journal Of Cell Biology 1988, 107: 1611-1619. PMID: 2459134, PMCID: PMC2115244, DOI: 10.1083/jcb.107.4.1611.
Tyrosinases of murine melanocytes with mutations at the albino locus.Halaban R, Moellmann G, Tamura A, Kwon BS, Kuklinska E, Pomerantz SH, Lerner AB. Tyrosinases of murine melanocytes with mutations at the albino locus. Proceedings Of The National Academy Of Sciences Of The United States Of America 1988, 85: 7241-7245. PMID: 3140237, PMCID: PMC282161, DOI: 10.1073/pnas.85.19.7241.
Cytogenetic analysis of melanocytes from premalignant nevi and melanomas.Cowan J, Halaban R, Francke U. Cytogenetic analysis of melanocytes from premalignant nevi and melanomas. Journal Of The National Cancer Institute 1988, 80: 1159-64. PMID: 3166071, DOI: 10.1093/jnci/80.14.1159.
bFGF as an autocrine growth factor for human melanomas.Halaban R, Kwon BS, Ghosh S, Delli Bovi P, Baird A. bFGF as an autocrine growth factor for human melanomas. Oncogene Research 1988, 3: 177-86. PMID: 3226725.
Sequence analysis of mouse tyrosinase cDNA and the effect of melanotropin on its gene expressionKwon B, Wakulchik M, Haq A, Halaban R, Kestler D. Sequence analysis of mouse tyrosinase cDNA and the effect of melanotropin on its gene expression. Biochemical And Biophysical Research Communications 1988, 153: 1301-1309. PMID: 3134020, DOI: 10.1016/s0006-291x(88)81370-6.
Cloning and characterization of a human tyrosinase cDNA.Kwon B, Haq A, Kim G, Pomerantz S, Halaban R. Cloning and characterization of a human tyrosinase cDNA. Progress In Clinical And Biological Research 1988, 256: 273-82. PMID: 2835779.
A melanocyte-specific complementary DNA clone whose expression is inducible by melanotropin and isobutylmethyl xanthine.Kwon B, Halaban R, Kim G, Usack L, Pomerantz S, Haq A. A melanocyte-specific complementary DNA clone whose expression is inducible by melanotropin and isobutylmethyl xanthine. Molecular Biology & Medicine 1987, 4: 339-55. PMID: 2449595.
Isolation and sequence of a cDNA clone for human tyrosinase that maps at the mouse c-albino locus.Kwon BS, Haq AK, Pomerantz SH, Halaban R. Isolation and sequence of a cDNA clone for human tyrosinase that maps at the mouse c-albino locus. Proceedings Of The National Academy Of Sciences Of The United States Of America 1987, 84: 7473-7477. PMID: 2823263, PMCID: PMC299318, DOI: 10.1073/pnas.84.21.7473.
Transplantation of Human MelanocytesLerner A, Halaban R, Klaus S, Moellmann G. Transplantation of Human Melanocytes. Journal Of Investigative Dermatology 1987, 89: 219-224. PMID: 3624895, DOI: 10.1111/1523-1747.ep12470973.
Normal murine melanocytes in cultureTamura A, Halaban R, Moellmann G, Cowan J, Lerner M, Lerner A. Normal murine melanocytes in culture. In Vitro Cellular & Developmental Biology 1987, 23: 519-522. PMID: 3610949, DOI: 10.1007/bf02628423.
Tyrosinase and Acid Phosphatase Activities in Melanocytes from Avian AlbinosBoissy R, Moellmann G, Halaban R. Tyrosinase and Acid Phosphatase Activities in Melanocytes from Avian Albinos. Journal Of Investigative Dermatology 1987, 88: 292-300. PMID: 3102623, DOI: 10.1111/1523-1747.ep12466164.
bFGF is the putative natural growth factor for human melanocytesHalaban R, Ghosh S, Baird A. bFGF is the putative natural growth factor for human melanocytes. In Vitro Cellular & Developmental Biology 1987, 23: 47-52. PMID: 3027025, DOI: 10.1007/bf02623492.
Phorbol Ester Serves As a Coepibolin in the Spreading of Primary Guinea Pig Epidermal CellsStenn K, Core N, Halaban R. Phorbol Ester Serves As a Coepibolin in the Spreading of Primary Guinea Pig Epidermal Cells. Journal Of Investigative Dermatology 1986, 87: 754-757. PMID: 2431072, DOI: 10.1111/1523-1747.ep12456946.
Human Melanocytes Cultured from Nevi and MelanomasHalaban R, Ghosh S, Duray P, Kirkwood J, Lerner A. Human Melanocytes Cultured from Nevi and Melanomas. Journal Of Investigative Dermatology 1986, 87: 95-101. PMID: 2425008, DOI: 10.1111/1523-1747.ep12523594.
The involvement of 6p in melanomaCowan J, Halaban R, Lane A, Francke U. The involvement of 6p in melanoma. Cancer Genetics 1986, 20: 255-261. PMID: 3943065, DOI: 10.1016/0165-4608(86)90081-6.
Primary melanoma cells of the vertical growth phase: similarities to metastatic cells.Herlyn M, Balaban G, Bennicelli J, Guerry D, Halaban R, Herlyn D, Elder D, Maul G, Steplewski Z, Nowell P. Primary melanoma cells of the vertical growth phase: similarities to metastatic cells. Journal Of The National Cancer Institute 1985, 74: 283-9. PMID: 3856042, DOI: 10.1093/jnci/74.2.283.
Establishment of Proliferative, Pure Cultures of Pigmented Chicken Melanocytes from Neural TubesBoissy R, Halaban R. Establishment of Proliferative, Pure Cultures of Pigmented Chicken Melanocytes from Neural Tubes. Journal Of Investigative Dermatology 1985, 84: 158-161. PMID: 3968448, DOI: 10.1111/1523-1747.ep12275408.
Selective elimination of fibroblasts from cultures of normal human melanocytesHalaban R, Alfano F. Selective elimination of fibroblasts from cultures of normal human melanocytes. In Vitro Cellular & Developmental Biology 1984, 20: 447-450. PMID: 6724622, DOI: 10.1007/bf02619590.
Tyrosinase activity and abundance in Cloudman melanoma cellsHalaban R, Pomerantz S, Marshall S, Lerner A. Tyrosinase activity and abundance in Cloudman melanoma cells. Archives Of Biochemistry And Biophysics 1984, 230: 383-387. PMID: 6201140, DOI: 10.1016/0003-9861(84)90121-8.
Regulation of tyrosinase in human melanocytes grown in culture.Halaban R, Pomerantz S, Marshall S, Lambert D, Lerner A. Regulation of tyrosinase in human melanocytes grown in culture. Journal Of Cell Biology 1983, 97: 480-488. PMID: 6411733, PMCID: PMC2112541, DOI: 10.1083/jcb.97.2.480.
Pigmentation and tumorigenicity of reconstituted, cybrid and hybrid mouse cellsHalaban R, Moellmann G, Godawska E, Eisenstadt J. Pigmentation and tumorigenicity of reconstituted, cybrid and hybrid mouse cells. Experimental Cell Research 1980, 130: 427-435. PMID: 7449860, DOI: 10.1016/0014-4827(80)90021-x.
Supermelanotic hybrids derived from mouse melanomas and normal mouse cellsHalaban R, Nordlund J, Francke U, Moellmann G, Eisenstadt J. Supermelanotic hybrids derived from mouse melanomas and normal mouse cells. Somatic Cell Genetics 1980, 6: 29-44. PMID: 6768142, DOI: 10.1007/bf01538694.
Phenylalanine hydroxylase in melanoma cellsBreakefield X, Castiglione C, Halaban R, Pawelek J, Shiman R. Phenylalanine hydroxylase in melanoma cells. Journal Of Cellular Physiology 1978, 94: 307-314. PMID: 23386, DOI: 10.1002/jcp.1040940308.
Tyrosinase and inhibition of proliferation of melanoma cells and fibroblastsHalaban R, Lerner A. Tyrosinase and inhibition of proliferation of melanoma cells and fibroblasts. Experimental Cell Research 1977, 108: 119-125. PMID: 408156, DOI: 10.1016/s0014-4827(77)80017-7.
The dual effect of melanocyte-stimulating hormone (MSH) on the growth of cultured mouse melanoma cellsHalaban R, Lerner A. The dual effect of melanocyte-stimulating hormone (MSH) on the growth of cultured mouse melanoma cells. Experimental Cell Research 1977, 108: 111-117. PMID: 196867, DOI: 10.1016/s0014-4827(77)80016-5.
Melanoma cells which require cyclic AMP for growthPAWELEK J, HALABAN R, CHRISTIE G. Melanoma cells which require cyclic AMP for growth. Nature 1975, 258: 539-540. PMID: 172800, DOI: 10.1038/258539a0.
Melanoma cells resistant to inhibition of growth by melanocyte stimulating hormone.Pawelek J, Sansone M, Koch N, Christie G, Halaban R, Hendee J, Lerner A, Varga J. Melanoma cells resistant to inhibition of growth by melanocyte stimulating hormone. Proceedings Of The National Academy Of Sciences Of The United States Of America 1975, 72: 951-955. PMID: 165495, PMCID: PMC432441, DOI: 10.1073/pnas.72.3.951.
Glucose transport-deficient mutant of Neurospora crassa with an unusual rhythmic growth pattern.Halaban R. Glucose transport-deficient mutant of Neurospora crassa with an unusual rhythmic growth pattern. Journal Of Bacteriology 1975, 121: 1056-63. PMID: 123245, PMCID: PMC246035, DOI: 10.1128/jb.121.3.1056-1063.1975.
Mitotic Index and Cell Cycle of Lemna perpusilla under Different PhotoperiodsHalaban R. Mitotic Index and Cell Cycle of Lemna perpusilla under Different Photoperiods. Plant Physiology 1972, 50: 308-310. PMID: 16658163, PMCID: PMC366131, DOI: 10.1104/pp.50.2.308.
Factors Affecting the Water-sensitive Phase of Flowering in the Short Day Plant Lemna perpusillaHalaban R, Hillman W. Factors Affecting the Water-sensitive Phase of Flowering in the Short Day Plant Lemna perpusilla. Plant Physiology 1971, 48: 760-764. PMID: 16657875, PMCID: PMC396943, DOI: 10.1104/pp.48.6.760.
Phytochrome and the Inductive Dark Period in ColeusHalaban R, Hillman W. Phytochrome and the Inductive Dark Period in Coleus. Plant Physiology 1970, 46: 757-758. PMID: 16657544, PMCID: PMC396675, DOI: 10.1104/pp.46.5.757.
Response of Lemma perpusilla to Periodic Transfer to Distilled WaterHalaban R, Hillman W. Response of Lemma perpusilla to Periodic Transfer to Distilled Water. Plant Physiology 1970, 46: 641-644. PMID: 16657522, PMCID: PMC396653, DOI: 10.1104/pp.46.5.641.
Effects of Light Quality on the Circadian Rhythm of Leaf Movement of a Short-Day-PlantHalaban R. Effects of Light Quality on the Circadian Rhythm of Leaf Movement of a Short-Day-Plant. Plant Physiology 1969, 44: 973-977. PMID: 16657167, PMCID: PMC396200, DOI: 10.1104/pp.44.7.973.
The Flowering Response of Coleus in Relation to Photoperiod and the Circadian Rhythm of Leaf MovementHalaban R. The Flowering Response of Coleus in Relation to Photoperiod and the Circadian Rhythm of Leaf Movement. Plant Physiology 1968, 43: 1894-1898. PMID: 16656987, PMCID: PMC1087100, DOI: 10.1104/pp.43.12.1894.
The Circadian Rhythm of Leaf Movement of Coleus blumei x C. frederici, a Short Day Plant. II. The Effects of Light and Temperature SignalsHalaban R. The Circadian Rhythm of Leaf Movement of Coleus blumei x C. frederici, a Short Day Plant. II. The Effects of Light and Temperature Signals. Plant Physiology 1968, 43: 1887-1893. PMID: 16656986, PMCID: PMC1087099, DOI: 10.1104/pp.43.12.1887.
The Circadian Rhythm of Leaf Movement of Coleus blumei x C. frederici, a Short Day Plant. I. Under Constant Light ConditionsHalaban R. The Circadian Rhythm of Leaf Movement of Coleus blumei x C. frederici, a Short Day Plant. I. Under Constant Light Conditions. Plant Physiology 1968, 43: 1883-1886. PMID: 16656985, PMCID: PMC1087098, DOI: 10.1104/pp.43.12.1883.

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Ruth Halaban, PhD

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