Masanori Sasaki, MD, PhD
Professor Adjunct of Neurology
Research & Publications
Biography
News
Extensive Research Description
My research
interest is in the area of cellular transplantation to repair spinal cord
injury. My work has primarily utilized neural cells derived from adult tissues
and processed for transplantation into injured spinal cord. I developed cells
from the olfactory system called olfactory ensheathing cells (OECs) that
display unique properties that assist normal axon growth of olfactory sensory
neurons into the brain. I have also engineered adult stem cells derived from
bone marrow to hypersecrete a neurotrophic factor and has found that these
cells are neuroprotective. Collectively, my research has important clinical
implications and could lead to a clinical study in spinal cord injury patients.
Coauthors
Selected Publications
- Repeated intravenous infusion of mesenchymal stem cells enhances recovery of motor function in a rat model with chronic spinal cord injuryKurihara K, Sasaki M, Nagahama H, Obara H, Fukushi R, Hirota R, Yoshimoto M, Teramoto A, Kocsis J, Yamashita T, Honmou O. Repeated intravenous infusion of mesenchymal stem cells enhances recovery of motor function in a rat model with chronic spinal cord injury. Brain Research 2023, 1817: 148484. PMID: 37442249, DOI: 10.1016/j.brainres.2023.148484.
- Therapeutic efficacy of intravenous infusion of mesenchymal stem cells in rat perinatal brain injuryTerada K, Sasaki M, Nagahama H, Kataoka-Sasaki Y, Oka S, Ukai R, Yokoyama T, Iizuka Y, Sakai T, Fukumura S, Tsugawa T, Kocsis J, Honmou O. Therapeutic efficacy of intravenous infusion of mesenchymal stem cells in rat perinatal brain injury. Pediatric Research 2023, 94: 1921-1928. PMID: 37422495, DOI: 10.1038/s41390-023-02717-9.
- Mesenchymal Stem Cell Transplantation for Spinal Cord Injury: Current Status and ProspectsHirota R, Sasaki M, Honmou O, Yamashita T. Mesenchymal Stem Cell Transplantation for Spinal Cord Injury: Current Status and Prospects. Spine Surgery And Related Research 2023, 7: 319-326. PMID: 37636138, PMCID: PMC10447197, DOI: 10.22603/ssrr.2022-0234.
- A practical protocol for high-spatial-resolution magnetic resonance angiography for cerebral arteries in ratsNagahama H, Sasaki M, Komatsu K, Sato K, Katagiri Y, Kamagata M, Kataoka-Sasaki Y, Oka S, Ukai R, Yokoyama T, Terada K, Kobayashi M, Kocsis J, Honmou O. A practical protocol for high-spatial-resolution magnetic resonance angiography for cerebral arteries in rats. Journal Of Neuroscience Methods 2023, 386: 109784. PMID: 36608904, DOI: 10.1016/j.jneumeth.2023.109784.
- Intravenous infusion of bone marrow-derived mesenchymal stem cells improves tissue perfusion in a rat hindlimb ischemia modelMaeda S, Kawamura T, Sasaki M, Shimamura K, Shibuya T, Harada A, Honmou O, Sawa Y, Miyagawa S. Intravenous infusion of bone marrow-derived mesenchymal stem cells improves tissue perfusion in a rat hindlimb ischemia model. Scientific Reports 2022, 12: 16986. PMID: 36216855, PMCID: PMC9551049, DOI: 10.1038/s41598-022-18485-1.
- Enhanced Network in Corticospinal Tracts after Infused Mesenchymal Stem Cells in Spinal Cord InjuryHirota R, Sasaki M, Kataoka-Sasaki Y, Oshigiri T, Kurihara K, Fukushi R, Oka S, Ukai R, Yoshimoto M, Kocsis JD, Yamashita T, Honmou O. Enhanced Network in Corticospinal Tracts after Infused Mesenchymal Stem Cells in Spinal Cord Injury. Journal Of Neurotrauma 2022, 39: 1665-1677. PMID: 35611987, PMCID: PMC9734021, DOI: 10.1089/neu.2022.0106.
- Intravenous Infusion of Autoserum-Expanded Autologous Mesenchymal Stem Cells in Patients With Chronic Brain Injury: Protocol for a Phase 2 TrialOka S, Yamaki T, Sasaki M, Ukai R, Takemura M, Yokoyama T, Kataoka-Sasaki Y, Onodera R, Ito YM, Kobayashi S, Kocsis JD, Iwadate Y, Honmou O. Intravenous Infusion of Autoserum-Expanded Autologous Mesenchymal Stem Cells in Patients With Chronic Brain Injury: Protocol for a Phase 2 Trial. JMIR Research Protocols 2022, 11: e37898. PMID: 35793128, PMCID: PMC9301565, DOI: 10.2196/37898.
- The Impact of Purple-Flesh Potato (Solanum tuberosum L.) cv. “Shadow Queen” on Minor Health Complaints in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled StudyMaeda-Yamamoto M, Honmou O, Sasaki M, Haseda A, Kagami-Katsuyama H, Shoji T, Namioka A, Namioka T, Magota H, Oka S, Kataoka-Sasaki Y, Ukai R, Takemura M, Nishihira J. The Impact of Purple-Flesh Potato (Solanum tuberosum L.) cv. “Shadow Queen” on Minor Health Complaints in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Study. Nutrients 2022, 14: 2446. PMID: 35745176, PMCID: PMC9227939, DOI: 10.3390/nu14122446.
- Pharmacological Difference Between Platelet Aggregations in Cardioembolic Stroke Patients with Direct Oral Anticoagulants: A Pilot StudyNakazaki M, Oka S, Magota H, Kiyose R, Onodera R, Ukai R, Kataoka-Sasaki Y, Sasaki M, Honmou O. Pharmacological Difference Between Platelet Aggregations in Cardioembolic Stroke Patients with Direct Oral Anticoagulants: A Pilot Study. Journal Of Stroke And Cerebrovascular Diseases 2022, 31: 106520. PMID: 35523052, DOI: 10.1016/j.jstrokecerebrovasdis.2022.106520.
- Repeated intravenous infusion of mesenchymal stem cells for enhanced functional recovery in a rat model of chronic cerebral ischemia.Takemura M, Sasaki M, Kataoka-Sasaki Y, Kiyose R, Nagahama H, Oka S, Ukai R, Yokoyama T, Kocsis J, Ueba T, Honmou O. Repeated intravenous infusion of mesenchymal stem cells for enhanced functional recovery in a rat model of chronic cerebral ischemia. Journal Of Neurosurgery 2021, 137: 1-10. PMID: 34861644, DOI: 10.3171/2021.8.jns21687.
- Possible role of intravenous administration of mesenchymal stem cells to alleviate interstitial cystitis/bladder pain syndrome in a Toll-like receptor-7 agonist-induced experimental animal model in ratTabata H, Sasaki M, Kataoka-Sasaki Y, Shinkai N, Ichihara K, Masumori N, Kocsis JD, Honmou O. Possible role of intravenous administration of mesenchymal stem cells to alleviate interstitial cystitis/bladder pain syndrome in a Toll-like receptor-7 agonist-induced experimental animal model in rat. BMC Urology 2021, 21: 156. PMID: 34774029, PMCID: PMC8590770, DOI: 10.1186/s12894-021-00923-3.
- Intravenous Infusion of Mesenchymal Stem Cells Promotes the Survival of Random Pattern Flaps in RatsNakagawa T, Sasaki M, Kataoka-Sasaki Y, Yotsuyanagi T, Radtke C, Kocsis JD, Honmou O. Intravenous Infusion of Mesenchymal Stem Cells Promotes the Survival of Random Pattern Flaps in Rats. Plastic & Reconstructive Surgery 2021, 148: 799-807. PMID: 34550936, DOI: 10.1097/prs.0000000000008327.
- Repeated infusion of mesenchymal stem cells maintain the condition to inhibit deteriorated motor function, leading to an extended lifespan in the SOD1G93A rat model of amyotrophic lateral sclerosisMagota H, Sasaki M, Kataoka-Sasaki Y, Oka S, Ukai R, Kiyose R, Onodera R, Kocsis JD, Honmou O. Repeated infusion of mesenchymal stem cells maintain the condition to inhibit deteriorated motor function, leading to an extended lifespan in the SOD1G93A rat model of amyotrophic lateral sclerosis. Molecular Brain 2021, 14: 76. PMID: 33962678, PMCID: PMC8103621, DOI: 10.1186/s13041-021-00787-6.
- Intravenous Infusion of Mesenchymal Stem Cells Enhances Therapeutic Efficacy of Reperfusion Therapy in Cerebral IschemiaKiyose R, Sasaki M, Kataoka-Sasaki Y, Nakazaki M, Nagahama H, Magota H, Oka S, Ukai R, Takemura M, Yokoyama T, Kocsis JD, Honmou O. Intravenous Infusion of Mesenchymal Stem Cells Enhances Therapeutic Efficacy of Reperfusion Therapy in Cerebral Ischemia. World Neurosurgery 2021, 149: e160-e169. PMID: 33618048, DOI: 10.1016/j.wneu.2021.02.056.
- Intravenous infusion of auto serum-expanded autologous mesenchymal stem cells in spinal cord injury patients: 13 case seriesHonmou O, Yamashita T, Morita T, Oshigiri T, Hirota R, Iyama S, Kato J, Sasaki Y, Ishiai S, Ito YM, Namioka A, Namioka T, Nakazaki M, Kataoka-Sasaki Y, Onodera R, Oka S, Sasaki M, Waxman SG, Kocsis JD. Intravenous infusion of auto serum-expanded autologous mesenchymal stem cells in spinal cord injury patients: 13 case series. Clinical Neurology And Neurosurgery 2021, 203: 106565. PMID: 33667953, DOI: 10.1016/j.clineuro.2021.106565.
- Focal brainstem infarction in the adult ratNamioka A, Namioka T, Sasaki M, Kocsis JD, Honmou O. Focal brainstem infarction in the adult rat. Lab Animal 2021, 50: 97-107. PMID: 33564191, DOI: 10.1038/s41684-021-00722-1.
- Postoperative spinal cord ischaemia: magnetic resonance imaging and clinical features.Yasuda N, Kuroda Y, Ito T, Sasaki M, Oka S, Ukai R, Nakanishi K, Mikami T, Shibata T, Harada R, Naraoka S, Kamada T, Kawaharada N. Postoperative spinal cord ischaemia: magnetic resonance imaging and clinical features. European Journal Of Cardio-Thoracic Surgery 2021, 60: 164-174. PMID: 33517384, DOI: 10.1093/ejcts/ezaa476.
- Intravenous infusion of mesenchymal stem cells delays disease progression in the SOD1G93A transgenic amyotrophic lateral sclerosis rat modelMagota H, Sasaki M, Kataoka-Sasaki Y, Oka S, Ukai R, Kiyose R, Onodera R, Kocsis JD, Honmou O. Intravenous infusion of mesenchymal stem cells delays disease progression in the SOD1G93A transgenic amyotrophic lateral sclerosis rat model. Brain Research 2021, 1757: 147296. PMID: 33516815, DOI: 10.1016/j.brainres.2021.147296.
- 3.神経再生治療によって惹起される神経可塑性の MRI による評価Nagahama H, Sasaki M, Kiyose R, Yasuda N, Honmou O. 3.神経再生治療によって惹起される神経可塑性の MRI による評価. Japanese Journal Of Radiological Technology 2021, 77: 1238-1244. PMID: 34670933, DOI: 10.6009/jjrt.2021_jsrt_77.10.1238.
- Prolonged lifespan in a spontaneously hypertensive rat (stroke prone) model following intravenous infusion of mesenchymal stem cellsNakazaki M, Oka S, Sasaki M, Kataoka-Sasaki Y, Nagahama H, Hashi K, Kocsis JD, Honmou O. Prolonged lifespan in a spontaneously hypertensive rat (stroke prone) model following intravenous infusion of mesenchymal stem cells. Heliyon 2020, 6: e05833. PMID: 33392407, PMCID: PMC7773587, DOI: 10.1016/j.heliyon.2020.e05833.
- Intravenous delivery of mesenchymal stem cells protects both white and gray matter in spinal cord ischemiaYasuda N, Sasaki M, Kataoka-Sasaki Y, Nagahama H, Kocsis JD, Kawaharada N, Honmou O. Intravenous delivery of mesenchymal stem cells protects both white and gray matter in spinal cord ischemia. Brain Research 2020, 1747: 147040. PMID: 32771405, DOI: 10.1016/j.brainres.2020.147040.
- “Chronic” State in Neural Diseases as the Target of Cellular Therapy with Mesenchymal Stem CellsSasaki M, Oka S, Kataoka-Sasaki Y, Kocsis JD, Honmou O. “Chronic” State in Neural Diseases as the Target of Cellular Therapy with Mesenchymal Stem Cells. World Neurosurgery 2020, 135: 375-376. PMID: 32143241, DOI: 10.1016/j.wneu.2019.12.137.
- Prevention of neointimal hyperplasia induced by an endovascular stent via intravenous infusion of mesenchymal stem cells.Nakazaki M, Oka S, Sasaki M, Kataoka-Sasaki Y, Onodera R, Komatsu K, Iihoshi S, Hiroura M, Kawaguchi A, Kocsis JD, Honmou O. Prevention of neointimal hyperplasia induced by an endovascular stent via intravenous infusion of mesenchymal stem cells. Journal Of Neurosurgery 2019, 133: 1773-1785. PMID: 31585431, DOI: 10.3171/2019.7.jns19575.
- Intravenous infusion of mesenchymal stem cells improves impaired cognitive function in a cerebral small vessel disease modelNakazaki M, Sasaki M, Kataoka-Sasaki Y, Oka S, Suzuki J, Sasaki Y, Nagahama H, Hashi K, Kocsis JD, Honmou O. Intravenous infusion of mesenchymal stem cells improves impaired cognitive function in a cerebral small vessel disease model. Neuroscience 2019, 408: 361-377. PMID: 30999031, DOI: 10.1016/j.neuroscience.2019.04.018.
- Detection of local and remote cellular damage caused by spinal cord and peripheral nerve injury using a heat shock signaling reporter systemHashimoto-Torii K, Sasaki M, Chang YW, Hwang H, Waxman SG, Kocsis JD, Rakic P, Torii M. Detection of local and remote cellular damage caused by spinal cord and peripheral nerve injury using a heat shock signaling reporter system. IBRO Neuroscience Reports 2018, 5: 91-98. PMID: 30480161, PMCID: PMC6240805, DOI: 10.1016/j.ibror.2018.11.003.
- Functional recovery after the systemic administration of mesenchymal stem cells in a rat model of neonatal hypoxia-ischemia.Sakai T, Sasaki M, Kataoka-Sasaki Y, Oka S, Nakazaki M, Fukumura S, Kobayashi M, Tsutsumi H, Kocsis JD, Honmou O. Functional recovery after the systemic administration of mesenchymal stem cells in a rat model of neonatal hypoxia-ischemia. Journal Of Neurosurgery Pediatrics 2018, 22: 513-522. PMID: 30074448, DOI: 10.3171/2018.5.peds1845.
- Intravenous infusion of mesenchymal stem cells for protection against brainstem infarction in a persistent basilar artery occlusion model in the adult rat.Namioka A, Namioka T, Sasaki M, Kataoka-Sasaki Y, Oka S, Nakazaki M, Onodera R, Suzuki J, Sasaki Y, Nagahama H, Kocsis JD, Honmou O. Intravenous infusion of mesenchymal stem cells for protection against brainstem infarction in a persistent basilar artery occlusion model in the adult rat. Journal Of Neurosurgery 2018, 131: 1-9. PMID: 30485204, DOI: 10.3171/2018.4.jns173121.
- Intravenous infusion of mesenchymal stem cells promotes functional recovery in a rat model of chronic cerebral infarction.Namioka T, Namioka A, Sasaki M, Kataoka-Sasaki Y, Oka S, Nakazaki M, Onodera R, Suzuki J, Sasaki Y, Nagahama H, Kocsis JD, Honmou O. Intravenous infusion of mesenchymal stem cells promotes functional recovery in a rat model of chronic cerebral infarction. Journal Of Neurosurgery 2018, 131: 1-8. PMID: 30485210, DOI: 10.3171/2018.5.jns18140.
- Intravenous Infusion of Mesenchymal Stem Cells Alters Motor Cortex Gene Expression in a Rat Model of Acute Spinal Cord InjuryOshigiri T, Sasaki T, Sasaki M, Kataoka-Sasaki Y, Nakazaki M, Oka S, Morita T, Hirota R, Yoshimoto M, Yamashita T, Hashimoto-Torii K, Honmou O. Intravenous Infusion of Mesenchymal Stem Cells Alters Motor Cortex Gene Expression in a Rat Model of Acute Spinal Cord Injury. Journal Of Neurotrauma 2018, 36: 411-420. PMID: 29901416, PMCID: PMC6352512, DOI: 10.1089/neu.2018.5793.
- Actin, alpha, cardiac muscle 1 (ACTC1) knockdown inhibits the migration of glioblastoma cells in vitroWanibuchi M, Ohtaki S, Ookawa S, Kataoka-Sasaki Y, Sasaki M, Oka S, Kimura Y, Akiyama Y, Mikami T, Mikuni N, Kocsis JD, Honmou O. Actin, alpha, cardiac muscle 1 (ACTC1) knockdown inhibits the migration of glioblastoma cells in vitro. Journal Of The Neurological Sciences 2018, 392: 117-121. PMID: 30055382, DOI: 10.1016/j.jns.2018.07.013.
- Preservation of interhemispheric cortical connections through corpus callosum following intravenous infusion of mesenchymal stem cells in a rat model of cerebral infarctionNagahama H, Nakazaki M, Sasaki M, Kataoka-Sasaki Y, Namioka T, Namioka A, Oka S, Onodera R, Suzuki J, Sasaki Y, Kocsis JD, Honmou O. Preservation of interhemispheric cortical connections through corpus callosum following intravenous infusion of mesenchymal stem cells in a rat model of cerebral infarction. Brain Research 2018, 1695: 37-44. PMID: 29802840, DOI: 10.1016/j.brainres.2018.05.033.
- Accelerating Cell Therapy for Stroke in JapanHoukin K, Shichinohe H, Abe K, Arato T, Dezawa M, Honmou O, Horie N, Katayama Y, Kudo K, Kuroda S, Matsuyama T, Miyai I, Nagata I, Niizuma K, Sakushima K, Sasaki M, Sato N, Sawanobori K, Suda S, Taguchi A, Tominaga T, Yamamoto H, Yamashita T, Yoshimine T. Accelerating Cell Therapy for Stroke in Japan. Stroke 2018, 49: e145-e152. PMID: 29581346, DOI: 10.1161/strokeaha.117.019216.
- Intravenous infusion of mesenchymal stem cells reduces epileptogenesis in a rat model of status epilepticusFukumura S, Sasaki M, Kataoka-Sasaki Y, Oka S, Nakazaki M, Nagahama H, Morita T, Sakai T, Tsutsumi H, Kocsis JD, Honmou O. Intravenous infusion of mesenchymal stem cells reduces epileptogenesis in a rat model of status epilepticus. Epilepsy Research 2018, 141: 56-63. PMID: 29475054, DOI: 10.1016/j.eplepsyres.2018.02.008.
- Digital Polymerase Chain Reaction Quantification of SERPINA1 Predicts Prognosis in High-Grade GliomaOokawa S, Wanibuchi M, Kataoka-Sasaki Y, Sasaki M, Oka S, Ohtaki S, Noshiro S, Komatsu K, Akiyama Y, Mikami T, Mikuni N, Kocsis JD, Honmou O. Digital Polymerase Chain Reaction Quantification of SERPINA1 Predicts Prognosis in High-Grade Glioma. World Neurosurgery 2018, 111: e783-e789. PMID: 29309973, DOI: 10.1016/j.wneu.2017.12.166.
- 8.前臨床MRI を用いた脳梗塞に対する再生治療メカニズムの評価Nagahama H, Suzuki J, Sasaki M, Nakazaki M, Honmou O. 8.前臨床MRI を用いた脳梗塞に対する再生治療メカニズムの評価. Japanese Journal Of Radiological Technology 2018, 74: 722-725. PMID: 30033967, DOI: 10.6009/jjrt.2018_jsrt_74.7.722.
- Intravenous Infusion of Bone Marrow–Derived Mesenchymal Stem Cells Reduces Erectile Dysfunction Following Cavernous Nerve Injury in RatsMatsuda Y, Sasaki M, Kataoka-Sasaki Y, Takayanagi A, Kobayashi K, Oka S, Nakazaki M, Masumori N, Kocsis JD, Honmou O. Intravenous Infusion of Bone Marrow–Derived Mesenchymal Stem Cells Reduces Erectile Dysfunction Following Cavernous Nerve Injury in Rats. Sexual Medicine 2017, 6: 49-57. PMID: 29275062, PMCID: PMC5815969, DOI: 10.1016/j.esxm.2017.10.005.
- Cerebral aneurysm neck diameter is an independent predictor of progressive occlusion after stent-assisted coilingNakazaki M, Nonaka T, Nomura T, Onda T, Yonemasu Y, Takahashi A, Hashimoto Y, Honda O, Oka S, Sasaki M, Daibo M, Honmou O. Cerebral aneurysm neck diameter is an independent predictor of progressive occlusion after stent-assisted coiling. Acta Neurochirurgica 2017, 159: 1313-1319. PMID: 28488070, DOI: 10.1007/s00701-017-3199-8.
- Elevated brain derived neurotrophic factor levels in plasma reflect in vivo functional viability of infused mesenchymal stem cells for stroke in rats.Nakamura H, Sasaki Y, Sasaki M, Kataoka-Sasaki Y, Oka S, Nakazaki M, Namioka T, Namioka A, Onodera R, Suzuki J, Nagahama H, Mikami T, Wanibuchi M, Kocsis JD, Honmou O. Elevated brain derived neurotrophic factor levels in plasma reflect in vivo functional viability of infused mesenchymal stem cells for stroke in rats. Journal Of Neurosurgical Sciences 2017, 63: 42-49. PMID: 28181779, DOI: 10.23736/s0390-5616.17.03989-3.
- Detection of vulnerable neurons damaged by environmental insults in uteroTorii M, Sasaki M, Chang YW, Ishii S, Waxman SG, Kocsis JD, Rakic P, Hashimoto-Torii K. Detection of vulnerable neurons damaged by environmental insults in utero. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 2367-2372. PMID: 28123061, PMCID: PMC5338500, DOI: 10.1073/pnas.1620641114.
- Interleukin-13 receptor alpha 2 as a marker of poorer prognosis in high-grade astrocytomas.Wanibuchi M, Kataoka-Sasaki Y, Sasaki M, Oka S, Otsuka Y, Yamaguchi M, Ohnishi H, Ohtaki S, Noshiro S, Ookawa S, Mikami T, Mikuni N, Honmou O. Interleukin-13 receptor alpha 2 as a marker of poorer prognosis in high-grade astrocytomas. Journal Of Neurosurgical Sciences 2017, 62: 239-244. PMID: 28079349, DOI: 10.23736/s0390-5616.16.03793-0.
- Co-expression of tissue factor and IL-6 in immature endothelial cells of cerebral cavernous malformationsNoshiro S, Mikami T, Kataoka-Sasaki Y, Sasaki M, Ohnishi H, Ohtaki S, Wanibuchi M, Mikuni N, Kocsis JD, Honmou O. Co-expression of tissue factor and IL-6 in immature endothelial cells of cerebral cavernous malformations. Journal Of Clinical Neuroscience 2017, 37: 83-90. PMID: 28087183, DOI: 10.1016/j.jocn.2016.12.023.
- Mesenchymal Stem CellsSasaki M, Honmou O. Mesenchymal Stem Cells. 2017, 147-156. DOI: 10.1007/978-4-431-56059-3_12.
- Intravenous infusion of mesenchymal stem cells inhibits intracranial hemorrhage after recombinant tissue plasminogen activator therapy for transient middle cerebral artery occlusion in rats.Nakazaki M, Sasaki M, Kataoka-Sasaki Y, Oka S, Namioka T, Namioka A, Onodera R, Suzuki J, Sasaki Y, Nagahama H, Mikami T, Wanibuchi M, Kocsis JD, Honmou O. Intravenous infusion of mesenchymal stem cells inhibits intracranial hemorrhage after recombinant tissue plasminogen activator therapy for transient middle cerebral artery occlusion in rats. Journal Of Neurosurgery 2017, 127: 917-926. PMID: 28059661, DOI: 10.3171/2016.8.jns16240.
- 実験的脳梗塞に対する骨髄間葉系幹細胞移植とリハビリテーションの併用による治療効果Sasaki Y, Sasaki M, Sasaki Y, Nakazaki M, Oka S, Namioka T, Namioka A, Kakizawa M, Honmou O. 実験的脳梗塞に対する骨髄間葉系幹細胞移植とリハビリテーションの併用による治療効果. Cerebral Blood Flow And Metabolism (Japanese Journal Of Cerebral Blood Flow And Metabolism) 2017, 28: 281-289. DOI: 10.16977/cbfm.28.2_281.
- Intravenous infusion of mesenchymal stem cells promotes functional recovery in a model of chronic spinal cord injuryMorita T, Sasaki M, Kataoka-Sasaki Y, Nakazaki M, Nagahama H, Oka S, Oshigiri T, Takebayashi T, Yamashita T, Kocsis JD, Honmou O. Intravenous infusion of mesenchymal stem cells promotes functional recovery in a model of chronic spinal cord injury. Neuroscience 2016, 335: 221-231. PMID: 27586052, DOI: 10.1016/j.neuroscience.2016.08.037.
- Biological relevance of tissue factor and IL-6 in arteriovenous malformationsNoshiro S, Mikami T, Kataoka-Sasaki Y, Sasaki M, Hashi K, Ohtaki S, Wanibuchi M, Mikuni N, Kocsis JD, Honmou O. Biological relevance of tissue factor and IL-6 in arteriovenous malformations. Neurosurgical Review 2016, 40: 359-367. PMID: 27542852, DOI: 10.1007/s10143-016-0780-1.
- Synergic Effects of Rehabilitation and Intravenous Infusion of Mesenchymal Stem Cells After Stroke in RatsSasaki Y, Sasaki M, Kataoka-Sasaki Y, Nakazaki M, Nagahama H, Suzuki J, Tateyama D, Oka S, Namioka T, Namioka A, Onodera R, Mikami T, Wanibuchi M, Kakizawa M, Ishiai S, Kocsis JD, Honmou O. Synergic Effects of Rehabilitation and Intravenous Infusion of Mesenchymal Stem Cells After Stroke in Rats. Physical Therapy 2016, 96: 1791-1798. PMID: 27174259, DOI: 10.2522/ptj.20150504.
- Double balloon protection during carotid artery stenting for vulnerable carotid stenosis reduces the incidence of new brain lesionsNakazaki M, Nonaka T, Takahashi A, Yonemasu Y, Nomura T, Onda T, Honda O, Hashimoto Y, Ohnishi H, Sasaki M, Daibo M, Honmou O. Double balloon protection during carotid artery stenting for vulnerable carotid stenosis reduces the incidence of new brain lesions. Acta Neurochirurgica 2016, 158: 1377-1386. PMID: 27138330, DOI: 10.1007/s00701-016-2816-2.
- ACTC1 as an invasion and prognosis marker in glioma.Ohtaki S, Wanibuchi M, Kataoka-Sasaki Y, Sasaki M, Oka S, Noshiro S, Akiyama Y, Mikami T, Mikuni N, Kocsis JD, Honmou O. ACTC1 as an invasion and prognosis marker in glioma. Journal Of Neurosurgery 2016, 126: 467-475. PMID: 27081897, DOI: 10.3171/2016.1.jns152075.
- Efficacy of Endovascular Treatment for Occlusive Lesions of a Single M2 Branch in Non-recombinant Tissue Plasminogen Activator Treated PatientsOnda T, Nakazaki M, Nomura T, Sasaki M, Yonemasu Y, Hashimoto Y, Takahashi A, Honda O, Daibou M, Nonaka T. Efficacy of Endovascular Treatment for Occlusive Lesions of a Single M2 Branch in Non-recombinant Tissue Plasminogen Activator Treated Patients. Journal Of Neuroendovascular Therapy 2016, 11: oa.2016-0024. DOI: 10.5797/jnet.oa.2016-0024.
- Preload of MSC Rescues Erectile FunctionTakayanagi A, Sasaki M, Kataoka-Sasaki Y, Kobayashi K, Matsuda Y, Oka S, Masumori N, Kocsis JD, Honmou O. Preload of MSC Rescues Erectile Function. The Journal Of Sexual Medicine 2015, 12: 1713-1721. PMID: 26211660, DOI: 10.1111/jsm.12957.
- 41 Preload of mesenchymal stem cells via intravenous infusion prevents erectile dysfunction in a rat model of cavernous nerve injuryTakayanagi A, Sasaki M, Kataoka-Sasaki Y, Kobayashi K, Matsuda Y, Oka S, Masumori N, Honmou O. 41 Preload of mesenchymal stem cells via intravenous infusion prevents erectile dysfunction in a rat model of cavernous nerve injury. European Urology Open Science 2015, 14: e41. DOI: 10.1016/s1569-9056(15)60044-6.
- Diffuse and persistent blood–spinal cord barrier disruption after contusive spinal cord injury rapidly recovers following intravenous infusion of bone marrow mesenchymal stem cellsMatsushita T, Lankford KL, Arroyo EJ, Sasaki M, Neyazi M, Radtke C, Kocsis JD. Diffuse and persistent blood–spinal cord barrier disruption after contusive spinal cord injury rapidly recovers following intravenous infusion of bone marrow mesenchymal stem cells. Experimental Neurology 2015, 267: 152-164. PMID: 25771801, DOI: 10.1016/j.expneurol.2015.03.001.
- Corrigendum to “Intravenous mesenchymal stem cell administration exhibits therapeutic effects against 6-hydroxydopamine-induced dopaminergic neurodegeneration and glial activation in rats” [Neurosci. Lett. 584 (2015) 276–281]Suzuki S, Kawamata J, Iwahara N, Matsumura A, Hisahara S, Matsushita T, Sasaki M, Honmou O, Shimohama S. Corrigendum to “Intravenous mesenchymal stem cell administration exhibits therapeutic effects against 6-hydroxydopamine-induced dopaminergic neurodegeneration and glial activation in rats” [Neurosci. Lett. 584 (2015) 276–281]. Neuroscience Letters 2015, 587: 5. DOI: 10.1016/j.neulet.2014.12.023.
- 脳梗塞後遺症の機能回復を目指した,骨髄間葉系幹細胞治療Nakazaki M, Oka S, Sasaki M, Honmou O. 脳梗塞後遺症の機能回復を目指した,骨髄間葉系幹細胞治療. Nippon Jibiinkoka Gakkai Kaiho 2015, 118: 93. PMID: 26495511, DOI: 10.3950/jibiinkoka.118.93.
- Intravenous mesenchymal stem cell administration exhibits therapeutic effects against 6-hydroxydopamine-induced dopaminergic neurodegeneration and glial activation in ratsSuzuki S, Kawamata J, Iwahara N, Matsumura A, Hisahara S, Matsushita T, Sasaki M, Honmou O, Shimohama S. Intravenous mesenchymal stem cell administration exhibits therapeutic effects against 6-hydroxydopamine-induced dopaminergic neurodegeneration and glial activation in rats. Neuroscience Letters 2014, 584: 276-281. PMID: 25449872, DOI: 10.1016/j.neulet.2014.10.039.
- Possible neural plasticity detected by fMRI associates with improved motor function following intravenous injection of mesenchymal stem cells in a rat stroke modelNakazaki M, Suzuki J, Sasaki M, Oka S, Sasaki Y, Honmou O. Possible neural plasticity detected by fMRI associates with improved motor function following intravenous injection of mesenchymal stem cells in a rat stroke model. Cerebral Blood Flow And Metabolism (Japanese Journal Of Cerebral Blood Flow And Metabolism) 2014, 25: 67. DOI: 10.16977/cbfm.25.2_67.
- Olfactory ensheathing cells, but not schwann cells, proliferate and migrate extensively within moderately X‐Irradiated juvenile rat brainLankford KL, Brown RJ, Sasaki M, Kocsis JD. Olfactory ensheathing cells, but not schwann cells, proliferate and migrate extensively within moderately X‐Irradiated juvenile rat brain. Glia 2013, 62: 52-63. PMID: 24166823, DOI: 10.1002/glia.22583.
- Bilateral cortical hyperactivity detected by fMRI associates with improved motor function following intravenous infusion of mesenchymal stem cells in a rat stroke modelSuzuki J, Sasaki M, Harada K, Bando M, Kataoka Y, Onodera R, Mikami T, Wanibuchi M, Mikuni N, Kocsis JD, Honmou O. Bilateral cortical hyperactivity detected by fMRI associates with improved motor function following intravenous infusion of mesenchymal stem cells in a rat stroke model. Brain Research 2012, 1497: 15-22. PMID: 23274536, DOI: 10.1016/j.brainres.2012.12.028.
- LOP08Radtke C, Lankford K, Sasaki M, Kocsis J, Vogt P. LOP08. Plastic & Reconstructive Surgery 2012, 130: 481. DOI: 10.1097/01.prs.0000418400.18580.18.
- Abstract 31PRadtke C, Reimers K, Lankford K, Sasaki M, Kocsis J, Vogt P. Abstract 31P. Plastic & Reconstructive Surgery 2012, 130: 99. DOI: 10.1097/01.prs.0000416229.44023.41.
- Mesenchymal stem cells: therapeutic outlook for strokeHonmou O, Onodera R, Sasaki M, Waxman SG, Kocsis JD. Mesenchymal stem cells: therapeutic outlook for stroke. Trends In Molecular Medicine 2012, 18: 292-297. PMID: 22459358, DOI: 10.1016/j.molmed.2012.02.003.
- CNPase Expression in Olfactory Ensheathing CellsRadtke C, Sasaki M, Lankford KL, Gallo V, Kocsis JD. CNPase Expression in Olfactory Ensheathing Cells. BioMed Research International 2011, 2011: 608496. PMID: 22174557, PMCID: PMC3228405, DOI: 10.1155/2011/608496.
- Development of a Middle Cerebral Artery Occlusion Model in the Nonhuman Primate and a Safety Study of I.V. Infusion of Human Mesenchymal Stem CellsSasaki M, Honmou O, Radtke C, Kocsis JD. Development of a Middle Cerebral Artery Occlusion Model in the Nonhuman Primate and a Safety Study of I.V. Infusion of Human Mesenchymal Stem Cells. PLOS ONE 2011, 6: e26577. PMID: 22039510, PMCID: PMC3200343, DOI: 10.1371/journal.pone.0026577.
- Remyelination after olfactory ensheathing cell transplantation into diverse demyelinating environmentsSasaki M, Lankford KL, Radtke C, Honmou O, Kocsis JD. Remyelination after olfactory ensheathing cell transplantation into diverse demyelinating environments. Experimental Neurology 2011, 229: 88-98. PMID: 21281634, DOI: 10.1016/j.expneurol.2011.01.010.
- Focal experimental autoimmune encephalomyelitis in the lewis rat induced by immunization with myelin oligodendrocyte glycoprotein and intraspinal injection of vascular endothelial growth factorSasaki M, Lankford KL, Brown RJ, Ruddle NH, Kocsis JD. Focal experimental autoimmune encephalomyelitis in the lewis rat induced by immunization with myelin oligodendrocyte glycoprotein and intraspinal injection of vascular endothelial growth factor. Glia 2010, 58: 1523-1531. PMID: 20645414, DOI: 10.1002/glia.21026.
- BDNF-Hypersecreting Human Mesenchymal Stem Cells Promote Functional Recovery, Axonal Sprouting, and Protection of Corticospinal Neurons after Spinal Cord InjurySasaki M, Radtke C, Tan AM, Zhao P, Hamada H, Houkin K, Honmou O, Kocsis JD. BDNF-Hypersecreting Human Mesenchymal Stem Cells Promote Functional Recovery, Axonal Sprouting, and Protection of Corticospinal Neurons after Spinal Cord Injury. Journal Of Neuroscience 2009, 29: 14932-14941. PMID: 19940189, PMCID: PMC2825276, DOI: 10.1523/jneurosci.2769-09.2009.
- Convergence of Cells from the Progenitor Fraction of Adult Olfactory Bulb Tissue to Remyelinating Glia in Demyelinating Spinal Cord LesionsMarkakis EA, Sasaki M, Lankford KL, Kocsis JD. Convergence of Cells from the Progenitor Fraction of Adult Olfactory Bulb Tissue to Remyelinating Glia in Demyelinating Spinal Cord Lesions. PLOS ONE 2009, 4: e7260. PMID: 19787061, PMCID: PMC2747269, DOI: 10.1371/journal.pone.0007260.
- A Rat Middle Cerebral Artery Occlusion Model and Intravenous Cellular DeliverySasaki M, Honmou O, Kocsis JD. A Rat Middle Cerebral Artery Occlusion Model and Intravenous Cellular Delivery. 2009, 549: 187-195. PMID: 19378204, DOI: 10.1007/978-1-60327-931-4_13.
- Unique in vivo properties of olfactory ensheathing cells that may contribute to neural repair and protection following spinal cord injuryKocsis JD, Lankford KL, Sasaki M, Radtke C. Unique in vivo properties of olfactory ensheathing cells that may contribute to neural repair and protection following spinal cord injury. Neuroscience Letters 2009, 456: 137-142. PMID: 19429149, PMCID: PMC2713444, DOI: 10.1016/j.neulet.2008.08.093.
- Development of a stroke model in the nonhuman primate and a safety study of IV infusion of human mesenchymal stem cellsSasaki M, Radtke C, Honmou O, Houkin K, Kocsis J. Development of a stroke model in the nonhuman primate and a safety study of IV infusion of human mesenchymal stem cells. Neuroscience Research 2009, 65: s127. DOI: 10.1016/j.neures.2009.09.613.
- Potential of olfactory ensheathing cells for cell-based therapy in spinal cord injuryRadtke C, Sasaki M, Lankford KL, Vogt PM, Kocsis JD. Potential of olfactory ensheathing cells for cell-based therapy in spinal cord injury. The Journal Of Rehabilitation Research And Development 2008, 45: 141-152. PMID: 18566933, DOI: 10.1682/jrrd.2007.03.0049.
- Olfactory ensheathing cells exhibit unique migratory, phagocytic, and myelinating properties in the X‐irradiated spinal cord not shared by Schwann cellsLankford KL, Sasaki M, Radtke C, Kocsis JD. Olfactory ensheathing cells exhibit unique migratory, phagocytic, and myelinating properties in the X‐irradiated spinal cord not shared by Schwann cells. Glia 2008, 56: 1664-1678. PMID: 18551623, DOI: 10.1002/glia.20718.
- 18 MULTIPLE SCLEROSIS: REMYELINATIONKOCSIS J, SASAKI M, LANKFORD K, RADTKE C. 18 MULTIPLE SCLEROSIS: REMYELINATION. 2008, 413-435. DOI: 10.1016/b978-012373994-0.50020-8.
- Demyelinating diseases and potential repair strategiesRadtke C, Spies M, Sasaki M, Vogt PM, Kocsis JD. Demyelinating diseases and potential repair strategies. International Journal Of Developmental Neuroscience 2007, 25: 149-153. PMID: 17408905, PMCID: PMC2692731, DOI: 10.1016/j.ijdevneu.2007.02.002.
- Remyelination of the injured spinal cordSasaki M, Li B, Lankford KL, Radtke C, Kocsis JD. Remyelination of the injured spinal cord. 2007, 161: 419-433. PMID: 17618995, PMCID: PMC2605400, DOI: 10.1016/s0079-6123(06)61030-3.
- Myelination and nodal formation of regenerated peripheral nerve fibers following transplantation of acutely prepared olfactory ensheathing cellsDombrowski MA, Sasaki M, Lankford KL, Kocsis JD, Radtke C. Myelination and nodal formation of regenerated peripheral nerve fibers following transplantation of acutely prepared olfactory ensheathing cells. Brain Research 2006, 1125: 1-8. PMID: 17112480, PMCID: PMC2673087, DOI: 10.1016/j.brainres.2006.09.089.
- Molecular Reconstruction of Nodes of Ranvier after Remyelination by Transplanted Olfactory Ensheathing Cells in the Demyelinated Spinal CordSasaki M, Black JA, Lankford KL, Tokuno HA, Waxman SG, Kocsis JD. Molecular Reconstruction of Nodes of Ranvier after Remyelination by Transplanted Olfactory Ensheathing Cells in the Demyelinated Spinal Cord. Journal Of Neuroscience 2006, 26: 1803-1812. PMID: 16467529, PMCID: PMC2605396, DOI: 10.1523/jneurosci.3611-05.2006.
- Protection of corticospinal tract neurons after dorsal spinal cord transection and engraftment of olfactory ensheathing cellsSasaki M, Hains BC, Lankford KL, Waxman SG, Kocsis JD. Protection of corticospinal tract neurons after dorsal spinal cord transection and engraftment of olfactory ensheathing cells. Glia 2005, 53: 352-359. PMID: 16288464, PMCID: PMC2605395, DOI: 10.1002/glia.20285.
- Plastic Surgery Research Council 2005 Clifford C. Snyder, MD Award: Myelination of Regenerated Sciatic Nerve Fibers by Engrafted Schwann Cells Identified with Gfp and Fluorescence In-situ Hybridization (Fish) for Y ChromosomesRadtke C, Sasaki M, Vogt P, Krause D, Kocsis J. Plastic Surgery Research Council 2005 Clifford C. Snyder, MD Award: Myelination of Regenerated Sciatic Nerve Fibers by Engrafted Schwann Cells Identified with Gfp and Fluorescence In-situ Hybridization (Fish) for Y Chromosomes. Plastic & Reconstructive Surgery 2005, 116: 57-58. DOI: 10.1097/00006534-200509011-00058.
- 28 Transplantation of Peripheral-Myelin-Forming Cells to Repair Demyelinated AxonsKocsis J, Sasaki M. 28 Transplantation of Peripheral-Myelin-Forming Cells to Repair Demyelinated Axons. 2005, 421-433. DOI: 10.1016/b978-012738761-1/50029-8.
- Autologous transplantation of expanded neural precursor cells into the demyelinated monkey spinal cordOka S, Honmou O, Akiyama Y, Sasaki M, Houkin K, Hashi K, Kocsis JD. Autologous transplantation of expanded neural precursor cells into the demyelinated monkey spinal cord. Brain Research 2004, 1030: 94-102. PMID: 15567341, DOI: 10.1016/j.brainres.2004.09.062.
- Identified Olfactory Ensheathing Cells Transplanted into the Transected Dorsal Funiculus Bridge the Lesion and Form MyelinSasaki M, Lankford KL, Zemedkun M, Kocsis JD. Identified Olfactory Ensheathing Cells Transplanted into the Transected Dorsal Funiculus Bridge the Lesion and Form Myelin. Journal Of Neuroscience 2004, 24: 8485-8493. PMID: 15456822, PMCID: PMC2605369, DOI: 10.1523/jneurosci.1998-04.2004.
- Transplantation of human neural stem cells into the stroke modelHonmou O, Oka S, Sasaki M, Takahashi A, Tanooka A, Houkin K, Hashi K. Transplantation of human neural stem cells into the stroke model. Nosotchu 2002, 24: 355. DOI: 10.3995/jstroke.24.355.
- Transplantation of an acutely isolated bone marrow fraction repairs demyelinated adult rat spinal cord axonsSasaki M, Honmou O, Akiyama Y, Uede T, Hashi K, Kocsis J. Transplantation of an acutely isolated bone marrow fraction repairs demyelinated adult rat spinal cord axons. Glia 2001, 35: 26-34. PMID: 11424189, PMCID: PMC2605363, DOI: 10.1002/glia.1067.
- [Remyelination by Schwann cell transplantation for CNS demyelinated axons: functional comparison with developmental myelination].Imaizumi T, Tsushima S, Sasaki M, Akiyama Y, Hashi K. [Remyelination by Schwann cell transplantation for CNS demyelinated axons: functional comparison with developmental myelination]. Brain And Nerve 脳と神経 2000, 52: 701-7. PMID: 11002480.
- [Comparison of myelin-forming cells as candidates for therapeutic transplantation in demyelinated CNS axons].Imaizumi T, Lankford K, Kocsis J, Sasaki M, Akiyama Y, Hashi K. [Comparison of myelin-forming cells as candidates for therapeutic transplantation in demyelinated CNS axons]. Brain And Nerve 脳と神経 2000, 52: 609-15. PMID: 10934721.
- DNA diagnosis of PKD 1 gene in cerebral aneurysm patientsHonmou O, Akiyama Y, Sasaki M, Uede T, Hashi K. DNA diagnosis of PKD 1 gene in cerebral aneurysm patients. Nosotchu 2000, 22: 457. DOI: 10.3995/jstroke.22.457.