María José Ortuño Romero, PhD
Associate Research Scientist in Genetics
Research & Publications
Biography
Coauthors
Selected Publications
- Melanocortin 4 receptor stimulation prevents antidepressant-associated weight gain in mice caused by long-term fluoxetine exposure.Ortuño MJ, Schneeberger M, Ilanges A, Marchildon F, Pellegrino K, Friedman JM, Ducy P. Melanocortin 4 receptor stimulation prevents antidepressant-associated weight gain in mice caused by long-term fluoxetine exposure. The Journal Of Clinical Investigation 2021, 131 PMID: 34673574, PMCID: PMC8670849, DOI: 10.1172/JCI151976.
- Serotonin-reuptake inhibitors act centrally to cause bone loss in mice by counteracting a local anti-resorptive effect.Ortuño MJ, Robinson ST, Subramanyam P, Paone R, Huang YY, Guo XE, Colecraft HM, Mann JJ, Ducy P. Serotonin-reuptake inhibitors act centrally to cause bone loss in mice by counteracting a local anti-resorptive effect. Nature Medicine 2016, 22: 1170-1179. PMID: 27595322, PMCID: PMC5053870, DOI: 10.1038/nm.4166.
- How understanding gut serotonin secretion could potentially lead to new treatments for osteoporosis.Ortuño MJ, Ducy P. How understanding gut serotonin secretion could potentially lead to new treatments for osteoporosis. Expert Review Of Endocrinology & Metabolism 2013, 8: 93-95. PMID: 30736168, DOI: 10.1586/eem.12.80.
- Osterix induces Col1a1 gene expression through binding to Sp1 sites in the bone enhancer and proximal promoter regions.Ortuño MJ, Susperregui AR, Artigas N, Rosa JL, Ventura F. Osterix induces Col1a1 gene expression through binding to Sp1 sites in the bone enhancer and proximal promoter regions. Bone 2013, 52: 548-56. PMID: 23159876, DOI: 10.1016/j.bone.2012.11.007.
- p38 regulates expression of osteoblast-specific genes by phosphorylation of osterix.Ortuño MJ, Ruiz-Gaspà S, Rodríguez-Carballo E, Susperregui AR, Bartrons R, Rosa JL, Ventura F. p38 regulates expression of osteoblast-specific genes by phosphorylation of osterix. The Journal Of Biological Chemistry 2010, 285: 31985-94. PMID: 20682789, PMCID: PMC2952199, DOI: 10.1074/jbc.M110.123612.
- BMP-2 induces Osterix expression through up-regulation of Dlx5 and its phosphorylation by p38.Ulsamer A, Ortuño MJ, Ruiz S, Susperregui AR, Osses N, Rosa JL, Ventura F. BMP-2 induces Osterix expression through up-regulation of Dlx5 and its phosphorylation by p38. The Journal Of Biological Chemistry 2008, 283: 3816-26. PMID: 18056716, DOI: 10.1074/jbc.M704724200.