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Lubna Pal

MBBS, FACOG, MS
Professor of Obstetrics, Gynecology & Reproductive Sciences; Director, Polycystic Ovary Syndrome (PCOS) Program; Director, Menopause Program

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Lubna Pal, MBBS, FACOG, MS
Yale Medicine

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Research Summary

  1. Ovarian reserve refers to the number of eggs available in the ovaries at any given age. While a decline in ovarian reserve with aging is clinically appreciable from mid 30's, as reflected by reduced likelihood to achieve pregnancy and increased risk of pregnancy losses, this process may be accelerated in some women. Our preliminary data sugest that declining ovarian reserve in premenopausal women is accompanied by deterioration in certain health parameters including the skeleton and surrogate markers for risk of cardiovascular disease.
  2. Role of vitamin D insufficiency in reproductive physiology is suggested: Our preliminary data suggest that pregnancy rates following in vitro fertilization may be influenced by patient's vitamin D status.
  3. Vitamin D insufficiency may be contributory to the pathophysiology of polycystic ovary syndrome. Ongoing clinical trial will hopefully clarify this hypothesis

Specialized Terms: Decline in ovarian reserve and multisystem implications thereof; Polycystic Ovarian Syndrome (PCOS) and metabolic implications; Menopause; Vitamin D and Reproductive Function

Extensive Research Description

1. Ovarian reserve refers to the number of eggs available in the ovaries at any given age. While a decline in ovarian reserve with aging is clinically appreciable from mid 30's, as reflected by reduced likelihood to achieve pregnancy and increased risk of pregnancy losses, this process may be accelerated in some women. Our preliminary data sugest that declining ovarian reserve in premenopausal women is accompanied by deterioration in certain health parameters including the skeleton and surrogate markers for risk of cardiovascular disease.

2. Role of vitamin D insufficiency in reproductive physiology is suggested: Our preliminary data suggest that pregnancy rates following in vitro fertilization may be influenced by patient's vitamin D status.

3. Vitamin D insufficiency may be contributory to the pathophysiology of polycystic ovary syndrome. Ongoing clinical trial will hopefully clarify this hypothesis.1. Role of vitamin D in the pathophysiology of polycystic ovary syndrome (PCOS): Ongoing unblinded 3 month trial of vitamin D and Calcium supplementation to assess effects on glucose and insulin homeostasis.

2. Endometrial effects of Metformin in women with PCOS.



Coauthors

Research Interests

Gynecology; Menopause; Polycystic Ovary Syndrome; Vitamin D; Premenopause; Reproductive Medicine

Selected Publications

Clinical Trials

ConditionsStudy Title
Women's HealthPre-IVF Treatment With a GnRH Antagonist in Women With Endometriosis (PREGnant)
Women's HealthFibroids and Unexplained Infertility Treatment with Epigallocatechin Gallate; A Natural CompounD in Green Tea (FRIEND)
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