David J Leffell, MDCM
Research & Publications
Biography
News
Locations
Research Summary
Dr. Leffell and colleagues discovered the skin cancer gene, PTCH, in 1996 and have directed subsequent research towards understanding how skin cancer develops. Other research includes studies of the p53 gene in skin cancer, epidemiology of skin cancer, innovative diagnostic devices and wound healing.
Extensive Research Description
When I founded the Dermatologic Surgery program at Yale in 1988, my goal was to combine state of the art patient care with clinical research. We often talk about bench to bedside as the framework for discovery in medicine but in fact most innovations related to disease proceed the other way: from bedside to bench. A doctor recognizes a pattern in a particular disease or makes a novel observation in a patient and that raises questions for investigation in the laboratory. Early in my career I observed an increase in basal cell cancer in young women. This was unusual for a disease typically noted in older men. Investigation into sun practices and related issues became the basis for a component of a SPORE grant that the department was awarded. Because we treat a very large number of skin cancers and melanoma and perform reconstructive surgery, a large focus of our research has also been on wound healing. We have published on the use of artificial skin substitutes to facilitate healing and I am involved with a commercial entity with a connexin43 molecule currently in clinical trials. In a broad sense my research collaborations extend from skin cancer in the immune compromised, to the biology of skin cancer in general and its epidemiology to the development of innovative treatments.
Coauthors
Research Interests
Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Epidermis; Head and Neck Neoplasms; Melanoma; Skin Neoplasms; Ultraviolet Rays; Wound Healing; Mohs Surgery; Genes, p53; Keratosis, Actinic
Selected Publications
- Predicting outcomes following second intent healing of periocular surgical defectsKibbi N, Khan Y, Leffell DJ, Christensen SR, Suozzi KC. Predicting outcomes following second intent healing of periocular surgical defects Archives Of Dermatological Research 2020, 313: 483-489. PMID: 32833078, DOI: 10.1007/s00403-020-02122-w.
- Melanoma in situ: Don't make the cure worse than the diseasePrassinos A, Glusac E, Leffell DJ. Melanoma in situ: Don't make the cure worse than the disease Journal Of The American Academy Of Dermatology 2020, 85: 520. PMID: 32387662, DOI: 10.1016/j.jaad.2020.04.168.
- Photodynamic therapy for cutaneous squamous cell carcinoma in situ: Impact of anatomic location, tumor diameter, and incubation time on effectivenessKibbi N, Zhang Y, Leffell DJ, Christensen SR. Photodynamic therapy for cutaneous squamous cell carcinoma in situ: Impact of anatomic location, tumor diameter, and incubation time on effectiveness Journal Of The American Academy Of Dermatology 2019, 82: 1124-1130. PMID: 31712171, DOI: 10.1016/j.jaad.2019.10.079.
- Optical Spectroscopy as a Method for Skin Cancer Risk AssessmentRodriguez‐Diaz E, Manolakos D, Christman H, Bonning MA, Geisse JK, A'Amar OM, Leffell DJ, Bigio IJ. Optical Spectroscopy as a Method for Skin Cancer Risk Assessment Photochemistry And Photobiology 2019, 95: 1441-1445. PMID: 31287160, DOI: 10.1111/php.13140.
- Squamous Cell Carcinoma of the Lip in a Patient With Graft-Versus-Host DiseaseKibbi N, Suozzi KC, Ko CJ, Leffell DJ. Squamous Cell Carcinoma of the Lip in a Patient With Graft-Versus-Host Disease Dermatologic Surgery 2019, Publish Ahead of Print: &na;. PMID: 31260417, DOI: 10.1097/dss.0000000000001706.
- Squamous Cell Carcinoma of the Lip in a Patient With Graft-Versus-Host DiseaseKibbi N, Suozzi K, Ko C, Leffell D. Squamous Cell Carcinoma of the Lip in a Patient With Graft-Versus-Host Disease Dermatologic Surgery 2018, 1. DOI: 10.1097/00042728-900000000-98571.
- Hypertrophic Lichen Planus and Well-Differentiated Squamous Cell CarcinomaTotonchy MB, Leventhal JS, Ko CJ, Leffell DJ. Hypertrophic Lichen Planus and Well-Differentiated Squamous Cell Carcinoma Dermatologic Surgery 2018, 44: 1466-1470. PMID: 29360655, DOI: 10.1097/dss.0000000000001465.
- Cutaneous immunohistochemical staining pattern of p53β isoformsKo CJ, Myung P, Leffell DJ, Bourdon JC. Cutaneous immunohistochemical staining pattern of p53β isoforms Journal Of Clinical Pathology 2018, 71: 1120. PMID: 30305316, DOI: 10.1136/jclinpath-2018-205098.
- Transparency and Dermatologic Device Approval by the US Food and Drug AdministrationEzaldein HH, Scott JF, Yin ES, Ventura A, DeRuyter NP, Leffell DJ. Transparency and Dermatologic Device Approval by the US Food and Drug Administration JAMA Dermatology 2018, 154: 273-280. PMID: 29365020, PMCID: PMC5885836, DOI: 10.1001/jamadermatol.2017.5757.
- Cross-sectional assessment of ultraviolet radiation–related behaviors among young people after a diagnosis of melanoma or basal cell carcinomaFerrucci LM, Cartmel B, Clare RA, Choy CC, Kershaw T, Leffell DJ, Mayne ST. Cross-sectional assessment of ultraviolet radiation–related behaviors among young people after a diagnosis of melanoma or basal cell carcinoma Journal Of The American Academy Of Dermatology 2017, 79: 149-152. PMID: 29291957, PMCID: PMC6004335, DOI: 10.1016/j.jaad.2017.12.056.
- Emerging concepts and recent advances in basal cell carcinomaTotonchy M, Leffell D. Emerging concepts and recent advances in basal cell carcinoma F1000Research 2017, 6: 2085. PMID: 29259776, PMCID: PMC5717469, DOI: 10.12688/f1000research.11314.1.
- Squamous proliferations on the legs of women: Qualitative examination of histopathology, TP53 sequencing, and implications for diagnosis in a series of 30 casesKo CJ, Glusac EJ, McNiff JM, Rodic N, Leffell DJ. Squamous proliferations on the legs of women: Qualitative examination of histopathology, TP53 sequencing, and implications for diagnosis in a series of 30 cases Journal Of The American Academy Of Dermatology 2017, 77: 1126-1132.e1. PMID: 28709693, DOI: 10.1016/j.jaad.2017.04.1119.
- Well‐differentiated neuroendocrine tumors in skin: Terminology and diagnostic utility of cytokeratin 5/6 and p63Panse G, Cowper SE, Leffell DJ, Pulitzer M, Ko CJ. Well‐differentiated neuroendocrine tumors in skin: Terminology and diagnostic utility of cytokeratin 5/6 and p63 Journal Of Cutaneous Pathology 2017, 44: 557-562. PMID: 28417484, DOI: 10.1111/cup.12952.
- Predictors of tanning dependence in white non‐Hispanic females and malesCartmel B, Bale AE, Mayne ST, Gelernter JE, DeWan AT, Spain P, Leffell DJ, Pagoto S, Ferrucci LM. Predictors of tanning dependence in white non‐Hispanic females and males Journal Of The European Academy Of Dermatology And Venereology 2017, 31: 1223-1228. PMID: 28129487, PMCID: PMC5522341, DOI: 10.1111/jdv.14138.
- Body mass index, height and early-onset basal cell carcinoma in a case-control studyZhang Y, Cartmel B, Choy CC, Molinaro AM, Leffell DJ, Bale AE, Mayne ST, Ferrucci LM. Body mass index, height and early-onset basal cell carcinoma in a case-control study Cancer Epidemiology 2016, 46: 66-72. PMID: 28039770, PMCID: PMC5272867, DOI: 10.1016/j.canep.2016.12.007.
- Histopathologic features of multiple cutaneous squamous cell carcinomas of the lower extremityMunday WR, Leffell DJ, McNiff JM, Ko CJ. Histopathologic features of multiple cutaneous squamous cell carcinomas of the lower extremity Journal Of Cutaneous Pathology 2016, 43: 759-765. PMID: 27220356, DOI: 10.1111/cup.12738.
- Body mass index, height and early-onset basal cell carcinoma in a case-control studyZhang Y, Cartmel B, Choy C, Molinaro A, Leffell D, Bale A, Mayne S, Ferucci L. Body mass index, height and early-onset basal cell carcinoma in a case-control study Dermatology Online Journal 2016, 22 DOI: 10.5070/d3229032524.
- Predictors of tanning dependence in white non-hispanic females and malesCartmel B, Mayne S, Bale A, Gelernter J, DeWan A, Leffell D, Pagoto S, Spain P, Ferrucci L. Predictors of tanning dependence in white non-hispanic females and males Dermatology Online Journal 2016, 22 DOI: 10.5070/d3229032556.
- Histopathologic assessment of depth of follicular invasion of squamous cell carcinoma (SCC) in situ (SCCis): Implications for treatment approachChristensen SR, McNiff JM, Cool AJ, Aasi SZ, Hanlon AM, Leffell DJ. Histopathologic assessment of depth of follicular invasion of squamous cell carcinoma (SCC) in situ (SCCis): Implications for treatment approach Journal Of The American Academy Of Dermatology 2015, 74: 356-362. PMID: 26670714, DOI: 10.1016/j.jaad.2015.09.060.
- Randomized comparison of the safety of Flublok® versus licensed inactivated influenza vaccine in healthy, medically stable adults ≥50 years of ageIzikson R, Leffell DJ, Bock SA, Patriarca PA, Post P, Dunkle LM, Cox MM. Randomized comparison of the safety of Flublok® versus licensed inactivated influenza vaccine in healthy, medically stable adults ≥50 years of age Vaccine 2015, 33: 6622-6628. PMID: 26529070, DOI: 10.1016/j.vaccine.2015.10.097.
- Abstract A50: Impact of indoor tanning and MC1R genotype on basal cell carcinoma risk in young peopleMolinaro A, Ferrucci L, Cartmel B, Loftfield E, Leffell D, Bale A, Mayne S. Abstract A50: Impact of indoor tanning and MC1R genotype on basal cell carcinoma risk in young people Cancer Prevention Research 2015, 8: a50-a50. DOI: 10.1158/1940-6215.prev-14-a50.
- Family history of skin cancer is associated with early-onset basal cell carcinoma independent of MC1R genotypeBerlin NL, Cartmel B, Leffell DJ, Bale AE, Mayne ST, Ferrucci LM. Family history of skin cancer is associated with early-onset basal cell carcinoma independent of MC1R genotype Cancer Epidemiology 2015, 39: 1078-1083. PMID: 26381319, PMCID: PMC4679454, DOI: 10.1016/j.canep.2015.09.005.
- Melanoma in situ Part I. Epidemiology, screening, and clinical featuresHiggins HW, Lee KC, Galan A, Leffell DJ. Melanoma in situ Part I. Epidemiology, screening, and clinical features Journal Of The American Academy Of Dermatology 2015, 73: 181-190. PMID: 26183967, DOI: 10.1016/j.jaad.2015.04.014.
- Melanoma in situ Part II. Histopathology, treatment, and clinical managementHiggins HW, Lee KC, Galan A, Leffell DJ. Melanoma in situ Part II. Histopathology, treatment, and clinical management Journal Of The American Academy Of Dermatology 2015, 73: 193-203. PMID: 26183968, DOI: 10.1016/j.jaad.2015.03.057.
- Subsequent skin cancer in patients with early‐onset basal cell carcinomaBerlin NL, Ferrucci LM, Cartmel B, Wang SY, Leffell DJ, McNiff JM, Mayne ST. Subsequent skin cancer in patients with early‐onset basal cell carcinoma Australasian Journal Of Dermatology 2015, 56: 236-237. PMID: 26201376, DOI: 10.1111/ajd.12338.
- Indoor Tanning and the MC1R Genotype: Risk Prediction for Basal Cell Carcinoma Risk in Young PeopleMolinaro AM, Ferrucci LM, Cartmel B, Loftfield E, Leffell DJ, Bale AE, Mayne ST. Indoor Tanning and the MC1R Genotype: Risk Prediction for Basal Cell Carcinoma Risk in Young People American Journal Of Epidemiology 2015, 181: 908-916. PMID: 25858289, PMCID: PMC4445390, DOI: 10.1093/aje/kwu356.
- Fast Absorbing Gut Suture versus Cyanoacrylate Tissue Adhesive in the Epidermal Closure of Linear Repairs Following Mohs Micrographic Surgery.Kim J, Singh Maan H, Cool AJ, Hanlon AM, Leffell DJ. Fast Absorbing Gut Suture versus Cyanoacrylate Tissue Adhesive in the Epidermal Closure of Linear Repairs Following Mohs Micrographic Surgery. The Journal Of Clinical And Aesthetic Dermatology 2015, 8: 24-9. PMID: 25741400, PMCID: PMC4345930.
- A Strategy for the Successful Management of Dermatofibrosarcoma ProtuberansGoldberg C, Hoang D, McRae M, Chung C, Leffell DJ, Narayan D. A Strategy for the Successful Management of Dermatofibrosarcoma Protuberans Annals Of Plastic Surgery 2015, 74: 80-84. PMID: 23788146, DOI: 10.1097/sap.0b013e3182898692.
- Mesenchymal stromal cells form vascular tubes when placed in fibrin sealant and accelerate wound healing in vivoMendez JJ, Ghaedi M, Sivarapatna A, Dimitrievska S, Shao Z, Osuji CO, Steinbacher DM, Leffell DJ, Niklason LE. Mesenchymal stromal cells form vascular tubes when placed in fibrin sealant and accelerate wound healing in vivo Biomaterials 2014, 40: 61-71. PMID: 25433608, PMCID: PMC4268422, DOI: 10.1016/j.biomaterials.2014.11.011.
- Alcohol intake and early‐onset basal cell carcinoma in a case–control studyZhang Y, Ferrucci LM, Cartmel B, Molinaro AM, Leffell DJ, Bale AE, Mayne ST. Alcohol intake and early‐onset basal cell carcinoma in a case–control study British Journal Of Dermatology 2014, 171: 1451-1457. PMID: 25059635, PMCID: PMC4272627, DOI: 10.1111/bjd.13291.
- Novel gene identified in an exome‐wide association study of tanning dependenceCartmel B, Dewan A, Ferrucci LM, Gelernter J, Stapleton J, Leffell DJ, Mayne ST, Bale AE. Novel gene identified in an exome‐wide association study of tanning dependence Experimental Dermatology 2014, 23: 757-759. PMID: 25041255, PMCID: PMC4204712, DOI: 10.1111/exd.12503.
- Tea, coffee, and caffeine and early-onset basal cell carcinoma in a case–control studyFerrucci LM, Cartmel B, Molinaro AM, Leffell DJ, Bale AE, Mayne ST. Tea, coffee, and caffeine and early-onset basal cell carcinoma in a case–control study European Journal Of Cancer Prevention 2014, 23: 296-302. PMID: 24841641, PMCID: PMC4059399, DOI: 10.1097/cej.0000000000000037.
- Systemic glucocorticoid use and early-onset basal cell carcinomaTroche JR, Ferrucci LM, Cartmel B, Leffell DJ, Bale AE, Mayne ST. Systemic glucocorticoid use and early-onset basal cell carcinoma Annals Of Epidemiology 2014, 24: 625-627. PMID: 24958637, PMCID: PMC4119504, DOI: 10.1016/j.annepidem.2014.05.009.
- Point of care cutaneous imaging technology in melanoma screening and mole mappingHiggins HW, Lee KC, Leffell DJ. Point of care cutaneous imaging technology in melanoma screening and mole mapping Faculty Reviews 2014, 6: 34. PMID: 24860656, PMCID: PMC4017910, DOI: 10.12703/p6-34.
- Intralesional interferon alfa-2b for refractory, recurrent squamous cell carcinoma of the faceHanlon A, Kim J, Leffell DJ. Intralesional interferon alfa-2b for refractory, recurrent squamous cell carcinoma of the face Journal Of The American Academy Of Dermatology 2013, 69: 1070-1072. PMID: 24238178, DOI: 10.1016/j.jaad.2013.02.032.
- Cutaneous squamous cell carcinomas of the lower extremity: A distinct subset of squamous cell carcinomasKim C, Ko CJ, Leffell DJ. Cutaneous squamous cell carcinomas of the lower extremity: A distinct subset of squamous cell carcinomas Journal Of The American Academy Of Dermatology 2013, 70: 70-74. PMID: 24210370, DOI: 10.1016/j.jaad.2013.09.026.
- Indoor Tanning and Tanning Dependence in Young People After a Diagnosis of Basal Cell CarcinomaCartmel B, Ferrucci LM, Spain P, Bale AE, Pagoto SL, Leffell DJ, Gelernter J, Mayne ST. Indoor Tanning and Tanning Dependence in Young People After a Diagnosis of Basal Cell Carcinoma JAMA Dermatology 2013, 149: 1110-1111. PMID: 23824273, PMCID: PMC3782995, DOI: 10.1001/jamadermatol.2013.5104.
- Single v. multiple measures of skin carotenoids by resonance Raman spectroscopy as a biomarker of usual carotenoid statusScarmo S, Cartmel B, Lin H, Leffell DJ, Ermakov IV, Gellermann W, Bernstein PS, Mayne ST. Single v. multiple measures of skin carotenoids by resonance Raman spectroscopy as a biomarker of usual carotenoid status British Journal Of Nutrition 2013, 110: 911-917. PMID: 23351238, PMCID: PMC3696054, DOI: 10.1017/s000711451200582x.
- Atlas of Practical Mohs HistopathologyAasi S, Leffell D, Lazova R. Atlas of Practical Mohs Histopathology 2013 DOI: 10.1007/978-1-4614-5161-7.
- Cutaneous Rosai-Dorfman disease of the right ear responsive to radiotherapyBunick CG, Leffell D, Bosenberg M, Yahalom J, Choi JN. Cutaneous Rosai-Dorfman disease of the right ear responsive to radiotherapy Journal Of The American Academy Of Dermatology 2012, 67: e225-e226. PMID: 23062927, DOI: 10.1016/j.jaad.2012.04.025.
- Abstract 635: Indoor tanning and risk of early-onset basal cell carcinomaFerrucci L, Cartmel B, Molinaro A, Leffell D, Bale A, Mayne S. Abstract 635: Indoor tanning and risk of early-onset basal cell carcinoma Cancer Research 2012, 72: 635-635. DOI: 10.1158/1538-7445.am2012-635.
- Desmoplastic trichoepithelioma with perineural involvement: a series of seven casesJedrych J, Leffell D, McNiff JM. Desmoplastic trichoepithelioma with perineural involvement: a series of seven cases Journal Of Cutaneous Pathology 2012, 39: 317-323. PMID: 22335590, DOI: 10.1111/j.1600-0560.2012.01876.x.
- Lifetime history of indoor tanning in young people: a retrospective assessment of initiation, persistence, and correlatesLostritto K, Ferrucci LM, Cartmel B, Leffell DJ, Molinaro AM, Bale AE, Mayne ST. Lifetime history of indoor tanning in young people: a retrospective assessment of initiation, persistence, and correlates BMC Public Health 2012, 12: 118. PMID: 22324969, PMCID: PMC3340300, DOI: 10.1186/1471-2458-12-118.
- Correlation of Global MicroRNA Expression With Basal Cell Carcinoma SubtypeHeffelfinger C, Ouyang Z, Engberg A, Leffell DJ, Hanlon AM, Gordon PB, Zheng W, Zhao H, Snyder MP, Bale AE. Correlation of Global MicroRNA Expression With Basal Cell Carcinoma Subtype G3: Genes, Genomes, Genetics 2012, 2: 279-286. PMID: 22384406, PMCID: PMC3284335, DOI: 10.1534/g3.111.001115.
- Indoor tanning and risk of early-onset basal cell carcinomaFerrucci LM, Cartmel B, Molinaro AM, Leffell DJ, Bale AE, Mayne ST. Indoor tanning and risk of early-onset basal cell carcinoma Journal Of The American Academy Of Dermatology 2011, 67: 552-562. PMID: 22153793, PMCID: PMC3307842, DOI: 10.1016/j.jaad.2011.11.940.
- Host Phenotype Characteristics and MC1R in Relation to Early-Onset Basal Cell CarcinomaFerrucci LM, Cartmel B, Molinaro AM, Gordon PB, Leffell DJ, Bale AE, Mayne ST. Host Phenotype Characteristics and MC1R in Relation to Early-Onset Basal Cell Carcinoma Journal Of Investigative Dermatology 2011, 132: 1272-1279. PMID: 22158557, PMCID: PMC3305835, DOI: 10.1038/jid.2011.402.
- Abstract A83: Host phenotype characteristics and MC1R in relation to early-onset basal cell carcinomaFerrucci L, Cartmel B, Molinaro A, Gordon P, Leffell D, Bale A, Mayne S. Abstract A83: Host phenotype characteristics and MC1R in relation to early-onset basal cell carcinoma Cancer Prevention Research 2011, 4: a83-a83. DOI: 10.1158/1940-6207.prev-11-a83.
- Melanoma and Nevi: Detection and DiagnosisChoi JN, Hanlon A, Leffell D. Melanoma and Nevi: Detection and Diagnosis Current Problems In Cancer 2011, 35: 138-161. PMID: 21911179, DOI: 10.1016/j.currproblcancer.2011.07.005.
- Tea and coffee and basal cell carcinoma in a case‐control studyFerrucci L, Cartmel B, Molinaro A, Leffell D, Bale A, Mayne S. Tea and coffee and basal cell carcinoma in a case‐control study The FASEB Journal 2011, 25: 978.2-978.2. DOI: 10.1096/fasebj.25.1_supplement.978.2.
- Chapter 2 Genetics of Skin CancerColegio O, Leffell D. Chapter 2 Genetics of Skin Cancer 2011, 12-22. DOI: 10.1016/b978-1-4377-1788-4.00002-2.
- Noninvasive assessment of dermal carotenoids as a biomarker of fruit and vegetable intakeMayne ST, Cartmel B, Scarmo S, Lin H, Leffell DJ, Welch E, Ermakov I, Bhosale P, Bernstein PS, Gellermann W. Noninvasive assessment of dermal carotenoids as a biomarker of fruit and vegetable intake American Journal Of Clinical Nutrition 2010, 92: 794-800. PMID: 20685953, PMCID: PMC3133234, DOI: 10.3945/ajcn.2010.29707.
- Significant correlations of dermal total carotenoids and dermal lycopene with their respective plasma levels in healthy adultsScarmo S, Cartmel B, Lin H, Leffell DJ, Welch E, Bhosale P, Bernstein PS, Mayne ST. Significant correlations of dermal total carotenoids and dermal lycopene with their respective plasma levels in healthy adults Archives Of Biochemistry And Biophysics 2010, 504: 34-39. PMID: 20637178, PMCID: PMC2957565, DOI: 10.1016/j.abb.2010.07.004.
- Squamoid Eccrine Ductal Carcinoma: A Case Report and Review of the LiteratureTerushkin E, Leffell DJ, Futoryan T, Cowper S, Lazova R. Squamoid Eccrine Ductal Carcinoma: A Case Report and Review of the Literature American Journal Of Dermatopathology 2010, 32: 287-292. PMID: 20010402, DOI: 10.1097/dad.0b013e3181b623c4.
- 16 Ellipse, Ellipse Variations, and Dog-ear RepairsBook S, Aasi S, Leffell D. 16 Ellipse, Ellipse Variations, and Dog-ear Repairs 2010, 239-250. DOI: 10.1016/b978-0-323-06575-7.00016-x.
- Adenosquamous carcinoma: a report of nine cases with p63 and cytokeratin 5/6 stainingKo CJ, Leffell DJ, McNiff JM. Adenosquamous carcinoma: a report of nine cases with p63 and cytokeratin 5/6 staining Journal Of Cutaneous Pathology 2009, 36: 448-452. PMID: 19278431, DOI: 10.1111/j.1600-0560.2008.01083.x.
- Mohs micrographic surgery histopathology concordanceMariwalla K, Aasi SZ, Glusac EJ, Leffell DJ. Mohs micrographic surgery histopathology concordance Journal Of The American Academy Of Dermatology 2009, 60: 94-98. PMID: 19103361, PMCID: PMC2632938, DOI: 10.1016/j.jaad.2008.09.061.
- LetterNEWMAN J, LEFFELL D. Letter Dermatologic Surgery 2008, 34: 853. DOI: 10.1097/00042728-200806000-00030.
- ReplyNEWMAN J, LEFFELL D. Reply Dermatologic Surgery 2008, 34: 853-853. DOI: 10.1111/j.1524-4725.2008.34161_1.x.
- Free Margin DistortionAasi S, Leffell D. Free Margin Distortion 2008, 95-114. DOI: 10.1007/978-0-387-73152-0_9.
- Management of nonmelanoma skin cancer in 2007Neville JA, Welch E, Leffell DJ. Management of nonmelanoma skin cancer in 2007 Nature Reviews Clinical Oncology 2007, 4: 462-469. PMID: 17657251, DOI: 10.1038/ncponc0883.
- Correlation of Embryonic Fusion Planes with the Anatomical Distribution of Basal Cell CarcinomaNEWMAN J, LEFFELL D. Correlation of Embryonic Fusion Planes with the Anatomical Distribution of Basal Cell Carcinoma Dermatologic Surgery 2007, 33: 957-965. DOI: 10.1097/00042728-200708000-00009.
- Correlation of Embryonic Fusion Planes with the Anatomical Distribution of Basal Cell CarcinomaNEWMAN JC, LEFFELL DJ. Correlation of Embryonic Fusion Planes with the Anatomical Distribution of Basal Cell Carcinoma Dermatologic Surgery 2007, 33: 957-965. PMID: 17661939, DOI: 10.1111/j.1524-4725.2007.33198.x.
- Flip‐Top Pigment TransplantationPennington B, Bolognia J, Leffell D. Flip‐Top Pigment Transplantation 2006, 134-138. DOI: 10.1002/9780470987568.ch17.
- Primary cutaneous carcinosarcoma arising in a patient with nevoid basal cell carcinoma syndromeBhattacharjee P, Leffell D, McNiff JM. Primary cutaneous carcinosarcoma arising in a patient with nevoid basal cell carcinoma syndrome Journal Of Cutaneous Pathology 2005, 32: 638-641. PMID: 16176303, DOI: 10.1111/j.0303-6987.2005.00384.x.
- Mohs micrographic surgery: established uses and emerging trends.Pennington BE, Leffell DJ. Mohs micrographic surgery: established uses and emerging trends. Oncology 2005, 19: 1165-71; discussion 1171-2, 1175. PMID: 16255133.
- Book ReviewPennington B, Leffell D. Book Review New England Journal Of Medicine 2005, 352: 2657-2657. DOI: 10.1056/nejm200506233522525.
- PTCH codon 1315 polymorphism and risk for nonmelanoma skin cancerAsplund A, Gustafsson AC, Wikonkal NM, Sela A, Leffell DJ, Kidd K, Lundeberg J, Brash DE, Pontén F. PTCH codon 1315 polymorphism and risk for nonmelanoma skin cancer British Journal Of Dermatology 2005, 152: 868-873. PMID: 15888139, DOI: 10.1111/j.1365-2133.2005.06464.x.
- Bilobed transposition flapAasi SZ, Leffell DJ. Bilobed transposition flap Dermatologic Clinics 2005, 23: 55-64. PMID: 15620619, DOI: 10.1016/j.det.2004.08.004.
- Chapter 18 Ellipse, Ellipse Variations, and Dog-ear RepairsBook S, Aasi S, Leffell D. Chapter 18 Ellipse, Ellipse Variations, and Dog-ear Repairs 2005, 259-272. DOI: 10.1016/b978-0-323-02752-6.50023-7.
- Correlation of embryonic fusion planes with the anatomical distribution of basal cell carcinoma1 1Disclosure not available at press time.Newman J, Leffell D. Correlation of embryonic fusion planes with the anatomical distribution of basal cell carcinoma1 1Disclosure not available at press time. Journal Of The American Academy Of Dermatology 2004, 50: p7. DOI: 10.1016/j.jaad.2003.10.032.
- Massive Pseudoepitheliomatous Hyperplasia: An Unusual Reaction to a TattooBalfour E, Olhoffer I, Leffell D, Handerson T. Massive Pseudoepitheliomatous Hyperplasia: An Unusual Reaction to a Tattoo American Journal Of Dermatopathology 2003, 25: 338-340. PMID: 12876493, DOI: 10.1097/00000372-200308000-00010.
- Complications in Dermatologic Surgery: How Safe Is Safe?Aasi SZ, Leffell DJ. Complications in Dermatologic Surgery: How Safe Is Safe? JAMA Dermatology 2003, 139: 213-214. PMID: 12588228, DOI: 10.1001/archderm.139.2.213.
- Clinical Efficacy of Devices for Nonablative PhotorejuvenationLeffell DJ. Clinical Efficacy of Devices for Nonablative Photorejuvenation JAMA Dermatology 2002, 138: 1503-1508. PMID: 12437458, DOI: 10.1001/archderm.138.11.1503.
- Histopathologic misdiagnoses and their clinical consequences.Olhoffer IH, Lazova R, Leffell DJ. Histopathologic misdiagnoses and their clinical consequences. JAMA Dermatology 2002, 138: 1381-3. PMID: 12374557, DOI: 10.1001/archderm.138.10.1381.
- Human Cadaveric Allograft for Repair of Nasal Defects After Extirpation of Basal Cell Carcinoma by Mohs Micrographic SurgeryCarucci JA, Kolenik SA, Leffell DJ. Human Cadaveric Allograft for Repair of Nasal Defects After Extirpation of Basal Cell Carcinoma by Mohs Micrographic Surgery Dermatologic Surgery 2002, 28: 340-343. PMID: 11966793, DOI: 10.1046/j.1524-4725.2002.01143.x.
- Human Cadaveric Allograft for Repair of Nasal Defects After Extirpation of Basal Cell Carcinoma by Mohs Micrographic SurgeryCARUCCI J, KOLENIK S, LEFFELL D. Human Cadaveric Allograft for Repair of Nasal Defects After Extirpation of Basal Cell Carcinoma by Mohs Micrographic Surgery Dermatologic Surgery 2002, 28: 340-343. DOI: 10.1097/00042728-200204000-00008.
- Repair of a defect of the lower lip.Carucci JA, Kolenik SA, Leffell DJ. Repair of a defect of the lower lip. Dermatologic Surgery : Official Publication For American Society For Dermatologic Surgery [et Al.] 2002, 28: 195-6. PMID: 11860438, DOI: 10.1046/j.1524-4725.2002.01250.x.
- Repair of a Defect of the Lower LipCARUCCI J, KOLENIK S, LEFFELL D. Repair of a Defect of the Lower Lip Dermatologic Surgery 2002, 28: 195-196. DOI: 10.1097/00042728-200202000-00022.
- Novel inactivating mutations of transforming growth factor‐β type I receptor gene in head‐and‐neck cancer metastasesChen T, Yan W, Wells R, Rimm D, McNiff J, Leffell D, Reiss M. Novel inactivating mutations of transforming growth factor‐β type I receptor gene in head‐and‐neck cancer metastases International Journal Of Cancer 2001, 93: 653-661. PMID: 11477574, DOI: 10.1002/ijc.1381.
- Surgical therapies, part II: flip‐top transplants in vitiligoMcGovern T, Leffell D. Surgical therapies, part II: flip‐top transplants in vitiligo Dermatologic Therapy 2001, 14: 15-19. DOI: 10.1046/j.1529-8019.2001.014001015.x.
- Common Benign and Malignant Skin LesionsAsgari M, Leffell D. Common Benign and Malignant Skin Lesions 2001, 867-884. DOI: 10.1007/978-1-4757-3432-4_61.
- The Dermatologic Surgery Issue: A New Face for the ARCHIVESLeffell D, Arndt K. The Dermatologic Surgery Issue: A New Face for the ARCHIVES JAMA Dermatology 2000, 136: 1404-1404. PMID: 11074706, DOI: 10.1001/archderm.136.11.1404.
- Electrosurgical Facial Resurfacing: A Prospective Multicenter Study of Efficacy and SafetyGrekin R, Tope W, Yarborough J, Olhoffer I, Lee P, Leffell D, Zachary C. Electrosurgical Facial Resurfacing: A Prospective Multicenter Study of Efficacy and Safety JAMA Dermatology 2000, 136: 1309-1316. PMID: 11074690, DOI: 10.1001/archderm.136.11.1309.
- Intralesional interferon alfa for treatment of recurrent lentigo maligna of the eyelid in a patient with primary acquired melanosis.Carucci J, Leffell D. Intralesional interferon alfa for treatment of recurrent lentigo maligna of the eyelid in a patient with primary acquired melanosis. JAMA Dermatology 2000, 136: 1415-6. PMID: 11074712, DOI: 10.1001/archderm.136.11.1415.
- The other side of the sunLeffell D. The other side of the sun The Lancet 2000, 356: 699. PMID: 11085686, DOI: 10.1016/s0140-6736(00)02625-8.
- The scientific basis of skin cancerLeffell D. The scientific basis of skin cancer Journal Of The American Academy Of Dermatology 2000, 42: s18-s22. PMID: 10607352, DOI: 10.1067/mjd.2000.103340.
- Status of residual tumor in patients with squamous cell carcinoma referred for Mohs micrographic surgery.McGovern T, Grossman D, Fitzgerald D, Glusac E, Leffell D. Status of residual tumor in patients with squamous cell carcinoma referred for Mohs micrographic surgery. JAMA Dermatology 1999, 135: 1557-9. PMID: 10606080, DOI: 10.1001/archderm.135.12.1557.
- Flip-Top Pigment Transplantation: A Novel Transplantation Procedure for the Treatment of DepigmentationMcGovern T, Bolognia J, Leffell D. Flip-Top Pigment Transplantation: A Novel Transplantation Procedure for the Treatment of Depigmentation JAMA Dermatology 1999, 135: 1305-1307. PMID: 10566827, DOI: 10.1001/archderm.135.11.1305.
- Mohs Surgery: The Informed ViewMcGovern T, Leffell D. Mohs Surgery: The Informed View JAMA Dermatology 1999, 135: 1255-1259. PMID: 10522675, DOI: 10.1001/archderm.135.10.1255.
- Use of a Lyophilized Bovine Collagen Matrix in Postoperative Wound HealingKolenik S, McGovern T, Leffell D. Use of a Lyophilized Bovine Collagen Matrix in Postoperative Wound Healing Dermatologic Surgery 1999, 25: 303-307. PMID: 10417587, DOI: 10.1046/j.1524-4725.1999.08230.x.
- Facial bowenoid papulosis secondary to human papillomavirus type 16.Olhoffer I, Davidson D, Longley J, Glusac E, Leffell D. Facial bowenoid papulosis secondary to human papillomavirus type 16. British Journal Of Dermatology 1999, 140: 761-2. PMID: 10233343.
- American College of Mohs Micrographic Surgery and Cutaneous OncologyZitelli J, Skouge J, Greenway H, Albom M, Day C, Dinehart S, Fewkes J, Geronemus R, Maloney M, Monheit G, Parlette H, Roenigk R, Robertson D, Fish F, Johnson T, Leffell D. American College of Mohs Micrographic Surgery and Cutaneous Oncology Dermatologic Surgery 1998, 24: 481-489. DOI: 10.1111/j.1524-4725.1998.tb04192.x.
- Frequent clones of p53-mutated keratinocytes in normal human skinJonason A, Kunala S, Price G, Restifo R, Spinelli H, Persing J, Leffell D, Tarone R, Brash D. Frequent clones of p53-mutated keratinocytes in normal human skin Proceedings Of The National Academy Of Sciences Of The United States Of America 1996, 93: 14025-14029. PMID: 8943054, PMCID: PMC19488, DOI: 10.1073/pnas.93.24.14025.
- The role of the human homologue of Drosophila patched in sporadic basal cell carcinomasGailani M, Ståhle-Bäckdahl M, Leffell D, Glyn M, Zaphiropoulos P, Undén A, Dean M, Brash D, Bale A, Toftgård R. The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas Nature Genetics 1996, 14: 78-81. PMID: 8782823, DOI: 10.1038/ng0996-78.
- Mutations of the Human Homolog of Drosophila patched in the Nevoid Basal Cell Carcinoma SyndromeHahn H, Wicking C, Zaphiropoulos P, Gailani M, Shanley S, Chidambaram A, Vorechovsky I, Holmberg E, Unden A, Gillies S, Negus K, Smyth I, Pressman C, Leffell D, Gerrard B, Goldstein A, Dean M, Toftgard R, Chenevix-Trench G, Wainwright B, Bale A. Mutations of the Human Homolog of Drosophila patched in the Nevoid Basal Cell Carcinoma Syndrome Cell 1996, 85: 841-851. PMID: 8681379, DOI: 10.1016/s0092-8674(00)81268-4.
- Tumor Suppressor Gene Mutations and PhotocarcinogenesisZiegler A, Jonason A, Simon J, Leffell D, Brash DE. Tumor Suppressor Gene Mutations and Photocarcinogenesis Photochemistry And Photobiology 1996, 63: 432-435. PMID: 8934758, DOI: 10.1111/j.1751-1097.1996.tb03064.x.
- Relationship Between Sunlight Exposure and a Key Genetic Alteration in Basal Cell CarcinomaGailani M, Leffell D, Ziegler A, Gross E, Brash D, Bale A. Relationship Between Sunlight Exposure and a Key Genetic Alteration in Basal Cell Carcinoma Journal Of The National Cancer Institute 1996, 88: 349-354. PMID: 8609643, DOI: 10.1093/jnci/88.6.349.
- Remote fire with the pulsed dye laser: Risk and preventionWaldorf H, Kauvar A, Geronemus R, Leffell D. Remote fire with the pulsed dye laser: Risk and prevention Journal Of The American Academy Of Dermatology 1996, 34: 503-506. PMID: 8609266, DOI: 10.1016/s0190-9622(96)90457-0.
- The Use of Cryopreserved Human Skin Allografts in Wound Healing following Mohs SurgeryKOLENIK S, LEFFELL D. The Use of Cryopreserved Human Skin Allografts in Wound Healing following Mohs Surgery Dermatologic Surgery 1995, 21: 615-620. PMID: 7606373, DOI: 10.1111/j.1524-4725.1995.tb00517.x.
- The Gorlin syndrome gene: a tumor suppressor active in basal cell carcinogenesis and embryonic development.Bale A, Gailani M, Leffell D. The Gorlin syndrome gene: a tumor suppressor active in basal cell carcinogenesis and embryonic development. Proceedings Of The Association Of American Physicians 1995, 107: 253-7. PMID: 8624861.
- Targetoid hemangioma associated with pregnancy and the menstrual cycleMorganroth G, Tigelaar R, Longley B, Luck L, Leffell D. Targetoid hemangioma associated with pregnancy and the menstrual cycle Journal Of The American Academy Of Dermatology 1995, 32: 282-284. PMID: 7829718, DOI: 10.1016/0190-9622(95)90149-3.
- Nevoid Basal Cell Carcinoma SyndromeBale A, Gailani M, Leffell D. Nevoid Basal Cell Carcinoma Syndrome Journal Of Investigative Dermatology 1994, 103: s126-s130. DOI: 10.1038/jid.1994.23.
- Nevoid basal cell carcinoma syndrome.Bale A, Gailani M, Leffell D. Nevoid basal cell carcinoma syndrome. Journal Of Investigative Dermatology 1994, 103: 126s-130s. PMID: 7963674, DOI: 10.1111/1523-1747.ep12399438.
- The Effect of Pre‐Education on Patient Compliance with Full‐Body Examination in a Public Skin Cancer ScreeningLEFFELL D, BERWICK M, BOLOGNIA J. The Effect of Pre‐Education on Patient Compliance with Full‐Body Examination in a Public Skin Cancer Screening Dermatologic Surgery 1993, 19: 660-663. PMID: 8349904, DOI: 10.1111/j.1524-4725.1993.tb00407.x.
- Interobserver agreement in a community skin cancer screening settingLeffell D, Chen Y, Berwick M, Bolognia J. Interobserver agreement in a community skin cancer screening setting Journal Of The American Academy Of Dermatology 1993, 28: 1003-1005. PMID: 8496441, DOI: 10.1016/s0190-9622(08)80653-6.
- Mutation hotspots due to sunlight in the p53 gene of nonmelanoma skin cancers.Ziegler A, Leffell DJ, Kunala S, Sharma HW, Gailani M, Simon JA, Halperin AJ, Baden HP, Shapiro PE, Bale AE. Mutation hotspots due to sunlight in the p53 gene of nonmelanoma skin cancers. Proceedings Of The National Academy Of Sciences Of The United States Of America 1993, 90: 4216-4220. PMID: 8483937, PMCID: PMC46477, DOI: 10.1073/pnas.90.9.4216.
- Nonexcisional Treatment of Benign and Premalignant Cutaneous LesionsMorganroth G, Leffell D. Nonexcisional Treatment of Benign and Premalignant Cutaneous Lesions Clinics In Plastic Surgery 1993, 20: 91-104. PMID: 8420713, DOI: 10.1016/s0094-1298(20)30775-6.
- Lasers in Dermatology and OphthalmologyLeffell D, Thompson J. Lasers in Dermatology and Ophthalmology Dermatologic Clinics 1992, 10: 687-700. PMID: 1395152, DOI: 10.1016/s0733-8635(18)30305-x.
- Developmental defects in gorlin syndrome related to a putative tumor suppressor gene on chromosome 9Gailani M, Bale S, Leffell D, DiGiovanna J, Peck G, Poliak S, Drum M, Pastakia B, McBride O, Kase R, Greene M, Mulvihill J, Bale A. Developmental defects in gorlin syndrome related to a putative tumor suppressor gene on chromosome 9 Cell 1992, 69: 111-117. PMID: 1348213, DOI: 10.1016/0092-8674(92)90122-s.
- Aggressive-Growth Basal Cell Carcinoma in Young AdultsLeffell DJ, Headington JT, Wong DS, Swanson NA. Aggressive-Growth Basal Cell Carcinoma in Young Adults JAMA Dermatology 1991, 127: 1663-1667. PMID: 1952969, DOI: 10.1001/archderm.1991.01680100063005.
- An educational device for Mohs micrographic surgery. A three-dimensional model of basal cell carcinoma.Leffell D. An educational device for Mohs micrographic surgery. A three-dimensional model of basal cell carcinoma. Dermatologic Surgery 1991, 17: 498-501. PMID: 2040753.
- Laser Vaporization: A Novel Treatment of BotryomycosisLEFFELL D, BROWN M, SWANSON N. Laser Vaporization: A Novel Treatment of Botryomycosis Dermatologic Surgery 1989, 15: 703-705. PMID: 2501368, DOI: 10.1111/j.1524-4725.1989.tb03615.x.
- In Vivo Fluorescence of Human Skin-ReplyLeffell D, Stetz M, Milstone L, Deckelbaum L. In Vivo Fluorescence of Human Skin-Reply JAMA Dermatology 1989, 125: 999-1000. DOI: 10.1001/archderm.1989.01670190133021.
- In vivo fluorescence of human skin. A potential marker of photoaging.Leffell DJ, Stetz ML, Milstone LM, Deckelbaum LI. In vivo fluorescence of human skin. A potential marker of photoaging. JAMA Dermatology 1988, 124: 1514-8. PMID: 3421727, DOI: 10.1001/archderm.124.10.1514.
- In Vivo Fluorescence of Human Skin: A Potential Marker of PhotoagingLeffell D, Stetz M, Milstone L, Deckelbaum L. In Vivo Fluorescence of Human Skin: A Potential Marker of Photoaging JAMA Dermatology 1988, 124: 1514-1518. DOI: 10.1001/archderm.1988.01670100016005.
- Familial multiple lipomatosis Report of a case and a review of the literatureLeffell D, Braverman I. Familial multiple lipomatosis Report of a case and a review of the literature Journal Of The American Academy Of Dermatology 1986, 15: 275-279. PMID: 3745530, DOI: 10.1016/s0190-9622(86)70166-7.