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Kieran O'Donnell, PhD

Assistant Professor

Research & Publications
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Selected Publications

Maternal sensitivity and child internalizing and externalizing behavior: a mediating role for glucocorticoid receptor gene (NR3C1) methylation?Creasey N, Beijers R, O'Donnell K, de Weerth C, Tollenaar M. Maternal sensitivity and child internalizing and externalizing behavior: a mediating role for glucocorticoid receptor gene (NR3C1) methylation? Development And Psychopathology 2023, 1-12. PMID: 36896668, DOI: 10.1017/s0954579423000226.
A sparse additive model for high-dimensional interactions with an exposure variableBhatnagar S, Lu T, Lovato A, Olds D, Kobor M, Meaney M, O'Donnell K, Yang A, Greenwood C. A sparse additive model for high-dimensional interactions with an exposure variable Computational Statistics & Data Analysis 2023, 179: 107624. DOI: 10.1016/j.csda.2022.107624.
Temperature variability and birthweight: epidemiological evidence from AfricaWang P, O'Donnell K, Warren J, Dubrow R, Chen K. Temperature variability and birthweight: epidemiological evidence from Africa Environment International 2023, 173: 107792. DOI: 10.1016/j.envint.2023.107792.
Investigating the effects of maltreatment and acute stress on the concordance of blood and DNA methylation methods of estimating immune cell proportionsApsley A, Etzel L, Hastings W, Heim C, Noll J, O’Donnell K, Schreier H, Shenk C, Ye Q, Shalev I. Investigating the effects of maltreatment and acute stress on the concordance of blood and DNA methylation methods of estimating immune cell proportions Clinical Epigenetics 2023, 15: 33. PMID: 36855187, PMCID: PMC9976543, DOI: 10.1186/s13148-023-01437-5.
Temperature variability and birthweight: Epidemiological evidence from AfricaWang P, O'Donnell K, Warren J, Dubrow R, Chen K. Temperature variability and birthweight: Epidemiological evidence from Africa Environment International 2023, 173: 107792. PMID: 36841185, DOI: 10.1016/j.envint.2023.107792.
Associations between epigenetic aging and childhood peer victimization, depression, and suicidal ideation in adolescence and adulthood: A study of two population-based samplesPerret L, Geoffroy M, Barr E, Parnet F, Provencal N, Boivin M, O'Donnell K, Suderman M, Power C, Turecki G, Ouellet-Morin I. Associations between epigenetic aging and childhood peer victimization, depression, and suicidal ideation in adolescence and adulthood: A study of two population-based samples Frontiers In Cell And Developmental Biology 2023, 10: 1051556. PMID: 36712964, PMCID: PMC9879289, DOI: 10.3389/fcell.2022.1051556.
Fetal Programming and Public PolicyGlover V, O'Connor T, O'Donnell K. Fetal Programming and Public Policy Journal Of The American Academy Of Child & Adolescent Psychiatry 2023 PMID: 36608741, DOI: 10.1016/j.jaac.2022.11.010.
Cumulative risk exposure and child cellular aging in a Dutch low‐risk community sampleBeijers R, Thije I, Bolhuis E, O'Donnell K, Tollenaar M, Shalev I, Hastings W, MacIsaac J, Lin D, Meaney M, Kobor M, Belsky J, Weerth C. Cumulative risk exposure and child cellular aging in a Dutch low‐risk community sample Psychophysiology 2022, 60: e14205. PMID: 36323627, DOI: 10.1111/psyp.14205.
To what extent do social support and mastery mediate the association between childhood maltreatment and depression? A sequential causal mediation analysisSu Y, Li M, D'Arcy C, Caron J, O'Donnell K, Meng X. To what extent do social support and mastery mediate the association between childhood maltreatment and depression? A sequential causal mediation analysis Epidemiology And Psychiatric Sciences 2022, 31: e77. PMID: 36263598, PMCID: PMC9677445, DOI: 10.1017/s2045796022000609.
Attachment insecurity and the biological embedding of reproductive strategies: Investigating the role of cellular agingBolhuis E, Belsky J, Frankenhuis WE, Shalev I, Hastings WJ, Tollenaar MS, O'Donnell KJ, McGill MG, Pokhvisneva I, Lin DTS, MacIsaac JL, Kobor MS, de Weerth C, Beijers R. Attachment insecurity and the biological embedding of reproductive strategies: Investigating the role of cellular aging Biological Psychology 2022, 175: 108446. PMID: 36272562, DOI: 10.1016/j.biopsycho.2022.108446.
Receptive Language Abilities for Females Exposed to Early Life Adversity: Modification by Epigenetic Age Acceleration at Midlife in a 30-year Prospective Cohort Study.Felt JM, Harrington KD, Ram N, O'Donnell KJ, Sliwinski MJ, Benson L, Zhang Z, Meaney MJ, Putnam FW, Noll JG, Shenk CE. Receptive Language Abilities for Females Exposed to Early Life Adversity: Modification by Epigenetic Age Acceleration at Midlife in a 30-year Prospective Cohort Study. The Journals Of Gerontology Series B 2022 PMID: 36190812, DOI: 10.1093/geronb/gbac158.
The Impact of COVID-19 on Maternal Mental Health during Pregnancy: A Comparison between Canada and China within the CONCEPTION CohortPagès N, Gorgui J, Wang C, Wang X, Zhao JP, Tchuente V, Lacasse A, Côté S, King S, Muanda F, Mufike Y, Boucoiran I, Nuyt AM, Quach C, Ferreira E, Kaul P, Winquist B, O'Donnell KJ, Eltonsy S, Chateau D, Hanley G, Oberlander T, Kassai B, Mainbourg S, Bernatsky S, Vinet É, Brodeur-Doucet A, Demers J, Richebé P, Zaphiratos V, Bérard A. The Impact of COVID-19 on Maternal Mental Health during Pregnancy: A Comparison between Canada and China within the CONCEPTION Cohort International Journal Of Environmental Research And Public Health 2022, 19: 12386. PMID: 36231687, PMCID: PMC9566261, DOI: 10.3390/ijerph191912386.
Polygenic risk score and peer victimisation independently predict depressive symptoms in adolescence: results from the Quebec Longitudinal Study of Children DevelopmentPerret LC, Boivin M, Morneau‐Vaillancourt G, Andlauer TFM, Paquin S, Langevin S, Girard A, Turecki G, O'Donnell K, Tremblay RE, Côté SM, Gouin J, Ouellet‐Morin I, Geoffroy M. Polygenic risk score and peer victimisation independently predict depressive symptoms in adolescence: results from the Quebec Longitudinal Study of Children Development Journal Of Child Psychology And Psychiatry 2022, 64: 388-396. PMID: 36124742, DOI: 10.1111/jcpp.13706.
To what extent do social support and coping strategies mediate the relation between childhood maltreatment and major depressive disorder: A longitudinal community-based cohort.Li M, O'Donnell K, Caron J, Meaney M, Kobor M, D'Arcy C, Su Y, Liu A, Meng X. To what extent do social support and coping strategies mediate the relation between childhood maltreatment and major depressive disorder: A longitudinal community-based cohort. Development And Psychopathology 2022, 1-12. PMID: 36102218, DOI: 10.1017/s0954579422000918.
Integrative PheWAS analysis in risk categorization of major depressive disorder and identifying their associations with genetic variants using a latent topic model approachMeng X, Wang M, O’Donnell K, Caron J, Meaney MJ, Li Y. Integrative PheWAS analysis in risk categorization of major depressive disorder and identifying their associations with genetic variants using a latent topic model approach Translational Psychiatry 2022, 12: 240. PMID: 35676267, PMCID: PMC9177831, DOI: 10.1038/s41398-022-02015-8.
Obesity and accelerated epigenetic aging in a high-risk cohort of childrenEtzel L, Hastings WJ, Hall MA, Heim CM, Meaney MJ, Noll JG, O’Donnell K, Pokhvisneva I, Rose EJ, Schreier HMC, Shenk CE, Shalev I. Obesity and accelerated epigenetic aging in a high-risk cohort of children Scientific Reports 2022, 12: 8328. PMID: 35585103, PMCID: PMC9117197, DOI: 10.1038/s41598-022-11562-5.
Maternal Prenatal Infection and Anxiety Predict Neurodevelopmental Outcomes in Middle ChildhoodO’Connor T, Ciesla AA, Sefair AV, Thornburg LL, Brown AS, Glover V, O’Donnell K. Maternal Prenatal Infection and Anxiety Predict Neurodevelopmental Outcomes in Middle Childhood Journal Of Psychopathology And Clinical Science 2022, 131: 422-434. PMID: 35238594, PMCID: PMC9069845, DOI: 10.1037/abn0000746.
Reply to: Crossing the “Birth Border” for Epigenetic EffectsMcGill MG, Pokhvisneva I, Clappison AS, McEwen LM, Beijers R, Tollenaar M, Pham H, Kee MZL, Garg E, de Mendonça Filho EJ, Karnani N, Silveira PP, Kobor MS, de Weerth C, Meaney MJ, O'Donnell KJ. Reply to: Crossing the “Birth Border” for Epigenetic Effects Biological Psychiatry 2022, 92: e25-e26. PMID: 35249723, DOI: 10.1016/j.biopsych.2021.12.008.
The COVID-19 Pandemic Impacted Maternal Mental Health Differently Depending on Pregnancy Status and Trimester of GestationBérard A, Gorgui J, Tchuente V, Lacasse A, Gomez YH, Côté S, King S, Muanda F, Mufike Y, Boucoiran I, Nuyt AM, Quach C, Ferreira E, Kaul P, Winquist B, O’Donnell K, Eltonsy S, Chateau D, Zhao JP, Hanley G, Oberlander T, Kassai B, Mainbourg S, Bernatsky S, Vinet É, Brodeur-Doucet A, Demers J, Richebé P, Zaphiratos V. The COVID-19 Pandemic Impacted Maternal Mental Health Differently Depending on Pregnancy Status and Trimester of Gestation International Journal Of Environmental Research And Public Health 2022, 19: 2926. PMID: 35270623, PMCID: PMC8910614, DOI: 10.3390/ijerph19052926.
Specific and cumulative lifetime stressors in the aetiology of major depression: A longitudinal community-based population studySu Y, D'Arcy C, Li M, O'Donnell K, Caron J, Meaney M, Meng X. Specific and cumulative lifetime stressors in the aetiology of major depression: A longitudinal community-based population study Epidemiology And Psychiatric Sciences 2022, 31: e3. PMID: 35078547, PMCID: PMC8851045, DOI: 10.1017/s2045796021000779.
Impulsivity mediates the relationship between childhood maltreatment and quality of life: Does social support make it different?Gao T, Mei S, Li M, O'Donnell K, Caron J, Meng X. Impulsivity mediates the relationship between childhood maltreatment and quality of life: Does social support make it different? Personality And Individual Differences 2022, 184: 111208. DOI: 10.1016/j.paid.2021.111208.
Cortisol trajectories measured prospectively across thirty years of female development following exposure to childhood sexual abuse: Moderation by epigenetic age acceleration at midlifeShenk CE, Felt JM, Ram N, O'Donnell KJ, Sliwinski MJ, Pokhvisneva I, Benson L, Meaney MJ, Putnam FW, Noll JG. Cortisol trajectories measured prospectively across thirty years of female development following exposure to childhood sexual abuse: Moderation by epigenetic age acceleration at midlife Psychoneuroendocrinology 2021, 136: 105606. PMID: 34896740, PMCID: PMC8724404, DOI: 10.1016/j.psyneuen.2021.105606.
Maternal Prenatal Anxiety and the Fetal Origins of Epigenetic AgingMcGill MG, Pokhvisneva I, Clappison AS, McEwen LM, Beijers R, Tollenaar MS, Pham H, Kee MZL, Garg E, de Mendonça Filho EJ, Karnani N, Silveira PP, Kobor MS, de Weerth C, Meaney MJ, O'Donnell KJ. Maternal Prenatal Anxiety and the Fetal Origins of Epigenetic Aging Biological Psychiatry 2021, 91: 303-312. PMID: 34756561, DOI: 10.1016/j.biopsych.2021.07.025.
Salivary cytokine cluster moderates the association between caregivers perceived stress and emotional functioning in youthParent C, Pokhvisneva I, de Mendonça Filho EJ, O'Donnell KJ, Meaney MJ, Kee MZL, Thng G, Wing H, Adler NE, Keeton V, Pantell MS, Hessler D, Gottlieb LM, Silveira PP. Salivary cytokine cluster moderates the association between caregivers perceived stress and emotional functioning in youth Brain Behavior And Immunity 2021, 94: 125-137. PMID: 33662503, DOI: 10.1016/j.bbi.2021.02.025.
Impact of parental socioeconomic status on offspring’s mental health: protocol for a longitudinal community-based studyLi M, O'Donnell KJ, Caron J, D'Arcy C, Meng X. Impact of parental socioeconomic status on offspring’s mental health: protocol for a longitudinal community-based study BMJ Open 2021, 11: e038409. PMID: 33593762, PMCID: PMC7888321, DOI: 10.1136/bmjopen-2020-038409.
Epigenetic Age Acceleration and Risk for Posttraumatic Stress Disorder following Exposure to Substantiated Child MaltreatmentShenk CE, O’Donnell K, Pokhvisneva I, Kobor MS, Meaney MJ, Bensman HE, Allen EK, Olson AE. Epigenetic Age Acceleration and Risk for Posttraumatic Stress Disorder following Exposure to Substantiated Child Maltreatment Journal Of Clinical Child & Adolescent Psychology 2021, 51: 651-661. PMID: 33471576, PMCID: PMC8289945, DOI: 10.1080/15374416.2020.1864738.
Internalizing symptoms associate with the pace of epigenetic aging in childhoodTollenaar MS, Beijers R, Garg E, Nguyen TTT, Lin DTS, MacIsaac JL, Shalev I, Kobor MS, Meaney MJ, O'Donnell KJ, de Weerth C. Internalizing symptoms associate with the pace of epigenetic aging in childhood Biological Psychology 2021, 159: 108021. PMID: 33460784, DOI: 10.1016/j.biopsycho.2021.108021.
DCC gene network in the prefrontal cortex is associated with total brain volume in childhoodMorgunova A, Pokhvisneva I, Nolvi S, Entringer S, Wadhwa P, Gilmore J, Styner M, Buss C, Sassi RB, Hall GBC, O'Donnell KJ, Meaney MJ, Silveira PP, Flores CA. DCC gene network in the prefrontal cortex is associated with total brain volume in childhood Journal Of Psychiatry And Neuroscience 2021, 46: e154-e163. PMID: 33206040, PMCID: PMC7955849, DOI: 10.1503/jpn.200081.
Maternal antenatal depression and child mental health: Moderation by genomic risk for attention-deficit/hyperactivity disorderChen LM, Tollenaar MS, Dass S, Bouvette-Turcot AA, Pokhvisneva I, Gaudreau H, Parent C, Diorio J, McEwen LM, MacIsaac JL, Kobor MS, Beijers R, de Weerth C, Silveira PP, Karama S, Meaney MJ, O'Donnell KJ. Maternal antenatal depression and child mental health: Moderation by genomic risk for attention-deficit/hyperactivity disorder Development And Psychopathology 2020, 32: 1810-1821. PMID: 33427178, DOI: 10.1017/s0954579420001418.
Amygdala 5-HTT Gene Network Moderates the Effects of Postnatal Adversity on Attention Problems: Anatomo-Functional Correlation and Epigenetic Changesde Lima RMS, Barth B, Arcego DM, de Mendonça Filho EJ, Clappison A, Patel S, Wang Z, Pokhvisneva I, Sassi RB, Hall GBC, Kobor MS, O'Donnell KJ, de Vasconcellos Bittencourt A, Meaney MJ, Dalmaz C, Silveira PP. Amygdala 5-HTT Gene Network Moderates the Effects of Postnatal Adversity on Attention Problems: Anatomo-Functional Correlation and Epigenetic Changes Frontiers In Neuroscience 2020, 14: 198. PMID: 32256307, PMCID: PMC7093057, DOI: 10.3389/fnins.2020.00198.
Epigenetics, Development, and PsychopathologyO'Donnell KJ, Meaney MJ. Epigenetics, Development, and Psychopathology Annual Review Of Clinical Psychology 2020, 16: 1-24. PMID: 32084320, DOI: 10.1146/annurev-clinpsy-050718-095530.
Genetically predicted gene expression of prefrontal DRD4 gene and the differential susceptibility to childhood emotional eating in response to positive environmentBarth B, Bizarro L, Miguel PM, Dubé L, Levitan R, O'Donnell K, Meaney MJ, Silveira PP. Genetically predicted gene expression of prefrontal DRD4 gene and the differential susceptibility to childhood emotional eating in response to positive environment Appetite 2020, 148: 104594. PMID: 31927071, DOI: 10.1016/j.appet.2020.104594.
Biological embedding of experience: A primer on epigeneticsAristizabal MJ, Anreiter I, Halldorsdottir T, Odgers CL, McDade TW, Goldenberg A, Mostafavi S, Kobor MS, Binder EB, Sokolowski MB, O'Donnell KJ. Biological embedding of experience: A primer on epigenetics Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 117: 23261-23269. PMID: 31624126, PMCID: PMC7519272, DOI: 10.1073/pnas.1820838116.
The PedBE clock accurately estimates DNA methylation age in pediatric buccal cellsMcEwen LM, O'Donnell KJ, McGill MG, Edgar RD, Jones MJ, MacIsaac JL, Lin DTS, Ramadori K, Morin A, Gladish N, Garg E, Unternaehrer E, Pokhvisneva I, Karnani N, Kee MZL, Klengel T, Adler NE, Barr RG, Letourneau N, Giesbrecht GF, Reynolds JN, Czamara D, Armstrong JM, Essex MJ, de Weerth C, Beijers R, Tollenaar MS, Bradley B, Jovanovic T, Ressler KJ, Steiner M, Entringer S, Wadhwa PD, Buss C, Bush NR, Binder EB, Boyce WT, Meaney MJ, Horvath S, Kobor MS. The PedBE clock accurately estimates DNA methylation age in pediatric buccal cells Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 117: 23329-23335. PMID: 31611402, PMCID: PMC7519312, DOI: 10.1073/pnas.1820843116.
Dissecting maternal care: Patterns of maternal parenting in a prospective cohort studyUnternaehrer E, Cost KT, Bouvette‐Turcot A, Gaudreau H, Massicotte R, Dhir SK, Dass S, O'Donnell KJ, Gordon‐Green C, Atkinson L, Levitan RD, Wazana A, Steiner M, Lydon JE, Clark R, Fleming AS, Meaney MJ, Team T. Dissecting maternal care: Patterns of maternal parenting in a prospective cohort study Journal Of Neuroendocrinology 2019, 31: e12784. PMID: 31442354, DOI: 10.1111/jne.12784.
Positive life events during pregnancy and cellular aging in infantsLazarides C, Epel E, Lin J, Blackburn E, Pokhvisneva I, Oldach M, Meaney M, O’Donnell K, Kobor M, MacIsaac J, Lin D, Buss C, Simhan H, Wadhwa P, Entringer S. Positive life events during pregnancy and cellular aging in infants Psychoneuroendocrinology 2019, 107: 34. DOI: 10.1016/j.psyneuen.2019.07.095.
Association between a biologically-informed polygenic score based on the mesocorticolimbic insulin receptor gene network and at-risk individual characteristics for mental health: A replication in a population-based longitudinal cohortOuellet-Morin I, Silveira P, Paquin S, Langevin S, Morneau-Vaillancourt G, O’Donnell K, Boivin M. Association between a biologically-informed polygenic score based on the mesocorticolimbic insulin receptor gene network and at-risk individual characteristics for mental health: A replication in a population-based longitudinal cohort Psychoneuroendocrinology 2019, 107: 80. DOI: 10.1016/j.psyneuen.2019.07.230.
Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-bornsCzamara D, Eraslan G, Page CM, Lahti J, Lahti-Pulkkinen M, Hämäläinen E, Kajantie E, Laivuori H, Villa PM, Reynolds RM, Nystad W, Håberg SE, London SJ, O’Donnell K, Garg E, Meaney MJ, Entringer S, Wadhwa PD, Buss C, Jones MJ, Lin DTS, MacIsaac JL, Kobor MS, Koen N, Zar HJ, Koenen KC, Dalvie S, Stein DJ, Kondofersky I, Müller NS, Theis FJ, Räikkönen K, Binder E. Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns Nature Communications 2019, 10: 2548. PMID: 31186427, PMCID: PMC6559955, DOI: 10.1038/s41467-019-10461-0.
F42. Childhood Internalizing Symptoms and Epigenetic AgingTollenaar M, Beijers R, Garg E, Nguyen T, Lin D, MacIsaac J, Shalev I, Kobor M, Meaney M, O'Donnell K, de Weerth C. F42. Childhood Internalizing Symptoms and Epigenetic Aging Biological Psychiatry 2019, 85: s228. DOI: 10.1016/j.biopsych.2019.03.579.
Prefrontal Cortex Dopamine Transporter Gene Network Moderates the Effect of Perinatal Hypoxic-Ischemic Conditions on Cognitive Flexibility and Brain Gray Matter Density in ChildrenMiguel PM, Pereira LO, Barth B, de Mendonça Filho EJ, Pokhvisneva I, Nguyen TTT, Garg E, Razzolini BR, Koh DXP, Gallant H, Sassi RB, Hall GBC, O'Donnell KJ, Meaney MJ, Silveira PP. Prefrontal Cortex Dopamine Transporter Gene Network Moderates the Effect of Perinatal Hypoxic-Ischemic Conditions on Cognitive Flexibility and Brain Gray Matter Density in Children Biological Psychiatry 2019, 86: 621-630. PMID: 31142432, DOI: 10.1016/j.biopsych.2019.03.983.
A biologically-informed polygenic score identifies endophenotypes and clinical conditions associated with the insulin receptor function on specific brain regionsDass S, McCracken K, Pokhvisneva I, Chen LM, Garg E, Nguyen TTT, Wang Z, Barth B, Yaqubi M, McEwen LM, MacIsaac JL, Diorio J, Kobor MS, O'Donnell KJ, Meaney MJ, Silveira PP. A biologically-informed polygenic score identifies endophenotypes and clinical conditions associated with the insulin receptor function on specific brain regions EBioMedicine 2019, 42: 188-202. PMID: 30922963, PMCID: PMC6491717, DOI: 10.1016/j.ebiom.2019.03.051.
A Role of Oxytocin Receptor Gene Brain Tissue Expression Quantitative Trait Locus rs237895 in the Intergenerational Transmission of the Effects of Maternal Childhood MaltreatmentToepfer P, O'Donnell KJ, Entringer S, Heim CM, Lin DTS, MacIsaac JL, Kobor MS, Meaney MJ, Provençal N, Binder EB, Wadhwa PD, Buss C. A Role of Oxytocin Receptor Gene Brain Tissue Expression Quantitative Trait Locus rs237895 in the Intergenerational Transmission of the Effects of Maternal Childhood Maltreatment Journal Of The American Academy Of Child & Adolescent Psychiatry 2019, 58: 1207-1216. PMID: 30858011, PMCID: PMC6733663, DOI: 10.1016/j.jaac.2019.03.006.
OXTR brain tissue expression quantitative locus rs237895 moderates the association between maternal childhood maltreatment and non-optimal maternal behavior with implications for offspring socio-emotional development and attachment securityToepfer P, O’Donnell K, Entringer S, Heim C, Lin D, MacIsaac J, Kobor M, Meaney M, Provencal N, Binder E, Wadhwa P, Buss C. OXTR brain tissue expression quantitative locus rs237895 moderates the association between maternal childhood maltreatment and non-optimal maternal behavior with implications for offspring socio-emotional development and attachment security Psychoneuroendocrinology 2019, 100: s48. DOI: 10.1016/j.psyneuen.2018.12.167.
Dynamic DNA methylation changes in the maternal oxytocin gene locus (OXT) during pregnancy predict postpartum maternal intrusivenessToepfer P, O'Donnell KJ, Entringer S, Garg E, Heim CM, Lin DTS, MacIsaac JL, Kobor MS, Meaney MJ, Provençal N, Binder EB, Wadhwa PD, Buss C. Dynamic DNA methylation changes in the maternal oxytocin gene locus (OXT) during pregnancy predict postpartum maternal intrusiveness Psychoneuroendocrinology 2019, 103: 156-162. PMID: 30690225, PMCID: PMC6554513, DOI: 10.1016/j.psyneuen.2019.01.013.
SU9 IDENTIFICATION OF GENES IN CHILD GENETIC RISK FOR ATTENTION DEFICIT/HYPERACTIVITY DISORDER THAT INTERACT WITH MATERNAL DEPRESSIVE SYMPTOMS IN PREDICTION OF INTERNALIZING PROBLEMSChen L, Bouvette-Turcot A, Garg E, Nguyen T, Silveira P, Diorio J, Kobor M, O'Donnell K, Meaney M. SU9 IDENTIFICATION OF GENES IN CHILD GENETIC RISK FOR ATTENTION DEFICIT/HYPERACTIVITY DISORDER THAT INTERACT WITH MATERNAL DEPRESSIVE SYMPTOMS IN PREDICTION OF INTERNALIZING PROBLEMS European Neuropsychopharmacology 2019, 29: s891. DOI: 10.1016/j.euroneuro.2017.08.198.
Integration of “omics” Data and Phenotypic Data Within a Unified Extensible Multimodal FrameworkDas S, Boucher X, Rogers C, Makowski C, Chouinard-Decorte F, Klein K, Beck N, Rioux P, Brown ST, Mohaddes Z, Zweber C, Foing V, Forest M, O’Donnell K, Clark J, Meaney MJ, Greenwood CMT, Evans AC. Integration of “omics” Data and Phenotypic Data Within a Unified Extensible Multimodal Framework Frontiers In Neuroinformatics 2018, 12: 91. PMID: 30631270, PMCID: PMC6315165, DOI: 10.3389/fninf.2018.00091.
Maternal antenatal mood and child development: an exploratory study of treatment effects on child outcomes up to 5 yearsMilgrom J, Holt CJ, Bleker LS, Holt C, Ross J, Ericksen J, Glover V, O’Donnell K, de Rooij SR, Gemmill AW. Maternal antenatal mood and child development: an exploratory study of treatment effects on child outcomes up to 5 years Journal Of Developmental Origins Of Health And Disease 2018, 10: 221-231. PMID: 30303063, DOI: 10.1017/s2040174418000739.
PRS-on-Spark (PRSoS): a novel, efficient and flexible approach for generating polygenic risk scoresChen LM, Yao N, Garg E, Zhu Y, Nguyen TTT, Pokhvisneva I, Hari Dass SA, Unternaehrer E, Gaudreau H, Forest M, McEwen LM, MacIsaac JL, Kobor MS, Greenwood CMT, Silveira PP, Meaney MJ, O’Donnell K. PRS-on-Spark (PRSoS): a novel, efficient and flexible approach for generating polygenic risk scores BMC Bioinformatics 2018, 19: 295. PMID: 30089455, PMCID: PMC6083617, DOI: 10.1186/s12859-018-2289-9.
Polygenic differential susceptibility to prenatal adversityBelsky J, Pokhvisneva I, Rema ASS, Broekman BFP, Pluess M, O'Donnell KJ, Meaney MJ, Silveira PP. Polygenic differential susceptibility to prenatal adversity Development And Psychopathology 2018, 31: 439-441. PMID: 30081968, DOI: 10.1017/s0954579418000378.
Prenatal maternal stress, fetal programming, and mechanisms underlying later psychopathology—A global perspectiveGlover V, O'Donnell KJ, O'Connor TG, Fisher J. Prenatal maternal stress, fetal programming, and mechanisms underlying later psychopathology—A global perspective Development And Psychopathology 2018, 30: 843-854. PMID: 30068411, DOI: 10.1017/s095457941800038x.
The early care environment and DNA methylome variation in childhoodGarg E, Chen L, Nguyen TTT, Pokhvisneva I, Chen LM, Unternaehrer E, MacIsaac JL, McEwen LM, Mah SM, Gaudreau H, Levitan R, Moss E, Sokolowski MB, Kennedy JL, Steiner MS, Meaney MJ, Holbrook JD, Silveira PP, Karnani N, Kobor MS, O'Donnell KJ. The early care environment and DNA methylome variation in childhood Development And Psychopathology 2018, 30: 891-903. PMID: 30068421, DOI: 10.1017/s0954579418000627.
Epigenetics and Early Life Adversity: Current Evidence and Considerations for Epigenetic Studies in the Context of Child MaltreatmentBouvette-Turcot A, Meaney M, O’Donnell K. Epigenetics and Early Life Adversity: Current Evidence and Considerations for Epigenetic Studies in the Context of Child Maltreatment 2018, 89-119. DOI: 10.1007/978-3-319-72589-5_7.
Associations between maternal prenatal cortisol and fetal growth are specific to infant sex: findings from the Wirral Child Health and Development StudyBraithwaite EC, Hill J, Pickles A, Glover V, O’Donnell K, Sharp H. Associations between maternal prenatal cortisol and fetal growth are specific to infant sex: findings from the Wirral Child Health and Development Study Journal Of Developmental Origins Of Health And Disease 2018, 9: 425-431. PMID: 29631648, PMCID: PMC6075696, DOI: 10.1017/s2040174418000181.
DNA methylome variation in a perinatal nurse-visitation program that reduces child maltreatment: a 27-year follow-upO’Donnell K, Chen L, MacIsaac JL, McEwen LM, Nguyen T, Beckmann K, Zhu Y, Chen LM, Brooks-Gunn J, Goldman D, Grigorenko EL, Leckman JF, Diorio J, Karnani N, Olds DL, Holbrook JD, Kobor MS, Meaney MJ. DNA methylome variation in a perinatal nurse-visitation program that reduces child maltreatment: a 27-year follow-up Translational Psychiatry 2018, 8: 15. PMID: 29317599, PMCID: PMC5802588, DOI: 10.1038/s41398-017-0063-9.
Agreement in DNA methylation levels from the Illumina 450K array across batches, tissues, and timeForest M, O'Donnell KJ, Voisin G, Gaudreau H, MacIsaac JL, McEwen LM, Silveira PP, Steiner M, Kobor MS, Meaney MJ, Greenwood CMT. Agreement in DNA methylation levels from the Illumina 450K array across batches, tissues, and time Epigenetics 2018, 13: 19-32. PMID: 29381404, PMCID: PMC5837078, DOI: 10.1080/15592294.2017.1411443.
Cumulative prenatal exposure to adversity reveals associations with a broad range of neurodevelopmental outcomes that are moderated by a novel, biologically informed polygenetic score based on the serotonin transporter solute carrier family C6, member 4 (SLC6A4) gene expressionSilveira PP, Pokhvisneva I, Parent C, Cai S, Rema ASS, Broekman BFP, Rifkin-Graboi A, Pluess M, O'Donnell KJ, Meaney MJ. Cumulative prenatal exposure to adversity reveals associations with a broad range of neurodevelopmental outcomes that are moderated by a novel, biologically informed polygenetic score based on the serotonin transporter solute carrier family C6, member 4 (SLC6A4) gene expression Development And Psychopathology 2017, 29: 1601-1617. PMID: 29162172, DOI: 10.1017/s0954579417001262.
Broader Focus Required to Understand the Effects of the Perinatal Environment on Child Neurodevelopment: Response to Bell and ChimataO'Donnell KJ, Meaney MJ. Broader Focus Required to Understand the Effects of the Perinatal Environment on Child Neurodevelopment: Response to Bell and Chimata American Journal Of Psychiatry 2017, 174: 999-1000. PMID: 28965461, DOI: 10.1176/appi.ajp.2017.17040376r.
Interaction between maternal cortisol in pregnancy and infant FKBP5 genotype on newborn hippocampal volume and infant stress reactivity at 12 monthsMoog N, Entringer S, Styner M, O’Donnell K, Gilmore J, Meaney M, Binder E, Heim C, Wadhwa P, Buss C. Interaction between maternal cortisol in pregnancy and infant FKBP5 genotype on newborn hippocampal volume and infant stress reactivity at 12 months Psychoneuroendocrinology 2017, 83: 26. DOI: 10.1016/j.psyneuen.2017.07.308.
New Insights into Prenatal Stress: Immediate- and Long-Term Effects on the Fetus and Their TimingO’Donnell K, Reissland N, Glover V. New Insights into Prenatal Stress: Immediate- and Long-Term Effects on the Fetus and Their Timing 2017, 75-85. DOI: 10.1007/978-3-319-53232-5_8.
Maternal prenatal anxiety and child COMT genotype predict working memory and symptoms of ADHDO'Donnell KJ, Glover V, Lahti J, Lahti M, Edgar RD, Räikkönen K, O'Connor TG. Maternal prenatal anxiety and child COMT genotype predict working memory and symptoms of ADHD PLOS ONE 2017, 12: e0177506. PMID: 28614354, PMCID: PMC5470664, DOI: 10.1371/journal.pone.0177506.
Dynamic interaction between fetal adversity and a genetic score reflecting dopamine function on developmental outcomes at 36 monthsBischoff AR, Pokhvisneva I, Léger É, Gaudreau H, Steiner M, Kennedy JL, O’Donnell K, Diorio J, Meaney MJ, Silveira PP, . Dynamic interaction between fetal adversity and a genetic score reflecting dopamine function on developmental outcomes at 36 months PLOS ONE 2017, 12: e0177344. PMID: 28505190, PMCID: PMC5432105, DOI: 10.1371/journal.pone.0177344.
551 Maternal History of Early Adversity and Offspring Temperament: Investigating Rearing Environmental and Genetic ContributionsBouvette-Turcot A, Unternäehrer E, O׳Donnell K, Chen L, Gaudreau H, Silveira P, Meaney M. 551 Maternal History of Early Adversity and Offspring Temperament: Investigating Rearing Environmental and Genetic Contributions Biological Psychiatry 2017, 81: s223. DOI: 10.1016/j.biopsych.2017.02.1159.
Intergenerational transmission of well being–genetic and epigenetic mechanismsUnternaehrer E, Greenlaw K, Dass S, Chen L, Bouvette-Turcot A, Cost K, O’Donnell K, Gaudreau H, McEwen L, MacIsaac J, Kobor M, Fleming A, Atkinson L, Lydon J, Steiner M, Ciampi A, Greenwood C, Meaney M. Intergenerational transmission of well being–genetic and epigenetic mechanisms European Psychiatry 2017, 41: s29-s30. DOI: 10.1016/j.eurpsy.2017.01.146.
Effects of Antenatal Maternal Depressive Symptoms and Socio-Economic Status on Neonatal Brain Development are Modulated by Genetic RiskQiu A, Shen M, Buss C, Chong YS, Kwek K, Saw SM, Gluckman PD, Wadhwa PD, Entringer S, Styner M, Karnani N, Heim CM, O'Donnell KJ, Holbrook JD, Fortier MV, Meaney MJ, . Effects of Antenatal Maternal Depressive Symptoms and Socio-Economic Status on Neonatal Brain Development are Modulated by Genetic Risk Cerebral Cortex 2017, 27: 1-13. PMID: 28334351, PMCID: PMC6057508, DOI: 10.1093/cercor/bhx065.
Maternal prenatal cortisol predicts infant negative emotionality in a sex-dependent mannerBraithwaite EC, Pickles A, Sharp H, Glover V, O'Donnell KJ, Tibu F, Hill J. Maternal prenatal cortisol predicts infant negative emotionality in a sex-dependent manner Physiology & Behavior 2017, 175: 31-36. PMID: 28322912, PMCID: PMC5429387, DOI: 10.1016/j.physbeh.2017.03.017.
The Drosophila foraging gene human orthologue PRKG1 predicts individual differences in the effects of early adversity on maternal sensitivitySokolowski HM, Vasquez OE, Unternaehrer E, Sokolowski DJ, Biergans SD, Atkinson L, Gonzalez A, Silveira PP, Levitan R, O’Donnell K, Steiner M, Kennedy J, Meaney MJ, Fleming AS, Sokolowski MB, teams O. The Drosophila foraging gene human orthologue PRKG1 predicts individual differences in the effects of early adversity on maternal sensitivity Cognitive Development 2016, 42: 62-73. PMID: 28827895, PMCID: PMC5562168, DOI: 10.1016/j.cogdev.2016.11.001.
Stress hormones and posttraumatic stress symptoms following paediatric critical illness: an exploratory studyAls LC, Picouto MD, O’Donnell K, Nadel S, Cooper M, Pierce CM, Kramer T, Glover VAS, Garralda ME. Stress hormones and posttraumatic stress symptoms following paediatric critical illness: an exploratory study European Child & Adolescent Psychiatry 2016, 26: 511-519. PMID: 27995329, PMCID: PMC5394132, DOI: 10.1007/s00787-016-0933-3.
Fetal Origins of Mental Health: The Developmental Origins of Health and Disease HypothesisO'Donnell KJ, Meaney MJ. Fetal Origins of Mental Health: The Developmental Origins of Health and Disease Hypothesis American Journal Of Psychiatry 2016, 174: 319-328. PMID: 27838934, DOI: 10.1176/appi.ajp.2016.16020138.
Inter-individual differences in the effects of maternal prenatal anxiety on child neurodevelopment: Implications for personalized medicine in perinatal mental healthO’Donnell K, Glover V, Edgar R, O’Connor T. Inter-individual differences in the effects of maternal prenatal anxiety on child neurodevelopment: Implications for personalized medicine in perinatal mental health Psychoneuroendocrinology 2016, 71: 6. DOI: 10.1016/j.psyneuen.2016.07.024.
Maternal prenatal depression is associated with decreased placental expression of the imprinted gene PEG3Janssen AB, Capron LE, O'Donnell K, Tunster SJ, Ramchandani PG, Heazell AE, Glover V, John RM. Maternal prenatal depression is associated with decreased placental expression of the imprinted gene PEG3 Psychological Medicine 2016, 46: 2999-3011. PMID: 27523184, PMCID: PMC5080674, DOI: 10.1017/s0033291716001598.
Chapter 7 Maternal Prenatal Stress and the Developmental Origins of Mental Health The Role of EpigeneticsO’Donnell K, Glover V. Chapter 7 Maternal Prenatal Stress and the Developmental Origins of Mental Health The Role of Epigenetics 2016, 103-126. DOI: 10.1016/b978-0-12-801383-0.00007-4.
Symptoms of major depressive disorder subsequent to child maltreatment: Examining change across multiple levels of analysis to identify transdiagnostic risk pathwaysShenk CE, Griffin AM, O'Donnell KJ. Symptoms of major depressive disorder subsequent to child maltreatment: Examining change across multiple levels of analysis to identify transdiagnostic risk pathways Development And Psychopathology 2015, 27: 1503-1514. PMID: 26535940, PMCID: PMC4774890, DOI: 10.1017/s0954579415000905.
Prenatal maternal depression and aberrant placental imprinting.Janssen AB, Capron LE, O'Donnell K, Tunster SJ, Heazell AE, Ramchandani PG, Glover V, John RM. Prenatal maternal depression and aberrant placental imprinting. Psychoneuroendocrinology 2015, 61: 4. PMID: 26383284.
Maternal early life adversities and the offspring's epigenome: A M.A.V.A.N. projectUnternaehrer E, O’Donnell K, Bouvette-Turcot A, Gaudreau H, Cost K, Fleming A, Steiner M, MacIsaac J, Mah S, McEwen L, Kobor M, Chen L, Pan H, Hui W, Holbrook J, Meaney M, MAVAN S. Maternal early life adversities and the offspring's epigenome: A M.A.V.A.N. project Psychoneuroendocrinology 2015, 61: 32. DOI: 10.1016/j.psyneuen.2015.07.477.
Prenatal maternal depression and aberrant placental imprintingJanssen A, Capron L, O’Donnell K, Tunster S, Heazell A, Ramchandani P, Glover V, John R. Prenatal maternal depression and aberrant placental imprinting Psychoneuroendocrinology 2015, 61: 4. DOI: 10.1016/j.psyneuen.2015.07.396.
Prenatal anxiety and depression, fetal programming and placental functionGlover V, O’Donnell K, O’Connor T, Ramchandani P, Capron L. Prenatal anxiety and depression, fetal programming and placental function Psychoneuroendocrinology 2015, 61: 3-4. DOI: 10.1016/j.psyneuen.2015.07.395.
funtooNorm: an R package for normalization of DNA methylation data when there are multiple cell or tissue typesOros Klein K, Grinek S, Bernatsky S, Bouchard L, Ciampi A, Colmegna I, Fortin JP, Gao L, Hivert MF, Hudson M, Kobor MS, Labbe A, MacIsaac JL, Meaney MJ, Morin AM, O'Donnell KJ, Pastinen T, Van Ijzendoorn MH, Voisin G, Greenwood CM. funtooNorm: an R package for normalization of DNA methylation data when there are multiple cell or tissue types Bioinformatics 2015, 32: 593-595. PMID: 26500152, PMCID: PMC4743629, DOI: 10.1093/bioinformatics/btv615.
Neuroanatomic Differences Associated With Stress Susceptibility and ResilienceAnacker C, Scholz J, O’Donnell K, Allemang-Grand R, Diorio J, Bagot RC, Nestler EJ, Hen R, Lerch JP, Meaney MJ. Neuroanatomic Differences Associated With Stress Susceptibility and Resilience Biological Psychiatry 2015, 79: 840-849. PMID: 26422005, PMCID: PMC5885767, DOI: 10.1016/j.biopsych.2015.08.009.
Epigenetics and the developmental origins of vulnerability for mental disordersMeaney M, O'Donnell K. Epigenetics and the developmental origins of vulnerability for mental disorders 2015, 317-329. DOI: 10.1002/9781118381953.ch25.
Maternal prenatal anxiety and child brain-derived neurotrophic factor (BDNF) genotype: Effects on internalizing symptoms from 4 to 15 years of ageO'Donnell KJ, Glover V, Holbrook JD, O'Connor TG. Maternal prenatal anxiety and child brain-derived neurotrophic factor (BDNF) genotype: Effects on internalizing symptoms from 4 to 15 years of age Development And Psychopathology 2014, 26: 1255-1266. PMID: 25422959, DOI: 10.1017/s095457941400100x.
Early life adversity and the epigenetic programming of hypothalamic-pituitary-adrenal functionAnacker C, O'Donnell KJ, Meaney MJ. Early life adversity and the epigenetic programming of hypothalamic-pituitary-adrenal function Dialogues In Clinical Neuroscience 2014, 16: 321-333. PMID: 25364283, PMCID: PMC4214175, DOI: 10.31887/dcns.2014.16.3/canacker.
Down regulation of placental PEG3 infers placental programming of maternal prenatal depressionJensen A, O'Donnell K, Tunster S, John R, Glover V. Down regulation of placental PEG3 infers placental programming of maternal prenatal depression Placenta 2014, 35: a35-a36. DOI: 10.1016/j.placenta.2014.06.118.
The persisting effect of maternal mood in pregnancy on childhood psychopathologyO'Donnell KJ, Glover V, Barker ED, O'Connor TG. The persisting effect of maternal mood in pregnancy on childhood psychopathology Development And Psychopathology 2014, 26: 393-403. PMID: 24621564, DOI: 10.1017/s0954579414000029.
Cortisol awakening response and subsequent depression: prospective longitudinal studyCarnegie R, Araya R, Ben-Shlomo Y, Glover V, O'Connor TG, O'Donnell KJ, Pearson R, Lewis G. Cortisol awakening response and subsequent depression: prospective longitudinal study The British Journal Of Psychiatry 2014, 204: 137-143. PMID: 24311550, PMCID: PMC3909839, DOI: 10.1192/bjp.bp.113.126250.
Maternal prenatal symptoms of depression and down regulation of placental monoamine oxidase A expressionBlakeley PM, Capron LE, Jensen AB, O'Donnell KJ, Glover V. Maternal prenatal symptoms of depression and down regulation of placental monoamine oxidase A expression Journal Of Psychosomatic Research 2013, 75: 341-345. PMID: 24119940, DOI: 10.1016/j.jpsychores.2013.07.002.
Stressful events and psychological difficulties: testing alternative candidates for sensitivityLaceulle OM, O’Donnell K, Glover V, O’Connor T, Ormel J, van Aken MA, Nederhof E. Stressful events and psychological difficulties: testing alternative candidates for sensitivity European Child & Adolescent Psychiatry 2013, 23: 103-113. PMID: 23756816, DOI: 10.1007/s00787-013-0436-4.
Prenatal maternal mood is associated with altered diurnal cortisol in adolescenceO’Donnell K, Glover V, Jenkins J, Browne D, Ben-Shlomo Y, Golding J, O’Connor T. Prenatal maternal mood is associated with altered diurnal cortisol in adolescence Psychoneuroendocrinology 2013, 38: 1630-1638. PMID: 23433748, PMCID: PMC3695029, DOI: 10.1016/j.psyneuen.2013.01.008.
Prenatal versus postnatal sex steroid hormone effects on autistic traits in children at 18 to 24 months of ageAuyeung B, Ahluwalia J, Thomson L, Taylor K, Hackett G, O’Donnell K, Baron-Cohen S. Prenatal versus postnatal sex steroid hormone effects on autistic traits in children at 18 to 24 months of age Molecular Autism 2012, 3: 17. PMID: 23231861, PMCID: PMC3554559, DOI: 10.1186/2040-2392-3-17.
Maternal prenatal anxiety and downregulation of placental 11β-HSD2O’Donnell K, Jensen A, Freeman L, Khalife N, O’Connor T, Glover V. Maternal prenatal anxiety and downregulation of placental 11β-HSD2 Psychoneuroendocrinology 2011, 37: 818-826. PMID: 22001010, DOI: 10.1016/j.psyneuen.2011.09.014.
P02-503 - Diurnal pattern of cortisol and amylase output in postnatal depressionKammerer M, Taylor A, Khalife N, O’Donnell K, Marks M, Glover V. P02-503 - Diurnal pattern of cortisol and amylase output in postnatal depression European Psychiatry 2011, 26: 1099. DOI: 10.1016/s0924-9338(11)72804-8.
Distinct neuropathologic phenotypes after disrupting the chloride transport proteins ClC-6 or ClC-7/Ostm1.Pressey SN, O'Donnell KJ, Stauber T, Fuhrmann JC, Tyynelä J, Jentsch TJ, Cooper JD. Distinct neuropathologic phenotypes after disrupting the chloride transport proteins ClC-6 or ClC-7/Ostm1. Journal Of Neuropathology And Experimental Neurology 2010, 69: 1228-46. PMID: 21107136, DOI: 10.1097/NEN.0b013e3181ffe742.
Anxiety, depression and saliva cortisol in women with a medical disorder during pregnancyKing NM, Chambers J, O’Donnell K, Jayaweera SR, Williamson C, Glover VA. Anxiety, depression and saliva cortisol in women with a medical disorder during pregnancy Archives Of Women's Mental Health 2010, 13: 339-345. PMID: 20101421, DOI: 10.1007/s00737-009-0139-5.
Maternal stress, anxiety, and depression during pregnancy: effects on the fetus and the childGlover V, O’Donnell K, O’Connor T. Maternal stress, anxiety, and depression during pregnancy: effects on the fetus and the child 2010, 266-270. DOI: 10.1093/med/9780199214365.003.0029.
Prenatal stress and the programming of the HPA axisGlover V, O’Connor T, O’Donnell K. Prenatal stress and the programming of the HPA axis Neuroscience & Biobehavioral Reviews 2009, 35: 17-22. PMID: 19914282, DOI: 10.1016/j.neubiorev.2009.11.008.
Salivary α-amylase stability, diurnal profile and lack of response to the cold hand test in young womenO'Donnell K, Kammerer M, O'Reilly R, Taylor A, Glover V. Salivary α-amylase stability, diurnal profile and lack of response to the cold hand test in young women Stress 2009, 12: 549-554. PMID: 19658030, DOI: 10.3109/10253890902822664.
Prenatal Stress and Neurodevelopment of the Child: Focus on the HPA Axis and Role of the PlacentaO’Donnell K, O’Connor T, Glover V. Prenatal Stress and Neurodevelopment of the Child: Focus on the HPA Axis and Role of the Placenta Developmental Neuroscience 2009, 31: 285-292. PMID: 19546565, DOI: 10.1159/000216539.
Stress-induced cytokine responses and central adiposity in young women.Brydon L, Wright CE, O'Donnell K, Zachary I, Wardle J, Steptoe A. Stress-induced cytokine responses and central adiposity in young women. International Journal Of Obesity (2005) 2008, 32: 443-50. PMID: 18059406, DOI: 10.1038/sj.ijo.0803767.
New Insights into Prenatal Stress: Immediate and Long-Term Effects on the Fetus and Their TimingO’Donnell K, Glover V. New Insights into Prenatal Stress: Immediate and Long-Term Effects on the Fetus and Their Timing 2008, 57-64. DOI: 10.1007/978-88-470-0732-1_8.

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