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Kadriye Nehir Cosgun, PhD

Associate Research Scientist

Research & Publications
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Selected Publications

β-catenin engages IKZF factors to control lymphopoiesisCosgun K, Jumaa H, Robinson M, Xu L, Xiao G, Arce D, Khanduja D, Chan L, Lee J, Schjerven H, Jellusova J, Müschen M. β-catenin engages IKZF factors to control lymphopoiesis. The Journal Of Immunology 2023, 210: 65.09-65.09. DOI: 10.4049/jimmunol.210.supp.65.09.
CD25 recruits inhibitory phosphatases for feedback control of B-cell receptor signalingSun R, Lee J, Robinson M, Kume K, Cosgun K, Chan L, Leveille E, Geng H, Vykunta V, Shy B, Marson A, Meffre E, Müschen M. CD25 recruits inhibitory phosphatases for feedback control of B-cell receptor signaling. The Journal Of Immunology 2023, 210: 154.23-154.23. DOI: 10.4049/jimmunol.210.supp.154.23.
Structural Elements of the BCR Determine Permissiveness to Oncogenic RAS-Driven B-Cell TransformationChan L, Robinson M, Cosgun K, Yu X, Leveille E, Geng H, Müschen M. Structural Elements of the BCR Determine Permissiveness to Oncogenic RAS-Driven B-Cell Transformation. Blood 2022, 140: 8758-8759. DOI: 10.1182/blood-2022-170079.
Divergent MYC- and BCL6-Driven Metabolic Programs Enable Dynamic Regulation of Cell Biomass in B-Cell MalignanciesKume K, Chen Z, Chan L, Robinson M, Leveille E, Lee J, Cosgun K, Arce D, Khanduja D, Klemm L, Müschen M. Divergent MYC- and BCL6-Driven Metabolic Programs Enable Dynamic Regulation of Cell Biomass in B-Cell Malignancies. Blood 2022, 140: 5900-5901. DOI: 10.1182/blood-2022-170396.
A Phosphatase Membrane-Shuttle Enables Feedback Control of B-Cell SignalingLee J, Kume K, Robinson M, Sun R, Ma N, Chen Z, Xiao G, Cosgun K, Chan L, Leveille E, Klemm L, Vykunta V, Shy B, Geng H, Luger S, Litzow M, Marson A, Paietta E, Vaidehi N, Meffre E, Müschen M. A Phosphatase Membrane-Shuttle Enables Feedback Control of B-Cell Signaling. Blood 2022, 140: 1698-1699. DOI: 10.1182/blood-2022-170324.
GSK3β Inhibition Is a Unique Vulnerability in Lymphoid MalignanciesCosgun K, Jumaa H, Robinson M, Chan L, Lee J, Kume K, Arce D, Jellusova J, Müschen M. GSK3β Inhibition Is a Unique Vulnerability in Lymphoid Malignancies. Blood 2022, 140: 3114-3115. DOI: 10.1182/blood-2022-169961.
Repressive β-Catenin-Ikaros Complexes Are Essential to Prevent Clonal Evolution of Human LymphopoiesisCosgun K, Liu W, Robinson M, Arce D, VanOudenhove J, Bigogno A, Flavell R, Halene S, Müschen M. Repressive β-Catenin-Ikaros Complexes Are Essential to Prevent Clonal Evolution of Human Lymphopoiesis. Blood 2022, 140: 8744-8745. DOI: 10.1182/blood-2022-170409.
Beta-Catenin Forms Repressive Complexes with Ikzf1 and Ikzf3 to Orchestrate Tumor-Suppression in B-Cell MalignanciesCosgun K, Robinson M, Chan L, Hur M, Leveille E, Song J, Chan W, Müschen M. Beta-Catenin Forms Repressive Complexes with Ikzf1 and Ikzf3 to Orchestrate Tumor-Suppression in B-Cell Malignancies. Blood 2021, 138: 29. DOI: 10.1182/blood-2021-148597.
Pharmacological Targeting of PI3K-Dependent Central Tolerance Mechanisms in Refractory Pre-Germinal Center B-Cell MalignanciesKume K, Lee J, Chan L, Robinson M, Cosgun K, Meffre E, Müschen M. Pharmacological Targeting of PI3K-Dependent Central Tolerance Mechanisms in Refractory Pre-Germinal Center B-Cell Malignancies. Blood 2021, 138: 2267. DOI: 10.1182/blood-2021-149806.
Leveraging Pathway-Interference to Overcome Drug-Resistance in Acute Lymphoblastic LeukemiaChan L, Murakami M, Hurtz C, Kume K, Lee J, Cosgun K, Geng H, Izraeli S, Weinstock D, Müschen M. Leveraging Pathway-Interference to Overcome Drug-Resistance in Acute Lymphoblastic Leukemia. Blood 2021, 138: 616. DOI: 10.1182/blood-2021-149773.
Identification of a Conserved Intracellular Loop (CIL) Structure That Scaffolds PIP3 to Amplify Oncogenic Signaling during Malignant B-Cell TransformationLee J, Robinson M, Ma N, Sadras T, Cosgun K, Chan L, Kume K, Thomas-Tikhonenko A, Weinstock D, Diamond M, Vaidehi N, Müschen M. Identification of a Conserved Intracellular Loop (CIL) Structure That Scaffolds PIP3 to Amplify Oncogenic Signaling during Malignant B-Cell Transformation. Blood 2021, 138: 868. DOI: 10.1182/blood-2021-149646.
Structural Basis of Feedback Control of Oncogenic Signaling in B-Lymphoid MalignanciesLee J, Robinson M, Ma N, Kume K, Artadji D, Sadras T, Cosgun K, Geng H, Paietta E, Buchner M, Vaidehi N, Weinstock D, Müschen M. Structural Basis of Feedback Control of Oncogenic Signaling in B-Lymphoid Malignancies. Blood 2021, 138: 355. DOI: 10.1182/blood-2021-149189.
Identification of BCL6 As Synthetic Lethality in RAS-Driven B-Cell TransformationChan L, Hurtz C, Leveille E, Kume K, Robinson M, Geng H, Cosgun K, Müschen M. Identification of BCL6 As Synthetic Lethality in RAS-Driven B-Cell Transformation. Blood 2021, 138: 792. DOI: 10.1182/blood-2021-148653.
Developmental partitioning of SYK and ZAP70 prevents autoimmunity and cancerSadras T, Martin M, Kume K, Robinson ME, Saravanakumar S, Lenz G, Chen Z, Song JY, Siddiqi T, Oksa L, Knapp AM, Cutler J, Cosgun KN, Klemm L, Ecker V, Winchester J, Ghergus D, Soulas-Sprauel P, Kiefer F, Heisterkamp N, Pandey A, Ngo V, Wang L, Jumaa H, Buchner M, Ruland J, Chan WC, Meffre E, Martin T, Müschen M. Developmental partitioning of SYK and ZAP70 prevents autoimmunity and cancer. Molecular Cell 2021, 81: 2094-2111.e9. PMID: 33878293, PMCID: PMC8239336, DOI: 10.1016/j.molcel.2021.03.043.
PON2 subverts metabolic gatekeeper functions in B cells to promote leukemogenesisPan L, Hong C, Chan LN, Xiao G, Malvi P, Robinson ME, Geng H, Reddy ST, Lee J, Khairnar V, Cosgun KN, Xu L, Kume K, Sadras T, Wang S, Wajapeyee N, Müschen M. PON2 subverts metabolic gatekeeper functions in B cells to promote leukemogenesis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2016553118. PMID: 33531346, PMCID: PMC7896313, DOI: 10.1073/pnas.2016553118.
IFITM3 functions as a PIP3 scaffold to amplify PI3K signalling in B cellsLee J, Robinson ME, Ma N, Artadji D, Ahmed MA, Xiao G, Sadras T, Deb G, Winchester J, Cosgun KN, Geng H, Chan LN, Kume K, Miettinen TP, Zhang Y, Nix MA, Klemm L, Chen CW, Chen J, Khairnar V, Wiita AP, Thomas-Tikhonenko A, Farzan M, Jung JU, Weinstock DM, Manalis SR, Diamond MS, Vaidehi N, Müschen M. IFITM3 functions as a PIP3 scaffold to amplify PI3K signalling in B cells. Nature 2020, 588: 491-497. PMID: 33149299, PMCID: PMC8087162, DOI: 10.1038/s41586-020-2884-6.
Signalling input from divergent pathways subverts B cell transformationChan LN, Murakami MA, Robinson ME, Caeser R, Sadras T, Lee J, Cosgun KN, Kume K, Khairnar V, Xiao G, Ahmed MA, Aghania E, Deb G, Hurtz C, Shojaee S, Hong C, Pölönen P, Nix MA, Chen Z, Chen CW, Chen J, Vogt A, Heinäniemi M, Lohi O, Wiita AP, Izraeli S, Geng H, Weinstock DM, Müschen M. Signalling input from divergent pathways subverts B cell transformation. Nature 2020, 583: 845-851. PMID: 32699415, PMCID: PMC7394729, DOI: 10.1038/s41586-020-2513-4.
Dynamic Assembly of a Feedback Complex to Regulate Oncogenic B-Cell Receptor-SignalingLee J, Kume K, Chen Z, Xiao G, Cosgun K, Chen L, Chan L, Klemm L, Chen C, Ma N, Chan W, Forman S, Zammarchi F, Van Berkel P, Melnick A, Ngo V, Geng H, Luger S, Litzow M, McManus M, Vaidehi N, Paietta E, Meffre E, Weinstock D, Müschen M. Dynamic Assembly of a Feedback Complex to Regulate Oncogenic B-Cell Receptor-Signaling. Blood 2019, 134: 393. DOI: 10.1182/blood-2019-131270.
Lgr5 Functions As a Critical Negative Regulator of Wnt/β-Catenin Signaling and Is Essential for B-Lymphopoiesis and Malignant B-Cell TransformationCosgun K, Deb G, Yang X, Xiao G, Sadras T, Lee J, Chan L, Kume K, Yang L, Geng H, Chan J, Song J, Jumaa H, Polson A, Clevers H, Müschen M. Lgr5 Functions As a Critical Negative Regulator of Wnt/β-Catenin Signaling and Is Essential for B-Lymphopoiesis and Malignant B-Cell Transformation. Blood 2019, 134: 748. DOI: 10.1182/blood-2019-127263.
Signaling Input from Divergent Pathways Subverts Malignant B-Cell TransformationChan L, Murakami M, Caesar R, Hurtz C, Kume K, Sadras T, Shojaee S, Pölönen P, Ugale A, Lee J, Cosgun K, Geng H, Heinäniemi M, Lohi O, Wiita A, Izraeli S, Weinstock D, Müschen M. Signaling Input from Divergent Pathways Subverts Malignant B-Cell Transformation. Blood 2019, 134: 3944. DOI: 10.1182/blood-2019-130774.
Ifitm3 Is Essential for PI(3,4,5)P3-Dependent B-Cell Activation and LeukemogenesisLee J, Xiao G, Cosgun K, Geng H, Ma N, Chan L, Kume K, Nix M, Chen Z, Chen C, Chen J, Khairnar V, Wiita A, Thomas-Tikhonenko A, Farzan M, Diamond M, Jung J, Vaidehi N, Müschen M. Ifitm3 Is Essential for PI(3,4,5)P3-Dependent B-Cell Activation and Leukemogenesis. Blood 2019, 134: 2782. DOI: 10.1182/blood-2019-127615.
IFITM3-Mediated Regulation of Cell Membrane Dynamics Is Essential for Malignant B-Cell TransformationLee J, Geng H, Dinson D, Xiao G, Cosgun K, Chan L, Chen Z, Farzan M, Jung J, Wiita A, Muschen M. IFITM3-Mediated Regulation of Cell Membrane Dynamics Is Essential for Malignant B-Cell Transformation. Blood 2018, 132: 552. DOI: 10.1182/blood-2018-99-117472.
Divergent Evolutionary Trajectories of Erk- and Stat5-Activating Lesions in Acute Lymphoblastic LeukemiaChan L, Shojaee S, Hurtz C, Auer F, Chen Z, Cosgun K, Geng H, Sadras T, White D, Muschen M. Divergent Evolutionary Trajectories of Erk- and Stat5-Activating Lesions in Acute Lymphoblastic Leukemia. Blood 2018, 132: 568. DOI: 10.1182/blood-2018-99-115536.
Lgr5 Enables Positive B-Cell Selection and Tumor-Initiation in B-Cell MalignanciesCosgun K, Deb G, Yang X, Xiao G, Sadras T, Auer F, Lee J, Abarientos A, Mangolini M, Aghajanirefah A, Geng H, Jumaa H, Polson A, Clevers H, Muschen M. Lgr5 Enables Positive B-Cell Selection and Tumor-Initiation in B-Cell Malignancies. Blood 2018, 132: 547. DOI: 10.1182/blood-2018-99-116956.
Cooperation between SYK and ZAP70 Kinases As a Driver of Oncogenic BCR-Signaling in B-Cell MalignanciesSadras T, Cutler J, Aguade-Gorgorio J, Chen Z, Cosgun K, Pandey A, Muschen M. Cooperation between SYK and ZAP70 Kinases As a Driver of Oncogenic BCR-Signaling in B-Cell Malignancies. Blood 2018, 132: 3922. DOI: 10.1182/blood-2018-99-116954.
Pre-BCR Surrogate Light Chain Components VPREB1 and IGLL1 Function As Pre-BCR-Independent Tumor Suppressors in Acute Lymphoblastic LeukemiaCosgun K, Hendriks R, Dickins R, Heisterkamp N, Muschen M. Pre-BCR Surrogate Light Chain Components VPREB1 and IGLL1 Function As Pre-BCR-Independent Tumor Suppressors in Acute Lymphoblastic Leukemia. Blood 2018, 132: 570. DOI: 10.1182/blood-2018-99-115522.
Ras-Driven B-Cell Transformation Targets Developmental Rewiring of Cytokine to Pre-B Cell Receptor SignalingChan L, Hurtz C, Geng H, Auer F, Chen Z, Xiao G, Lee J, Cosgun K, Ye B, Muschen M. Ras-Driven B-Cell Transformation Targets Developmental Rewiring of Cytokine to Pre-B Cell Receptor Signaling. Blood 2018, 132: 1336. DOI: 10.1182/blood-2018-99-115514.
CD25-Dependent Feedback Control of the B-Cell Receptor and Its Oncogenic Mimics in B-Cell MalignanciesLee J, Kume K, Chen Z, Xiao G, Cosgun K, Chan L, Chen C, Pillai R, Chan W, Forman S, Kwak L, Zammarchi F, Van Berkel P, Weinstock D, Melnick A, Ngo V, Geng H, Luger S, Litzow M, Belot A, Uzel G, McManus M, Paietta E, Meffre E, Muschen M. CD25-Dependent Feedback Control of the B-Cell Receptor and Its Oncogenic Mimics in B-Cell Malignancies. Blood 2018, 132: 776. DOI: 10.1182/blood-2018-99-117553.
3154 T-Cell Associated ZAP70 Kinase Contributes to B-Cell Receptor Signaling in Malignant LymphopoiesisSadras T, Chen Z, Klemm L, Cosgun K, Müschen M. 3154 T-Cell Associated ZAP70 Kinase Contributes to B-Cell Receptor Signaling in Malignant Lymphopoiesis. Experimental Hematology 2018, 64: s99. DOI: 10.1016/j.exphem.2018.06.137.
3021 LGR5 Mediates Positive B-Cell Selection and is Critical for Survival of Normal and Transformed B CellsCosgun K, Yang X, Mangolini M, Xiao G, Abarientos A, Aghajanirefah A, Klemm L, Sadras T, Geng H, Yang L, Song Q, Zeng D, Zeng D, Jumaa H, Polson A, Clevers H, Muschen M. 3021 LGR5 Mediates Positive B-Cell Selection and is Critical for Survival of Normal and Transformed B Cells. Experimental Hematology 2018, 64: s59-s60. DOI: 10.1016/j.exphem.2018.06.206.
Abstract 4515: Lgr5 mediates positive B-cell selection and is critical for initiation and survival of B-cell malignanciesCosgun K, Hecht A, Yang X, Mangolini M, Aghajanirefah A, Xiao G, Sadras T, Chen Z, Klemm L, Geng H, Hong C, Song Q, Zeng D, Jumaa H, Zeng D, Clevers H, Muschen M. Abstract 4515: Lgr5 mediates positive B-cell selection and is critical for initiation and survival of B-cell malignancies. Cancer Research 2018, 78: 4515-4515. DOI: 10.1158/1538-7445.am2018-4515.
Abstract 2983: CD25 enables oncogenic BCR- and TCR-signaling and represents a therapeutic target in lymphoblastic malignanciesLee J, Geng H, Chen Z, Xiao G, Cosgun K, Zammarchi F, Berkel P, Melnick A, Paietta E, Muschen M. Abstract 2983: CD25 enables oncogenic BCR- and TCR-signaling and represents a therapeutic target in lymphoblastic malignancies. Cancer Research 2018, 78: 2983-2983. DOI: 10.1158/1538-7445.am2018-2983.
Author Correction: Metabolic gatekeeper function of B-lymphoid transcription factorsChan LN, Chen Z, Braas D, Lee JW, Xiao G, Geng H, Cosgun KN, Hurtz C, Shojaee S, Cazzaniga V, Schjerven H, Ernst T, Hochhaus A, Kornblau SM, Konopleva M, Pufall MA, Cazzaniga G, Liu GJ, Milne TA, Koeffler HP, Ross TS, Sánchez-García I, Borkhardt A, Yamamoto KR, Dickins RA, Graeber TG, Müschen M. Author Correction: Metabolic gatekeeper function of B-lymphoid transcription factors. Nature 2018, 558: e5-e5. PMID: 29849140, DOI: 10.1038/s41586-018-0164-5.
B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell MalignanciesXiao G, Chan LN, Klemm L, Braas D, Chen Z, Geng H, Zhang QC, Aghajanirefah A, Cosgun KN, Sadras T, Lee J, Mirzapoiazova T, Salgia R, Ernst T, Hochhaus A, Jumaa H, Jiang X, Weinstock DM, Graeber TG, Müschen M. B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies. Cell 2018, 173: 470-484.e18. PMID: 29551267, PMCID: PMC6284818, DOI: 10.1016/j.cell.2018.02.048.
Abstract 93: Transcriptional control of glucocorticoid responses in leukemiaChan L, Chen Z, Xiao G, Lee J, Cosgun K, Geng H, Cazzaniga V, Schjerven H, Dickins R, Muschen M. Abstract 93: Transcriptional control of glucocorticoid responses in leukemia. Cancer Research 2017, 77: 93-93. DOI: 10.1158/1538-7445.am2017-93.
Metabolic gatekeeper function of B-lymphoid transcription factorsChan LN, Chen Z, Braas D, Lee JW, Xiao G, Geng H, Cosgun KN, Hurtz C, Shojaee S, Cazzaniga V, Schjerven H, Ernst T, Hochhaus A, Kornblau SM, Konopleva M, Pufall MA, Cazzaniga G, Liu GJ, Milne TA, Koeffler HP, Ross TS, Sánchez-García I, Borkhardt A, Yamamoto KR, Dickins RA, Graeber TG, Müschen M. Metabolic gatekeeper function of B-lymphoid transcription factors. Nature 2017, 542: 479-483. PMID: 28192788, PMCID: PMC5621518, DOI: 10.1038/nature21076.
CD25 Enables Oncogenic BCR Signaling and Represents a Therapeutic Target in Refractory B Cell MalignanciesLee J, Geng H, Chen Z, Klemm L, Cosgun K, Xiao G, Masouleh B, Hurtz C, Parekh S, Kornblau S, Melnick A, Abbas A, Paietta E, Müschen M. CD25 Enables Oncogenic BCR Signaling and Represents a Therapeutic Target in Refractory B Cell Malignancies. Blood 2016, 128: 4088. DOI: 10.1182/blood.v128.22.4088.4088.
Identification of the Energy Stress Sensor AMPK As Therapeutic Target in Acute Lymphoblastic LeukemiaChan L, Lee J, Cosgun K, Geng H, Xiao G, Chen Z, Ernst T, Hochhaus A, Müschen M. Identification of the Energy Stress Sensor AMPK As Therapeutic Target in Acute Lymphoblastic Leukemia. Blood 2016, 128: 2771. DOI: 10.1182/blood.v128.22.2771.2771.
IFITM3 Is a Central Regulator of Lipid Raft Signaling and Essential for CD19 Surface Expression and PI3K Signaling in Human B Cell MalignanciesLee J, Geng H, Cosgun K, Chan L, Chen Z, Park E, Klemm L, Bailey C, Müschen M. IFITM3 Is a Central Regulator of Lipid Raft Signaling and Essential for CD19 Surface Expression and PI3K Signaling in Human B Cell Malignancies. Blood 2016, 128: 2738. DOI: 10.1182/blood.v128.22.2738.2738.
PTEN opposes negative selection and enables oncogenic transformation of pre-B cellsShojaee S, Chan LN, Buchner M, Cazzaniga V, Cosgun KN, Geng H, Qiu YH, von Minden MD, Ernst T, Hochhaus A, Cazzaniga G, Melnick A, Kornblau SM, Graeber TG, Wu H, Jumaa H, Müschen M. PTEN opposes negative selection and enables oncogenic transformation of pre-B cells. Nature Medicine 2016, 22: 379-387. PMID: 26974310, PMCID: PMC5178869, DOI: 10.1038/nm.4062.
Kit Regulates HSC Engraftment across the Human-Mouse Species BarrierCosgun KN, Rahmig S, Mende N, Reinke S, Hauber I, Schäfer C, Petzold A, Weisbach H, Heidkamp G, Purbojo A, Cesnjevar R, Platz A, Bornhäuser M, Schmitz M, Dudziak D, Hauber J, Kirberg J, Waskow C. Kit Regulates HSC Engraftment across the Human-Mouse Species Barrier. Cell Stem Cell 2014, 15: 227-238. PMID: 25017720, DOI: 10.1016/j.stem.2014.06.001.
Clonal expansion capacity defines two consecutive developmental stages of long-term hematopoietic stem cellsGrinenko T, Arndt K, Portz M, Mende N, Günther M, Cosgun KN, Alexopoulou D, Lakshmanaperumal N, Henry I, Dahl A, Waskow C. Clonal expansion capacity defines two consecutive developmental stages of long-term hematopoietic stem cells. Journal Of Experimental Medicine 2014, 211: 209-215. PMID: 24446490, PMCID: PMC3920556, DOI: 10.1084/jem.20131115.

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