Julie Rose Hens
PhD, MS, BA
Research Scientist
Research & Publications
Biography
News
Research Summary
Dr. Hens is working on a project that demonstrates that methionine restriction (MR) can affect mitochondrial function in triple negative breast cancer. Her preliminary data
suggests that MR increases apoptosis through a mitochondrial specific mechanism. Additionally, Dr. Hens is working in John Wysolmerski’s laboratory focusing on the role of parathyroid hormone related protein (PTHrP), calcium sensing receptor(CaSR) and GABAR1 and GABAR2 interactions in breast cancer and mammary function. Present projects also include examining the role of dietary fats on breast cancer and metastasis, in addition examining lactation and possible protective effects on metabolism.
Coauthors
Research Interests
Breast Neoplasms; Methionine; Triple Negative Breast Neoplasms
Selected Publications
- THU313 Lactation As A Possible Protective Factor For Postpartum Diabetes In Women With Gestational Diabetes Mellitus: A Retrospective AnalysisDávila-Parrilla V, Stanton C, Hackerson C, Song H, Hens J, Wysolmerski J, Merriam A, De Aguiar R. THU313 Lactation As A Possible Protective Factor For Postpartum Diabetes In Women With Gestational Diabetes Mellitus: A Retrospective Analysis. Journal Of The Endocrine Society 2023, 7: bvad114.747. PMCID: PMC10553496, DOI: 10.1210/jendso/bvad114.747.
- THU302 Protective Effects Of Lactation On Maternal MetabolismHens J, Ding Y, Brown S, Song H, Wysolmerski J, De Aguiar R. THU302 Protective Effects Of Lactation On Maternal Metabolism. Journal Of The Endocrine Society 2023, 7: bvad114.737. PMCID: PMC10554876, DOI: 10.1210/jendso/bvad114.737.
- Hyperinsulinemia induces early and dyssynchronous puberty in lean female mice.Saleh FL, Joshi AA, Tal A, Xu P, Hens J, Wong SL, Flannery C. Hyperinsulinemia induces early and dyssynchronous puberty in lean female mice. Journal Of Endocrinology 2022, 254: 121-135. PMID: 35904489, PMCID: PMC9837806, DOI: 10.1530/joe-21-0447.
- PTHrP induces STAT5 activation, secretory differentiation and accelerates mammary tumor developmentGrinman DY, Boras-Granic K, Takyar FM, Dann P, Hens JR, Marmol C, Lee J, Choi J, Chodosh LA, Sola MEG, Wysolmerski JJ. PTHrP induces STAT5 activation, secretory differentiation and accelerates mammary tumor development. Breast Cancer Research 2022, 24: 30. PMID: 35440032, PMCID: PMC9020078, DOI: 10.1186/s13058-022-01523-1.
- NHERF1 Is Required for Localization of PMCA2 and Suppression of Early Involution in the Female Lactating Mammary GlandJeong J, Kim W, Hens J, Dann P, Schedin P, Friedman PA, Wysolmerski JJ. NHERF1 Is Required for Localization of PMCA2 and Suppression of Early Involution in the Female Lactating Mammary Gland. Endocrinology 2019, 160: 1797-1810. PMID: 31087002, PMCID: PMC6619491, DOI: 10.1210/en.2019-00230.
- METHIONINE RESTRICTION ALTERS HEPATIC MIRNAS INVOLVED IN METABOLISM IN YOUNG, OBESE, AND AGED MICEPark M, Cooke D, Plummer J, Ables G, Hens J. METHIONINE RESTRICTION ALTERS HEPATIC MIRNAS INVOLVED IN METABOLISM IN YOUNG, OBESE, AND AGED MICE. Innovation In Aging 2017, 1: 857-857. PMCID: PMC6184731, DOI: 10.1093/geroni/igx004.3084.
- Erratum to: Methionine-restricted diet inhibits growth of MCF10AT1-derived mammary tumors by increasing cell cycle inhibitors in athymic nude miceHens J, Sinha I, Perodin F, Cooper T, Sinha R, Plummer J, Perrone C, Orentreich D. Erratum to: Methionine-restricted diet inhibits growth of MCF10AT1-derived mammary tumors by increasing cell cycle inhibitors in athymic nude mice. BMC Cancer 2016, 16: 474. PMID: 27417544, PMCID: PMC4944442, DOI: 10.1186/s12885-016-2404-0.
- Methionine‐Restricted Diet Increases miRNAs That Can Target RUNX2 Expression and Alters Bone Structure in Young MicePlummer J, Park M, Perodin F, Horowitz MC, Hens JR. Methionine‐Restricted Diet Increases miRNAs That Can Target RUNX2 Expression and Alters Bone Structure in Young Mice. Journal Of Cellular Biochemistry 2016, 118: 31-42. PMID: 27191548, PMCID: PMC5426510, DOI: 10.1002/jcb.25604.
- Methionine-restricted diet inhibits growth of MCF10AT1-derived mammary tumors by increasing cell cycle inhibitors in athymic nude miceHens JR, Sinha I, Perodin F, Cooper T, Sinha R, Plummer J, Perrone CE, Orentreich D. Methionine-restricted diet inhibits growth of MCF10AT1-derived mammary tumors by increasing cell cycle inhibitors in athymic nude mice. BMC Cancer 2016, 16: 349. PMID: 27255182, PMCID: PMC4891836, DOI: 10.1186/s12885-016-2367-1.
- Methionine restriction beyond life‐span extensionAbles GP, Hens JR, Nichenametla SN. Methionine restriction beyond life‐span extension. Annals Of The New York Academy Of Sciences 2016, 1363: 68-79. PMID: 26916321, DOI: 10.1111/nyas.13014.
- Parathyroid hormone-related protein activates Wnt signaling to specify the embryonic mammary mesenchymeHiremath M, Dann P, Fischer J, Butterworth D, Boras-Granic K, Hens J, Van Houten J, Shi W, Wysolmerski J. Parathyroid hormone-related protein activates Wnt signaling to specify the embryonic mammary mesenchyme. Development 2012, 139: 4239-4249. PMID: 23034629, PMCID: PMC3478689, DOI: 10.1242/dev.080671.
- The role and function of cadherins in the mammary glandAndrews JL, Kim AC, Hens JR. The role and function of cadherins in the mammary gland. Breast Cancer Research 2012, 14: 203. PMID: 22315958, PMCID: PMC3496113, DOI: 10.1186/bcr3065.
- Localization of CTGF in mouse embryonic mammary gland developmentSambamurty A, Kim A, Barkley T, Hens J. Localization of CTGF in mouse embryonic mammary gland development. Developmental Biology 2011, 356: 144. DOI: 10.1016/j.ydbio.2011.05.148.
- Regulation and expression of CTGF during adult mammary gland morphogenesisKim A, Sambamurty A, Barkley T, Hens J. Regulation and expression of CTGF during adult mammary gland morphogenesis. Developmental Biology 2011, 356: 144. DOI: 10.1016/j.ydbio.2011.05.149.
- Cadherin-11 functions during mammary gland branching morphogenesisHens J, Kumar A, Nuttall J, Sanyal N, Vos M. Cadherin-11 functions during mammary gland branching morphogenesis. Developmental Biology 2010, 344: 446. DOI: 10.1016/j.ydbio.2010.05.137.
- Analysis of gene expression in PTHrP−/− mammary buds supports a role for BMP signaling and MMP2 in the initiation of ductal morphogenesisHens J, Dann P, Hiremath M, Pan T, Chodosh L, Wysolmerski J. Analysis of gene expression in PTHrP−/− mammary buds supports a role for BMP signaling and MMP2 in the initiation of ductal morphogenesis. Developmental Dynamics 2009, 238: 2713-2724. PMID: 19795511, PMCID: PMC2862621, DOI: 10.1002/dvdy.22097.
- Preservation of β-Galactosidase Transgene in Decalcified Murine Bone Specimens Embedded in ParaffinDann P, Hens J, Troiano N, Wysolmerski J, Kacena M. Preservation of β-Galactosidase Transgene in Decalcified Murine Bone Specimens Embedded in Paraffin. Journal Of Histotechnology 2008, 31: 61-64. DOI: 10.1179/his.2008.31.2.61.
- Preservation of b-galactosidase transgene in decalcified murine bone specimens embedded in paraffinDann P, Hens JR, Troiano NW, Wysolmerski J, Kacena MA. Preservation of b-galactosidase transgene in decalcified murine bone specimens embedded in paraffin. J Histotech 31(2): 61-64, 2008
- BMP4 and PTHrP interact to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle inductionHens JR, Dann P, Zhang JP, Harris S, Robinson GW, Wysolmerski J. BMP4 and PTHrP interact to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction. Development 2007, 134: 1221-1230. PMID: 17301089, DOI: 10.1242/dev.000182.
- Initial Characterization of PTH‐Related Protein Gene‐Driven lacZ Expression in the Mouse*Chen X, Macica CM, Dreyer BE, Hammond VE, Hens JR, Philbrick WM, Broadus AE. Initial Characterization of PTH‐Related Protein Gene‐Driven lacZ Expression in the Mouse*. Journal Of Bone And Mineral Research 2006, 21: 113-123. PMID: 16355280, DOI: 10.1359/jbmr.051005.
- Key stages of mammary gland development: Molecular mechanisms involved in the formation of the embryonic mammary glandHens JR, Wysolmerski JJ. Key stages of mammary gland development: Molecular mechanisms involved in the formation of the embryonic mammary gland. Breast Cancer Research 2005, 7: 220. PMID: 16168142, PMCID: PMC1242158, DOI: 10.1186/bcr1306.
- TOPGAL Mice Show That the Canonical Wnt Signaling Pathway Is Active During Bone Development and Growth and Is Activated by Mechanical Loading In Vitro*Hens JR, Wilson KM, Dann P, Chen X, Horowitz MC, Wysolmerski JJ. TOPGAL Mice Show That the Canonical Wnt Signaling Pathway Is Active During Bone Development and Growth and Is Activated by Mechanical Loading In Vitro*. Journal Of Bone And Mineral Research 2005, 20: 1103-1113. PMID: 15940363, DOI: 10.1359/jbmr.050210.
- Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesisChu EY, Hens J, Andl T, Kairo A, Yamaguchi TP, Brisken C, Glick A, Wysolmerski JJ, Millar SE. Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis. Development 2004, 131: 4819-4829. PMID: 15342465, DOI: 10.1242/dev.01347.
- Introduction of the human growth hormone gene into the guinea pig mammary gland by in vivo transfection promotes sustained expression of human growth hormone in the milk throughout lactationHens J, Amstutz M, Schanbacher F, Mather I. Introduction of the human growth hormone gene into the guinea pig mammary gland by in vivo transfection promotes sustained expression of human growth hormone in the milk throughout lactation. Biochimica Et Biophysica Acta 2000, 1523: 161-171. PMID: 11042380, DOI: 10.1016/s0304-4165(00)00117-3.
- Associations of the Epithelial Mucin, PAS-1, with Yield, Health, and Reproductive Traits in Holstein Dairy CowsHens JR, Rogers GW, Huott ML, Patton S. Associations of the Epithelial Mucin, PAS-1, with Yield, Health, and Reproductive Traits in Holstein Dairy Cows. Journal Of Dairy Science 1995, 78: 2473-2480. PMID: 8747338, DOI: 10.3168/jds.s0022-0302(95)76875-8.
- Polymorphic forms of the epithelial mucin, PAS-I (MUC1), in milk of Holstein cows (Bos taurus)Huott M, Josephson R, Hens J, Rogers G, Patton S. Polymorphic forms of the epithelial mucin, PAS-I (MUC1), in milk of Holstein cows (Bos taurus). Comparative Biochemistry And Physiology Part B Biochemistry And Molecular Biology 1995, 111: 559-565. PMID: 8574921, DOI: 10.1016/0305-0491(95)00042-7.
- Associations of the Epithelial Mucin, PAS-1, with Yield, Health, and Reproductive Traits in Holstein Dairy CowsHens, JR, Rogers, GW, Huott, ML, and Patton. S. Associations of PAS-1 with production, health, and reproductive traits in Holstein dairy cows. J. Dairy Sci. 1995; 78:2473 80.