John Wysolmerski, MD

• Alan S Kliger
• Catherine Sullivan
• David F. Stern
• David Rimm
• Diana Athonvarangkul
• Joshua VanHouten
• Julie Rose Hens
• Karl Insogna
• Laleh Ardeshirpour
• Leonard Milstone
• Margaret Bia
• Robert Camp
• Valerie Horsley
• Wenxue Li
• William Philbrick
• Yansheng Liu

Bone Diseases; Breast Neoplasms; Endocrine System Diseases; Neoplasms; Paraneoplastic Endocrine Syndromes; Parathyroid Diseases

• Crosstalk within a brain-breast-bone axis regulates mineral and skeletal metabolism during lactationAthonvarangkul D, Wysolmerski J. Crosstalk within a brain-breast-bone axis regulates mineral and skeletal metabolism during lactation. Frontiers In Physiology 2023, 14: 1121579. PMID: 36875035, PMCID: PMC9979219, DOI: 10.3389/fphys.2023.1121579.
• PSAT208 A Case of Hypercalcemia From PTHrP-Producing Fibromyxoid Sarcoma Responsive to Glucocorticoid TherapyNiu I, Hsiao E, Wustrack R, Wysolmerski J, Dann P, Masharani U. PSAT208 A Case of Hypercalcemia From PTHrP-Producing Fibromyxoid Sarcoma Responsive to Glucocorticoid Therapy. Journal Of The Endocrine Society 2022, 6: a212-a213. PMCID: PMC9624585, DOI: 10.1210/jendso/bvac150.436.
• Cancer-Associated Hypercalcemia. Reply.Guise TA, Wysolmerski JJ. Cancer-Associated Hypercalcemia. Reply. New England Journal Of Medicine 2022, 386: 2540. PMID: 35767456, DOI: 10.1056/nejmc2206287.
• PTHrP induces STAT5 activation, secretory differentiation and accelerates mammary tumor developmentGrinman DY, Boras-Granic K, Takyar FM, Dann P, Hens JR, Marmol C, Lee J, Choi J, Chodosh LA, Sola MEG, Wysolmerski JJ. PTHrP induces STAT5 activation, secretory differentiation and accelerates mammary tumor development. Breast Cancer Research 2022, 24: 30. PMID: 35440032, PMCID: PMC9020078, DOI: 10.1186/s13058-022-01523-1.
• Cancer-Associated HypercalcemiaGuise TA, Wysolmerski JJ. Cancer-Associated Hypercalcemia. New England Journal Of Medicine 2022, 386: 1443-1451. PMID: 35417639, DOI: 10.1056/nejmcp2113128.
• MAL2 mediates the formation of stable HER2 signaling complexes within lipid raft-rich membrane protrusions in breast cancer cellsJeong J, Shin JH, Li W, Hong JY, Lim J, Hwang JY, Chung JJ, Yan Q, Liu Y, Choi J, Wysolmerski J. MAL2 mediates the formation of stable HER2 signaling complexes within lipid raft-rich membrane protrusions in breast cancer cells. Cell Reports 2021, 37: 110160. PMID: 34965434, PMCID: PMC8762588, DOI: 10.1016/j.celrep.2021.110160.
• The butyrophilin 1a1 knockout mouse revisited: Ablation of Btn1a1 leads to concurrent cell death and renewal in the mammary epithelium during lactationJeong J, Kadegowda AKG, Meyer TJ, Jenkins LM, Dinan JC, Wysolmerski JJ, Weigert R, Mather IH. The butyrophilin 1a1 knockout mouse revisited: Ablation of Btn1a1 leads to concurrent cell death and renewal in the mammary epithelium during lactation. FASEB BioAdvances 2021, 3: 971-997. PMID: 34938960, PMCID: PMC8664049, DOI: 10.1096/fba.2021-00059.
• Calcium metabolism and breast cancer: Echoes of lactation?Grinman D, Athonvarungkul D, Wysolmerski J, Jeong J. Calcium metabolism and breast cancer: Echoes of lactation? Current Opinion In Endocrine And Metabolic Research 2020, 15: 63-70. PMID: 33299957, PMCID: PMC7720883, DOI: 10.1016/j.coemr.2020.11.006.
• Chapter 14 The Onset and Maintenance of Human Lactation and its Endocrine RegulationSadovnikova A, Wysolmerski J, Hovey R. Chapter 14 The Onset and Maintenance of Human Lactation and its Endocrine Regulation. 2020, 189-205. DOI: 10.1016/b978-0-12-814823-5.00014-3.
• Cathepsin K-deficient osteocytes prevent lactation-induced bone loss and parathyroid hormone suppressionLotinun S, Ishihara Y, Nagano K, Kiviranta R, Carpentier VT, Neff L, Parkman V, Ide N, Hu D, Dann P, Brooks D, Bouxsein ML, Wysolmerski J, Gori F, Baron R. Cathepsin K-deficient osteocytes prevent lactation-induced bone loss and parathyroid hormone suppression. Journal Of Clinical Investigation 2019, 129: 3058-3071. PMID: 31112135, PMCID: PMC6668688, DOI: 10.1172/jci122936.
• NHERF1 Is Required for Localization of PMCA2 and Suppression of Early Involution in the Female Lactating Mammary GlandJeong J, Kim W, Hens J, Dann P, Schedin P, Friedman PA, Wysolmerski JJ. NHERF1 Is Required for Localization of PMCA2 and Suppression of Early Involution in the Female Lactating Mammary Gland. Endocrinology 2019, 160: 1797-1810. PMID: 31087002, PMCID: PMC6619491, DOI: 10.1210/en.2019-00230.
• Inhibition of ezrin causes PKCα-mediated internalization of erbb2/HER2 tyrosine kinase in breast cancer cellsJeong J, Choi J, Kim W, Dann P, Takyar F, Gefter JV, Friedman PA, Wysolmerski J. Inhibition of ezrin causes PKCα-mediated internalization of erbb2/HER2 tyrosine kinase in breast cancer cells. Journal Of Biological Chemistry 2018, 294: 887-901. PMID: 30463939, PMCID: PMC6341383, DOI: 10.1074/jbc.ra118.004143.
• Adipocyte hypertrophy and lipid dynamics underlie mammary gland remodeling after lactationZwick RK, Rudolph MC, Shook BA, Holtrup B, Roth E, Lei V, Van Keymeulen A, Seewaldt V, Kwei S, Wysolmerski J, Rodeheffer MS, Horsley V. Adipocyte hypertrophy and lipid dynamics underlie mammary gland remodeling after lactation. Nature Communications 2018, 9: 3592. PMID: 30181538, PMCID: PMC6123393, DOI: 10.1038/s41467-018-05911-0.
• Chapter 46 Parathyroid Hormone, Parathyroid Hormone–Related Protein, and CalcitoninWysolmerski J. Chapter 46 Parathyroid Hormone, Parathyroid Hormone–Related Protein, and Calcitonin. 2018, 849-870. DOI: 10.1016/b978-0-12-809965-0.00046-x.
• HER2 signaling regulates HER2 localization and membrane retentionJeong J, Kim W, Kim LK, VanHouten J, Wysolmerski JJ. HER2 signaling regulates HER2 localization and membrane retention. PLOS ONE 2017, 12: e0174849. PMID: 28369073, PMCID: PMC5378417, DOI: 10.1371/journal.pone.0174849.
• The scaffolding protein NHERF1 regulates the stability and activity of the tyrosine kinase HER2Jeong J, VanHouten JN, Kim W, Dann P, Sullivan C, Choi J, Sneddon WB, Friedman PA, Wysolmerski JJ. The scaffolding protein NHERF1 regulates the stability and activity of the tyrosine kinase HER2. Journal Of Biological Chemistry 2017, 292: 6555-6568. PMID: 28235801, PMCID: PMC5399107, DOI: 10.1074/jbc.m116.770883.
• Abstract P3-05-05: PTHrP affects breast cancer initiation and progression through Stat5 signaling pathwayTakyar F, Boras-Granic K, Kim W, Dann P, Wysolmerski J. Abstract P3-05-05: PTHrP affects breast cancer initiation and progression through Stat5 signaling pathway. Cancer Research 2017, 77: p3-05-05-p3-05-05. DOI: 10.1158/1538-7445.sabcs16-p3-05-05.
• Calcium-Sensing Receptor in Breast Physiology and CancerKim W, Wysolmerski JJ. Calcium-Sensing Receptor in Breast Physiology and Cancer. Frontiers In Physiology 2016, 7: 440. PMID: 27746743, PMCID: PMC5043011, DOI: 10.3389/fphys.2016.00440.
• Calcium-Sensing Receptor Promotes Breast Cancer by Stimulating Intracrine Actions of Parathyroid Hormone–Related ProteinKim W, Takyar FM, Swan K, Jeong J, VanHouten J, Sullivan C, Dann P, Yu H, Fiaschi-Taesch N, Chang W, Wysolmerski J. Calcium-Sensing Receptor Promotes Breast Cancer by Stimulating Intracrine Actions of Parathyroid Hormone–Related Protein. Cancer Research 2016, 76: 5348-5360. PMID: 27450451, PMCID: PMC5026591, DOI: 10.1158/0008-5472.can-15-2614.
• Abstract 2859: Chloroquine and vitamin D3 modulate proliferation in early stage breast cancer modelsEspina V, Yeon S, VanHouten J, Wysolmerski J, Liotta L. Abstract 2859: Chloroquine and vitamin D3 modulate proliferation in early stage breast cancer models. Cancer Research 2016, 76: 2859-2859. DOI: 10.1158/1538-7445.am2016-2859.
• PMCA2 regulates HER2 protein kinase localization and signaling and promotes HER2-mediated breast cancerJeong J, VanHouten JN, Dann P, Kim W, Sullivan C, Yu H, Liotta L, Espina V, Stern DF, Friedman PA, Wysolmerski JJ. PMCA2 regulates HER2 protein kinase localization and signaling and promotes HER2-mediated breast cancer. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: e282-e290. PMID: 26729871, PMCID: PMC4725473, DOI: 10.1073/pnas.1516138113.
• Chapter 64 Hypercalcemia of MalignancySwan K, Wysolmerski J. Chapter 64 Hypercalcemia of Malignancy. 2016, 1125-1134.e3. DOI: 10.1016/b978-0-323-18907-1.00064-0.
• Chapter 57 Parathyroid Hormone-Related ProteinWysolmerski J. Chapter 57 Parathyroid Hormone-Related Protein. 2016, 991-1003.e5. DOI: 10.1016/b978-0-323-18907-1.00057-3.
• OPG Treatment Prevents Bone Loss During Lactation But Does Not Affect Milk Production or Maternal Calcium MetabolismArdeshirpour L, Dumitru C, Dann P, Sterpka J, VanHouten J, Kim W, Kostenuik P, Wysolmerski J. OPG Treatment Prevents Bone Loss During Lactation But Does Not Affect Milk Production or Maternal Calcium Metabolism. Endocrinology 2015, 156: 2762-2773. PMID: 25961842, PMCID: PMC4511126, DOI: 10.1210/en.2015-1232.
• Chapter 13 Physiological Actions of Parathyroid Hormone (PTH) and PTH-related Protein Epidermal, Mammary, Reproductive, and Pancreatic TissuesWysolmerski J. Chapter 13 Physiological Actions of Parathyroid Hormone (PTH) and PTH-related Protein Epidermal, Mammary, Reproductive, and Pancreatic Tissues. 2015, 203-221. DOI: 10.1016/b978-0-12-397166-1.00013-8.
• Embryonic cells contribute directly to the quiescent stem cell population in the adult mouse mammary glandBoras-Granic K, Dann P, Wysolmerski JJ. Embryonic cells contribute directly to the quiescent stem cell population in the adult mouse mammary gland. Breast Cancer Research 2014, 16: 487. PMID: 25467960, PMCID: PMC4308878, DOI: 10.1186/s13058-014-0487-6.
• Role of PTHrP in Mammary Gland Development and Breast CancerHiremath M, Wysolmerski J. Role of PTHrP in Mammary Gland Development and Breast Cancer. Clinical Reviews In Bone And Mineral Metabolism 2014, 12: 178-189. DOI: 10.1007/s12018-014-9170-9.
• Deletion of the Nuclear Localization Sequences and C-Terminus of PTHrP Impairs Embryonic Mammary Development but also Inhibits PTHrP ProductionBoras-Granic K, Dann P, VanHouten J, Karaplis A, Wysolmerski J. Deletion of the Nuclear Localization Sequences and C-Terminus of PTHrP Impairs Embryonic Mammary Development but also Inhibits PTHrP Production. PLOS ONE 2014, 9: e90418. PMID: 24785493, PMCID: PMC4006745, DOI: 10.1371/journal.pone.0090418.
• Parathyroid Hormone‐Related ProteinWysolmerski J. Parathyroid Hormone‐Related Protein. 2013, 215-223. DOI: 10.1002/9781118453926.ch27.
• Mammary-Specific Ablation of the Calcium-Sensing Receptor During Lactation Alters Maternal Calcium Metabolism, Milk Calcium Transport, and Neonatal Calcium AccrualMamillapalli R, VanHouten J, Dann P, Bikle D, Chang W, Brown E, Wysolmerski J. Mammary-Specific Ablation of the Calcium-Sensing Receptor During Lactation Alters Maternal Calcium Metabolism, Milk Calcium Transport, and Neonatal Calcium Accrual. Endocrinology 2013, 154: 3031-3042. PMID: 23782944, PMCID: PMC3749485, DOI: 10.1210/en.2012-2195.
• Parathyroid Hormone-Related Protein Specifies the Mammary Mesenchyme and Regulates Embryonic Mammary DevelopmentHiremath M, Wysolmerski J. Parathyroid Hormone-Related Protein Specifies the Mammary Mesenchyme and Regulates Embryonic Mammary Development. Journal Of Mammary Gland Biology And Neoplasia 2013, 18: 171-177. PMID: 23640717, PMCID: PMC3696739, DOI: 10.1007/s10911-013-9283-7.
• The calcium-sensing receptor in the breastVanHouten JN, Wysolmerski JJ. The calcium-sensing receptor in the breast. Best Practice & Research Clinical Endocrinology & Metabolism 2013, 27: 403-414. PMID: 23856268, PMCID: PMC3713417, DOI: 10.1016/j.beem.2013.02.011.
• Attacking Breast Cancer at the Preinvasion Stage by Targeting AutophagyEspina V, Wysolmerski J, Edmiston K, Liotta LA. Attacking Breast Cancer at the Preinvasion Stage by Targeting Autophagy. Women's Health 2013, 9: 157-170. PMID: 23477322, PMCID: PMC3779365, DOI: 10.2217/whe.13.5.
• Osteocytes remove and replace perilacunar mineral during reproductive cyclesWysolmerski JJ. Osteocytes remove and replace perilacunar mineral during reproductive cycles. Bone 2013, 54: 230-236. PMID: 23352996, PMCID: PMC3624069, DOI: 10.1016/j.bone.2013.01.025.
• Chapter 66 Disorders of Calcium MetabolismDumitru C, Wysolmerski J. Chapter 66 Disorders of Calcium Metabolism. 2013, 2273-2309. DOI: 10.1016/b978-0-12-381462-3.00066-5.
• Osteocytic osteolysis: time for a second look?Wysolmerski JJ. Osteocytic osteolysis: time for a second look? BoneKEy Reports 2012, 1: 229. PMID: 24363929, PMCID: PMC3868715, DOI: 10.1038/bonekey.2012.229.
• Parathyroid hormone-related protein activates Wnt signaling to specify the embryonic mammary mesenchymeHiremath M, Dann P, Fischer J, Butterworth D, Boras-Granic K, Hens J, Van Houten J, Shi W, Wysolmerski J. Parathyroid hormone-related protein activates Wnt signaling to specify the embryonic mammary mesenchyme. Development 2012, 139: 4239-4249. PMID: 23034629, PMCID: PMC3478689, DOI: 10.1242/dev.080671.
• Parathyroid Hormone-Related Protein: An UpdateWysolmerski JJ. Parathyroid Hormone-Related Protein: An Update. The Journal Of Clinical Endocrinology & Metabolism 2012, 97: 2947-2956. PMID: 22745236, PMCID: PMC3431578, DOI: 10.1210/jc.2012-2142.
• PTHrP and breast cancer: more than hypercalcemia and bone metastasesBoras-Granic K, Wysolmerski JJ. PTHrP and breast cancer: more than hypercalcemia and bone metastases. Breast Cancer Research 2012, 14: 307. PMID: 22546075, PMCID: PMC3446368, DOI: 10.1186/bcr3129.
• Demonstration of osteocytic perilacunar/canalicular remodeling in mice during lactationQing H, Ardeshirpour L, Pajevic PD, Dusevich V, Jähn K, Kato S, Wysolmerski J, Bonewald LF. Demonstration of osteocytic perilacunar/canalicular remodeling in mice during lactation. Journal Of Bone And Mineral Research 2012, 27: 1018-1029. PMID: 22308018, PMCID: PMC3770147, DOI: 10.1002/jbmr.1567.
• 253 The Parathyroid Glands, Hypercalcemia, and HypocalcemiaWysolmerski J, Insogna K. 253 The Parathyroid Glands, Hypercalcemia, and Hypocalcemia. 2012, 1591-1601. DOI: 10.1016/b978-1-4377-1604-7.00253-0.
• Site‐specific changes in bone microarchitecture, mineralization, and stiffness during lactation and after weaning in miceLiu XS, Ardeshirpour L, VanHouten JN, Shane E, Wysolmerski JJ. Site‐specific changes in bone microarchitecture, mineralization, and stiffness during lactation and after weaning in mice. Journal Of Bone And Mineral Research 2011, 27: 865-875. PMID: 22189918, DOI: 10.1002/jbmr.1503.
• Parathyroid Hormone-Related Protein Is Not Required for Normal Ductal or Alveolar Development in the Post-Natal Mammary GlandBoras-Granic K, VanHouten J, Hiremath M, Wysolmerski J. Parathyroid Hormone-Related Protein Is Not Required for Normal Ductal or Alveolar Development in the Post-Natal Mammary Gland. PLOS ONE 2011, 6: e27278. PMID: 22087279, PMCID: PMC3210770, DOI: 10.1371/journal.pone.0027278.
• Skeletal recovery after weaning does not require PTHrP*Kirby BJ, Ardeshirpour L, Woodrow JP, Wysolmerski JJ, Sims NA, Karaplis AC, Kovacs CS. Skeletal recovery after weaning does not require PTHrP*. Journal Of Bone And Mineral Research 2011, 26: 1242-1251. PMID: 21308774, PMCID: PMC3179289, DOI: 10.1002/jbmr.339.
• Chapter 41 Parathyroid Hormone, Parathyroid Hormone-Related Protein, and CalcitoninHolt E, Wysolmerski J. Chapter 41 Parathyroid Hormone, Parathyroid Hormone-Related Protein, and Calcitonin. 2011, 725-745. DOI: 10.1016/b978-0-12-381978-9.10041-1.
• Increased PTHrP and Decreased Estrogens Alter Bone Turnover but Do Not Reproduce the Full Effects of Lactation on the SkeletonArdeshirpour L, Brian S, Dann P, VanHouten J, Wysolmerski J. Increased PTHrP and Decreased Estrogens Alter Bone Turnover but Do Not Reproduce the Full Effects of Lactation on the Skeleton. Endocrine Reviews 2010, 31: 940-940. DOI: 10.1210/edrv.31.6.9976.
• Increased PTHrP and Decreased Estrogens Alter Bone Turnover but Do Not Reproduce the Full Effects of Lactation on the SkeletonArdeshirpour L, Brian S, Dann P, VanHouten J, Wysolmerski J. Increased PTHrP and Decreased Estrogens Alter Bone Turnover but Do Not Reproduce the Full Effects of Lactation on the Skeleton. The Journal Of Clinical Endocrinology & Metabolism 2010, 95: 5454-5454. DOI: 10.1210/jcem.95.12.9987.
• Increased PTHrP and Decreased Estrogens Alter Bone Turnover but Do Not Reproduce the Full Effects of Lactation on the SkeletonArdeshirpour L, Brian S, Dann P, VanHouten J, Wysolmerski J. Increased PTHrP and Decreased Estrogens Alter Bone Turnover but Do Not Reproduce the Full Effects of Lactation on the Skeleton. Endocrinology 2010, 151: 5591-5601. PMID: 21047946, PMCID: PMC2999486, DOI: 10.1210/en.2010-0566.
• PMCA2 regulates apoptosis during mammary gland involution and predicts outcome in breast cancerVanHouten J, Sullivan C, Bazinet C, Ryoo T, Camp R, Rimm DL, Chung G, Wysolmerski J. PMCA2 regulates apoptosis during mammary gland involution and predicts outcome in breast cancer. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 11405-11410. PMID: 20534448, PMCID: PMC2895115, DOI: 10.1073/pnas.0911186107.
• Molecular Mechanisms Guiding Embryonic Mammary Gland DevelopmentCowin P, Wysolmerski J. Molecular Mechanisms Guiding Embryonic Mammary Gland Development. Cold Spring Harbor Perspectives In Biology 2010, 2: a003251. PMID: 20484386, PMCID: PMC2869520, DOI: 10.1101/cshperspect.a003251.
• Interactions between breast, bone, and brain regulate mineral and skeletal metabolism during lactationWysolmerski JJ. Interactions between breast, bone, and brain regulate mineral and skeletal metabolism during lactation. Annals Of The New York Academy Of Sciences 2010, 1192: 161-169. PMID: 20392232, PMCID: PMC3777748, DOI: 10.1111/j.1749-6632.2009.05249.x.
• Characterization of the Six1 homeobox gene in normal mammary gland morphogenesisColetta RD, McCoy EL, Burns V, Kawakami K, McManaman JL, Wysolmerski JJ, Ford HL. Characterization of the Six1 homeobox gene in normal mammary gland morphogenesis. BMC Developmental Biology 2010, 10: 4. PMID: 20074369, PMCID: PMC2823684, DOI: 10.1186/1471-213x-10-4.
• The calcium-sensing receptor couples to Gαs and regulates PTHrP and ACTH secretion in pituitary cellsMamillapalli R, Wysolmerski J. The calcium-sensing receptor couples to Gαs and regulates PTHrP and ACTH secretion in pituitary cells. Journal Of Endocrinology 2009, 204: 287-297. PMID: 20032198, PMCID: PMC3777408, DOI: 10.1677/joe-09-0183.
• Analysis of gene expression in PTHrP−/− mammary buds supports a role for BMP signaling and MMP2 in the initiation of ductal morphogenesisHens J, Dann P, Hiremath M, Pan T, Chodosh L, Wysolmerski J. Analysis of gene expression in PTHrP−/− mammary buds supports a role for BMP signaling and MMP2 in the initiation of ductal morphogenesis. Developmental Dynamics 2009, 238: 2713-2724. PMID: 19795511, PMCID: PMC2862621, DOI: 10.1002/dvdy.22097.
• Switching of G-protein Usage by the Calcium-sensing Receptor Reverses Its Effect on Parathyroid Hormone-related Protein Secretion in Normal Versus Malignant Breast Cells*Mamillapalli R, VanHouten J, Zawalich W, Wysolmerski J. Switching of G-protein Usage by the Calcium-sensing Receptor Reverses Its Effect on Parathyroid Hormone-related Protein Secretion in Normal Versus Malignant Breast Cells*. Journal Of Biological Chemistry 2008, 283: 24435-24447. PMID: 18621740, PMCID: PMC2528989, DOI: 10.1074/jbc.m801738200.
• Preservation of β-Galactosidase Transgene in Decalcified Murine Bone Specimens Embedded in ParaffinDann P, Hens J, Troiano N, Wysolmerski J, Kacena M. Preservation of β-Galactosidase Transgene in Decalcified Murine Bone Specimens Embedded in Paraffin. Journal Of Histotechnology 2008, 31: 61-64. DOI: 10.1179/his.2008.31.2.61.
• Wnt signaling in breast organogenesisBoras-Granic K, Wysolmerski JJ. Wnt signaling in breast organogenesis. Organogenesis 2008, 4: 116-122. PMID: 19279723, PMCID: PMC2634257, DOI: 10.4161/org.4.2.5858.
• Chapter 33 Physiological Actions of Parathyroid Hormone (PTH) and PTH-Related Protein Epidermal, Mammary, Reproductive, Pancreatic TissuesWysolmerski J, Stewart A, Kovacs C. Chapter 33 Physiological Actions of Parathyroid Hormone (PTH) and PTH-Related Protein Epidermal, Mammary, Reproductive, Pancreatic Tissues. 2008, 713-731. DOI: 10.1016/b978-0-12-373884-4.00051-3.
• Transcellular Calcium Transport in Mammary Epithelial CellsVanHouten JN, Wysolmerski JJ. Transcellular Calcium Transport in Mammary Epithelial Cells. Journal Of Mammary Gland Biology And Neoplasia 2007, 12: 223-235. PMID: 17999165, DOI: 10.1007/s10911-007-9057-1.
• The Calcium-Sensing Receptor Regulates Plasma Membrane Calcium Adenosine Triphosphatase Isoform 2 Activity in Mammary Epithelial Cells: A Mechanism for Calcium-Regulated Calcium Transport into MilkVanHouten JN, Neville MC, Wysolmerski JJ. The Calcium-Sensing Receptor Regulates Plasma Membrane Calcium Adenosine Triphosphatase Isoform 2 Activity in Mammary Epithelial Cells: A Mechanism for Calcium-Regulated Calcium Transport into Milk. Endocrinology 2007, 148: 5943-5954. PMID: 17823248, PMCID: PMC7108505, DOI: 10.1210/en.2007-0850.
• Conversations between breast and bone: Physiological bone loss during lactation as evolutionary template for osteolysis in breast cancer and pathological bone loss after menopauseWysolmerski J. Conversations between breast and bone: Physiological bone loss during lactation as evolutionary template for osteolysis in breast cancer and pathological bone loss after menopause. BoneKEy Reports 2007, 4: 209-225. DOI: 10.1138/20070268.
• Weaning triggers a decrease in receptor activator of nuclear factor-kappaB ligand expression, widespread osteoclast apoptosis, and rapid recovery of bone mass after lactation in mice.Ardeshirpour L, Dann P, Adams DJ, Nelson T, VanHouten J, Horowitz MC, Wysolmerski JJ. Weaning triggers a decrease in receptor activator of nuclear factor-kappaB ligand expression, widespread osteoclast apoptosis, and rapid recovery of bone mass after lactation in mice. Endocrinology 2007, 148: 3875-86. PMID: 17495007, DOI: 10.1210/en.2006-1467.
• BMP4 and PTHrP interact to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle inductionHens JR, Dann P, Zhang JP, Harris S, Robinson GW, Wysolmerski J. BMP4 and PTHrP interact to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction. Development 2007, 134: 1221-1230. PMID: 17301089, DOI: 10.1242/dev.000182.
• The calcium-sensing receptor regulates PTHrP production and calcium transport in the lactating mammary glandArdeshirpour L, Dann P, Pollak M, Wysolmerski J, VanHouten J. The calcium-sensing receptor regulates PTHrP production and calcium transport in the lactating mammary gland. Bone 2005, 38: 787-793. PMID: 16377269, DOI: 10.1016/j.bone.2005.11.009.
• Hypercalcemia of malignancy due to ectopic transactivation of the parathyroid hormone gene.VanHouten JN, Yu N, Rimm D, Dotto J, Arnold A, Wysolmerski JJ, Udelsman R. Hypercalcemia of malignancy due to ectopic transactivation of the parathyroid hormone gene. The Journal Of Clinical Endocrinology & Metabolism 2005, 91: 580-3. PMID: 16263810, DOI: 10.1210/jc.2005-2095.
• Continuous PTH and PTHrP Infusion Causes Suppression of Bone Formation and Discordant Effects on 1,25(OH)2Vitamin DHorwitz MJ, Tedesco MB, Sereika SM, Syed MA, Garcia‐Ocaña A, Bisello A, Hollis BW, Rosen CJ, Wysolmerski JJ, Dann P, Gundberg C, Stewart AF. Continuous PTH and PTHrP Infusion Causes Suppression of Bone Formation and Discordant Effects on 1,25(OH)2Vitamin D. Journal Of Bone And Mineral Research 2005, 20: 1792-1803. PMID: 16160737, DOI: 10.1359/jbmr.050602.
• Key stages of mammary gland development: Molecular mechanisms involved in the formation of the embryonic mammary glandHens JR, Wysolmerski JJ. Key stages of mammary gland development: Molecular mechanisms involved in the formation of the embryonic mammary gland. Breast Cancer Research 2005, 7: 220. PMID: 16168142, PMCID: PMC1242158, DOI: 10.1186/bcr1306.
• TOPGAL Mice Show That the Canonical Wnt Signaling Pathway Is Active During Bone Development and Growth and Is Activated by Mechanical Loading In Vitro*Hens JR, Wilson KM, Dann P, Chen X, Horowitz MC, Wysolmerski JJ. TOPGAL Mice Show That the Canonical Wnt Signaling Pathway Is Active During Bone Development and Growth and Is Activated by Mechanical Loading In Vitro*. Journal Of Bone And Mineral Research 2005, 20: 1103-1113. PMID: 15940363, DOI: 10.1359/jbmr.050210.
• Calcium handling by the lactating breast and its relationship to calcium-related complications of breast cancer.Wysolmerski J. Calcium handling by the lactating breast and its relationship to calcium-related complications of breast cancer. Journal Of Mammary Gland Biology And Neoplasia 2005, 10: 101-3. PMID: 16025217, DOI: 10.1007/s10911-005-5393-1.
• Hypercalcemia in Breast Cancer: An Echo of Bone Mobilization During Lactation?DeMauro S, Wysolmerski J. Hypercalcemia in Breast Cancer: An Echo of Bone Mobilization During Lactation? Journal Of Mammary Gland Biology And Neoplasia 2005, 10: 157-167. PMID: 16025222, DOI: 10.1007/s10911-005-5398-9.
• Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesisChu EY, Hens J, Andl T, Kairo A, Yamaguchi TP, Brisken C, Glick A, Wysolmerski JJ, Millar SE. Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis. Development 2004, 131: 4819-4829. PMID: 15342465, DOI: 10.1242/dev.01347.
• The calcium-sensing receptor regulates mammary gland parathyroid hormone–related protein production and calcium transportVanHouten J, Dann P, McGeoch G, Brown EM, Krapcho K, Neville M, Wysolmerski JJ. The calcium-sensing receptor regulates mammary gland parathyroid hormone–related protein production and calcium transport. Journal Of Clinical Investigation 2004, 113: 598-608. PMID: 14966569, PMCID: PMC338258, DOI: 10.1172/jci18776.
• Mammary-specific deletion of parathyroid hormone-related protein preserves bone mass during lactationVanHouten J, Dann P, Stewart A, Watson C, Pollak M, Karaplis A, Wysolmerski J. Mammary-specific deletion of parathyroid hormone-related protein preserves bone mass during lactation. Journal Of Clinical Investigation 2004, 113: 492-492. DOI: 10.1172/jci19504c1.
• Mammary-specific deletion of parathyroid hormone–related protein preserves bone mass during lactationVanHouten JN, Dann P, Stewart AF, Watson CJ, Pollak M, Karaplis AC, Wysolmerski JJ. Mammary-specific deletion of parathyroid hormone–related protein preserves bone mass during lactation. Journal Of Clinical Investigation 2003, 112: 1429-1436. PMID: 14597768, PMCID: PMC228471, DOI: 10.1172/jci19504.
• Low estrogen and high parathyroid hormone-related peptide levels contribute to accelerated bone resorption and bone loss in lactating mice.VanHouten JN, Wysolmerski JJ. Low estrogen and high parathyroid hormone-related peptide levels contribute to accelerated bone resorption and bone loss in lactating mice. Endocrinology 2003, 144: 5521-9. PMID: 14500568, DOI: 10.1210/en.2003-0892.
• Parathyroid Hormone-Related Protein (PTHrP)Van Houten J, Wysolmerski J. Parathyroid Hormone-Related Protein (PTHrP). 2003, 153-161. DOI: 10.1016/b0-12-341103-3/00235-7.
• A syndrome of hypocalciuric hypercalcemia caused by autoantibodies directed at the calcium-sensing receptor.Kifor O, Moore FD, Delaney M, Garber J, Hendy GN, Butters R, Gao P, Cantor TL, Kifor I, Brown EM, Wysolmerski J. A syndrome of hypocalciuric hypercalcemia caused by autoantibodies directed at the calcium-sensing receptor. The Journal Of Clinical Endocrinology & Metabolism 2003, 88: 60-72. PMID: 12519831, DOI: 10.1210/jc.2002-020249.
• The Evolutionary Origins of Maternal Calcium and Bone Metabolism During LactationWysolmerski JJ. The Evolutionary Origins of Maternal Calcium and Bone Metabolism During Lactation. Journal Of Mammary Gland Biology And Neoplasia 2002, 7: 267-276. PMID: 12751891, DOI: 10.1023/a:1022800716196.
• Overexpression of Parathyroid Hormone‐Related Protein Causes Hypercalcemia but Not Bone Metastases in a Murine Model of Mammary Tumorigenesis*Wysolmerski JJ, Dann PR, Zelazny E, Dunbar ME, Insogna KL, Guise TA, Perkins AS. Overexpression of Parathyroid Hormone‐Related Protein Causes Hypercalcemia but Not Bone Metastases in a Murine Model of Mammary Tumorigenesis*. Journal Of Bone And Mineral Research 2002, 17: 1164-1170. PMID: 12096830, DOI: 10.1359/jbmr.2002.17.7.1164.
• Nipple connective tissue and its development: insights from the K14-PTHrP mouseAbdalkhani A, Sellers R, Gent J, Wulitich H, Childress S, Stein B, Boissy RE, Wysolmerski JJ, Foley J. Nipple connective tissue and its development: insights from the K14-PTHrP mouse. Cells And Development 2002, 115: 63-77. PMID: 12049768, DOI: 10.1016/s0925-4773(02)00092-8.
• Introduction: Endocrine Influences on Mammary Development and Breast Cancer RiskWysolmerski J, Chodosh L. Introduction: Endocrine Influences on Mammary Development and Breast Cancer Risk. Journal Of Mammary Gland Biology And Neoplasia 2002, 7: 1-2. DOI: 10.1023/a:1015742821350.
• Chapter 29 Physiological Actions of Parathyroid Hormone (PTH) and PTH-Related Protein Epidermal, Mammary, Reproductive, and Pancreatic TissuesWysolmerski J, Stewart A, Martin T. Chapter 29 Physiological Actions of Parathyroid Hormone (PTH) and PTH-Related Protein Epidermal, Mammary, Reproductive, and Pancreatic Tissues. 2002, 515-530. DOI: 10.1016/b978-012098652-1.50131-1.
• Treatment of Osteoporosis and Osteopenia in Long‐term Renal Transplant Patients with AlendronateCruz DN, Brickel HM, Wysolmerski JJ, Gundberg CG, Simpson CA, Kliger AS, Lorber MI, Basadonna GP, Friedman AL, Insogna KL, Bia MJ. Treatment of Osteoporosis and Osteopenia in Long‐term Renal Transplant Patients with Alendronate. American Journal Of Transplantation 2002, 2: 62-67. PMID: 12095058, DOI: 10.1034/j.1600-6143.2002.020111.x.
• Temporally regulated overexpression of parathyroid hormone-related protein in the mammary gland reveals distinct fetal and pubertal phenotypesDunbar ME, Dann P, Brown CW, Van Houton J, Dreyer B, Philbrick WP, Wysolmerski JJ. Temporally regulated overexpression of parathyroid hormone-related protein in the mammary gland reveals distinct fetal and pubertal phenotypes. Journal Of Endocrinology 2001, 171: 403-416. PMID: 11739006, DOI: 10.1677/joe.0.1710403.
• PARAMETERS OF HIGH BONE-TURNOVER PREDICT BONE LOSS IN RENAL TRANSPLANT PATIENTS: A LONGITUDINAL STUDY1,2Cruz D, Wysolmerski J, Brickel H, Gundberg C, Simpson C, Mitnick M, Kliger A, Lorber M, Basadonna G, Friedman A, Insogna K, Bia M. PARAMETERS OF HIGH BONE-TURNOVER PREDICT BONE LOSS IN RENAL TRANSPLANT PATIENTS: A LONGITUDINAL STUDY1,2. Transplantation 2001, 72: 83-88. PMID: 11468539, DOI: 10.1097/00007890-200107150-00017.
• Absence of functional type 1 parathyroid hormone (PTH)/PTH-related protein receptors in humans is associated with abnormal breast development and tooth impaction.Wysolmerski J, Cormier S, Philbrick W, Dann P, Zhang J, Roume J, Delezoide A, Silve C. Absence of functional type 1 parathyroid hormone (PTH)/PTH-related protein receptors in humans is associated with abnormal breast development and tooth impaction. The Journal Of Clinical Endocrinology & Metabolism 2001, 86: 1788-94. PMID: 11297619, DOI: 10.1210/jcem.86.4.7404.
• Parathyroid hormone-related protein maintains mammary epithelial fate and triggers nipple skin differentiation during embryonic breast developmentFoley J, Dann P, Hong J, Cosgrove J, Dreyer B, Rimm D, Dunbar M, Philbrick W, Wysolmerski J. Parathyroid hormone-related protein maintains mammary epithelial fate and triggers nipple skin differentiation during embryonic breast development. Development 2001, 128: 513-525. PMID: 11171335, DOI: 10.1242/dev.128.4.513.
• Mammary ductal and alveolar development: Lesson learned from genetically manipulated miceDunbar M, Wysolmerski J. Mammary ductal and alveolar development: Lesson learned from genetically manipulated mice. Microscopy Research And Technique 2001, 52: 163-170. PMID: 11169864, DOI: 10.1002/1097-0029(20010115)52:2<163::aid-jemt1002>3.0.co;2-r.
• Chapter 17 Physiologic Actions of PTH and PTHrP V. Epidermal, Mammary, Reproductive, and Pancreatic TissuesWysolmerski J, Stewart A, Martin J. Chapter 17 Physiologic Actions of PTH and PTHrP V. Epidermal, Mammary, Reproductive, and Pancreatic Tissues. 2001, 275-291. DOI: 10.1016/b978-012098651-4/50019-5.
• POSTTRANSPLANT BONE DISEASE: EVIDENCE FOR A HIGH BONE RESORPTION STATECayco A, Wysolmerski J, Simpson C, Mitnick M, Gundberg C, Kliger A, Lorber M, Silver D, Basadonna G, Friedman A, Insogna K, Cruz D, Bia M. POSTTRANSPLANT BONE DISEASE: EVIDENCE FOR A HIGH BONE RESORPTION STATE. Transplantation 2000, 70: 1722-1728. PMID: 11152104, DOI: 10.1097/00007890-200012270-00011.
• Activation of PTHrP Gene Expression in Squamous Carcinoma Cell Lines by Mutant Isoforms of the Tumor Suppressor p53Foley J, King CS, Jiménez JA, Wysolmerski JJ, Philbrick WM. Activation of PTHrP Gene Expression in Squamous Carcinoma Cell Lines by Mutant Isoforms of the Tumor Suppressor p53. Oncology Research Featuring Preclinical And Clinical Cancer Therapeutics 2000, 12: 71-81. PMID: 11132926, DOI: 10.3727/096504001108747549.
• Regulation of parathyroid hormone-related protein gene expression in murine keratinocytes by E1A isoforms: a role for basal promoter and Ets-1 siteFoley J, Wysolmerski J, Missero C, King C, Philbrick W. Regulation of parathyroid hormone-related protein gene expression in murine keratinocytes by E1A isoforms: a role for basal promoter and Ets-1 site. Molecular And Cellular Endocrinology 1999, 156: 13-23. PMID: 10612419, DOI: 10.1016/s0303-7207(99)00151-3.
• The Role of PTHrP in Mammary Gland Development and TumorigenesisWysolmerski J. The Role of PTHrP in Mammary Gland Development and Tumorigenesis. 1999 DOI: 10.21236/ada386538.
• Parathyroid hormone-related protein signaling is necessary for sexual dimorphism during embryonic mammary developmentDunbar M, Dann P, Robinson G, Hennighausen L, Zhang J, Wysolmerski J. Parathyroid hormone-related protein signaling is necessary for sexual dimorphism during embryonic mammary development. Development 1999, 126: 3485-3493. PMID: 10409496, DOI: 10.1242/dev.126.16.3485.
• Parathyroid Hormone-Related Protein: A Developmental Regulatory Molecule Necessary for Mammary Gland DevelopmentDunbar M, Wysolmerski J. Parathyroid Hormone-Related Protein: A Developmental Regulatory Molecule Necessary for Mammary Gland Development. Journal Of Mammary Gland Biology And Neoplasia 1999, 4: 21-34. PMID: 10219904, DOI: 10.1023/a:1018700502518.
• PTHrP Regulates Epidermal Differentiation in Adult MiceFoley J, Wysolmerski J, Dreyer B, Broadus A, Philbrick W, Longely B. PTHrP Regulates Epidermal Differentiation in Adult Mice. Journal Of Investigative Dermatology 1998, 111: 1122-1128. PMID: 9856827, DOI: 10.1046/j.1523-1747.1998.00428.x.
• Stromal Cells Are Critical Targets in the Regulation of Mammary Ductal Morphogenesis by Parathyroid Hormone-Related ProteinDunbar M, Young P, Zhang J, McCaughern-Carucci J, Lanske B, Orloff J, Karaplis A, Cunha G, Wysolmerski J. Stromal Cells Are Critical Targets in the Regulation of Mammary Ductal Morphogenesis by Parathyroid Hormone-Related Protein. Developmental Biology 1998, 203: 75-89. PMID: 9806774, DOI: 10.1006/dbio.1998.9029.
• THE PHYSIOLOGY OF PARATHYROID HORMONE-RELATED PROTEIN: An Emerging Role as a Developmental FactorWysolmerski JJ, Stewart AF. THE PHYSIOLOGY OF PARATHYROID HORMONE-RELATED PROTEIN: An Emerging Role as a Developmental Factor. Annual Review Of Physiology 1998, 60: 431-460. PMID: 9558472, DOI: 10.1146/annurev.physiol.60.1.431.
• Rescue of the parathyroid hormone-related protein knockout mouse demonstrates that parathyroid hormone-related protein is essential for mammary gland developmentWysolmerski J, Philbrick W, Dunbar M, Lanske B, Kronenberg H, Karaplis A, Broadus A. Rescue of the parathyroid hormone-related protein knockout mouse demonstrates that parathyroid hormone-related protein is essential for mammary gland development. Development 1998, 125: 1285-1294. PMID: 9477327, DOI: 10.1242/dev.125.7.1285.
• Parathyroid Hormone-Related Protein: From Hypercalcemia of Malignancy to Developmental Regulatory MoleculeDunbar M, Wysolmerski J, Broadus A. Parathyroid Hormone-Related Protein: From Hypercalcemia of Malignancy to Developmental Regulatory Molecule. The American Journal Of The Medical Sciences 1996, 312: 287-294. PMID: 8969618, DOI: 10.1097/00000441-199612000-00007.
• Parathyroid Hormone-Related Protein: From Hypercalcemia of Malignancy to Developmental Regulatory MoleculeDunbar M, Wysolmerski J, Broadus A. Parathyroid Hormone-Related Protein: From Hypercalcemia of Malignancy to Developmental Regulatory Molecule. The American Journal Of The Medical Sciences 1996, 312: 287-294. DOI: 10.1016/s0002-9629(15)41844-0.
• Parathyroid hormone-related protein gene expression in human squamous carcinoma cells is repressed by mutant isoforms of p53.Foley J, Wysolmerski JJ, Broadus AE, Philbrick WM. Parathyroid hormone-related protein gene expression in human squamous carcinoma cells is repressed by mutant isoforms of p53. Cancer Research 1996, 56: 4056-62. PMID: 8752179.
• Transactivation of the PTHrP gene in squamous carcinomas predicts the occurrence of hypercalcemia in athymic mice.Wysolmerski JJ, Vasavada R, Foley J, Weir EC, Burtis WJ, Kukreja SC, Guise TA, Broadus AE, Philbrick WM. Transactivation of the PTHrP gene in squamous carcinomas predicts the occurrence of hypercalcemia in athymic mice. Cancer Research 1996, 56: 1043-9. PMID: 8640759.
• Defining the roles of parathyroid hormone-related protein in normal physiologyPhilbrick WM, Wysolmerski JJ, Galbraith S, Holt E, Orloff JJ, Yang KH, Vasavada RC, Weir EC, Broadus AE, Stewart AF. Defining the roles of parathyroid hormone-related protein in normal physiology. Physiological Reviews 1996, 76: 127-173. PMID: 8592727, DOI: 10.1152/physrev.1996.76.1.127.
• Overexpression of parathyroid hormone-related protein or parathyroid hormone in transgenic mice impairs branching morphogenesis during mammary gland developmentWysolmerski J, McCaughern-Carucci J, Daifotis A, Broadus A, Philbrick W. Overexpression of parathyroid hormone-related protein or parathyroid hormone in transgenic mice impairs branching morphogenesis during mammary gland development. Development 1995, 121: 3539-3547. PMID: 8582268, DOI: 10.1242/dev.121.11.3539.
• Overexpression of parathyroid hormone-related protein in the skin of transgenic mice interferes with hair follicle development.Wysolmerski JJ, Broadus AE, Zhou J, Fuchs E, Milstone LM, Philbrick WM. Overexpression of parathyroid hormone-related protein in the skin of transgenic mice interferes with hair follicle development. Proceedings Of The National Academy Of Sciences Of The United States Of America 1994, 91: 1133-1137. PMID: 7508121, PMCID: PMC521468, DOI: 10.1073/pnas.91.3.1133.
• HYPERCALCEMIA OF MALIGNANCY: The Central Role of Parathyroid Hormone-Related ProteinWysolmerski J, Broadus A. HYPERCALCEMIA OF MALIGNANCY: The Central Role of Parathyroid Hormone-Related Protein. Annual Review Of Medicine 1994, 45: 189-200. PMID: 8198376, DOI: 10.1146/annurev.med.45.1.189.
• Identification and characterization of a GC-rich promoter of the human parathyroid hormone-related peptide gene.Vasavada RC, Wysolmerski JJ, Broadus AE, Philbrick WM. Identification and characterization of a GC-rich promoter of the human parathyroid hormone-related peptide gene. Endocrinology 1993, 7: 273-82. PMID: 8469240, DOI: 10.1210/mend.7.2.8469240.
• Identification of a novel 17,000-dalton parathyroid hormone-like adenylate cyclase-stimulating protein from a tumor associated with humoral hypercalcemia of malignancy.Burtis WJ, Wu T, Bunch C, Wysolmerski JJ, Insogna KL, Weir EC, Broadus AE, Stewart AF. Identification of a novel 17,000-dalton parathyroid hormone-like adenylate cyclase-stimulating protein from a tumor associated with humoral hypercalcemia of malignancy. Journal Of Biological Chemistry 1987, 262: 7151-7156. PMID: 3584110, DOI: 10.1016/s0021-9258(18)48217-8.