Jessica Tuan
MD, MS, AAHIVS
Assistant Professor of Medicine (Infectious Diseases); Affiliated Faculty, Yale Institute for Global Health; Associate Director, Yale Antivirals & Vaccines Research Program, Infectious Diseases
Research & Publications
Biography
News
Research Summary
Dr. Tuan serves as a Principal Investigator for the following Yale School of Medicine research studies: 1) Evaluating Pitavastatin to Reduce Risk of Cardiovascular Disease in HIV-Infected Adults (REPRIEVE) (NIH/ACTG-funded clinical trial), 2) Pfizer mRNA Influenza vaccine clinical trial, 3) ACTG AIDS Clinical Trial Group STOMP Study: Trial of the Safety & Efficacy of Tecovirimat for Treatment of Human Monkeypox Virus Disease (Co-PI): 4) Qualitative Assessment of SARS-CoV-2 Immunogenicity (QUASI) after COVID-19 vaccination in People Living with HIV, 5) Outcomes of Pregnant Women Exposed to Sotrovimab for Treatment of COVID-19 in the Omicron Predominant Era (PRESTO).
She is a Sub-Investigator for the Yale Pfizer/BioNTech (adult, pediatric, booster) & Sanofi COVID-19 vaccine clinical trials. She is a Sub-Investigator for Yale School of Medicine HIV clinical trials: 1) Study to Assess the Effectiveness & Safety of Lenacapavir for HIV Pre-Exposure Prophylaxis (PURPOSE 2); 2) Evaluating the Safety & Efficacy of Bictegravir/Lenacapavir vs. Stable Baseline Regimen in Virologically Suppressed People With HIV-1 on Stable Complex Treatment Regimens, 3) Study of Broadly Neutralizing Antibodies GS-5423 & GS-2872 in Combination With Lenacapavir in Virologically Suppressed Adults With HIV-1. Her other research focus is as a Sub-Investigator for the NIH/NIMH R21 grant "HIV PrEP Perspectives of Liberian Adolescent Girls & Young Women and their Providers," in collaboration with physicians at the John F. Kennedy Medical Center Hospital in Monrovia, Liberia.
Coauthors
Research Interests
HIV; Global Health; COVID-19
Selected Publications
- Pitavastatin to Prevent Cardiovascular Disease in HIV Infection.Grinspoon SK, Fitch KV, Zanni MV, Fichtenbaum CJ, Umbleja T, Aberg JA, Overton ET, Malvestutto CD, Bloomfield GS, Currier JS, Martinez E, Roa JC, Diggs MR, Fulda ES, Paradis K, Wiviott SD, Foldyna B, Looby SE, Desvigne-Nickens P, Alston-Smith B, Leon-Cruz J, McCallum S, Hoffmann U, Lu MT, Ribaudo HJ, Douglas PS, REPRIEVE Investigators. Pitavastatin to Prevent Cardiovascular Disease in HIV Infection. N Engl J Med 2023, 389: 687-699. PMID: 37486775, DOI: 10.1056/NEJMoa2304146.
- Lenacapavir: a twice-yearly treatment for adults with multidrug-resistant HIV infection and limited treatment optionsTuan J, Ogbuagu O. Lenacapavir: a twice-yearly treatment for adults with multidrug-resistant HIV infection and limited treatment options. Expert Review Of Anti-infective Therapy 2023, 21: 565-570. PMID: 37067160, DOI: 10.1080/14787210.2023.2203913.
- HIV risk profile and prevention needs of individuals seeking monkeypox (mpox) vaccination in an urban clinic in the U.S.: a brief reportOgbuagu O, Sharma M, Igiraneza G, Andrews L, Tuan J, Barakat L. HIV risk profile and prevention needs of individuals seeking monkeypox (mpox) vaccination in an urban clinic in the U.S.: a brief report. BMC Infectious Diseases 2023, 23: 146. PMID: 36890468, PMCID: PMC9993362, DOI: 10.1186/s12879-023-08075-5.
- Outcomes of pregnant women exposed to Sotrovimab for the treatment of COVID-19 in the BA.1 Omicron predominant era (PRESTO)Tuan, J.J., Sharma M, Kayani J, Davis M, McManus D, Topal J, Ogbuagu O. Outcomes of pregnant women exposed to Sotrovimab for the treatment of COVID-19 in the BA.1 Omicron predominant era (PRESTO). BMC Infect Dis 23, 258 (April 2023). https://doi.org/10.1186/s12879-023-08198-9
- Acute cytomegalovirus proctitis and epididymitis acquired via sexual transmission in an immunocompetent patient: a case reportOyeyemi, D.M., Chan, E., Montano, M., Belzer, A., Ogbuagu, O., Zapata, H., Tuan J. Acute cytomegalovirus proctitis and epididymitis acquired via sexual transmission in an immunocompetent patient: a case report. J Med Case Reports 17, 489 (2023). https://doi.org/10.1186/s13256-023-04216-1
- Acute kidney injury due to myoglobin cast nephropathy in the setting of coronavirus disease 2019-mediated rhabdomyolysis: a case reportTuan J, Ogbuagu O, Kumar D, Altice F, Fikrig M. Acute kidney injury due to myoglobin cast nephropathy in the setting of coronavirus disease 2019-mediated rhabdomyolysis: a case report. Journal Of Medical Case Reports 2022, 16: 491. PMID: 36578087, PMCID: PMC9795945, DOI: 10.1186/s13256-022-03721-z.
- LB1577. Outcomes of Pregnant Women Exposed to Sotrovimab for the Treatment of COVID-19 in the Omicron Predominant Era (PRESTO)Tuan J, Sharma M, Kayani J, Davis M, McManus D, Topal J, Ogbuagu O. LB1577. Outcomes of Pregnant Women Exposed to Sotrovimab for the Treatment of COVID-19 in the Omicron Predominant Era (PRESTO). Open Forum Infectious Diseases 2022, 9: ofac492.1887. PMCID: PMC9752459, DOI: 10.1093/ofid/ofac492.1887.
- Clinical Outcomes following Dalbavancin Administration in Patients with Barriers to Outpatient Parenteral Antimicrobial TherapyTuan, J., Kayani, J., Fisher, A., Kotansky, B., Dembry, L., & Datta, R. (2022). Clinical outcomes following dalbavancin administration in patients with barriers to outpatient parenteral antimicrobial therapy. Antimicrobial Stewardship & Healthcare Epidemiology, 2(1), E83. doi:10.1017/ash.2022.229
- Important Zoonotic Pandemics and Epidemics of the 21st Century: A Review.Tuan, J. Important Zoonotic Pandemics and Epidemics of the 21st Century: A Review. Advances in Health and Disease, Volume 56, July 2022.
- Long-term Quantitative Assessment of Anti-SARS-CoV-2 Spike Protein Immunogenicity (QUASI) after COVID-19 vaccination in Older People Living with HIVTuan J, Zapata H, Barakat L, Andrews L, Behnegar A, Kim YW, Kayani J, Mutic S, Ryall L, Turcotte B, Critch-Gilfillan T, Zhao, M, Salahuddin S, Gupta S, Sutton R, Friedland, G, Emu, B, Ogbuagu O. Long-term Quantitative Assessment of Anti-SARS-CoV-2 Spike Protein Immunogenicity (QUASI) after COVID-19 vaccination in Older People Living with HIV. BMC Infectious Diseases Journal, 22, 744 (21 September 2022).
- Four Human Cases of Eastern Equine Encephalitis in Connecticut, USA, during a Larger Regional Outbreak, 2019 - Volume 27, Number 8—August 2021 - Emerging Infectious Diseases journal - CDCBrown SC, Cormier J, Tuan J, Lier AJ, McGuone D, Armstrong PM, Kaddouh F, Parikh S, Landry ML, Gobeske KT. Four Human Cases of Eastern Equine Encephalitis in Connecticut, USA, during a Larger Regional Outbreak, 2019 - Volume 27, Number 8—August 2021 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2021, 27: 2042-2051. PMID: 34289334, PMCID: PMC8314835, DOI: 10.3201/eid2708.203730.
- Race and ethnicity do not impact eligibility for remdesivir: A single-center experiencePischel L, Walelo M, Benson J, Osborn R, Schrier R, Tuan J, Barakat L, Ogbuagu O. Race and ethnicity do not impact eligibility for remdesivir: A single-center experience. PLOS ONE 2021, 16: e0250735. PMID: 33956849, PMCID: PMC8101938, DOI: 10.1371/journal.pone.0250735.
- Increasing face-mask compliance among healthcare personnel during the coronavirus disease 2019 (COVID-19) pandemicDatta R, Glenn K, Pellegrino A, Tuan J, Linde B, Kayani J, Patel K, Calo L, Dembry LM, Fisher A. Increasing face-mask compliance among healthcare personnel during the coronavirus disease 2019 (COVID-19) pandemic. Infection Control And Hospital Epidemiology 2021, 43: 616-622. PMID: 33938417, PMCID: PMC8144836, DOI: 10.1017/ice.2021.205.
- A new positive SARS-CoV-2 test months after severe COVID-19 illness: reinfection or intermittent viral shedding?Tuan J, Spichler-Moffarah A, Ogbuagu O. A new positive SARS-CoV-2 test months after severe COVID-19 illness: reinfection or intermittent viral shedding? BMJ Case Reports 2021, 14: e240531. PMID: 33542020, PMCID: PMC8098910, DOI: 10.1136/bcr-2020-240531.
- Four Human Cases of Eastern Equine Encephalitis in Connecticut, USA, during a Larger Regional Outbreak, 2019Brown SC, Cormier J, Tuan J, et al. Four Human Cases of Eastern Equine Encephalitis in Connecticut, USA, during a Larger Regional Outbreak, 2019. Emerging Infectious Diseases. 2021;27(8):2042-2051. doi:10.3201/eid2708.203730
- Qualitative assessment of anti-SARS-CoV-2 spike protein immunogenicity (QUASI) after COVID- 19 vaccination in older people living with HIVTuan JJ, Zapata H, Critch-Gilfillan, T, Ryall L, Turcotte B, Mutic S, Andrews L, Roh M, Friedland G, Barakat L, Ogbuagu O. Qualitative assessment of anti-SARS-CoV-2 spike protein immunogenicity (QUASI) after COVID-19 vaccination in older people living with HIV. HIV Medicine. 2021; 00: 1– 8. doi:10.1111/hiv.13188
- Infectious Diseases as Mimickers of StrokeTuan J, Verma G, Ogbuagu O. "Infectious Diseases as Mimickers of Stroke," Storm Brain. Cardiovascular Research Trust/Hippocrates Initiative. London, UK. November 24, 2021.
- Mycobacterium marinum: nodular hand lesions after a fishing expeditionTuan J, Spichler-Moffarah A, Ogbuagu O. Mycobacterium marinum: nodular hand lesions after a fishing expedition. BMJ Case Reports 2020, 13: e238835. PMID: 33318281, PMCID: PMC7737068, DOI: 10.1136/bcr-2020-238835.
- Case Report: Disseminated Strongyloidiasis in a Patient with COVID-19Lier AJ, Tuan JJ, Davis MW, Paulson N, McManus D, Campbell S, Peaper DR, Topal JE. Case Report: Disseminated Strongyloidiasis in a Patient with COVID-19. American Journal Of Tropical Medicine And Hygiene 2020, 103: 1590-1592. PMID: 32830642, PMCID: PMC7543803, DOI: 10.4269/ajtmh.20-0699.
- Disseminated Cysticercosis in Rwanda—Case Report of a Patient Presenting with Difficulty with Walking and Skin NodulesTuan J, Kailani L, Ngabitsinze P, et al. “Disseminated Cysticercosis in Rwanda—Case Report of a Patient Presenting with Difficulty with Walking and Skin Nodules,” Rwanda Medical Journal, Vol 77, no 2, pp 1-4, 2020.
- When infection and malignancy intersect in Rwanda: A diagnostic challenge in the tropics-Case ReportTuan J, Nkeshimana M, Masaisa F, et al. When infection and malignancy intersect in Rwanda: A diagnostic challenge in the tropics-Case Report. Rwanda Medical Journal, Vol 76, no 4, pp. 1-5, 2019.
- Lab-on-a-chip devices as an emerging platform for stem cell biologyGupta K, Kim DH, Ellison D, Smith C, Kundu A, Tuan J, Suh KY, Levchenko A. Lab-on-a-chip devices as an emerging platform for stem cell biology. Lab On A Chip 2010, 10: 2019-2031. PMID: 20556297, DOI: 10.1039/c004689b.