Jacky Yeung, MD
Research & Publications
Biography
News
Research Summary
Neurosurgeon-scientist capable of strategizing minimally invasive surgical cytoreduction of brain/spinal tumors and developing novel adjuvant therapeutics based on immunogenetic profiling of tumors
Extensive Research Description
1) Tumor immunology: To study how brain tumors evade anti-tumor immunity by exclusion of cytotoxic T cells
2) Functional connectomics: Leverage machine learning to understand the human functional connectome during health and disease and to facilitate connectome-based interventional neurorehabilitation (transcranial magnetic stimulation)
Coauthors
Research Interests
Central Nervous System Diseases; Cranial Nerve Neoplasms; Craniocerebral Trauma; Spinal Cord Compression; Spinal Cord Injuries; Spinal Cord Neoplasms; Cerebrovascular Trauma; Trochlear Nerve Diseases; Spinal Cord Vascular Diseases; Peripheral Nerve Injuries
Selected Publications
- Topology of the lateral visual system: The fundus of the superior temporal sulcus and parietal area H connect nonvisual cerebrum to the lateral occipital lobeDadario N, Tanglay O, Stafford J, Davis E, Young I, Fonseka R, Briggs R, Yeung J, Teo C, Sughrue M. Topology of the lateral visual system: The fundus of the superior temporal sulcus and parietal area H connect nonvisual cerebrum to the lateral occipital lobe. Brain And Behavior 2023, 13: e2945. PMID: 36912573, PMCID: PMC10097165, DOI: 10.1002/brb3.2945.
- Connectivity model of the anatomic substrates and network abnormalities in major depressive disorder: A coordinate meta-analysis of resting-state functional connectivityYoung I, Dadario N, Tanglay O, Chen E, Cook B, Taylor H, Crawford L, Yeung J, Nicholas P, Doyen S, Sughrue M. Connectivity model of the anatomic substrates and network abnormalities in major depressive disorder: A coordinate meta-analysis of resting-state functional connectivity. Journal Of Affective Disorders Reports 2023, 11: 100478. DOI: 10.1016/j.jadr.2023.100478.
- Delayed, Progressive Multivessel Occlusion After Resection of a Recurrent GliomaTanglay O, Dadario N, Young I, Yeung J, Teo C, Sughrue M, Yeung J. Delayed, Progressive Multivessel Occlusion After Resection of a Recurrent Glioma. Cureus 2022, 14: e33019. PMID: 36721529, PMCID: PMC9879796, DOI: 10.7759/cureus.33019.
- NCOG-46. PERSONALIZED, PARCEL-GUIDED RTMS FOR NEURO-REHABILITATION AFTER TUMOR NEUROSURGERY: SAFETY AND PROOF OF CONCEPTYeung J, Tang J, Holle J, Teo C, Sughrue M. NCOG-46. PERSONALIZED, PARCEL-GUIDED RTMS FOR NEURO-REHABILITATION AFTER TUMOR NEUROSURGERY: SAFETY AND PROOF OF CONCEPT. Neuro-Oncology 2022, 24: vii207-vii208. DOI: 10.1093/neuonc/noac209.797.
- Improving quality of life post-tumor craniotomy using personalized, parcel-guided TMS: safety and proof of conceptTang S, Holle J, Lesslar O, Teo C, Sughrue M, Yeung J. Improving quality of life post-tumor craniotomy using personalized, parcel-guided TMS: safety and proof of concept. Journal Of Neuro-Oncology 2022, 160: 413-422. PMID: 36308593, DOI: 10.1007/s11060-022-04160-y.
- A connectivity model of the anatomic substrates underlying Gerstmann syndromeShahab Q, Young I, Dadario N, Tanglay O, Nicholas P, Lin Y, Fonseka R, Yeung J, Bai M, Teo C, Doyen S, Sughrue M. A connectivity model of the anatomic substrates underlying Gerstmann syndrome. Brain Communications 2022, 4: fcac140. PMID: 35706977, PMCID: PMC9189613, DOI: 10.1093/braincomms/fcac140.
- Surgical treatment of symptomatic pineal cysts without hydrocephalus—meta-analysis of the published literatureMasina R, Ansaripour A, Beneš V, Berhouma M, Choque-Velasquez J, Eide P, Fedorko S, Fleck S, Hernesniemi J, Koziarski A, Májovský M, Podgorski A, Schroeder H, Teo C, Unterberg A, Yeung J, Kolias A, Santarius T. Surgical treatment of symptomatic pineal cysts without hydrocephalus—meta-analysis of the published literature. Acta Neurochirurgica 2021, 164: 61-77. PMID: 34854993, PMCID: PMC8761144, DOI: 10.1007/s00701-021-05054-0.
- Changes in the Brain Connectome Following Repetitive Transcranial Magnetic Stimulation for Stroke RehabilitationYeung J, Young I, Doyen S, Teo C, Sughrue M, Yeung J. Changes in the Brain Connectome Following Repetitive Transcranial Magnetic Stimulation for Stroke Rehabilitation. Cureus 2021, 13: e19105. PMID: 34858752, PMCID: PMC8614179, DOI: 10.7759/cureus.19105.
- Reducing the Cognitive Footprint of Brain Tumor SurgeryDadario NB, Brahimaj B, Yeung J, Sughrue ME. Reducing the Cognitive Footprint of Brain Tumor Surgery. Frontiers In Neurology 2021, 12: 711646. PMID: 34484105, PMCID: PMC8415405, DOI: 10.3389/fneur.2021.711646.
- Using Quicktome for Intracerebral Surgery: Early Retrospective Study and Proof of ConceptYeung JT, Taylor HM, Nicholas PJ, Young IM, Jiang I, Doyen S, Sughrue ME, Teo C. Using Quicktome for Intracerebral Surgery: Early Retrospective Study and Proof of Concept. World Neurosurgery 2021, 154: e734-e742. PMID: 34358688, DOI: 10.1016/j.wneu.2021.07.127.
- Optimal timing of post-operative enoxaparin after neurosurgery: A single institution experienceBriggs RG, Lin YH, Dadario NB, Young IM, Conner AK, Xu W, Tanglay O, Kim SJ, Fonseka RD, Bonney PA, Chakraborty AR, Nix CE, Flecher LR, Yeung JT, Teo C, Sughrue ME. Optimal timing of post-operative enoxaparin after neurosurgery: A single institution experience. Clinical Neurology And Neurosurgery 2021, 207: 106792. PMID: 34233235, DOI: 10.1016/j.clineuro.2021.106792.
- A connectivity model of the anatomic substrates underlying ideomotor apraxia: A meta-analysis of functional neuroimaging studiesO'Neal CM, Ahsan SA, Dadario NB, Fonseka RD, Young IM, Parker A, Maxwell BD, Yeung JT, Briggs RG, Teo C, Sughrue ME. A connectivity model of the anatomic substrates underlying ideomotor apraxia: A meta-analysis of functional neuroimaging studies. Clinical Neurology And Neurosurgery 2021, 207: 106765. PMID: 34237682, DOI: 10.1016/j.clineuro.2021.106765.
- Targeting the CSF1/CSF1R axis is a potential treatment strategy for malignant meningiomas.Yeung J, Yaghoobi V, Miyagishima D, Vesely MD, Zhang T, Badri T, Nassar A, Han X, Sanmamed MF, Youngblood M, Peyre M, Kalamarides M, Rimm DL, Gunel M, Chen L. Targeting the CSF1/CSF1R axis is a potential treatment strategy for malignant meningiomas. Neuro-Oncology 2021, 23: 1922-1935. PMID: 33914067, PMCID: PMC8563319, DOI: 10.1093/neuonc/noab075.
- Resection of Symptomatic Pineal Cysts Provides Durable Clinical Improvement: A Breakdown of Presenting Symptoms and Lessons LearnedYeung JT, Young IM, Profyris C, Katsos K, Sughrue ME, Teo C. Resection of Symptomatic Pineal Cysts Provides Durable Clinical Improvement: A Breakdown of Presenting Symptoms and Lessons Learned. World Neurosurgery 2021, 150: e668-e674. PMID: 33771749, DOI: 10.1016/j.wneu.2021.03.087.
- Aggressive Progression of a WHO Grade I Meningioma of the Posterior Clinoid Process: An Illustration of the Risks Associated With Observation of Skull Base MeningiomasYoung IM, Yeung J, Glenn C, Teo C, Sughrue ME. Aggressive Progression of a WHO Grade I Meningioma of the Posterior Clinoid Process: An Illustration of the Risks Associated With Observation of Skull Base Meningiomas. Cureus 2021, 13: e14005. PMID: 33884246, PMCID: PMC8054942, DOI: 10.7759/cureus.14005.
- Radical Exenteration of the Skull Base for End-Stage, Locally Advanced Sinonasal Malignancies: Challenging the Dictum of UnresectabilityYeung JT, Caminer DM, Young IM, Sughrue ME, Teo C. Radical Exenteration of the Skull Base for End-Stage, Locally Advanced Sinonasal Malignancies: Challenging the Dictum of Unresectability. World Neurosurgery 2021, 150: e102-e107. PMID: 33647490, DOI: 10.1016/j.wneu.2021.02.092.
- Spatially Resolved and Quantitative Analysis of the Immunological Landscape in Human Meningiomas.Yeung J, Yaghoobi V, Aung TN, Vesely MD, Zhang T, Gaule P, Gunel M, Rimm DL, Chen L. Spatially Resolved and Quantitative Analysis of the Immunological Landscape in Human Meningiomas. Journal Of Neuropathology & Experimental Neurology 2021, 80: 150-159. PMID: 33393633, DOI: 10.1093/jnen/nlaa152.
- Anatomy and White Matter Connections of the Parahippocampal GyrusLin YH, Dhanaraj V, Mackenzie AE, Young IM, Tanglay O, Briggs RG, Chakraborty AR, Hormovas J, Fonseka RD, Kim SJ, Yeung JT, Teo C, Sughrue ME. Anatomy and White Matter Connections of the Parahippocampal Gyrus. World Neurosurgery 2021, 148: e218-e226. PMID: 33412321, DOI: 10.1016/j.wneu.2020.12.136.
- In Silico Analysis of the Immunological Landscape of Pituitary AdenomasYeung J, Vesely M, Miyagishima D. In Silico Analysis of the Immunological Landscape of Pituitary Adenomas. Neurosurgery 2020, 67 DOI: 10.1093/neuros/nyaa447_813.
- In Silico Analysis of Changes in Immunological Landscape During Malignant Transformation of IDH-mutant Low-grade GliomasYeung J, Vesely M, Antonios J, Miyagishima D. In Silico Analysis of Changes in Immunological Landscape During Malignant Transformation of IDH-mutant Low-grade Gliomas. Neurosurgery 2020, 67 DOI: 10.1093/neuros/nyaa447_835.
- Unexpected hubness: a proof-of-concept study of the human connectome using pagerank centrality and implications for intracerebral neurosurgeryYeung JT, Taylor HM, Young IM, Nicholas PJ, Doyen S, Sughrue ME. Unexpected hubness: a proof-of-concept study of the human connectome using pagerank centrality and implications for intracerebral neurosurgery. Journal Of Neuro-Oncology 2020, 151: 249-256. PMID: 33170473, DOI: 10.1007/s11060-020-03659-6.
- The Surgical Resection of Brainstem Glioma: Outcomes and Prognostic FactorsFaulkner H, Arnaout O, Hoshide R, Young IM, Yeung JT, Sughrue ME, Teo C. The Surgical Resection of Brainstem Glioma: Outcomes and Prognostic Factors. World Neurosurgery 2020, 146: e639-e650. PMID: 33152495, DOI: 10.1016/j.wneu.2020.10.147.
- Clinical and economic burden of neurofibromatosis type 2 in the United StatesKoo AB, Yeung JT, Freedman IG, Lee JH, Ahmed OM, Ma AK, Miyagishima DF, DiLuna M, Kahle K. Clinical and economic burden of neurofibromatosis type 2 in the United States. Clinical Neurology And Neurosurgery 2020, 197: 106053. PMID: 32683193, DOI: 10.1016/j.clineuro.2020.106053.
- Does neurofibromatosis 1 status impact outcomes for pediatric/young adults undergoing spinal fusion?Freedman I, Koo A, Yeagle E, Diluna M, Kolb L, Yeung J. Does neurofibromatosis 1 status impact outcomes for pediatric/young adults undergoing spinal fusion? Surgical Neurology International 2020, 11: 60. PMID: 32363055, PMCID: PMC7193189, DOI: 10.25259/sni_39_2020.
- In silico analysis of the immunological landscape of pituitary adenomasYeung JT, Vesely MD, Miyagishima DF. In silico analysis of the immunological landscape of pituitary adenomas. Journal Of Neuro-Oncology 2020, 147: 595-598. PMID: 32236778, PMCID: PMC7261241, DOI: 10.1007/s11060-020-03476-x.
- Tumor Location and Treatment Modality are Associated with Overall Survival in Adult MedulloblastomaK A, Freedman I, Lee JH, Miyagishima D, Ahmed O, Yeung J. Tumor Location and Treatment Modality are Associated with Overall Survival in Adult Medulloblastoma. Cureus 2020, 12: e7061. PMID: 32226663, PMCID: PMC7089624, DOI: 10.7759/cureus.7061.
- High-Resolution Vessel Wall MRI in Ruptured Cranial Dural Arteriovenous FistulasSommaruga S, Cord B, Santarosa C, Yeung J, Johnson M, Hebert R, Bijlenga P, Schaller K, Matouk C. High-Resolution Vessel Wall MRI in Ruptured Cranial Dural Arteriovenous Fistulas. Journal Of Neurological Surgery Part A Central European Neurosurgery 2018, 79: s1-s27. DOI: 10.1055/s-0038-1660759.
- E-050 First-Line Treatment by Embolization with Intention-to-Cure in the Management of Cranial Dural Arteriovenous FistulasCord B, Sommaruga S, Yeung J, Johnson M, Matouk C. E-050 First-Line Treatment by Embolization with Intention-to-Cure in the Management of Cranial Dural Arteriovenous Fistulas. Journal Of NeuroInterventional Surgery 2016, 8: a70. DOI: 10.1136/neurintsurg-2016-012589.122.
- Macrovascular Lesions Underlying Spontaneous Intracerebral HemorrhageYeung J, Cord BJ, O'Rourke TK, Maina RM, Sommaruga S, Matouk CC. Macrovascular Lesions Underlying Spontaneous Intracerebral Hemorrhage. Seminars In Neurology 2016, 36: 244-253. PMID: 27214699, DOI: 10.1055/s-0036-1581994.
- High-resolution Vessel Wall Magnetic Resonance Imaging in Intracranial Aneurysms and Brain Arteriovenous MalformationsMatouk CC, Cord BJ, Yeung J, Malhotra A, Johnson MH, Minja FJ. High-resolution Vessel Wall Magnetic Resonance Imaging in Intracranial Aneurysms and Brain Arteriovenous Malformations. Topics In Magnetic Resonance Imaging 2016, 25: 49-55. PMID: 27049241, DOI: 10.1097/rmr.0000000000000084.
- Impact of Deferring Radiation Therapy in Patients With Epidermal Growth Factor Receptor–Mutant Non-Small Cell Lung Cancer Who Develop Brain MetastasesMagnuson WJ, Yeung JT, Guillod PD, Gettinger SN, Yu JB, Chiang VL. Impact of Deferring Radiation Therapy in Patients With Epidermal Growth Factor Receptor–Mutant Non-Small Cell Lung Cancer Who Develop Brain Metastases. International Journal Of Radiation Oncology • Biology • Physics 2016, 95: 673-679. PMID: 27034176, DOI: 10.1016/j.ijrobp.2016.01.037.
- Neurovascular SurgeryAbdulrauf S, Abla A, Adel J, Albuquerque F, Alderazi Y, Alexander M, Al-Mefty O, Almefty K, Almefty R, de Almeida J, Amin-Hanjani S, Aoun S, Arthur A, Ashour R, Awad I, Aziz-Sultan M, Barrow D, Batjer H, Bauer A, Bäzner H, Becske T, Bendok B, Bertalanffy H, Bhardwaj G, Bjerregaard J, Bookland M, Brorson J, Brott T, Bruneau M, Guilherme J, Caldas M, Campero A, Carrau R, Case D, Cavalcanti D, Cawley C, Chaddad F, Chalouhi N, Chang S, Robert C, Powell J, Charbel F, Chen F, Cheshire W, Chitale R, Chowdhry S, Chowdhary A, Connolly E, Cook D, Coon A, Crowley R, Dannenbaum M, David C, Day A, de Oliveira E, Dempsey R, Dey M, Dlouhy B, van Doormaal T, Dorsey C, Ducruet A, Dumont A, Dumont T, Eddleman C, Ahmadieh T, Elhammady M, Eller J, Ellis J, Elsharkawy A, Tecle N, Esquenazi Y, Fairhall J, Ferreira M, Ferreira M, Ferreira R, Fiorella D, Flexman A, Flickinger J, Fox B, Francis I, Freeman W, Frösen J, Frudit M, Fukushima T, George B, Gerganov V, Ghiassi M, Ghiassi M, Ghodke B, Giannotta S, Goldstein H, González L, Gooderham P, Gupta G, Hakma Z, Hanel R, Hayes S, Heiserman J, Henkes H, Hernesniemi J, Heros R, Higashida R, Hoh B, Hopf N, Hopkins L, Howard J, Huang J, Jabbour P, Jaffe R, Jannetta P, Kalani M, Yashar M, Kalani S, Kalb S, Kano H, Karim S, Kassam A, Kim J, Kim L, Kivisaari R, Kondziolka D, Kondziolka D, Korja M, Krisht A, Kumar G, Kushel Y, Laakso A, Lansberg M, Lanzino G, Lawton M, Lee J, Lee J, Lee S, Lehecka M, Lehto H, Levitt M, Levy E, Little A, Liu S, Loftus C, Lorenzo J, Lunsford L, Mack W, Mai J, Malone H, Martinez R, McDougall C, McLaughlin N, Mendelow A, Mendes G, Meyer F, Meyers P, Miller D, Mirzadeh Z, Mocco J, Mokin M, Morcos J, Musahl C, Nakaji P, Nanney A, Nelson P, Niemelä M, Nussbaum E, Ogilvy C, Oppenlander M, Osbun J, Pacione D, Paterno V, Perez M, Pérez-Orribo L, Maria P, Potts M, Pouleau H, Prevedello D, Puglia P, Rabinstein A, Leonardo R, Raz E, Regli L, Reynolds M, Rhoton A, Riina H, Ana R, Romani R, Rosenwasser R, Rubino P, Russin J, Ryan R, Samson S, Savitz S, Schirmer C, Schramm J, Schuette A, Sekhar L, Shapiro M, Shetty V, Siddiqui A, Simon M, Singh P, Snyder K, Solomon R, Soltys S, Sorkin G, Spetzler R, Steinberg G, Stofko D, Sweeney J, Talke P, Tamargo R, Tariq F, Taussky P, Tawk R, Teleb M, Teo C, Tjoumakaris S, Tulleken C, Tymianski M, Cristian V, van der Zwan A, van Loveren H, Vance A, Veznedaroglu E, von der Brelie C, Walcott B, Wang M, Watanabe K, Weissbach C, Welch B, White W, Shawn E, Yapicilar B, Yeung J, Yonekawa Y, Yonekawa Y, Youssef A, Zabramski J, Zaidi H, Zipfel G, Zuckerman S, Zumofen D. Neurovascular Surgery. 2015 DOI: 10.1055/b-003-122312.
- Endovascular Revascularization for Basilar Artery OcclusionYeung JT, Matouk CC, Bulsara KR, Sheth KN. Endovascular Revascularization for Basilar Artery Occlusion. Interventional Neurology 2014, 3: 31-40. PMID: 25999990, PMCID: PMC4436532, DOI: 10.1159/000368968.
- Hemifacial Spasm and Neurovascular CompressionLu AY, Yeung JT, Gerrard JL, Michaelides EM, Sekula RF, Bulsara KR. Hemifacial Spasm and Neurovascular Compression. The Scientific World JOURNAL 2014, 2014: 349319. PMID: 25405219, PMCID: PMC4227371, DOI: 10.1155/2014/349319.
- Radiosurgery for spinal arteriovenous malformations and fistulaeKarim S, Yeung J, Soltys S, Chang S. Radiosurgery for spinal arteriovenous malformations and fistulae. 2014, 288-294. DOI: 10.1017/cbo9781139523943.026.
- Multi-Session Radiosurgery of Benign Intracranial TumorsYeung JT, Karim SA, Chang SD. Multi-Session Radiosurgery of Benign Intracranial Tumors. Neurosurgery Clinics Of North America 2013, 24: 543-551. PMID: 24093572, DOI: 10.1016/j.nec.2013.06.003.
- LOH in the HLA Class I Region at 6p21 Is Associated with Shorter Survival in Newly Diagnosed Adult GlioblastomaYeung JT, Hamilton RL, Ohnishi K, Ikeura M, Potter DM, Nikiforova MN, Ferrone S, Jakacki RI, Pollack IF, Okada H. LOH in the HLA Class I Region at 6p21 Is Associated with Shorter Survival in Newly Diagnosed Adult Glioblastoma. Clinical Cancer Research 2013, 19: 1816-1826. PMID: 23401227, PMCID: PMC3618546, DOI: 10.1158/1078-0432.ccr-12-2861.
- Effect of cocaine use on outcomes in traumatic brain injuryYeung JT, Williams J, Bowling WM. Effect of cocaine use on outcomes in traumatic brain injury. Journal Of Emergencies Trauma And Shock 2013, 6: 189-194. PMID: 23960376, PMCID: PMC3746441, DOI: 10.4103/0974-2700.115337.
- Increased expression of tumor-associated antigens in pediatric and adult ependymomas: implication for vaccine therapyYeung JT, Hamilton RL, Okada H, Jakacki RI, Pollack IF. Increased expression of tumor-associated antigens in pediatric and adult ependymomas: implication for vaccine therapy. Journal Of Neuro-Oncology 2012, 111: 103-111. PMID: 23179498, PMCID: PMC3546121, DOI: 10.1007/s11060-012-0998-x.
- Pegylated interferon-α-2b for children with recurrent craniopharyngioma.Yeung JT, Pollack IF, Panigrahy A, Jakacki RI. Pegylated interferon-α-2b for children with recurrent craniopharyngioma. Journal Of Neurosurgery Pediatrics 2012, 10: 498-503. PMID: 23061825, DOI: 10.3171/2012.9.peds12225.
- Optic pathway glioma as part of a constitutional mismatch‐repair deficiency syndrome in a patient meeting the criteria for neurofibromatosis type 1Yeung JT, Pollack IF, Shah S, Jaffe R, Nikiforova M, Jakacki RI. Optic pathway glioma as part of a constitutional mismatch‐repair deficiency syndrome in a patient meeting the criteria for neurofibromatosis type 1. Pediatric Blood & Cancer 2012, 60: 137-139. PMID: 22848017, DOI: 10.1002/pbc.24254.
- Cervical disc herniation presenting with neck pain and contralateral symptoms: a case reportYeung JT, Johnson JI, Karim AS. Cervical disc herniation presenting with neck pain and contralateral symptoms: a case report. Journal Of Medical Case Reports 2012, 6: 166. PMID: 22741922, PMCID: PMC3411405, DOI: 10.1186/1752-1947-6-166.
- Intracranial parafalcine chondroma in a pregnant patientYeung JT, Krznarich TS, Moreno EA, Mukkamala A, Karim AS. Intracranial parafalcine chondroma in a pregnant patient. Surgical Neurology International 2012, 3: 44. PMID: 22574253, PMCID: PMC3347491, DOI: 10.4103/2152-7806.94930.
- Positive Serum Cocaine Level and Mortality in Traumatic Brain InjuryYeung J, Williams J, Bowling W. Positive Serum Cocaine Level and Mortality in Traumatic Brain Injury. Journal Of Surgical Research 2012, 172: 348. DOI: 10.1016/j.jss.2011.11.964.
- Complete spinal cord transection from a stab wound with surgical precisionYeung J, Karim A. Complete spinal cord transection from a stab wound with surgical precision. Journal Of Emergencies Trauma And Shock 2012, 5: 204. PMID: 22787358, PMCID: PMC3391852, DOI: 10.4103/0974-2700.96503.
- Familial glioblastoma: A case report of glioblastoma in two brothers and review of literatureUgonabo I, Bassily N, Beier A, Yeung JT, Hitchcock L, De Mattia F, Karim A. Familial glioblastoma: A case report of glioblastoma in two brothers and review of literature. Surgical Neurology International 2011, 2: 153. PMID: 22140638, PMCID: PMC3228386, DOI: 10.4103/2152-7806.86833.
- Tectal plate glioblastoma multiformeNemer MD, Blight C, Yeung JT, Fram KM, Karim AS. Tectal plate glioblastoma multiforme. Surgical Neurology International 2011, 2: 101. PMID: 21811707, PMCID: PMC3144597, DOI: 10.4103/2152-7806.83025.