Huaxin Yu, PhD
Postdoctoral Associate
Research & Publications
Biography
Research Summary
In the Liu Lab, Dr. Yu uses cryo-electron tomography (cryo-ET) as a major tool to determine high-resolution in-situ structures of large macromolecular complexes. Combined with extensive experience gained at Okayama University and the University of Hyogo in biochemistry, single particle cryo-electron microscopy (cryo-EM), and bioinformatics, he aims to develop a high-throughput cryo-ET workflow at Yale that advances diverse projects addressing fundamental biological questions.
Research Interests
Electronic Data Processing; Microbiology; Programming Languages; Tomography; Molecular Structure; Cryoelectron Microscopy; Informatics
Selected Publications
- Excited-state intermediates in a designer protein encoding a phototrigger caught by an X-ray free-electron laser.Liu X, Liu P, Li H, Xu Z, Jia L, Xia Y, Yu M, Tang W, Zhu X, Chen C, Zhang Y, Nango E, Tanaka R, Luo F, Kato K, Nakajima Y, Kishi S, Yu H, Matsubara N, Owada S, Tono K, Iwata S, Yu LJ, Shen JR, Wang J. Excited-state intermediates in a designer protein encoding a phototrigger caught by an X-ray free-electron laser. Nature Chemistry 2022, 14: 1054-1060. PMID: 35851837, DOI: 10.1038/s41557-022-00992-3.
- Cryo-EM structure of monomeric photosystem II at 2.78 Å resolution reveals factors important for the formation of dimer.Yu H, Hamaguchi T, Nakajima Y, Kato K, Kawakami K, Akita F, Yonekura K, Shen JR. Cryo-EM structure of monomeric photosystem II at 2.78 Å resolution reveals factors important for the formation of dimer. Biochimica Et Biophysica Acta. Bioenergetics 2021, 1862: 148471. PMID: 34216574, DOI: 10.1016/j.bbabio.2021.148471.