Huafeng Wang
Associate Research Scientist in Pharmacology
Research & Publications
Biography
Coauthors
Selected Publications
- A CUG-initiated CATSPERθ functions in the CatSper channel assembly and serves as a checkpoint for flagellar traffickingHuang X, Miyata H, Wang H, Mori G, Iida-Norita R, Ikawa M, Percudani R, Chung J. A CUG-initiated CATSPERθ functions in the CatSper channel assembly and serves as a checkpoint for flagellar trafficking. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2304409120. PMID: 37725640, PMCID: PMC10523455, DOI: 10.1073/pnas.2304409120.
- Widespread association of the Argonaute protein AGO2 with meiotic chromatin suggests a distinct nuclear function in mammalian male reproductionGriffin KN, Walters BW, Li H, Wang H, Biancon G, Tebaldi T, Kaya CB, Kanyo J, Lam TT, Cox AL, Halene S, Chung JJ, Lesch BJ. Widespread association of the Argonaute protein AGO2 with meiotic chromatin suggests a distinct nuclear function in mammalian male reproduction. Genome Research 2022, 32: 1655-1668. PMID: 36109149, PMCID: PMC9528986, DOI: 10.1101/gr.276578.122.
- Selenoprotein TXNRD3 supports male fertility via the redox regulation of spermatogenesisDou Q, Turanov AA, Mariotti M, Hwang JY, Wang H, Lee SG, Paulo JA, Yim SH, Gygi SP, Chung JJ, Gladyshev VN. Selenoprotein TXNRD3 supports male fertility via the redox regulation of spermatogenesis. Journal Of Biological Chemistry 2022, 298: 102183. PMID: 35753352, PMCID: PMC9352919, DOI: 10.1016/j.jbc.2022.102183.
- 3D structure and in situ arrangements of CatSper channel in the sperm flagellumZhao Y, Wang H, Wiesehoefer C, Shah NB, Reetz E, Hwang JY, Huang X, Wang TE, Lishko PV, Davies KM, Wennemuth G, Nicastro D, Chung JJ. 3D structure and in situ arrangements of CatSper channel in the sperm flagellum. Nature Communications 2022, 13: 3439. PMID: 35715406, PMCID: PMC9205950, DOI: 10.1038/s41467-022-31050-8.
- Redox regulation by TXNRD3 during epididymal maturation underlies capacitation-associated mitochondrial activity and sperm motility in miceWang H, Dou Q, Jeong KJ, Choi J, Gladyshev VN, Chung JJ. Redox regulation by TXNRD3 during epididymal maturation underlies capacitation-associated mitochondrial activity and sperm motility in mice. Journal Of Biological Chemistry 2022, 298: 102077. PMID: 35643315, PMCID: PMC9218152, DOI: 10.1016/j.jbc.2022.102077.
- C2cd6-encoded CatSperτ targets sperm calcium channel to Ca2+ signaling domains in the flagellar membraneHwang JY, Wang H, Lu Y, Ikawa M, Chung JJ. C2cd6-encoded CatSperτ targets sperm calcium channel to Ca2+ signaling domains in the flagellar membrane. Cell Reports 2022, 38: 110226. PMID: 34998468, PMCID: PMC8857959, DOI: 10.1016/j.celrep.2021.110226.
- Mitochondria–cytoskeleton interactions in mammalian sperm revealed by cryoelectron tomographyWang H, Chung JJ. Mitochondria–cytoskeleton interactions in mammalian sperm revealed by cryoelectron tomography. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2118020118. PMID: 34819381, PMCID: PMC8640839, DOI: 10.1073/pnas.2118020118.
- Physiologically detectable bisphenol A impairs human sperm functions by reducing protein-tyrosine phosphorylationLi N, Kang H, Peng Z, Wang H, Weng S, Zeng X. Physiologically detectable bisphenol A impairs human sperm functions by reducing protein-tyrosine phosphorylation. Ecotoxicology And Environmental Safety 2021, 221: 112418. PMID: 34146982, DOI: 10.1016/j.ecoenv.2021.112418.
- Genetic Defects in DNAH2 Underlie Male Infertility With Multiple Morphological Abnormalities of the Sperm Flagella in Humans and MiceHwang JY, Nawaz S, Choi J, Wang H, Hussain S, Nawaz M, Lopez-Giraldez F, Jeong K, Dong W, Oh JN, Bilguvar K, Mane S, Lee CK, Bystroff C, Lifton RP, Ahmad W, Chung JJ. Genetic Defects in DNAH2 Underlie Male Infertility With Multiple Morphological Abnormalities of the Sperm Flagella in Humans and Mice. Frontiers In Cell And Developmental Biology 2021, 9: 662903. PMID: 33968937, PMCID: PMC8103034, DOI: 10.3389/fcell.2021.662903.
- Sperm ion channels and transporters in male fertility and infertilityWang H, McGoldrick LL, Chung JJ. Sperm ion channels and transporters in male fertility and infertility. Nature Reviews Urology 2020, 18: 46-66. PMID: 33214707, PMCID: PMC7852504, DOI: 10.1038/s41585-020-00390-9.
- A novel copy number variation in CATSPER2 causes idiopathic male infertility with normal semen parameters.Luo T, Chen H, Zou Q, Wang T, Cheng Y, Wang H, Wang F, Jin Z, Chen Y, Weng S, Zeng X. A novel copy number variation in CATSPER2 causes idiopathic male infertility with normal semen parameters. Human Reproduction 2019, 34: 414-423. PMID: 30629171, DOI: 10.1093/humrep/dey377.
- Exposure to Cadmium Impairs Sperm Functions by Reducing CatSper in MiceWang H, Chang M, Peng T, Yang Y, Li N, Luo T, Cheng Y, Zhou M, Zeng X, Zheng L. Exposure to Cadmium Impairs Sperm Functions by Reducing CatSper in Mice. Cellular Physiology And Biochemistry 2017, 42: 44-54. PMID: 28554186, DOI: 10.1159/000477113.
- Diethylstilbestrol activates CatSper and disturbs progesterone actions in human spermatozoa.Zou Q, Peng Z, Zhao Q, Chen H, Cheng Y, Liu Q, He Y, Weng S, Wang H, Wang T, Zheng L, Luo T. Diethylstilbestrol activates CatSper and disturbs progesterone actions in human spermatozoa. Human Reproduction 2016, 32: 290-298. PMID: 28031325, DOI: 10.1093/humrep/dew332.
- Bisphenol A Impairs Mature Sperm Functions by a CatSper-Relevant Mechanism.Wang H, Liu M, Li N, Luo T, Zheng L, Zeng X. Bisphenol A Impairs Mature Sperm Functions by a CatSper-Relevant Mechanism. Toxicological Sciences 2016, 152: 145-54. PMID: 27125968, DOI: 10.1093/toxsci/kfw070.
- Matrine compromises mouse sperm functions by a [Ca2+]i-related mechanismLuo T, Zou Q, He Y, Wang H, Wang T, Liu M, Chen Y, Wang B. Matrine compromises mouse sperm functions by a [Ca2+]i-related mechanism. Reproductive Toxicology 2016, 60: 69-75. PMID: 26867864, DOI: 10.1016/j.reprotox.2016.02.003.
- Matrine Inhibits Mouse Sperm Function by Reducing Sperm [Ca2+]i and Phospho-ERK1/2Luo T, Zou Q, He Y, Wang H, Li N, Zeng X. Matrine Inhibits Mouse Sperm Function by Reducing Sperm [Ca2+]i and Phospho-ERK1/2. Cellular Physiology And Biochemistry 2015, 35: 374-385. PMID: 25591778, DOI: 10.1159/000369703.
- Sperm-specific ion channels: targets holding the most potential for male contraceptives in developmentZheng L, Wang H, Li B, Zeng X. Sperm-specific ion channels: targets holding the most potential for male contraceptives in development. Contraception 2013, 88: 485-491. PMID: 23845210, DOI: 10.1016/j.contraception.2013.06.002.